Danilo Demarchi

Danilo Demarchi
Politecnico di Torino | polito · DET - Department of Electronics and Telecommunications

PhD in Electronics Engineering

About

321
Publications
40,620
Reads
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4,007
Citations
Citations since 2016
168 Research Items
3492 Citations
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20162017201820192020202120220200400600
20162017201820192020202120220200400600
Introduction
Tenures of “Bio-Micro&Nano Systems”, “CAD for Microsystems” and “NanoElectronics”. Lecturer at PhD School of EPFL Lausanne for the course "Nanocomputing", Biomolecular computing module. Working on micro and nano systems for electronics and biomedical applications. Member of BioCAS Technical Committee, Associate Editor of the Transactions on Biomedical Circuits and Systems (TBioCAS), Associate Editor of IEEE Sensors and of the Springer Journal BioNanoScience.
Additional affiliations
September 2015 - present
École Polytechnique Fédérale de Lausanne
Position
  • Lecturer
Description
  • Biomolecular Computing Module, Doctoral Program in Electrical Engineering
July 2015 - present
Politecnico di Torino
Position
  • Professor (Associate)
March 2012 - present
Istituto Italiano di Tecnologia
Position
  • Affiliated Researcher
Education
January 1993 - December 1995
Politecnico di Torino
Field of study
  • Electronics Engineering

