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Danko D. Georgiev

Danko D. Georgiev
Institute for Advanced Study, Varna

M.D., Ph.D.

About

100
Publications
42,245
Reads
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1,100
Citations
Introduction
I perform interdisciplinary research on quantum foundations, quantum physics, quantum chemistry, neuroscience, information science and applied mathematics.
Additional affiliations
April 2014 - March 2015
University of Pittsburgh
Position
  • PostDoc Position
September 2011 - November 2011
University of Pittsburgh
Position
  • Visiting Researcher
October 2008 - March 2013
Kanazawa University
Position
  • PostDoc Position
Education
October 2005 - September 2008
Kanazawa University
Field of study
  • Pharmaceutical Sciences
October 1998 - November 2004
Medical University of Varna
Field of study
  • Medicine

Publications

Publications (100)
Book
Full-text available
This book addresses the fascinating cross-disciplinary field of quantum information theory applied to the study of brain function. It offers a self-study guide to probe the problems of consciousness, including a concise but rigorous introduction to classical and quantum information theory, theoretical neuroscience, and philosophy of the mind. It ai...
Article
Full-text available
Capacity of conscious agents to perform genuine choices among future alternatives is a prerequisite for moral responsibility. Determinism that pervades classical physics, however, forbids free will, undermines the foundations of ethics, and precludes meaningful quantification of personal biases. To resolve that impasse, we utilize the characteristi...
Article
Full-text available
Protein α-helices provide an ordered biological environment that is conducive to soliton-assisted energy transport. The nonlinear interaction between amide I excitons and phonon deformations induced in the hydrogen-bonded lattice of peptide groups leads to self-trapping of the amide I energy, thereby creating a localized quasiparticle (soliton) tha...
Article
Full-text available
Entanglement measures quantify the amount of quantum entanglement that is contained in quantum states. Typically, different entanglement measures do not have to be partially ordered. The presence of a definite partial order between two entanglement measures for all quantum states, however, allows for meaningful conceptualization of sensitivity to e...
Article
Full-text available
Macromolecular protein complexes catalyze essential physiological processes that sustain life. Various interactions between protein subunits could increase the effective mass of certain peptide groups, thereby compartmentalizing protein α-helices. Here, we study the differential effects of applied massive barriers upon the soliton-assisted energy t...
Preprint
Full-text available
Macromolecular protein complexes catalyze essential physiological processes that sustain life. Various interactions between protein subunits could increase the effective mass of certain peptide groups, thereby compartmentalizing protein $\alpha$-helices. Here, we study the differential effects of applied massive barriers upon the soliton-assisted e...
Article
Full-text available
The rapid progress achieved by quantum information science in recent decades was made possible by the realization that genuine quantum phenomena, for which their occurrences are forbidden by classical physics, are not a defect of quantum theory but are useful physical resources [...]
Preprint
Full-text available
Protein α-helices provide an ordered biological environment that is conducive to soliton-assisted energy transport. The nonlinear interaction between amide I excitons and phonon deformations induced in the hydrogen-bonded lattice of peptide groups leads to self-trapping of the amide I energy, thereby creating a localized quasiparticle (soliton) tha...
Preprint
Full-text available
Capacity of conscious agents to perform genuine choices among future alternatives is a prerequisite for moral responsibility. Determinism that pervades classical physics, however, forbids free will, undermines the foundations of ethics, and precludes meaningful quantification of personal biases. To resolve that impasse, we utilize the characteristi...
Preprint
Full-text available
Human creativity generates novel ideas to solve real-world problems. This thereby grants us the power to transform the surrounding world and extend our human attributes beyond what is currently possible. Creative ideas are not just new and unexpected, but are also successful in providing solutions that are useful, efficient and valuable. Thus, crea...
Article
Full-text available
Complementarity between one-particle visibility and two-particle visibility in discrete systems can be extended to bipartite quantum-entangled Gaussian states implemented with continuous-variable quantum optics. The meaning of the two-particle visibility originally defined by Jaeger, Horne, Shimony, and Vaidman with the use of an indirect method th...
Preprint
Full-text available
Identifying the physiological processes in the central nervous system that underlie our conscious experiences has been at the forefront of cognitive neuroscience. While the principles of classical physics were long found to be unaccommodating for a causally effective consciousness, the inherent indeterminism of quantum physics, together with its ch...
