Dapeng Shi

• Henan Provincial People’s Hospital

MVI is a risk assessment factor related to hepatocellular carcinoma (HCC) recurrence after hepatectomy or liver transplantation. The goal of this paper is to study the preoperative diagnosis of microvascular invasion (MVI) by using a deep learning algorithm in non-contrast T2 weighted magnetic resonance imaging (MRI) images instead of pathological...

Purpose To assess the value of various diffusion parameters obtained from monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging (DWI) models for staging hepatic fibrosis (HF) and grading inflammatory activity in patients with chronic hepatitis B (CHB). Methods 82 patients with CHB and 30 healthy volunteers underwent...

The mutation status of the epidermal growth factor receptor (EGFR) is an important clinical reference indicator for lung cancer diagnosis and treatment. However, the extraction of effective discriminative features for non-invasive computer-aided EGFR mutation prediction still poses a big challenge. In this paper, multiple types of features are desi...

To achieve the robust high-performance computer-aided diagnosis systems for lymph nodes, CT images may be typically collected from multicenter data, which cause the isolated performance of the model based on different data source centers. The variability adaptation problem of lymph node data which is related to the problem of domain adaptation in d...

Lung cancer ranks among the most common types of cancer. Noninvasive computer-aided diagnosis can enable large-scale rapid screening of potential patients with lung cancer. Deep learning methods have already been applied for the automatic diagnosis of lung cancer in the past. Due to restrictions caused by single modality images of dataset as well a...

Objective To compare the ability of MR elastography (MRE) with transient elastography (TE) and intravoxel incoherent motion (IVIM) diffusion-weighted MRI in staging hepatic fibrosis (HF). Materials and methods 100 patients with chronic liver disease and 25 healthy volunteers underwent preoperative MRE, IVIM on a 3T MRI unit, and ultrasound-based T...

Purpose To appraise the ability of the computed tomography (CT) radiomics signature for prediction of early recurrence (ER) in patients with hepatocellular carcinoma (HCC). Methods A set of 325 HCC patients were enrolled in this retrospective study and the whole dataset was divided into 2 cohorts, including “training set” (225 patients) and “test...

In order to solve the pathological grading of hepatocellular carcinomas (HCC) which depends on biopsy or surgical pathology invasively, a quantitative analysis method based on radiomics signature was proposed for pathological grading of HCC in non-contrast magnetic resonance imaging (MRI) images. The MRI images were integrated to predict clinical o...

Breast tumor segmentation plays a crucial role in subsequent disease diagnosis, and most algorithms need interactive prior to firstly locate tumors and perform segmentation based on tumor-centric candidates. In this paper, we propose a fully convolutional network to achieve automatic segmentation of breast tumor in an end-to-end manner. Considering...

Purpose This study was conducted in order to investigate the value of magnetic resonance imaging (MRI)-based radiomics signatures for the preoperative prediction of hepatocellular carcinoma (HCC) grade. Methods Data from 170 patients confirmed to have HCC by surgical pathology were divided into a training group (n = 125) and a test group (n = 45)....

We propose to discriminate the pathological grades directly on digital mammograms instead of pathological images. An end-to-end learning algorithm based on the combined multi-level features is proposed. Low-level features are extracted and selected by supervised LASSO logistic regression. Convolutional Neural Network (CNN) is designed to extract hi...

Recent neuroimaging studies have elucidated many interesting and promising findings on sexuality regarding the neural underpinnings of both normal and abnormal sexual processes. Psychogenic erectile dysfunction (pED) consists of a major part of male sexual dysfunction in China, but the understanding of the central mechanism of pED is still in its i...

Background Robust parameters to evaluate pathological aggressiveness are needed to provide individualized therapy for cervical cancer patients. Purpose To investigate the radiomics analysis of multiparametric MRI to evaluate tumor grade, lymphovascular space invasion (LVSI), and lymph node (LN) metastasis of cervical squamous cell carcinoma (CSCC)...