Publications

Publications (321)
Article
Delivery of small molecules and anticancer agents to malignant cells or specific regions within a tumor is limited by penetration depth and poor spatial drug distribution, hindering anticancer efficacy. Herein, we demonstrate control over gold nanoparticle (GNP) penetration and spatial distribution across solid tumors by administering GNPs with dif...
Preprint
p> Objective : we present a portable automatic kinetic perimeter based on a virtual reality (VR) headset device as innovative and alternative solution for the screening visual field clinical examination. We compared the performances of our solution with a gold standard perimeter, validating the test on healthy subjects. Methods : The system is comp...
Preprint
p> Objective : we present a portable automatic kinetic perimeter based on a virtual reality (VR) headset device as innovative and alternative solution for the screening visual field clinical examination. We compared the performances of our solution with a gold standard perimeter, validating the test on healthy subjects. Methods : The system is comp...
Article
Full-text available
Hand gesture recognition has recently increased its popularity as Human-Machine Interface (HMI) in the biomedical field. Indeed, it can be performed involving many different non-invasive techniques, e.g., surface ElectroMyoGraphy (sEMG) or PhotoPlethysmoGraphy (PPG). In the last few years, the interest demonstrated by both academia and industry bro...
Article
Full-text available
The integration of flexible and stretchable electronics into biohybrid soft robotics can spur the development of new approaches for fabricating biohybrid soft machines, thus enabling a wide variety of innovative applications. Inspired by flexible and stretchable wireless‐based bioelectronic devices, untethered biohybrid soft robots are developed th...
Article
Full-text available
Biohybrid Soft Robots In article number 2202674, Su Ryon Shin and co‐workers demonstrate untethered biohybrid soft robots comprised of human cardiac muscle actuators and wirelessly powered bioelectronics that allows for electrically controlled movement without the need for batteries and wires. The direct and seamless integration strategy herein int...
Article
Molecular transport in nanofluidic systems exhibits properties that are unique to the nanoscale. Here, the electrostatic and steric interactions between particle and surfaces become dominant in determining particle transport. At the solid-liquid interface of charged surfaces an electric double layer (EDL) forms due to electrostatic interactions bet...
Conference Paper
This paper describes the implementation and testing of a modular software for multichannel control of Functional Electrical Stimulation (FES). Moving towards an embedded scenario, the core of the system is a Raspberry Pi, whose different models (with different computing powers) best suit two different system use-cases: user-supervised and stand-alo...
Article
Full-text available
Objective To demonstrate an ultra-high field (UHF) 7 T delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) protocol for quantitative post-traumatic osteoarthritis (PTOA) detection and monitoring in a rabbit anterior cruciate ligament transection (ACLT) model. Design ACL transections were performed unilaterally in 5 rabbits (33-weeks-old, 3.5 ±...
Article
Full-text available
Liver fibrosis is a key pathological precondition for hepatocellular carcinoma in which the severity is confidently correlated with liver cancer. Liver fibrosis, characterized by gradual cell loss and excessive extracellular matrix deposition, can be reverted if detected at the early stage. The gold standard for staging and diagnosis of liver fibro...
Article
Full-text available
Food security is a major problem nowadays. Ensuring enough food for the entire human population is becoming harder due to climate change and world population growth. Smart agriculture is a promising solution: integrating sensors and data analysis in agriculture is leading to a reduction of food production waste and an increase in production yield....
Article
Full-text available
In this work, a system for controlling Functional Electrical Stimulation (FES) has been experimentally evaluated. The peculiarity of the system is to use an event-driven approach to modulate stimulation intensity, instead of the typical feature extraction of surface ElectroMyoGraphic (sEMG) signal. To validate our methodology, the system capability...
Article
Full-text available
Action observation treatment (AOT) exploits a neurophysiological mechanism, matching an observed action on the neural substrates where that action is motorically represented. This mechanism is also known as mirror mechanism. In a typical AOT session, one can distinguish an observation phase and an execution phase. During the observation phase, the...
Conference Paper
Over 2 billion people across the world are affected by some visual impairment - mostly related to optical issues, and this number is estimated to grow. Often, particularly in the elderly, more than one condition can affect the eyes at the same time, e.g., myopia and presbyopia. Bifocal or multifocal lenses can be used, these however may become unco...
Conference Paper
Simulations of electroneurogram recording could help find the optimal set of electrodes and algorithms for selective neural recording. However, no flexible methods are established for selective neural recording as for neural stimulation. This paper proposes a method to couple a compartmental and a FEM nerve model, implemented in NEURON and COMSOL,...
Article
Full-text available
Biofouling is the unwanted adsorption of cells, proteins, or intracellular and extracellular biomolecules that can spontaneously occur on the surface of metal nanocomplexes. It represents a major issue in bioinorganic chemistry because it leads to the creation of a protein corona, which can destabilize a colloidal solution and result in undesired m...
Article
PurposeThe objective of this work is to evaluate the performances of a novel integrated device, based on passive head-mounted display (HMD), for the pattern reversal visual evoked potential (PR-VEP) clinical test.Methods Google Cardboard® is used as passive HMD to generate the checkerboard pattern stimuli through an Android® application. Electroenc...
Preprint
Biofouling is the unwanted adsorption of cells, proteins, or intracellular and extracellular bio-molecules that can spontaneously occur on the surface of metal nanocomplexes. It represents a major issue in bioinorganic chemistry because it leads to the creation of a protein corona, which can destabilize a colloidal solution and result in undesired...
Article
Full-text available
Electrical impedance spectroscopy has been suggested as a sensing method for plants. Here, a theoretical approach for electrical conduction via the plant stem is presented and validated, linking its living electrical characteristics to its internal structure. An electrical model for the alternating current conduction and the associated impedance in...
Article
This Special Issue of the IEEE Journal on Emerging and Selected Topics in Circuits and Systems (JETCAS) is dedicated to circuits and systems applied to innovative products for the agriculture and food value chain.
Article
Full-text available
Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis,...
Article
Full-text available
Device wearability and operating time are trending topics in recent state-of-art works on surface ElectroMyoGraphic (sEMG) muscle monitoring. No optimal trade-off, able to concurrently address several problems of the acquisition system like robustness, miniaturization, versatility, and power efficiency, has yet been found. In this tutorial we prese...
