Darius J. Devlin

Baylor College of Medicine | BCM · Department of Pathology & Immunology

Objective To evaluate the feasibility of generating a center-specific embryo morphokinetic algorithm by time-lapse microscopy to predict clinical pregnancy rate. Design Retrospective cohort analysis Setting Academic fertility clinic in a tertiary hospital setting Patients Patients who underwent in vitro fertilization with embryos that underwent...

As the world population continues to increase to unsustainable levels, the importance of birth control and the development of new contraceptives are emerging. To date, male contraceptive options have been lagging behind those available to women, and those few options available are not satisfactory to everyone. To solve this problem, we have been se...

Developing a safe and effective male contraceptive remains a challenge in the field of medical science. Molecules that selectively target the male reproductive tract and whose targets are indispensable for male reproductive function serve among the best candidates for a novel non-hormonal male contraceptive method. To determine the function of thes...

CRISPR/Cas9-based genome editing in mice uncovers 13 testis-or epididymis-enriched genes individually dispensable for male reproduction Running title: Genome editing reveals dispensable testis-and epididymis-enriched genes Summary sentence: Thirteen testis-or epididymis-enriched genes are individually dispensable for male fertility based on phenoty...

Family with sequence similarity 170 members A and B (FAM170A and FAM170B) are two testis-specific, paralogous proteins that share 31% amino acid identity and are conserved throughout mammals. While in vitro experiments in previous literature suggested that FAM170B, an acrosome-localized protein, plays a role in the mouse sperm acrosome reaction and...

ECF systems are new transporters that take up various vitamins, cobalt, or nickel with a high affinity. Here, we establish the GAS SiaFGH proteins as a new ECF module that imports heme and demonstrate its importance in virulence. SiaFGH is the first heme ECF system described in bacteria. We identified homologous systems in the genomes of related pa...

Globozoospermia (sperm with an abnormally round head shape) and asthenozoospermia (defective sperm motility) are known causes of male infertility in human patients. Despite many studies, the molecular details of the globozoospermia etiology are still poorly understood. Serine-rich single pass membrane protein 1 (Ssmem1) is a conserved testis-specif...

Receptor accessory protein 6 (REEP6) is a member of the REEP/Ypt-interacting protein (Yip) family that we recently identified as essential for normal endoplasmic reticulum (ER) homeostasis and protein trafficking in the retina of mice and humans. Interestingly, in addition to the loss of REEP6 in our knockout (KO) mouse model recapitulating the ret...

Background Spermatozoa become competent for fertilization during transit through the epididymis. As spermatozoa from the proximal caudal epididymis can fertilize eggs, proteins from the caput and corpus epididymis are required for sperm maturation. Objectives Microarray analysis identified that more than 17,000 genes are expressed in the epididymi...