Article
Full-text available
Identifying the physiological processes in the central nervous system that underlie our conscious experiences has been at the forefront of cognitive neuroscience. While the principles of classical physics were long found to be unaccommodating for a causally effective consciousness, the inherent indeterminism of quantum physics, together with its ch...
Article
Full-text available
Our access to computer-generated worlds changes the way we feel, how we think, and how we solve problems. In this review, we explore the utility of different types of virtual reality, immersive or non-immersive, for providing controllable, safe environments that enable individual training, neurorehabilitation, or even replacement of lost functions....
Preprint
Full-text available
Complementarity between one-particle visibility and two-particle visibility in discrete systems can be extended to bipartite quantum-entangled Gaussian states implemented with continuous-variable quantum optics. The meaning of the two-particle visibility originally defined by Jaeger, Horne, Shimony, and Vaidman with the use of an indirect method th...
Preprint
Full-text available
The brain is composed of electrically excitable neuronal networks regulated by the activity of voltage-gated ion channels. Further portraying the molecular composition of the brain, however, will not reveal anything remotely reminiscent of a feeling, a sensation or a conscious experience. In classical physics, addressing the mind-brain problem is a...
Article
Full-text available
The brain is composed of electrically excitable neuronal networks regulated by the activity of voltage-gated ion channels. Further portraying the molecular composition of the brain, however, will not reveal anything remotely reminiscent of a feeling, a sensation or a conscious experience. In classical physics, addressing the mind–brain problem is a...
Article
Full-text available
The essential biological processes that sustain life are catalyzed by protein nano-engines, which maintain living systems in far-from-equilibrium ordered states. To investigate energetic processes in proteins, we have analyzed the system of generalized Davydov equations that govern the quantum dynamics of multiple amide I exciton quanta propagating...
Chapter
To find out whether neuronal microtubules could translate and input the information carried by electric signals entering into the brain cortex, a detailed investigation of the local electromagnetic field structure is performed. The electric and magnetic field strengths in different neuronal compartments, including dendrites, soma, and axons, are as...
Preprint
Full-text available
The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, respectively. For a proper asse...
Article
Full-text available
The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, respectively. For a proper asse...
Article
Full-text available
Biological order provided by α-helical secondary protein structures is an important resource exploitable by living organisms for increasing the efficiency of energy transport. In particular, self-trapping of amide I energy quanta by the induced phonon deformation of the hydrogen-bonded lattice of peptide groups is capable of generating either pinne...
Preprint
Full-text available
Biological order provided by $\alpha$-helical secondary protein structures is an important resource exploitable by living organisms for increasing the efficiency of energy transport. In particular, self-trapping of amide I energy quanta by the induced phonon deformation of the hydrogen-bonded lattice of peptide groups is capable of generating eithe...
Article
Full-text available
To objectively and quantitatively study transcribed protocols of design conversations, we apply a semantic analysis approach based on dynamic semantic networks of nouns. We examined the applicability of the approach focused on a dynamic evaluation of the design problem solving process in engineering design educational settings. Using a case of real...
Preprint
Full-text available
The essential biological processes that sustain life are catalyzed by protein nano-engines, which maintain living systems in far-from-equilibrium ordered states. To investigate energetic processes in proteins, we have analyzed the system of generalized Davydov equations that govern the quantum dynamics of multiple amide I exciton quanta propagating...
Article
Full-text available
Although regarded today as an important resource in quantum information, nonlocality has yielded over the years many conceptual conundrums. Among the latter are nonlocal aspects of single particles which have been of major interest. In this paper, the nonlocality of single quanta is studied in a square nested Mach–Zehnder interferometer with spatia...
Article
Full-text available
In this somewhat pedagogical paper we revisit complementarity relations in bipartite quantum systems. Focusing on continuous-variable systems, we examine the influential class of EPR-like states through a generalization to Gaussian states and present some new quantitative relations between entanglement and local interference within symmetric and as...
Preprint
Full-text available
In this somewhat pedagogical paper we revisit complementarity relations in bipartite quantum systems. Focusing on continuous variable systems, we examine the influential class of EPR-like states through a generalization to Gaussian states and present some new quantitative relations between entanglement and local interference within symmetric and as...
Article
Full-text available
The human mind is constituted by inner, subjective, private, first-person conscious experiences that cannot be measured with physical devices or observed from an external, objective, public, third-person perspective. The qualitative, phenomenal nature of conscious experiences also cannot be communicated to others in the form of a message composed o...
