Danijela Ristic-Medic

Verified

Danijela verified their affiliation via an institutional email.

Learn more

Verified

Danijela verified their affiliation via an institutional email.

Learn more

• MD. PhD
• Profesor at Institute for Medical Research, Serbia

It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintena...

Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies. The objective was to assess the usefulness of biomarkers of iodine status in humans by systematically reviewing intervention studies that altered iodine status. We performed a structu...

Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets—the Mediterranean diet (Med diet) and low-fat diet—on liver status, c...

Background: Desaturation and elongation are critical processes in endogenous metabolic fatty acid pathways. Zinc (Zn) is a cofactor for desaturases and elongases enzymes. There is limited evidence regarding the relationships between biomarkers of Zn status, nutritional intake, plasma phospholipid fatty acid profile and clinical outcomes among patie...

Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). In general, oxidative stress is actively involved in initiation and progression of liver damage. The liver metabolizes various compounds that produce free radicals. Maintaining the oxidative/antioxidative...

Epidemiological studies report inconsistent findings regarding the association between dietary polyunsaturated fatty acid (PUFA) intake and cancer risk. Genetic variations—particularly single-nucleotide polymorphisms (SNPs) in the FADS1 and FADS2 genes—affect PUFA metabolism, linking circulating PUFA levels to the risk of several cancers, including...

Infertility is a multifaceted and pressing global health challenge, with male reproductive impairment playing a significant role in its overall burden. Zinc (Zn), a biologically indispensable trace element, is fundamental to spermatogenesis and overall male reproductive function. This narrative review explores the following aspects: (1) the mechani...

Background To strengthen the scientific evidence linking dietary sugar consumption with health outcomes, it's essential to look beyond the usual focus on non-communicable diseases (NCDs) and tooth decay. We thus hypothesize that considering other dimensions of health beyond physical health will meaningfully complement the evidence and expand our un...

Background Multiple studies have shown that children with developmental disabilities (CDD) often live with unrecognized and untreated pain, consume inadequate diet and have inadequate levels of physical activity. This study aimed to analyze pain, dietary habits and physical activity of CDD in Croatia, North Macedonia and Serbia. Methods A cross-se...

Background/Objectives: Numerous risk factors associated with development of cardiovascular disease (CVD) have been unfavorably altered in patients with chronic kidney disease (CKD). Low omega-3 polyunsaturated fatty acid (PUFA) intake and vitamin D deficiency are potential cardiometabolic risk factors in patients with CKD. The aim of this study was...

Background/Objectives: Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular disease (CVD). Carotid intima-media thickness (C-IMT) is a non-invasive marker of atherosclerosis. Low omega-3 polyunsaturated fatty acids (PUFA) intake and vitamin D deficiency are potential cardiometabolic risk factors in patients with CKD....

The objectives were to examine if there is a causal relationship between osteosarcopenic adiposity (OSA) syndrome (coexistence of osteopenia/osteoporosis, sarcopenia, and excess adiposity) and cardiometabolic disorders or if these disorders initiate the development of OSA and its worsening. The search was conducted in PubMed, Scopus, and Web of Sci...

Background Parents/caregivers of children with developmental disabilities (CDD) have a wide range of support needs and there are various interventions available. Support, challenges, and needs among parents/caregivers of CDD likely vary in different geographical settings. This study aimed to analyze the perceptions of support, challenges, and needs...

Background/Aim. Since the coronavirus disease 2019 (COVID-19) pandemic led to a strict lockdown in Serbia, the population has experienced drastic lifestyle changes. Physical distancing, self-isolation, limited availability of essential food products, and the stress related to the availability of therapy during the pandemic particularly affected the...

Background and objectives: Higenamine is an alkaloid found in different plant species like Aconitum japonica, Nandina domestica, Gnetum parvifolium, and Asarum heterotropoides. According to the available data in the literature, its dietary intake leads to an enhancement of lipolysis. The objective of this study was to explore whether the ingestion...