The present study investigated changes in the regional cerebral metabolic rates of glucose uptake (rCMRglc) using 18F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and regional homogeneity (ReHo), together with resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), in patients with major de...

Objective: To (a) assess the diagnostic performance of material decomposition (MD) water (iodine) images for the evaluation of cervical intervertebral discs (IVDs) in patients who underwent dual-energy head and neck CT angiography (HNCTA) compared with 70-keV images and (b) to explore the correlation of water concentration with the T2 relaxation t...

To evaluate hepatic fibrosis with a monoexponential model of intravoxel incoherent motion magnetic resonance imaging, and assess the potential application value of intravoxel incoherent motion (IVIM) in diffusion-weighted imaging (IVIMDWI) in determining staging of liver fibrosis. 28 patients with hepatic fibrosis and 25 volunteers with healthy liv...

Objective: To investigate the correlation between dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) quantitative parameters and pathological grading in esophageal squamous cell carcinoma(SCC). Methods: Prospective analysis of esophageal squamous cell carcinoma confirmed by electronic gastrointestinal endoscopy was performed. Thirty...

Objective: To explore the value of various diffusion parameters obtained from monoexponential, biexponential and stretched exponential diffusion-weighted imaging models in assessing hepatic fibrosis in chronic hepatitis B (CHB). Methods: A total of 52 patients who were diagnosed hepatitis B by the markers of hepatitis and were confirmed by liver bi...

This study investigated the topological characteristics of brain functional networks in chronic insomnia disorder (CID) patients. The resting-state functional magnetic resonance imaging and graph theory analysis method were applied to investigate the brain functional connectome patterns among 45 CID patients and 32 healthy controls. The brain funct...

Correlation coefficients between the node betweenness of right PCL and clinical data (PSQI, HAMA, HAMD scores) with or without outliers in CID patients

Several diseases are characterized by cognitive instability, which is amplified in the conditions of sleep deprivation (SD). Cognitive instability in SD can be examined by number of lapses on the psychomotor vigilance test (PVT), which is considered to be a gold standard in the field. However, the number of PVT lapses widely range according to inte...

Objective: To compare 2D and 3D radiomics features prognostic performance differences in CT images of non-small cell lung cancer (NSCLC). Method: We enrolled 588 NSCLC patients from three independent cohorts. Two sets of 463 patients from two different institutes were used as the training cohort. The remaining cohort with 125 patients was set as...

Objective: To prospectively determine the feasibility of high-resolution in vivo MR imaging in the evaluation of esophageal carcinoma invasion at 3.0 T. Methods: One hundred and eighteen patients with esophageal carcinoma, proven by the gastroscopic biopsy, were prospectively studied using 3.0 T MR. The esophageal specimens were sectioned transvers...

The aim of this study was to explore the functions of cerebral blood perfusion and glucose metabolism in the prefrontal lobe of patients with major depression disorder (MDD), and to analyze the correlations between these functional changes and depressive symptoms. 3D-arterial spin labeling (ASL) and¹⁸F-fluorodeoxyglucose (FDG) positron emission tom...

Objectives: To determine the diagnostic value of monoexponential, biexponential and stretched exponential models for identifying lymph nodes (LNs) in patients with cervical cancer. Materials and methods: Fifty female patients with cervical cancer underwent preoperative magnetic resonance imaging. The diffusion parameters of the LNs were calculat...

Most previous studies exploring the neural mechanism of psychogenic erectile dysfunction (pED) focused on brain activity under tasks. We suggest that the resting brain activity is equally important in pED studies, in that the patterns of spontaneous neural activities is independent of modalities of sensory input, therefore providing substantial inf...

Initial patient information

Objective: The aims of this study were to evaluate the dependence of diffusion parameters on the b values adopted for intravoxel incoherent motion diffusion-weighted magnetic resonance imaging and to investigate the application value of multiple diffusion parameters obtained from monoexponential and biexponential models in subjects with a normal c...