Preprint
Full-text available
The human mind is constituted by inner, subjective, private, first-person conscious experiences that cannot be measured with physical devices or observed from an external, objective, public, third-person perspective. The qualitative, phenomenal nature of conscious experiences also cannot be communicated to others in the form of a message composed o...
Preprint
Full-text available
Although regarded today as an important resource in quantum information, nonlocality has yielded over the years many conceptual conundrums. Among the latter are nonlocal aspects of single particles which have been of major interest. In this paper, the nonlocality of single quanta is studied in a square nested Mach--Zehnder interferometer with spati...
Article
The principles of classical physics, including deterministic dynamics and observability of physical states, are incompatible with the existence of unobservable conscious minds that possess free will. Attempts to directly accommodate consciousness in a classical world lead to philosophical paradoxes such as causally ineffective consciousness and pos...
Article
Full-text available
To objectively and quantitatively study transcribed protocols of design problem solving conversations, we propose a semantic analysis approach based on dynamic semantic networks of nouns constructed with WordNet 3.1 lexical database. We examined the applicability of the semantic approach focused on a dynamic evaluation of the design problem solving...
Article
Full-text available
Protein clamps provide the cell with effective mechanisms for sensing of environmental changes and triggering adaptations that maintain homeostasis. The general physical mechanism behind protein clamping action, however, is poorly understood. Here, we explore the Davydov model for quantum transport of amide I energy, which is self-trapped in solito...
Article
Full-text available
The transport of energy inside protein α-helices is studied by deriving a system of quantum equations of motion from the Davydov Hamiltonian with the use of the Schrödinger equation and the generalized Ehrenfest theorem. Numerically solving the system of quantum equations of motion for different initial distributions of the amide I energy over the...
Article
Full-text available
Feynman's sum-over-histories formulation of quantum mechanics has been considered a useful calculational tool in which virtual Feynman histories entering into a coherent quantum superposition cannot be individually measured. Here we show that sequential weak values, inferred by consecutive weak measurements of projectors, allow direct experimental...
Article
Twenty five years ago, Sir John Carew Eccles together with Friedrich Beck proposed a quantum mechanical model of neurotransmitter release at synapses in the human cerebral cortex. The model endorsed causal influence of human consciousness upon the functioning of synapses in the brain through quantum tunneling of unidentified quasiparticles that tri...
Article
Full-text available
Human creativity generates novel ideas to solve real-world problems. This thereby grants us the power to transform the surrounding world and extend our human attributes beyond what is currently possible. Creative ideas are not just new and unexpected, but are also successful in providing solutions that are useful, efficient and valuable. Thus, crea...
Chapter
Full-text available
This chapter presents the fundamental principles that underlie the scientific conception of the real world. Science and scientific theories are logically consistent, communicable knowledge about ourselves and the physical world in which we live. Science unravels the physical causes behind observed physical phenomena and explains why the physical wo...
Chapter
Full-text available
This chapter illustrates how quantum physics could be applied to neuroscience and provides a number of open questions for future work. The brain cortex, which is the seat of consciousness, inputs sensory information and outputs motor information in the form of electric signals transmitted along the neuronal projections. Because the quantum electrod...
Chapter
Full-text available
This chapter formulates seven long-standing problems related to consciousness using introspection and a certain amount of experimental evidence provided by biomedical sciences. The physical boundary problem is to find a rule that sets the boundary between our own conscious mind and the rest of the physical world. The binding problem is to explain w...
Chapter
Full-text available
This chapter introduces the reader to the wondrous world of quantum physics. The quantum particles that build up quantum physical systems possess a wave function composed of complex valued quantum probability amplitudes. The wave function determines the probabilities for different physical quantities to have a certain value, but itself is unobserva...
Chapter
Full-text available
This chapter constructs an axiomatic quantum information theory of consciousness and uses fundamental quantum information theorems to address the main problems of consciousness. The unobservable quantum wave function of non-factorizable quantum states is identified with the conscious mind thereby explaining the inner privacy of consciousness and ou...
Chapter
Full-text available
This chapter highlights determinism and observability of physical states as the two fundamental principles that underlie the world of classical physics. The material particles that build up classical physical systems possess definite mass, energy, charge, position and velocity, all of which are observable physical quantities. The dynamics of classi...
Chapter
Full-text available
This chapter explains the origin of various difficulties encountered when one applies classical information theorems to study consciousness. Two characteristic features of classical physics, determinism and observability of physical states, are singled out as the worst adversaries to consciousness and free will. If the conscious mind is considered...