Background and Objectives: High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. The quality of dietary protein may also play a role in kidney health. Several observational studies have shown that compared with protein from plant sources, animal protein is...

Background and objectives: Osteosarcopenic obesity/adiposity (OSO/OSA) syndrome describes the concurrent deterioration of bone, muscle, and adipose tissue. The objective of this review was to evaluate human studies addressing serum biomarkers in relation to OSA. Methods: A search in the PubMed, Scopus, and Web of Science databases was conducted to...

Background/Aim. Obesity is a chronic and relapsing condition, and since recently, it has been considered a global epidemic. Current guidelines for tripartite treatment of obesity emphasize a program of lifestyle modifications such as medical nutrition therapy, aerobic exercise, and behavioral intervention. The aim of the study was to evaluate wheth...

The objective of this research was to evaluate the effects of the consumption of Pomegranate juice (PJ) on blood pressure and lipid metabolism in subjects with dyslipidemia and metabolic syndrome. Twelve females with established dyslipidemia and 12 females with metabolic syndrome consumed 300 mL of PJ daily for 2 and 6 weeks respectively. PJ consum...

Omega-3 fatty acids (FA), particularly eicosapentaenoic and docosahexaenoic acids, play a vital role throughout life. These essential molecules are integral to cell membranes and serve as precursors to various bioactive metabolites that can contribute to the prevention of numerous chronic non-communicable diseases. Since our bodies cannot produce o...

Objective: Vitamin D (VitD) plays various roles, promotes musculoskeletal health, maintains parathyroid hormone levels, and supports the immune processes. Vitamin D deficiency is common among cancer patients including thyroid cancer. Some data indicate that preoperative VitD levels in cancer patients correlate with the further prognosis of the dise...

Metabolic syndrome (MetS) is a global public health challenge and one of the main risk factors for cardiovascular diseases. Its pandemic prevalence created a demand for developing a relevant model system for deep insight into the molecular basis of MetS. Animal models, especially Wistar rats, are commonly used for that purpose. However, there are n...

Given our current knowledge and insights into the nature of nutrition, a simplistic approach to understanding the role of nutrition in relation to health outcomes appears insufficient as a scientific base for setting nutrition policies. To raise this issue, we performed a scoping review to evaluate the relationship between sugar intake, quality of...

It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of...

Osteosarcopenic adiposity (OSA) syndrome denotes the confluence of bone, muscle, and adipose tissue deterioration. Being a complex entity, numerous uncertainties about OSA still exist, despite the extensive research on the topic. Our objectives were to evaluate human studies addressing dietary intake/nutritional status and the quantity/types of phy...

The intake and status of micronutrients represent a significant research area aimed at preventing and treating the progression of renal impairment. Polyunsaturated fatty acids (PUFA), play a significant role in cardiovascular health and renal function. The study aimed to investigate the relationship between dietary magnesium, zinc, and vitamin B6 i...

Polyunsaturated fatty acid (PUFA) dietary intake, status, and serum key fatty acid (FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate the effects of a lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in erythrocyte phospholipids in moderately hyperlipidemic su...

Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid (FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in erythrocyte phospholipids in moderately hyperlipidemic subje...

The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can man...

Objective This systematic review aimed to identify the characteristics and application of citation analyses in evaluating the justification, design, and placement of the research results of clinical health studies in the context of earlier, similar studies. Study Design We searched MEDLINE (OVID), Embase (OVID), and the Cochrane Methodology Regist...

Objectives: Industrially produced trans fatty acid (iTFA) have adverse health effects and thus their consumption should be limited. The aim of this study was to determine and compare the iTFA content in frequently consumed food products by young adults from the Serbian and Slovenian market with supposedly elevated iTFA content in 2015. At the time...

The status of essential and toxic trace elements in patients with different stages of chronic kidney disease (CKD) is still unclear and not well characterized. The present study examined the circulatory levels of a wide panel of trace elements (Al, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Cd, Pb, and U) in hemodialysis patients (HD group) and pre-di...

