Daniele Ugo Tari

Azienda Sanitaria Locale Caserta · UO Diagnostic Senology

Background: The assessment of breast density is one of the main goals of radiologists because the masking effect of dense fibroglandular tissue may affect the mammographic identification of lesions. The BI-RADS 5th Edition has revised the mammographic breast density categories, focusing on a qualitative evaluation rather than a quantitative one. O...

Female breasts can suffer from a wide spectrum of pathologies, ranging from inflammatory diseases to benign and malignant tumors [...]

Aim: To evaluate the local impact of the coronavirus disease 2019 (COVID-19) pandemic on breast cancer (BC) care, with particular attention to the economical and psychological consequences of the possible delay of new diagnoses and treatments. Methods: Three years' activity (from 2019 to 2021) has been compared. The number of BCs diagnosed from...

Breast cancer (BC) is the most common cancer in women of all ages, with more than 2 million diagnoses every year and a high economic and psychological impact on both the health care system and the population [...]

Ductal carcinoma in situ (DCIS) of male breast is a rare lesion, often associated with invasive carcinoma. When the in situ component is present in pure form, histological grade is usually low or intermediate. Imaging is difficult as gynaecomastia is often present and can mask underlying findings. We report a rare case of pure high-grade DCIS in a...

Introduction: Since breast imaging requires very close contact with patients, a protocol is needed to perform safe daily screening activities during the COVID-19 pandemic. Materials and methods: Patients were triaged and separated into three different clinical scenarios by performing a telephone questionnaire before each diagnostic exam or a nasoph...

Background: During the COVID-19 public health emergency, our breast cancer screening activities have been interrupted. In June 2020, they resumed, calling for mandatory safe procedures to properly manage patients and staff. Methods: A protocol supporting medical activities in breast cancer screening was created, based on six relevant articles pu...

Breast cancer is a clear example of excellent survival when it is detected and properly treated in the early stage. Currently, screening of this cancer relies on mammography, which may be integrated by new imaging techniques for more exhaustive evaluation. The Personalized, Integrated, Network, Knowledge (P.I.N.K.) study is a longitudinal multicent...

Purpose Erythropoiesis‐stimulating agents (ESAs), are used for treating chronic kidney disease (CKD)‐related anemia, contributing to CKD costs. The study was aimed at investigating direct healthcare costs of CKD patients treated with ESAs and the potential savings achievable by increasing the use of biosimilars and preventing inappropriate ESA use....

Scopo: Analizzare gli effetti dell'adesione al follow-up del programma di screening per il Ca.mammario nell'Azienda Sanitaria Locale di Caserta dal 2015 al 2019. Materiali e metodi: Il programma di screening è rivolto a pazienti(Pz) dai 45 ai 50aa(Gruppo A) con controlli annuali e dai 50 ai 70aa(Gruppo B) con controlli biennali(1-2),salvo diverse i...

Scopo: Nel 2019, l'ASL Caserta ha completato il percorso diagnostico-terapeutico-assistenziale (PDTA) per il tumore della mammella, aggiungendo alla popolazione target ministeriale (50-69 anni) anche quella 45-49 anni e valutando l'impatto dello screening personalizzato sulla diagnosi precoce attraverso il portale Sani.ARP (Fig. 1). In particolar m...

An amendment to this paper has been published and can be accessed via the original article.

Background and objectives: Switching between different erythropoiesis-stimulating agents (ESAs) during the first year of therapy is frequent (15-20%), much more so toward reference products than biosimilars. The objectives of this study were to investigate the frequency and identify the potential predictors of switching between biosimilar and orig...

Introduction Analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs), weak and strong opioids are commonly used among elderly persons. The aim of this study was to describe the demographic and clinical characteristics of elderly analgesic users and to measure the frequency of analgesic use, including the frequency of potentially inappropr...

Purpose The aim of the present study was to describe antipsychotic utilization patterns among patients with schizophrenic disorder in Italy, Spain, the UK, and the USA. Methods A retrospective cohort study was conducted. Patients aged 15 and over with schizophrenic disorder were identified in the Caserta claims database (Italy), the Valencia elect...

INTRODUZIONE In un contesto sociale ove persiste la difficoltà all'affermarsi di una forte cultura della prevenzione, l'ASL Caserta ha sviluppato un nuovo percorso diagnostico-terapeutico-assistenziale (PDTA) per lo screening e la cura del tumore della mammella. Riportiamo, pertanto, i risultati dell'applicazione di tale PDTA presso l'UO di Diagnos...

In a social background of lack of knowledge about the importance of early diagnosis, Caserta Local Health Authority has developed a new screening protocol for breast cancer. We report our experience and the preliminary results of the first two years activity’s at the Department of Diagnostic Senology, Marcianise, Caserta, Italy. METHODS: 10747 wome...

PurposeSomatropin [recombinant growth hormone (rGH)] is approved in children and adults for several conditions involving growth disturbances and the corresponding biosimilar is available in Italy since 2006. No population-based data are available on the pattern of rGH use in Italian clinical practice. This study aimed at exploring the pattern of bi...