Chapter
Full-text available
This chapter wraps up the presentation by highlighting the importance of conscious experiences for the growth of scientific knowledge. Because science is objective knowledge about the real world, the empirical adequacy of scientific theories needs to be evaluated in view of experimental data. Experiments alone, can neither verify a theory, since un...
Article
Full-text available
In the cortex of subjects with schizophrenia, expression of glutamic acid decarboxylase 67 (GAD67), the enzyme primarily responsible for cortical GABA synthesis, is reduced in the subset of GABA neurons that express parvalbumin (PV). This GAD67 deficit is accompanied by lower cortical levels of other GABA-associated transcripts, including GABA tran...
Article
Full-text available
Significance statement: Bexarotene-activated retinoid X receptors (RXRs) ameliorate memory deficits in Alzheimer's disease mouse models, including mice expressing human apolipoprotein E (APOE) isoforms. The goal of this study was to gain further insight into molecular mechanisms whereby ligand-activated RXR can affect or restore cognitive function...
Article
Full-text available
I commence this work with a comprehensive outline of a recent no-go quantum informational theorem and discuss its implications for Stapp’s quantum mind model. Then I provide results from Monte Carlo simulations illustrating both quantum Zeno effect in the absence of environmental decoherence and the breakdown of quantum Zeno effect in the presence...
Article
Full-text available
Environmental decoherence appears to be the biggest obstacle for successful construction of quantum mind theories. Nevertheless, the quantum physicist Henry Stapp promoted the view that the mind could utilize quantum Zeno effect to influence brain dynamics and that the efficacy of such mental efforts would not be undermined by environmental decoher...
Article
Full-text available
We commence this review by outlining the challenges faced by physical theories of consciousness and briefly describe the two main approaches based on classical or quantum mechanics. Next, we provide a detailed exposition of the motivation, the theoretical construction and experimental falsification of the celebrated model due to Beck and Eccles con...
Article
Full-text available
Objective: In schizophrenia, alterations in markers of cortical GABA neurotransmission are prominent in parvalbumin-containing neurons. Parvalbumin neurons selectively express KCNS3, the gene encoding the Kv9.3 potassium channel α-subunit. Kv9.3 subunits are present in voltage-gated potassium channels that contribute to the precise detection of co...
Article
Full-text available
Our conscious minds exist in the Universe, therefore they should be identified with physical states that are subject to physical laws. In classical theories of mind, the mental states are identified with brain states that satisfy the deterministic laws of classical mechanics. This approach, however, leads to insurmountable paradoxes such as epiphen...
Article
Full-text available
Objective: In schizophrenia, alterations within the prefrontal cortical GABA system appear to be most prominent in neurons that contain parvalbumin or somatostatin but not calretinin. The transcription factors Lhx6 and Sox6 play critical roles in the specification, migration, and maturation of parvalbumin and somatostatin neurons, but not calretin...
Article
Full-text available
In this article we present the mathematical formalism of Quantum Zeno Effect (QZE) and explain how the QZE arises from suppression of coherent evolution due to external strong probing action. Then we prove that the model advocated by Henry Stapp, in which mind efforts are able to exert QZE upon brain states, is not robust against environmental deco...
Article
Full-text available
The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST). Identification of molecular mechanisms that operate selectively in these neurons is essential for developing targeted therapeutic strategies tha...
Data
Primer sets used for cloning of DNA templates. (DOC)
Data
Identification of neurons specifically labeled for KCNS3, LHX6, KCNAB1 and PPP1R2 mRNAs. (A, C, E, G) High magnification view of Nissl-stained emulsion-coated sections hybridized with 35S-labeled antisense riboprobes for each of the four mRNAs (KCNS3, LHX6, KCNAB1 and PPP1R2). Silver grain clusters were observed over large and faintly stained neuro...
Chapter
We describe a neurobiological framework for membrane fusion and exocytosis within the SNARE (SNARE is an acronym for soluble NSF attachment protein receptor, where NSF abbreviates N-ethylmaleimide–sensitive fusion protein) complex using vibrationally assisted tunneling and a quantum Davydov soliton mechanism. The main feature concerns how the resul...
Article
Full-text available
We discuss the origin of quantum complementarity using Feynman's sum-over-histories approach to Quantum Mechanics (QM). We analyze two experimental setups introduced by W. G. Unruh and S. Afshar and show how one should consistently calculate the existence of which-way information using interfering quantum histories. Then we discuss the possible pro...