Article
Full-text available
Manipulation of ions and molecules by external control at the nanoscale is highly relevant to biomedical applications. We report a biocompatible electrode-embedded nanofluidic channel membrane designed for electrofluidic applications such as ionic field-effect transistors for implantable drug-delivery systems. Our nanofluidic membrane includes a po...
Preprint
Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis,...
Article
Background: Large artery stiffness, assessed by carotid--femoral pulse wave velocity (cfPWV), is a major risk factor for cardiovascular events, commonly used for risk stratification. Currently, the reference device for noninvasive cfPWV is SphygmoCor but its cost and technically challenging use limit its diffusion in clinical practice. Aim: To v...
Conference Paper
Nanomedicine's inability to penetrate throughout an entire tumor volume, resulting from heterogeneous distribution within the tumor mass, remains a crucial limiting factor for a vast range of theranostic applications. Despite innumerable studies conducted on the topic that have shown efficacy and biocompatibility of colloidal gold nanoparticles (GN...
Article
In recent years the worldwide research community has highlighted innumerable benefits of nanomaterials in cancer detection and therapy. Nevertheless, the development of cancer nanomedicines and other bionanotechnology requires a huge amount of considerations about the interactions of nanomaterials and biological systems, since long-term effects are...
Article
Full-text available
Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesiologist and patient with continuous drug monitoring. Direct detection of drugs is achieved wit...
Article
This paper presents a low cost, noninvasive, clinical-grade Pulse Wave Velocity evaluation device. The proposed system relies on a simultaneous acquisition of femoral and carotid pulse waves to improve estimation accuracy and correctness. The sensors used are two high precision MEMS force sensors, encapsulated in two ergonomic probes, and connected...
Article
Full-text available
The heterogeneous distribution of delivery or treatment modalities within the tumor mass is a crucial limiting factor for a vast range of theranostic applications. Understanding the interactions between a nanomaterial and the tumor microenvironment will help to overcome challenges associated with tumor heterogeneity, as well as the clinical transla...
Preprint
Heterogeneous distribution of delivery or treatment modalities within the tumor mass is a crucial limiting factor for a vast range of theranostic applications. Understanding the interactions between a nanomaterial and the tumor microenvironment will help to overcome challenges associated with tumor heterogeneity as well as the clinical translation...
Article
Objective To report the clinical validation of an innovative, artificial intelligence (AI)-powered, portable and non-invasive medical device called Wound Viewer. The AI medical device uses dedicated sensors and AI algorithms to remotely collect objective and precise clinical data, including three-dimensional (3D) wound measurements, tissue composit...
Conference Paper
Full-text available
Nanomedicines’ inability to penetrate throughout the entire volume of a tumor due to heterogeneous distribution within the tumor mass remains a crucial limiting factor for a vast range of theranostic applications, including image-guided radiation therapy. Despite many studies conducted on the topic having shown the efficacy and biocompatibility of...
Conference Paper
Lung cancer produces the highest number of cancer-related deaths worldwide. Currently, Non-Small Cell Lung Cancer (NSCLC) accounts for more than 85% of those cases. To date, achieving an early and precise diagnosis of NSCLC remains challenging due to extensive intratumor heterogeneity, which concerns not only to tumor epithelial cells but also the...
Conference Paper
Full-text available
Direct and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly appealing because of speed and accuracy, while blood spot sampling and fluidic devices are discou...
Article
We present a new method for electrochemical sensing, which compensates the fouling effect of propofol through machine learning (ML) model. Direct and continuous monitoring of propofol is crucial in the development of automatic systems for control of drug infusion in anaesthesiology. The fouling effect on electrodes discourages the possibility of co...
Article
Full-text available
Falls in the home environment are a primary cause of injury in older adults. According to the U.S. Centers for Disease Control and Prevention, every year, one in four adults 65 years of age and older reports experiencing a fall. A variety of different technologies have been proposed to detect fall events. However, the need to detect all fall instan...
Article
Full-text available
Biomolecular computing is the field of engineering where computation, storage, communication, and coding are obtained by exploiting interactions between biomolecules, especially DNA, RNA, and enzymes. They are a promising solution in a long-term vision, bringing huge parallelism and negligible power consumption. Despite significant efforts in takin...
Article
Full-text available
Body channel communication (BCC) is a technique for data transmission exploiting the human body as communication channel. Even though it was pioneered about 25 years ago, the identification of a good electrical model behind its functioning is still an open research question. The proposed distributed model can then serve as a supporting tool for the...
Article
Full-text available
Goal: The aim of the study herein reported was to review mobile health (mHealth) technologies and explore their use to monitor and mitigate the effects of the COVID-19 pandemic. Methods: A Task Force was assembled by recruiting individuals with expertise in electronic Patient-Reported Outcomes (ePRO), wearable sensors, and digital contact tracing t...
Article
A B S T R A C T Interest in impedance-based cellular assays is rising due to their remarkable advantages, including label-free, low cost, non-invasive, non-destructive, quantitative and real-time monitoring. In order to test their potential in cancer treatment decision and early detection of chemoresistance, we devised a new custom-made impedance m...
Conference Paper
Full-text available
This study aims to evaluate the in vivo distribution of Gold Nanoparticles (GNPs) at different time points after intratumoral (IT) injection, exploiting their properties as contrast agents for Computed Tomography (CT). GNPs approximately 40 nm in diameter were synthesized with a surface plasmon peak at ~530 nm, capped with Bovine Serum Albumin (BSA...
Article
Full-text available
Individualized long-term management of chronic pathologies remains an elusive goal despite recent progress in drug formulation and implantable devices. The lack of advanced systems for therapeutic administration that can be controlled and tailored based on patient needs precludes optimal management of pathologies, such as diabetes, hypertension, rh...
Article
Full-text available
We present a 6DOF magnetic tracking system based on a low-complexity algorithm, operating with an Inertial Measurement Unit (IMU) orientation estimation and regression functions formed with simulated data sets, capable of running using only a single microcontroller unit (MCU), for use in low-complexity wearable and wireless systems. A prototype bas...