Being characterized by progressive and severe damage in neuronal cells, neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the elderly, imposing a significant economic and social burden. As major components of the central nervous system, lipids play important roles in neural health and pathology. Disturbed lipid me...

The aim of this study was to compare dietary intake and status of polyunsaturated fatty acids (PUFA) in plasma and erythrocyte phospholipids metabolically healthy and unhealthy, and obese and nonobese persons. Metabolic health status in 171 participants was defined according to criteria for metabolic syndrome. Obese and nonobese metabolically unhea...

Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The re...

The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & f...

Background/Aim. Consensus on the exercise effect on the fatty acid metabolism has not been reached, and probably depends on the type of sports (aerobic, anaerobic or mixed). The aim of this study was to investigate effect of long-term handball training on the body composition, lipid profile and the plasma phospholipid fatty acid composition in fema...

It is clear that dietary components can modulate blood glucose levels. Diets that improve glycemic control are rich in whole grains, fruits, vegetables, legumes, and nuts; poor in refined grains, red or processed meats, and sugar-sweetened beverages; and moderate in alcohol consumption. Low-carbohydrate, low-glycemic index, Mediterranean, and high-...

Introduction/Objective. Although smoking is the main risk factor for lung cancer (LC), studies have shown that diet could also play an important role. The aims of this study was to analyze dietary intake of newly diagnosed LC patients and to compare with sex and age matched healthy controls. Methods. Sixty-nine non-treated LC patients (50 male, 19...

Background/Aim. Inflammation is the most important factor in the genesis of vascular complication in the endstage renal disease. The serum C-reactive protein (CRP) level is a sensitive marker of systemic inflammation as well as a predisposing factor for cardiovascular and all cause mortality in patients on hemodialysis. Albumin is the negative acut...

Background/Aim. Obesity is the chronic disease and health threatening condition. The number of obese people in the world has taken epidemic conditions. Medical nutritional therapy is the first choice in the treatment of obesity, but it is also accompanied with a great percentage of attrition and a significant weight regain. The aim of our study was...

Adequate dietary iodine intake is essential for the production of thyroid hormones. Most people get iodine in their diet from seafood and iodized salt. The absorption of dietary iodine is higher than 90%. Iodide is absorbed by an active transport protein called the sodium–iodide symporter. The body of a healthy adult contains approximately 10–20 mg...

Dominant factors that determine cholesterol balance are those responsible for cholesterol absorption, synthesis, and clearance. Age and sex differences in cholesterol metabolism exist. There are large evidences of strong connections between common variants in the genes involved in cholesterol metabolism through various enzyme activities. Influences...

Interaction of polyphenolic molecules with human serum albumin (HSA) could lead to changes of HSA Cys34 thiol group (HSA-SH) reactivity. The influences of enterolactone (EL) and enterodiol (ED) binding on HSA-SH reactivity in fatty acid (FA) free HSA and HSA with bound stearic acid (S) in S/HSA molar ratios (1:1 and 4:1), were investigated by deter...

Introduction/Aim: Obesity is an established risk factor for numerous chronic diseases. The aim of this study was to investigate the effect of well-balanced different caloric restriction (CR) diets on anthropometric parameters and standard biochemical cardiovascular risk markers (lipid profile, glucose homeostasis and hs-CRP) in overweight/obese fem...

Introduction/Aim: Overweight/obesity has become important health problem in developed countries. It may be related to presence of low-grade inflammation in white adipose tissue. The aim of this survey is to investigate the levels of inflammatory marker C-reactive protein (CRP) and its relation to anthropometric parameters in overweight and obese fe...

Background: Paraoxonase–1 (PON1) enzymatic activity appears to play a role in maintaining the endothelial-atheroprotective effects of high density lipoprotein (HDL)-cholesterol and has been linked to vascular disease and diabetes. The objective of this study was to determine the effect of fish oil consumption on antioxidative capacity of HDL-choles...

Background Childhood obesity, dental caries, and periodontal disease are major public health problems due to their adverse impact on the growth and development of children.AimTo examine the association between nutritional status, oral health, and lifestyle habits among schoolchildren in Serbia.DesignThis cross-sectional study assessed 422 children...