Article
Full-text available
While looking for evidence of quantum coherent states within the brain, many quantum mind advocates proposed experiments based on the assumption that the coherent state of a photon entering the visual system could somehow be preserved through the neural processing, or in other words they suppose that photons collapse not in the retina, but in the b...
Article
Full-text available
While looking for evidence of quantum coherent states within the brain, many quantum mind advocates proposed experiments based on the assumption that the coherent state of a photon entering the visual system could somehow be preserved through the neural processing, or in other words they suppose that photons collapse not in the retina, but in the b...
Article
Full-text available
Our minds, constituted by conscious experiences, are both the most familiar and most mysterious aspect of our lives. Despite the large amount of clinical evidence suggesting an intimate relationship between the brain function and the mind, the nature of this relationship remains poorly understood. In this Commentary we discuss some of the problems...
Article
Full-text available
In the beginning of the 20th century the groundbreaking work of Ramon y Cajal firmly established the neuron doctrine, according to which neurons are the basic structural and functional units of the nervous system. Von Weldeyer coined the term “neuron” in 1891, but the huge leap forward in neuroscience was due to Cajal’s meticulous microscopic obser...
Article
Full-text available
Neurons have a large fraction of stable brain microtubules forming the cytoskeleton of the cell, which provide a mechanical support for the extended dendrites and axonal arborizations and serve as railroads for molecular and vesicular transport. Except for the latter two functions it has been hypothesized that these stable microtubules might also a...
Article
Full-text available
Stuart Hameroff has wrongly estimated that a typical brain neuron has 10<sup>7</sup> tubulin dimers and wrongly attributed this result to Yu and Baas. In this letter we show that Hameroff’s estimate is based on misunderstanding of the results provided by Yu and Baas, who actually measured the total microtubule length in a single axonal projection w...
Article
Full-text available
Stuart Hameroff has wrongly estimated that a typical brain neuron has 10^7^ tubulin dimers and wrongly attributed this result to Yu and Baas, J. Neurosci. 1994; 14: 2818-2829. In this letter we show that Hameroff’s estimate is based on misunderstanding of the results provided by Yu and Baas, who actually measured the total microtubule length in a s...
Article
Full-text available
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathological circumstances such as ischemia, NMDARs might have proapoptotic excitotoxic activity. In contrast brain-derived neurotrophic factor (BDNF) signa...
Thesis
Full-text available
We have investigated the role of N-methyl-D-aspartate receptors (NMDARs) and γ-aminobutyric acid receptors type A (GABAARs) at an early DIV 2-4 stage of P19 neuronal differentiation. With the use of RT-PCR we have verified the expression of various NMDAR and GABAAR in the process of P19 neuronal differentiation and we established the functionality...
Article
Neural progenitor cell is a generic term for undifferentiated cell populations composed of neural stem, neuronal progenitor, and glial progenitor cells with abilities for self-renewal and multipotentiality. In this study, we have attempted to evaluate the possible functional expression of N-methyl-D-aspartate (NMDA) receptors by neural progenitor c...
Article
We have investigated the role of N-methyl-d-aspartate receptors (NMDARs) and gamma-aminobutyric acid receptors type A (GABA(A)Rs) at an early stage of P19 neuronal differentiation. The subunit expression was profiled in 24-hour intervals with RT-PCR and functionality of the receptors was verified via fluo-3 imaging of Ca(2+) dynamics in the immatur...
Article
We have attempted to elucidate mechanisms underlying differential vulnerability to glutamate (Glu) using cultured neurons prepared from discrete structures of embryonic rat brains. Brief exposure to Glu led to a significant decrease in the mitochondrial activity in hippocampal neurons cultured for 9 or 12 days at 10 muM to 1 mM with an apoptosis-li...
Article
Full-text available
In the paper "Incompatibility between quantum theory and consciousness" by Daegene Song is presented mathematical argument according to which quantum theory and self-observing consciousness are incompatible. Here we spot a critical mathematical error in Song's equations, showing that Song's argument is mathematically messed and is quite irrelevant...
Article
N-methyl-D-aspartate (NMDA) receptor is a calcium-permeable ionotropic glutamate receptor and plays a role in many neurologic disorders such as brain ischemia through its involvement in excitotoxicity. We have performed differential display PCR to identify changes in gene expression that occur in the hippocampus of the mouse brain after intraperito...