Aim: To obtain the parameters from stretched-exponential and mono-exponential models of multiple b-value diffusion weighted imaging (DWI) and to compare the value of these parameters in detecting and staging hepatic fibrosis (HF). Methods: The apparent diffusion coefficient (ADCst), distributed diffusion coefficient (DDC) and intravoxel water diffu...

Objective: To explore the value of 3.0 T high-resolution MR imaging in diagnosis of esophageal carcinoma in stage T1a, T1b and T2. Methods: Thirty four esophageal specimens were obtained from 34 consecutive esophageal carcinoma patients, who had proven by gastroscopy biopsy preoperatively, and the postoperative specimens were scanned by MRI as path...

High-resolution magnetic resonance (MR) images clearly depict the normal oesophageal wall as consisting of eight layers, which correlates well with histopathological findings. In 56 (91.8%) of 61 lesions, the depth of oesophageal wall invasion determined through MR imaging was consistent with histopathological staging (r = 0.975, P < 0.001). The se...

Several functional imaging studies have investigated the regional effects of sleep deprivation (SD) on impaired brain function; however, potential changes in the functional interactions between the cerebral hemispheres after SD are not well understood. In this study, we used a recently validated approach, voxel-mirrored homotopic connectivity (VMHC...

Prostate cancer and prostatic calcifications have a high incidence in elderly men. We aimed to investigate the diagnostic capabilities of susceptibility-weighted imaging in detecting prostate cancer and prostatic calcifications. A total number of 156 men, including 34 with prostate cancer and 122 with benign prostate were enrolled in this study. Co...

Real-time fMRI neurofeedback (rtfMRI-nf) is a promising tool for enhancing emotion regulation capability of subjects and for the potential alleviation of neuropsychiatric disorders. The amygdala is composed of structurally and functionally distinct nuclei, such as the basolateral amygdala (BLA) and centromedial amygdala (CMA), both of which are inv...

Background: Contemporary functional MRI (fMRI) methods can provide a wealth of information about the neural mechanisms associated with primary insomnia (PI), which centrally involve neural network circuits related to spatial working memory. Methods: A total of 30 participants diagnosed with PI and without atypical brain anatomy were selected alo...

Objective: To explore abnormal brain activation of spatial working memory in primary insomnia and its potential neuromechanism. Methods: we recruited 30 cases primary insomnia (PI) patients and 30 cases age, gender matched healthy control (HC) subjects from July 2013 to December 2013, the diagnosis of primary insomnia matched the diagnosis crite...

Male sexual arousal (SA) has been known as a multidimensional experience involving closely interrelated and coordinated neurobehavioral components that rely on widespread brain regions. Recent functional neuroimaging studies have shown relation between abnormal/altered dynamics in these circuits and male sexual dysfunction. However, alterations in...

Objective: To assess abnormal default mode network (DMN) and its potential mechanisms in insomnia patients with varying depression symptom via resting state functional magnetic resonance imaging (fMRI). Methods: We recruited 15 cases of primary insomnia (PI) without depression symptom, 40 cases of insomnia patients with varying depressions, includi...

The etiology and maintenance of insomnia are proposed to be associated with increased cognitive and physiological arousal caused by acute stressors and associated cognitive rumination. A core feature of such hyperarousal theory of insomnia involves increased sensory processing that interferes with the onset and maintenance of sleep. In this work, w...

Supplementary Figure S1 illustrates the anatomical locations of the seed regions for structural covariance network construction, which were delineated using the AAL atlas.

The aim of the present study was to investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can predict an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy. A total of 25 patients with who were pathologically confirmed stage II‑III esophageal carcinoma underwent...

Substantial individual differences characterize the changes induced by total sleep deprivation on cognitive functions. Despite some progress having been achieved, the mechanisms of individual differences in response to total sleep deprivation have not been clearly elucidated. Cerebral metabolism in the resting state is among the key physiological p...

