Danka BukvickiUniversity of Belgrade · Faculty of Biology
Danka Bukvicki
PhD
About
36
Publications
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Citations since 2017
Introduction
Danka Bukvicki is Senior Research Associate at University of Belgrade-Faculty of Biology. Her research topics deal with 1) isolation and identification of liverworts and vascular plant secondary metabolites (bis-bibenzyls , flavonoids, terpenoids) 2) biological activities of extracts/EOs and isolated compounds 3) study on natural food preservatives, in particular, investigation on natural antimicrobials against pathogenic and spoilage microbial strains and their use in food systems.
Additional affiliations
April 2018 - present
February 2017 - April 2017
May 2016 - November 2016
Publications
Publications (36)
Through secondary or specialised metabolites plants adapt to their environment. A myriad of different compounds plays a significant role in the plant–environment interaction. These compounds help plants in attracting pollinators or deterring herbivores, in their protection from pathogen microorganisms, or in protection from various abiotic stresses...
Plant-based natural products have been used as a source for therapeutics since the dawn of civilization. According to the World Health Organization (WHO), more than 80% of the world’s population relies on traditional medicine for their primary healthcare. Numerous natural extracts, widely known in Traditional Chinese Medicine, Indian Ayurveda medic...
The Marchantiophyta (liverworts) are rich sources of phenolic substances, especially cyclic and acyclic bis-bibenzyls, which are rare natural products in the plant kingdom, together with bibenzyls and characteristic terpenoids. At present, more than 125 bis-bibenzyls have been found in liverworts. They are biosynthesized from the dimerization of lu...
Liverworts are characterized by a high content of bioactive compounds reported to show antimicrobial, anticancer, and antioxidant properties. In this study, the biological effects of the methanol extract of the liverwort Pellia endiviifolia and its constituents, bis-bibenzyls perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin...
Twenty-one accessions of Primula veris subsp. macrocalyx (Primulaceae) were chemically analyzed to clarify the presence of naturally rare macrocyclic bis-bibenzyls (BB). These compounds are typically found in liverworts but not known from higher plants, with the exception of the species under study. However, data are scarce concerning organ specifi...
Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines. From the methylene-chloride/methanol extract of the liverwort Pellia endiviifolia, three bis-bibenzyls of the perro...
The main aim of this work was to verify the metabolic and functional aptitude of 15 vaginal strains belonging to Lactobacillus crispatus, Lactobacillus gasseri, and Limosilactobacillus vaginalis (previously Lactobacillus vaginalis), already characterized for their technological and antimicrobial properties. In order to evaluate the metabolic profil...
Lamiaceae (Labiatae) are an important group of medicinal plants, which have been used for treating heart disease in traditional medicine for centuries. These mainly aromatic plants are used as essential oils, extracts or isolated components (polyphenols, phenolic compounds, terpenes, iridoids etc.). Some Labiatae species (more than 30, such as corn...
Antimicrobial activity of methanol extracts of three thalloid liverworts, Marchantia polymorpha, Conocephalum conicum and Pellia endiviifolia and bis-bibenzyl marchantin A, the most dominant compound of M. polymorpha methanol extract, have been investigated in this research. 1H NMR spectroscopy revealed that the liverwort?s extract contains terpene...
Little attention has been paid to the bryophytes as sources for human diet despite of the presence of 23000 species in the world. Some mosses contain vitamin B1, tocopherols, prostaglandin-like highly unsaturated fatty acids and phenolic compounds. On the other hand, liverworts contain enantiomeric mono-, sesqui- and diterpenoids to those found in...
Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have been isolated using reversed phase semipreparative HPLC and their structures were established to be 8-hydroxyperrottetin F, C-7-C-8 cleaved product, and perrottetin F 6’-sulfate...
This research, developed within an exchange program between Italy and Canada, represents the first step of a three-year project intended to evaluate the potential of nisin-producing Lactococcus lactis strains isolated from Italian and Canadian dairy products to select a consortium of strains to be used as biocontrol agents in Crescenza and Cheddar...
This study aimed at evaluating the effects of the addition of an oil/beer/lemon marinade solution with or without the inclusion of oregano, rosemary and juniper essential oils on the quality, the technological properties as well as the shelf-life and safety of vacuum-packed pork loin meat. The results obtained suggested that, aside from the additio...
Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzy...
The activity of edible Nepeta nuda L. (Lamiaceae) tincture and Listerine towards a selected group of oral pathogenic microorganisms (4 bacteria and 9 fungi) has been explored. Their potential to inhibit formation of biofilm and to diminish established biofilm has been compared. The amount of N. nuda tincture and swishing time necessary for reaching...
Spices are not only just herbs used in culinary for improving the taste of dishes. They are also sources of a numerous bioactive compounds significantly beneficial for health. They have been used since ancient times because of their antimicrobial, anti-inflammatory and carminative properties. Several scientific studies have suggested their protecti...
A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus Niger. GC/MS analyses of the original and biotransformed essential oil have reveal...
The essential oil of Thymus algeriensis was analyzed as a potential preservative in soft cheese. We developed a novel method to test the preserving properties of essential oil in soft cheese. Contamination incidence of Penicillium aurantiogriseum was absent after 30 d of storage at 4°C with 25 µL of essential oil added. The antimicrobial activity w...
This manuscript describes the first detailed chemical investigation of endemic species Iris adriatica, including isolation and structure elucidation. Chemical analyses of the rhizome CH2Cl2/MeOH (2:1) extract revealed fourteen secondary metabolites, mainly isoflavonoids. Among isoflavonoids, two groups have been found: nigricin-type and tectorigeni...
