Danilo OlivierUniversidade Federal do Norte to Tocantins
Danilo Olivier
PhD
About
23
Publications
8,541
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106
Citations
Citations since 2017
Introduction
Additional affiliations
May 2018 - August 2019
Position
- Professor (Assistant)
April 2017 - March 2018
October 2014 - January 2015
Education
January 2005 - December 2009
Publications
Publications (23)
Arboviruses such as Dengue, yellow fever, West Nile, and Zika are flaviviruses vector-borne RNA viruses transmitted biologically among vertebrate hosts by blood-taking vectors. Many flaviviruses are associated with neurological, viscerotropic, and hemorrhagic diseases, posing significant health and socioeconomic concerns as they adapt to new enviro...
Despite all efforts to combat the pandemic of COVID-19, we are still living with high numbers of infected persons, an overburdened health care system, and the lack of an effective and definitive treatment. Understanding the pathophysiology of the disease is crucial for the development of new technologies and therapies for the best clinical manageme...
Due to their general cytotoxic effects, anticancer drugs pose a great risk to aquatic species, yet they have been among the least studied groups of drugs regarding their environmental impact. The present study aimed to identify the effects of the antileukemia drug cytarabine, also known as cytosine arabinoside (ara-C), on the development and neurob...
Several neurotropic viruses are members of the flavivirus and alphavirus families. Infections caused by these viruses may cause long-term neurological sequelae in humans. The continuous emergence of infections caused by viruses around the world, such as the chikungunya virus (CHIKV) (Alphavirus genus), the zika virus (ZIKV) and the yellow fever vir...
The C30 endopeptidase (3C-like protease; 3CLpro) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and, hence, is a promising drug target. Molecules isolated from animals, insects, plants, or microorganisms can serve as a scaffold for...
The C30 Endopeptidase (3C-like protease; 3CL pro ) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and is hence a promising drug target. Molecules isolated from animals, insects, plants or microorganisms can serve as a scaffold for t...
Herein we reported the synthesis of 20 novel fluorescent 5-carbonylated 2-arylindolizines derivatives through the reaction between organolithium intermediates with different electrophiles. To investigate the effects of the substituents on the wavelengths of electronic absorption spectra, fluorescence emission, quantum yield and Stokes shift, the ph...
Ubiquitous in citrus plants, Hesperidin and Hesperetin flavanones possess several biological functions, including antiviral activity. Arbovirus infections pose an ever-increasing threat to global healthcare systems. Among the severe arboviral infections currently known are those caused by members of the Flavivirus genus, for example, Dengue Virus—D...
Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) the WHO reported more than 148 million confirmed cases and 3.1 million losses globally up to now. The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide, resulting in a pandemic of unprecedented magnitude. To date, several clinically safe and efficient vacc...
1. dengue virus peptide 2. lipid peptide interaction 3. fluorescence spectroscopy 4. vesicles diffusion coefficient ABSTRACT: Dengue fever is a widespread infectious disease caused by Dengue viruses and responsible for millions of cases per year. One of the key steps during the infection is the fusion between the cell membrane and the lipidic bilay...
The potential outcome of flavivirus and alphavirus co-infections is worrisome due to the development of severe diseases. Hundreds of millions of people worldwide live under the risk of infections caused by viruses like chikungunya virus (CHIKV, genus Alphavirus ), dengue virus (DENV, genus Flavivirus ), and zika virus (ZIKV, genus Flavivirus ). So...
Mosquito borne viruses and their corresponding human infections have a fast growing impact on worldwide public health systems; in particular, Aedes aegypti and Aedes albopictus are transmitting these viruses. Only female mosquitoes bite and spread diseases. Male development in A. aegypti is initiated by male determining factors. These factors are p...
Since the first report of a new pneumonia disease in December 2019 (Wuhan, China) up to now WHO reported more than 50 million confirmed cases and more than one million losses, globally. The causative agent of COVID-19 (SARS-CoV-2) has spread worldwide resulting in a pandemic of unprecedented magnitude. To date, no clinically safe drug or vaccine is...