Functional neuroimaging studies have revealed abnormal brain dynamics of male sexual arousal (SA) in psychogenic erectile dysfunction (pED). However, the neuroanatomical correlates of pED are still unclear. In this work, we obtained cortical thickness (CTh) measurements from structural magnetic resonance images of 40 pED patients and 39 healthy con...

Purpose: To quantitatively compare the potential of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging models and diffusion kurtosis imaging in the grading of gliomas. Materials and methods: This study was approved by the local ethics committee, and written informed con...

Objective: To investigate the value of dynamic contrast-enhanced MRI (DCE-MRI) in the differential diagnosis of glioblastoma and brain metastases. Methods: Twenty patients with high grade gliomas and 20 cases patients with brain metastases proved by surgery and pathology were collected, and patients were examined with conventional MRI and DCE-MRI p...

Chronic insomnia is one of the most prevalent central nervous system disorders; however, its neurobiology has not been well understood. It has been proposed that the etiology and maintenance of insomnia may be associated with increased cognitive and physiological arousal caused by acute stressors and associated cognitive rumination. A core feature...

Background: A pilot study has shown that real-time fMRI (rtfMRI) neurofeedback could be an alternative approach for chronic pain treatment. Considering the relative small sample of patients recruited and not strictly controlled condition, it is desirable to perform a replication as well as a double-blinded randomized study with a different control...

Background: Cerebral glucose metabolism changes are always observed in patients suffering from malignant tumors. This preliminary study aimed to investigate the brain glucose metabolism changes in patients with lung cancer of different histological types. Methods: One hundred and twenty patients with primary untreated lung cancer, who visited Pe...

Non-contrast enhanced (NCE) inflow inversion recovery (IFIR) magnetic resonance venography(MRV)and digital subtraction angiography (DSA) examination were carried out in thirty-five patients who were suspected of Budd-Chiari syndrome(BCS). With DSA as the reference, NCE MRV got 100% in the diagnostic sensitivity, 67.8% in the specificity, 97.1% in t...

Background: The diagnosis of liver fibrosis is a difficult task at any time using conventional clinical imaging. Intravoxel incoherent motion (IVIM) can be used to investigate both diffusion and perfusion changes in tissues. This study was designed to determine the value of IVIM in the diagnosis and staging of liver fibrosis. Methods: IVIM exami...

Background: Crossed cerebellar diaschisis (CCD) was a common radiological phenomenon manifested as reduced blood flow and metabolism in the cerebellar hemisphere contralateral to a supratentorial cerebral lesion. The hypoperfusion and hypometabolism in the contralateral cerebellum in CCD was traditionally detected by positron emission tomography (...

Background Primary insomnia can severely impair daytime function by disrupting attention and working memory and imposes a danger to self and others by increasing the risk of accidents. We speculated that the neurobiological changes impeding working memory in primary insomnia patients would be revealed by resting-state functional MRI (R-fMRI), which...

Objective: To prospectively evaluate the diagnostic effectiveness of contrast-enhanced whole-heart coronary magnetic resonance angiography (CE-CMRA) in patients with suspected coronary artery disease (CAD) with conventional coronary angiography as the reference standard. Methods: A total of 72 subjects with suspected CAD scheduled for convention...

This work aims to explore the effects of adaptive statistical iterative reconstruction (ASiR) and model-based iterative reconstruction (MBIR) algorithms in reducing computed tomography (CT) radiation dosages in abdominal imaging. CT scans on a standard male phantom were performed at different tube currents. Images at the different tube currents wer...

PURPOSE The purpose of this study was to evaluate the image quality and radiation dose of lower extremity arterial imaging using 80kVp with automatic tube current modulation technique compared with traditional 120 kVp scan. METHOD AND MATERIALS 60 consecutive outpatients with lower extremity occlusive disease performed 64-slices CT scan were rando...

PURPOSE To evaluate image quality and radiation dose of spectral imaging of renal angiography compared with low kVp CTA scan. METHOD AND MATERIALS 10 patients(BMI>25,group A)referred to renal CT angiography underwent gemstone spectral CTA with pitch of 1.375 using Iodixanol270(1ml/kg,5ml/s),10 patients (BMI>25,group B) performed conventional 100 k...