In the vascular flora of Serbia, the genus Euphorbia is represented with 36 species belonging to the subgenera Esula, Chamaesyce, Euphorbia and Rhizanthium. Five species of E. subg. Chamaesyce have been recorded so far in Serbia: E. chamaesyce, E. maculata, E. humifusa, E. nutans and E. davidii. During our research on the flora of Belgrade in 2012,...
The chemical composition, antimicrobial and antiquorum sensing activity of the essential oil of Micromeria thymifolia (Scop.) Fritsch were investigated. Limonene, piperitone epoxide and piperitenone epoxide were found as the main constituents using a gas chromatography-mass spectrometry technique. In vitro antimicrobial activity of the oil was test...
Spices have been used since ancient times. Although they have been employed mainly as flavoring and coloring agents, their role in food safety and preservation have also been studied in vitro and in vivo. Spices have exhibited numerous health benefits in preventing and treating a wide variety of diseases such as cancer, aging, metabolic, neurologic...
During the revision of moss collection of the University of Belgrade Herbarium from the Ostrozub Mountain
which was collected in period from 1950 to 1953 it has been found that numerous specimens had not been
determined. In total, 132 species were recorded: 23 liverwort, 109 moss species were found on the Mt.
Ostrozub. Out of those, 38 taxa (6, 25...
Diabetic bacterial foot infections (DBFIs) are limb-threatening complications in patients with diabetes mellitus, accounting for 50% of diabetes related lower limb amputations in developing countries, representing approximately 20 percent of all diabetes-related hospital admissions with significant healthcare-related costs involved. The widespread...
Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-1'-methyl ether was newly isolated together with thr...
Twenty-four species from the genus Sphagnum have been known up to now in the flora of Serbia. Based on a detailed analysis of herbarium material collected on Mt. Ostrozub, we identified S. fimbriatum Wilson, a species new to the bryoflora of Serbia.
The chemical composition of the methanolic and ethyl acetate extracts of liverwort Lophozia ventricosa (Dicks.) Dumort. was determined by solid phase microextraction-gas chromatography mass spectrometry (SPME-GC/MS). The dominant compounds in L. ventricosa methanolic extract were o-cymene (38.87 %), β-barbatene (26.35 %), and α-barbatene (8.30 %),...
In this study, the application of eucalyptus essential oil/vapour as beverages preservative is reported. The chemical composition of eucalyptus oil was determined by gas chromatography-mass spectrometry (GC-MS) and solid phase microextraction GC-MS (SPME/GC-MS) analyses. GC-MS revealed that the major constituents were 1,8-cineole (80.5%), limonene...
The chemical composition of Scapania aspera extracts was determined by solid phase micro extraction gas chromatography-mass spectrometry (SPME GC-MS) and 96 constituents were identified. The dominant compounds in the methanol extract were beta-barbatene (25.1%), o-cymene (14.0%), alpha-barbatene (5.7%), allo-aromadendrene (4.9%) and beta-bourbonene...
The chemical composition of Porella arboris-vitae extracts was determined by solid phase microextraction, gas chromatography-mass spectrometry (SPME GC-MS), and 66 constituents were identified. The dominant compounds in methanol extract of P. arboris-vitae were β-caryophyllene (14.7%), α-gurjunene (10.9%), α-selinene (10.8%), β-elemene (5.6%), γ-mu...
Chemical constituents of liverwort (Porella cordaeana) extracts have been identified using solid-phase microextraction-gas chromatography mass spectrometry (SPME-GC/MS). The methanol, ethanol and ethyl acetate extracts were rich in terpenoids such as sesquiterpene hydrocarbons (53.12%, 51.68%, 23.16%), and monoterpene hydrocarbons (22.83%, 18.90%,...
The antibacterial and antifungal activity of methanol extracts of the genuine mosses Abietinella abietina, Neck-era crispa, Platyhypnidium riparoides, Cratoneuron filicinum var. filicinum and Campylium protensum were evaluated. An-tibacterial activity was tested against Gram (+) Staphylococcus aureus, Micrococcus flavus, Bacillus cereus and Gram (-...
Projects
Projects (2)
The Mediterranean region, as one of the centers of plant diversity, is a very important source of diverse indigenous plants for fundamental and applied research. Although plant species have been intensively studied in this region, some areas have still not been sufficiently explored. Micromorphological, anatomical, phytochemical and molecular markers will be analyzed in order to find new taxonomic characters that are important for the delimitation of individual taxons and the clarification of their related relationships. Variability within and between populations of particular species, as well as phylogenetic relationships between the types of selected genera, will be analyzed using appropriate molecular markers. Special emphasis will be on the extraction and isolation of new biologically active substances, with potential application in the food industry, pharmacy, medicine, cosmetics and other applied disciplines. Plant species from the Balkans and North Africa (Libya) will be explored, based on whether they are aromatic, endemic, relict, endangered, edible or potentially economically important, primarily from the Lamiaceae family, Asteraceae and Apiaceae. The results of the research that are expected after a comprehensive analysis of individual taxa should complete the picture of the importance of autochthonous flora of this region, not only from the fundamental - systematic, ecological, phylogenetic and evolutionary aspects, but also to provide valid data on the economic potential of the species analyzed.
Working with traditional healers to discover compounds to treat multi-drug resistant bacteria from plants. Research in collaboration with Dr Rietie Venter, University of South Australia
