Daniil Degterev

• PhD
• Head of Department at Moscow Clinical Scientific Center

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an increased recognition of its potential to induce neurological complications in the post-infection phase. This paper presents the case study of a 67-year-old male who experienced a severe SARS-CoV-2 infection, followed by the development of myopathy after 11–...

Background. Stress, individual characteristics of each patient, visceral hypersensitivity and intestinal motility have the key importance in the pathogenesis of irritable bowel syndrome (IBS). In recent years, there has been growing interest in the use of selective serotonin and norepinephrine reuptake inhibitors (SNRIs) in the complex therapy of I...

This article presents a clinical case of thrombophilia in a patient with short bowel syndrome. Thrombophilia is characterized by a disorder of the blood clotting system, in which the risk of thrombosis increases. Thrombophilia, local vascular insufficiency, intestinal obstruction with fistula formation requiring intestinal resection play a signific...

Background: Irritable bowel syndrome (IBS) is a biopsychosocial model based on the malfunction of "brain-intestinal linking". Aim: To improve diagnostics of the severe IBS accompanied with somatoform disorders by using balloon dilatation test (BDT) and optimize the therapy by using antidepressants from the serotonin and noradrenaline reuptake in...

Introduction: Vulto-van Silfhout-de Vries Syndrome (VSVS; OMIM#615828) is a rare hereditary disease associated with impaired intellectual development and speech, delayed psychomotor development, and behavioral anomalies, including autistic behavioral traits and poor eye contact. To date, 27 patients with VSVS have been reported in the literature. M...

Introduction: VULTO-VAN SILFHOUT-DE VRIES SYNDROME (VSVS;OMIM#615828) is an extremely rare hereditary disease associated with impaired intellectual development and speech, delayed psychomotor development and behavioral anomalies, including autistic behavioral traits and poor eye contact. To date, 27 patients with VSVS have been reported in the worl...

Cowden syndrome is a rare disease characterized by multiple hamartomas and increased breast, thyroid, kidney and uterine neoplasm risk. The lifetime breast cancer risk for patients with Cowden syndrome is 85 %, with an average age of diagnosis between 38 and 46 years. The diagnostic criteria for Cowden syndrome have been established by the Internat...

Cowden syndrome is a rare disease characterized by multiple hamartomas and increased breast, thyroid, kidney and uterine neoplasm risk. The lifetime breast cancer risk for patients with Cowden syndrome is 85 %, with an average age of diagnosis between 38 and 46 years. The diagnostic criteria for Cowden syndrome have been established by the Internat...

Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Neuropathologically, AD is characterized by the deposition of a 39- to 42-amino acid long β-amyloid (Aβ) peptide in the form of senile plaques. Several post-translational modifications (PTMs) in the N-terminal domain have been shown to increase the aggregation and cytotoxi...

The article presents a clinical case of a 23-year-old patient with an extremely severe congenital form of chronic intestinal pseudoobstruction coupled with a neuromyopathy,colon malrotation, malabsorption, bacterial overgrowth syndrome, cholelithiasis and gastrostasis, which excluded bowel transplantation. Long-term treatment in the intensive care...

Psychogenic or functional neurological disorders (FND) often occur in the practice of a neurologist. Diagnosis of FND usually causes significant difficulties. Among FND, psychogenic non-epileptic seizures (PNES) comprise around 40% cases. Sometimes it is necessary to differentiate PNES from narcolepsy. We describe a 55-year-old man with frequent br...

Coeliac disease and non-celiac gluten sensitivity are disorders whose diagnosis can be delayed for many years from the first clinical manifestations. Typical debut of coeliac disease is an extraintestinal manifestation as gluten-related disorders. One of such impairments is headache. There are currently data about gluten-associated headache includi...

The patient E., aged 39, was described with a severe form of the irritable bowel syndrome that developed after the stress. In addition to the clinical manifestations of IBS, the patient got the somatoform disorders, which manifested itself with a large number of extraintestinal symptoms and led to a disability. According to the recommendations of t...

The article has observed pathogenesis, clinical and rehabilitation aspects of stroke. Authors payed their attention to the importance of neuroplastic processes in the rehabilitation, the role of cerebral connections. Adverse recovery factors after stroke have been presented.

The article presents data concerning the determination of acetylcholine (Ah) and cholinesterase activity (HAE) in the serum of patients with PUD, chronic pancreatitis of alcoholic etiology (AKHP) and inflammatory bowel disease (ulcerative colitis, Crohn’s disease), IBD. Established that healthy individuals can be divided into three groups with diff...

The paper presents the All-Russian consensus on the diagnosis and treatment of celiac disease in children and adults, which has been elaborated by leading experts, such as gastroenterologists and pediatricians of Russia on the basis of the existing Russian and international guidelines. The consensus approved at the 42nd Annual Scientific Session of...

The review considers the pathogenetic, clinical, and therapeutic aspects of neurological disorders associated with gluten sensitivity. Gluten ataxia and polyneuropathy are most common. The clinical features of neurological disorders in patients with gluten sensitivity and the effects of a gluten-free diet are described.

Different aspects of polyneuropathies (PN) developed due to the deficit of group B vitamins in intestinal diseases are considered. Neurological disturbances related to intestinal diseases are caused by malabsorption that leads to the deficit of some compounds extremely important for normal cell metabolism, pathological changes of mucous coat of the...

The number of bariatric (weight loss) surgeries have increased steadily in the past decade. Along with the tangible benefit of this treatment, there is a risk for postoperative complications, the main cause of which is impaired absorption of nutrients. The paper describes polyradiculoneuropathy running as a type of Guillain-Barré syndrome.

Macro- and micronutritional deficiencies may occur in some bariatric patients post surgery, which can result in serious neurological complications. In this article, the authors describe the case of a patient who developed polyradiculoneuropathy, a variation of acute inflammatory demyelinating polyneuropathy or Guillain-Barré syndrome, following Rou...

Unlabelled: The objective of the present study was to compare the safety and effectiveness of navigated and non-navigated rhythmic transcranial magnetic stimulation rTMS in the patients presenting with post-stroke hemiparesis. Methods: Group 1 consisted of 31 patients with post-stroke hemiparesis treated by navigated rTMS. Thirty comparable pati...

The article reports a clinical case of primary cerebral lymphoma in a patient aged 49 years old. The items concerning etiology, pathogenesis, clinical manifestations, diagnostic approaches, differential diagnosis and treatment of primary lymphoma of the central nervouse system are discussed.

To determine the role of histological diagnosis of lymphadenopathy (LAP) associated with clinico-laboratory picture in patients with HIV infection/AIDS. Target biopsy of the peripheral lymph node was made in 80 HIV-infected patients from 2002 to 2005. Histological diagnosis was made in all the patients with light microscopy, in some patients at imm...