Darío R. Quiñones Colomer

• PhD in Technologies for Health and Well-Being
• PhD at Polytechnic University of Valencia

Introduction Functional magnetic resonance imaging (fMRI) is one of the most highly regarded techniques in the neuroimaging field. This technique is based on vascular responses to neuronal activation and is extensively used in clinical and animal research studies. In preclinical settings, fMRI is usually applied to anesthetized animals. However, an...

Neuroscience is a field that covers many specialties. The objective of this thesis is to correct some technological deficiencies that exist in current methods of animal experimentation in neuroscience. In this thesis, six projects are presented, which will aim to improve the "Principle of the three Rs" in animal experimentation enunciated by the En...

In biology and neuroscience courses, brain anatomy is usually explained using Magnetic Resonance (MR) images or histological sections of different orientations. These can show the most important macroscopic areas in an animals’ brain. However, this method is neither dynamic nor intuitive. In this work, an anatomical 3D printed rat brain with educat...

In OECD (Organization for Economic Co-operation and Development) countries, cancer is one of the main causes of death, lung cancer being one of the most aggressive. There are several techniques for the treatment of lung cancer, among which radiotherapy is one of the most effective and least invasive for the patient. However, it has associated diffi...

Positional tracking systems could hugely benefit a number of niches, including performance art, athletics, neuroscience, and medicine. Commercial solutions can precisely track a human inside a room with sub-millimetric precision. However, these systems can track only a few objects at a time; are too expensive to be easily accessible; and their cont...

The study and analysis of tissues has always been an important part of the subject in biology. For this reason, obtaining specimens of tissue has been vital to morphological and functionality research. Historically, the main tools used to obtain slices of tissue have been microtomes and vibratomes. However, they are largely unsatisfactory. This is...

Behavior is one of the most important aspects of animal life. This behavior depends on the link between animals, their nervous systems and their environment. In order to study the behavior of laboratory animals several tools are needed, but a tracking tool is essential to perform a thorough behavioral study. Currently, several visual tracking tools...