PURPOSE To investigate the feasibility of low kVp CT scans with iso-osmolar low concentration contrast applied in renal artery imaging. METHOD AND MATERIALS 10 patients (BMI<25,group A)referred to renal CT angiography underwent 100kVp CTA with Noise Index of 11.5,pitch of 1.375 using Iodixanol 270(1ml/kg,5ml/s), 10 patients (BMI<25,group B) perfor...

PURPOSE To investigate the feasibility of prospective ECG-triggered axial scan applied in renal artery imaging. METHOD AND MATERIALS 72 patients referred to renal CT angiography were randomly divided into 2 groups. Group A(n=37)underwent prospective ECG-triggered axial scan.Group B (n=35) performed conventional 120 kVp CTA with Noise Index of 8,pi...

PURPOSE The purpose of this study was to determine whether comparable results to the standard 120kVp protocol could be obtained with reduced radiation dose for lower extremity arterial imaging by 64-slice CT at a tube voltage of 80 kVp. METHOD AND MATERIALS Eighty-two consecutive outpatients with lower extremity occlusive disease were randomly div...

HIV is a neurotropic virus which can cause brain white matter demyelination, gliosis, and other pathological changes that appear as HIV encephalitis or AIDS dementia. The purpose of this study was to investigate the change of the diffused condition of water molecules in brain white matter in early acquired immune deficiency syndrome (AIDS) patients...

Brains can perceive or recognize a face even though we are subjectively unaware of the existence of that face. However, the exact neural correlates of such covert face processing remain unknown. Here, we compared the fMRI activities between a prosopagnosic patient and normal controls when they saw famous and unfamiliar faces. When compared with obj...

Introduction: To investigate the association of quantitative 3-T diffusion tensor imaging (DTI) with retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and clinical severity in detecting optic nerve degeneration in patients with primary closed-angle glaucoma. Methods: Twenty three patients (42 eyes; 9 men,...

Susceptibility weighted imaging (SWI) is a new MRI technique which has been proved very useful in the diagnosis of brain diseases, but few study was performed on its value in prostatic diseases. The aim of the present study was to investigate the value of SWI in distinguishing prostate cancer from benign prostatic hyperplasia and detecting prostati...

PURPOSE To investigate the utility of spectral CT renal angiography (CTRA) for reducing contrast medium using single source dual-energy CT. METHOD AND MATERIALS This prospective study was approved by the institutional review board with patient informed consent. 48 consecutive patients (29 men, 19 women; mean age, 45.4±12.6 years) with suspected re...

PURPOSE To compare image quality and visualization of pulmonary nodules smaller than 10mm on chest computed tomography (CT) with adaptive statistical iterative reconstruction (ASiR) and filtered back projection (FBP) reconstruction techniques and determine optimum reconstruction mode for visualization of lung nodules. METHOD AND MATERIALS This ret...

To explore the findings of diffusion-weighted imaging (DWI) and the diffusion characteristics on patellar cartilage in healthy adults. Thirty healthy subjects were studied on SIEMENS 3.0-T Trio Tim magnetic resonance (MR) scanner. The apparent diffusion coefficient (ADC) values of the patellar cartilage were measured in different areas. The patella...

Distinction between postoperative recurrent glioma and radiation injury remains a tough diagnostic problem for routine imaging methods. The purpose of this study is to evaluate the differentiated effectiveness of perfusion weighted imaging (PWI) for the two entities. PWI was performed using Siemens 3.0-T MR system for 35 patients with new contrast-...

To prospectively evaluate the diagnostic value of non-enhanced inflow-sensitive inversion recovery (IFIR) MR angiography for the detection of renal artery stenosis (RAS), with enhanced CT angiography performed as the reference standard. Sixty consecutive patients suspected of RAS underwent both of IFIR MR and enhanced CT angiography. Subjective ima...