ASSOCIATION BETWEEN OBESITY, ORAL HEALTH AND LIFE STYLE FACTORS Book of abstracts PP342 D. Ristic Medic1, D. Markovic2, I. Karadzic1, J. Nikolic Ivosevic3, V. Vucic1 1Institute for Medical Research University of Belgrade, Belgrade, Serbia 2Faculty of Dentistry University of Belgrade, Belgrade, Serbia, 3Health Centre Subotica, Subotica, Serbia Ba...

The objective of this systematic review was to identify studies investigating iodine intake and biomarkers of iodine status, to assess the data of the selected studies, and to estimate dose-response relationships using meta-analysis. All randomized controlled trials, prospective cohort studies, nested case-control studies, and cross-sectional studi...

Background: Plant seeds have gained interest for their health benefits due to their fatty acid content. The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and inflammatory factors in patients on hemodialysis....

Background. Plant seeds have gained interest for their health benefits due to their fatty acid content.The objective of this study was to determine the effects of dietary consumption of milled sesame/pumpkin/flax seed mixture on glycemic control, serum lipids, phospholipid fatty acid status, and inflammatory factors in patients on hemodialysis. Met...

Our earlier studies found that in vitro estradiol modulates mitochondrial Ca2+ transport in discrete brain regions. The present study examined the role of estradiol receptors (ERs) in estradiol-induced inhibition of Ca2+ efflux from synaptosomal mitochondria isolated from rat caudate nuclei and brain stems. Radioactively labeled CaCl2 (0.6-0.75 mu...

Current dietary recommendations are based on a reduced saturated fatty acid (SFA) consumption to prevent cardiovascular disease (CVD). The role of individual SFA in metabolic disease is not fully understandable. One type of SFA present in many common foods (dairy, meat, palm and coconut oil) is palmitic acid (16:0). A number of epidemiological stud...

The quantity and quality of fats consumed in the diet can have important effects on prevention and/or improvement clustering metabolic abnormalities of the metabolic syndrome. Fatty acids as food ingredients regulate cholesterol homeostasis and concentrations of blood lipoproteins, and affect the levels of other cardiometabolic risk factors, such a...

Polyunsaturated fatty acids (PUFAs) are necessary for overall health. Two PUFAs families, n-6 and n-3 fatty acids, are physiologically and metabolically distinct. The proportion of PUFAs in serum and erythrocyte phospholipids, which depends on endogenous metabolism controlled by genetic polymorphisms and dietary intake, is an important determinant...

Iodine is an essential component of thyroid hormones, and current recommendations for intake are based on urinary iodine excretion, assessment of thyroid size, thyroidal iodine accumulation and turnover, radioactive iodine uptake, balance studies, and epidemiological studies. Dietary iodine is rapidly and almost completely absorbed. The prevalence...

The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. To...

A number of epidemiological and experimental evidences have linked polyunsaturated fatty acids (PUFA) of n-3 series to reduced cancer risk. Particularly the long chain n-3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to have potent antitumor effects. Increased consumption of EPA and DHA, found naturally in sea foo...

The aim of the present paper was to investigate the serum concentration of total phospholipids and distribution of the phospholipid classes in patients with diabetes mellitus type 2 and dyslipidemia. We analyzed the serum phospholipids in 28 newly diagnosed patients with diabetes type 2, of which 12 men and 16 postmenopausal women aged 43-70 years....

ABSTRACT: The aim of this study was to determine whether there is a correlation between body weight, oral health and life-style habits among children in Serbia. The study population included two hundred children aged 6 to 18 who attended the Institute for mother and child health care “Dr Vukan Cupic” in Belgrade, Serbia. The analyzed dental paramet...

Background: Placental supply of fatty acids (FA) is essential for normal foetal development but in premature infants this supply is interrupted. To investigate the association of intrautrine growth restriction with serum phospholipid and breast milk FA composition, we compared preterm infants small for gestational age (SGA) and matched appropriate...

Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The ba...

In general, patients with end-stage renal disease treated with chronic hemodialysis have plasma and cell membrane fatty acid profiles that indicate essential fatty acid deficiency, with low omega (n)- 3 and n-6 polyunsaturated fatty acid (PUFA) products, including dihomo-γ-linolenic, arachidonic, and eicosapentaenoic and docosahexaenoic acids. Abno...

OBESITY AND OVERWEIGHT SCHOOLCHILDREN AND ADULTS IN SERBIA Mirjana Gurinovic1, Maria Glibetic1, Milija Vukotic2 , Ivana Novakovic2, Danijela Ristic Medic1 , Milena Radanov Radicev3 1 University of Belgrade, Institute for Medical Research, Nutrition Department, Belgrade, Serbia 2 University of Belgrade, Medical Faculty, Belgrade, Serbia 3Statisti...

Many reports review the evidence that the precursors of atherosclerosis begin in childhood. The majority of risk factors are connected with eating habits and life style patterns already adopted in childhood and youth. Overweight in childhood has been associated with increased risks of hypertension, adverse lipid profiles, type II diabetes, and earl...

The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients...

In order to assess nutritional adequacy, reliable estimates of nutrient intake are required. Specifically, the EURopean micronutrient RECommendations Aligned (EURRECA) Network of Excellence needs clear guidelines on methods suitable for assessing micronutrient intakes among vulnerable population groups. The objective of this project was to collect,...

This study examines the relationship between erythrocyte phospholipid FA composition and insulin sensitiv­ity in obese patients on a typical Serbian diet. In 30 patients, two insulin sensitivity groups were formed and their FAs analyzed. The shares of 22:5n-3, 22:6n-3, and total n-3 PUFAs, as well as a measure of Δ5 desaturase activity (the 20:4n-6...

Muscle wasting is independent predictor of mortality in end-stage renal disease (ESRD) patients on maintenance hemodialysis (MHD). We investigated the effect of insulin resistance on lean body mass (LBM), and association between insulin resistance, chronic inflammation, and body composition in these patients. We analyzed cross-sectionally body comp...

Hyperlipidemia is found to be associated with changes in fatty acid (FA) profiles. The aim of this study was to investigate the effects of AHA-Step-1 dietary treatment and combination of fibrates (gemfibrozil) with dietary intervention on serum and erythrocyte phospholipid FA composition in human hyperlipidemia. 78 study participants with hyperlipi...

Blood cholesterol levels are affected by diet and in particular by the type of fat intake. We originally showed that a significant but variable amount of cholesterol is firmly bound to haemoglobin (Hb) yielding the Hb-lipid adduct (Hb-Ch) in erythrocytes isolated from normo-lipidemic males. To establish whether dietary lipids affect the level of Hb...

Dietary fat and its relation to obesity has been a controversial issue for many years. Experimental data shows that most, though not all animals, which consume a high fat diet, will become obese. However, the effect of fatty acids on animal obesity has not been studied in detail. In order to evaluate the effects of low versus high fat diet on serum...

Nutrition as an aetiological factor participates a great deal in premature atherosclerosis in haemodialysis (HD) patients. The basic mechanisms of end-stage renal disease and premature atherosclerosis are connected with changes in cell functions at the membrane level. We investigated the red cell membrane fatty acids and the effects of fish oil sup...

Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects...

The primary objective of our research was to investigate the nutritional status in Belgrade schoolchildren (aged 12–15). The second objective was to compare the children and parents view about the children nutritional status. The study was carried out in two phases: (a) questionnaires for children and parents (questionnaire-c and questionnaire-p) w...

Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid...

The present study investigated the quantitative effect of dietary fats and ingestion of alcohol on serum and liver lipids, fatty acid bound to phospholipids and their class distribution of male Wistar rats. The rats in C (control) and A (alcohol) groups were fed a standard laboratory diet, HFC (high fat-control) and HFA (high fat-alcohol) groups we...