Introduzione: Dimostrare l’efficacia del nuovo protocollo di screening per il tumore della mammella presso l’U.O.S. di Diagnostica Senologica del P.O. di Marcianise in relazione a problematiche territoriali quali la difficoltà ad affermarsi di una cultura della prevenzione e la scarsità di risorse umane e tecnologiche. Riportiamo esperienza e risul...

Breast cancer (BC) is the most frequently diagnosed cancer in women in Italy, occurring with a standardized incidence of 114/100.000/year. The anticipation of diagnosis and an increased application of more effective surgical and medical treatment protocols, have allowed an improvement in the survival rate. Despite this, there is still a disadvantag...

Purpose: To explore the frequency of polypharmacy, functional and cognitive capacity among the elderly in Southern Italy. Methods: Population-based retrospective cross-sectional study. Information were retrieved from electronic-geriatric-forms matched by record-linkage to outpatient pharmacy-records. The following domains were collected from ger...

Aim: The aim is to evaluate prescriptive patterns of atypical antipsychotic drugs for the treatment of schizophrenia in the LHU Caserta in 2011-2013, and to indicate potentially inappropriate therapy; to plan or schedule corrective/preventive activities to support the continuous improvement of health services. Methods: Retrospective cohort study...

Background and objectives: Diabetes mellitus in patients with chronic kidney disease (CKD) is known as diabetic kidney disease (DKD). Pharmacological management of DKD is challenging due to reduced renal excretion of some antidiabetic drugs. The aim of this population-based study was to explore antidiabetic drug use in DKD patients from Southern I...

To explore the prescription patterns of erythropoiesis-stimulating agents (ESAs) in four large Italian geographic areas, where different health policy interventions to promote biosimilar use in routine care are undertaken. A retrospective drug utilization study was conducted during the years 2009-2013. The data sources were the administrative datab...

The treatment of diabetes in the elderly is a major challenge both in terms of clinical management and of public health. Evidence about prescribing patterns in the elderly diabetic population is limited. The aim was to describe trends in antidiabetic drug (AD) utilization patterns in the elderly in Southern Italy with a focus on drugs for cardiovas...

BACKGROUND: Non-steroidal anti-inflammatory agents (NSAIDs) are known to be associated with renal damage. No clear evidence exists regarding differential risk of chronic kidney disease (CKD), specifically, across various NSAIDs. AIM: The aim of this population-based case-control study was to evaluate the association between use of individual NSAIDs...

AimsTo analyse the prescribing pattern of both newer and older AEDs.MethodsA population of almost 150,000 individuals registered with 123 general practitioners was included in this study. Patients who received at least one AED prescription over 2005-2011 were identified. The one-year prevalence and cumulative incidence of AED use, by drug class and...

Background: Screening-based CKD estimates may not provide a sufficient insight into the impact of CKD on the use of healthcare resources in clinical practice. The aim of this study was to evaluate the epidemiology of "medicalized" CKD, that is, CKD requiring healthcare services, in an outpatient setting. Design, setting, participants, and measure...

Lowering blood cholesterol levels reduces the risk of coronary heart disease. However, the effect of interventions depends on the patients' adherence to treatment. Primary care plays an important role in the detection, treatment and monitoring of disease, therefore different educational programs (EP) have been implemented to improve disease managem...

Diabetic mastopathy represents an uncommon tumor-like proliferation of fibrous tissue of the breast that usually occurs in patients who suffered from type 1 diabetes mellitus for a long time. We report an uncommon case of diabetic mastopathy presenting in a type 2 non-insulin dependent diabetes mellitus 61-year-old postmenopausal woman. Physical ex...

The use of nephrotoxic drugs can further worsening renal function in chronic kidney disease (CKD) patients. It is therefore imperative to explore prescribing practices that can negatively affect CKD patients. To analyze the use of nephrotoxic drugs in CKD patients in a general population of Southern Italy during the years 2006-2011. The general pra...

Adrenal adenomas are the most common adrenal benign lesions detected on pathological studies in about 6% of patients over 60 years of age (1). The predominant characteristic of adrenal adenomas is the fatty content; because of this property, adrenal adenomas are suitable for MR imaging showing signal hypointensity relative to liver parenchyma on bo...

The aims of the study were to assess the trend of older and newer anti-epileptic drugs (AEDs) in the elderly population and to analyze the effects of a health-policy intervention with regard to AED use in general practice in a setting in Southern Italy. Data were extracted from the 'Caserta-1' Local-Health-Unit Arianna database in the years 2004-07...

To analyse the prescribing pattern of newer and older antiepileptic drugs (AEDs) during the years 2003-2005. From the Caserta-1 Local Health Service database, 93 general practitioners (GPs) were recruited. Among 127,389 individuals aged > or =15 years registered in the lists of these GPs, we selected patients who received at least one AED prescript...

In October 2004, rofecoxib was removed from the world market because of an increased risk of myocardial infarction. The aim of the present study was to compare the trend of nonsteroidal antiinflammatory drug (NSAID) use and other analgesics in osteoarthritis (OA) treatment before and after rofecoxib withdrawal in Italian general practice. From the...

Objective To assess whether the prescribing pattern of lipid-lowering drugs (LLD) changed after reimbursement criteria revision in a general practice in southern Italy. Methods From the Caserta-1 Local Health Service database, 93 general practitioners (GPs) who had consistently sent data about their patients during the years 2003-2005 were recruite...