Vitamin B12 acts as a cofactor for various metabolic reactions important in living organisms. The Vitamin B12 biosynthesis is restricted to prokaryotes, which means, all eukaryotic organisms must acquire this molecule through diet. This study presents the investigation of Vitamin B12 metabolism and the characterization of precorrin-4 C(11)-methyltr...
Carbendazim (MBC) is a fungicide widely used in agriculture which allows the high productivity of several cultures, a necessary condition considering the growing of the world population. Moreover, MBC has environmental impact mainly on the soil and water sources, and consequently, on animal and human lives. However, even though the toxicity of fung...
Currently no effective treatment is available to combat infections caused by Corynebacterium pseudotuberculosis in livestock. Survival of this Gram-positive bacterium in rapidly-growing pathogens in hostile environments is strongly dependent on the existence of a robust DNA repair system to prevent DNA mutations and contribute to bacterial coloniza...
Zika virus infection is the focus of much research due to the medical and social repercussions. Due the role of the viral NS2B/NS3 proteinase in maturation of the viral proteins, it had become an attractive antiviral target. Numerous investigations on viral epidemiology, structure and function analysis, vaccines, and therapeutic drugs have been con...
Phospholipase-B-like (SVPLB-like) enzymes are present in relatively small amounts in a number of venoms, however, their biological function and mechanisms of action are un-clear. A three-dimensional model of the SVPLB-like enzyme from Crotalus adamanteus was generated by homology modeling based on the crystal structures of bovine Ntn-hydrolyases an...
In pathogens, the thioredoxin system forms part of the defense against oxidative stress and ensures the formation of the proper disulfide bonds to ensure protein function. In Corynebacterium pseudotuberculosis, the role and mechanism of TrxA1 has not been elucidated, but, the significant homology among different Trxs and the conservation of the res...
Green propolis, a mixture of beeswax and resinous compounds processed by Apis mellifera, displays several pharmacological properties. Artepillin C, the major compound in green propolis, consists of two prenylated groups bound to a phenyl group. Several studies have focused on the therapeutic effects of Artepillin C, but there is no evidence that it...
Questions
Questions (5)
Hi everybody,
I am studying the the interactions of DMPC and viral peptides using SAXS measurements. The problem is that our scattering pattern for DMPC unilamellar vesicles is weird, the second lobe is flat. This is different to all the other PC-head lipids that we found in literature. We tried several methods for preparation of the vesicles and we cannot avoid this strange pattern. Does anyone know how to avoid this? Or What is the meaning of this flat lobe?
Thank you in advance,
Danilo
Hi All, I am trying to simulate one DMPG lipid bilayer in interaction with some fusion peptides. First I am preparing the membrane, and I am facing the problem: How to enable the NAMD to use NBFix parameters for SOD ions? Does anyone know how to set up this using NAMD and Charmm 36 FF?
Thanks in advance!
I'm working with interaction between peptide-lipid bilayer systems, and I was wondering how to correctly analyse and show the statistics of my simulations. I mean, are there one correct way to express some results with average values and error? Does anyone know one paper or other source where can I find and learn about statistics in MD simulations?
Thanks in advance!
I'm doing some electronic spectra calculations of small molecules (up to 20 atoms) at B3LYP/TZVP level using Gaussian09. There was an error: Warning!!: The largest alpha MO coefficient is #########" and my job went down. I'd like to know if anyone has experienced this problem, and how to fix it. Thanks in advanced.
Danilo
I'm performing a MD with a mixed lipid bilayer DPPC:DPPG (4:1). Using Charmm-gui I built a lipid bilayer constituted by 100 lipids. In pure lipid bilayer for example DPPC, I could compare area per lipid, thickness and deuterium order parameter. My doubt is which parameters do I have to monitor during the simulation. How can I see if this bilayer were stabilized? Does anyone have experience in this kind of situation?
Projects
Projects (2)
To test and validate C(pH,E)MD simulation using Amber Computational Package. We intend to apply this methodology in heme-protein systems (e.g., cytochrome c and/or cytochrome c3).
The goal of this project is to understand how antimicrobial peptides interacts with model membranes.