To prospectively evaluate noncontrast-enhanced (NCE), time resolved, four-dimensional (4D) magnetic resonance angiography (MRA) for assessment of cerebral arteriovenous malformation (AVM), with intraarterial digital subtraction angiography (DSA) performed as the reference standard. Fifteen patients (ten men, five women; age range 2-59 years, mean 2...

In this study, the Regional Homogeneity (ReHo) approach was used to investigate the abnormal brain areas in individuals infected with Human Immunodeficiency Virus (HIV) compared with the controls, on the resting state with fMRI. Significantly decreased brain regions were found at multiple brain locations. However, no increased brain region appeared...

To investigate the added value of volume on post-contrast three dimensional (3D) T1-weighted image (T1WI) over classical cross-sectional area on two dimensional (2D) T1WI in evaluating tumor response in glioblastoma multiforme (GBM). Tumor cross-sectional area and volume measurements were performed on 104 MRI studies from 42 adult patients with GBM...

The pathological abnormalities of the AIDS patients lie in the subcortical regions of the brain, specifically the deep white matter and basal ganglia, while the extent of pathology generally correlates with the severity of cognitive impairments in the white matter and basal ganglia. Brain metabolite changes of these lesions can reflect the patholog...

Susceptibility weighted imaging (SWI) is sensitive to deoxyhemoglobin and blood products such as hemosiderin in detecting microbleeds in the brain. However, there are no studies on SWI in the spine cord injury so far. The purpose of this study was to evaluate the role of SWI in detecting hemorrhage in acute cervical spinal cord injury (SCI). Twenty...

This study aims to evaluate the differentiated effectiveness of MR diffusion tensor imaging (DTI) to postoperative recurrent glioma and radiation injury. Conventional MRI and DTI examination were performed using Siemens 3.0 T MR System for patients with new contrast-enhancing lesions at the site of treated tumor with postoperative radiotherapy. The...

PURPOSE To investigate the value of diffusion tensor imaging (DTI) in patients with severe optic nerve injury METHOD AND MATERIALS 20 eyes in 20 patients (18 male, 2 female; mean age 35 years, range 18-50 years) with severe optic nerve injury were imaged using a 3.0T MRI system (TrioTim, Siemens Medical Solutions) within 10 days of trauma and the...

PURPOSE To investigate the correlation between fractional anisotropy (FA) by diffusion tensor imaging （DTI） and retinal nerve fiber layer （RNFL） thickness measured by optical coherent tomography（OCT) in primary closure angle glaucoma. METHOD AND MATERIALS 54 eyes in 30 patients with primary angle-closure glaucoma were imaged with DTI using 3.0T MR...

Change in tumor size is a frequent endpoint in cancer clinical trials, but whether change in size should be measured using volume on two-dimensional (2D) or three-dimensional (3D) images is not certain. We compared volumetric measurements on post-contrast 2D and high-resolution 3D T1-weighted MR images (T1WI) in evaluating tumor response in gliobla...

PURPOSE To evaluate the value of diffusion tensor imaging (DTI) combining with MR angiography (MRA) in cerebral infarction in patients with diabetes. METHOD AND MATERIALS Both DTI and MRA were performed in 30 adult patients with cerebral infarction following diabetes using 3.0T MRI (TimTrio, Siemens Medical Solutions, Malvern, PA). The fiber tract...

To compare conventional radiography and magnetic resonance imaging (MRI) in the assessment of epiphyseal and physeal injury. Seventeen cases with epiphyseal and physeal injury were examined with conventional radiography and MRI. Two blinded experienced radiologists separately evaluated the results retrospectively. Two Salter-Harris II fractures sho...

To study the role of MRI in diagnosis of adult pulmonary tuberculosis. MRI and X-ray appearance of 55 adult pulmonary tuberculosis cases were reviewed. No obvious difference was found between the images of MRI and chest radiography which reflect infiltrative and proliferative pathologic changes of pulmonary tuberculosis (including cavity, tuberculo...