Daniela Vergara

Daniela Vergara
University of Colorado Boulder | CUB · Department of Ecology and Evolutionary Biology (EBIO)

PhD

About

46
Publications
21,340
Reads
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810
Citations
Citations since 2017
28 Research Items
630 Citations
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2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
Additional affiliations
August 2007 - August 2013
Indiana University Bloomington
Position
  • PhD Student

Publications

Publications (46)
Article
Full-text available
The legal status of Cannabis is changing, fueling an increasing diversity of Cannabis -derived products. Because Cannabis contains dozens of chemical compounds with potential psychoactive or medicinal effects, understanding this phytochemical diversity is crucial. The legal Cannabis industry heavily markets products to consumers based on widely use...
Article
Full-text available
Currently, the amount of genetic data for Cannabis is lacking due to the illegal nature of the plant. Our study used 73 Cannabis sativa whole genome shotgun libraries to reveal eight different mtDNA haplotypes. The most common haplotype contained 60 of the 73 samples studied and was composed of only dioecious individuals. However, other haplotypes...
Article
Full-text available
The National Institute on Drug Abuse (NIDA) is the sole producer of Cannabis for research purposes in the United States, including medical investigation. Previous research established that cannabinoid profiles in the NIDA varieties lacked diversity and potency relative to the Cannabis produced commercially. Additionally, microsatellite marker analy...
Preprint
Full-text available
The legal status of Cannabis is changing, fueling an increased diversity of Cannabis-derived products. Because Cannabis contains dozens of chemical compounds with potential psychoactive or medicinal effects, understanding its phytochemical diversity is crucial. The legal Cannabis industry heavily markets products to consumers based on widely used l...
Article
Full-text available
The flowering plant Cannabis sativa , cultivated for centuries for multiple purposes, displays extensive variation in phenotypic traits in addition to its wide array of secondary metabolite production. Notably, Cannabis produces two well-known secondary-metabolite cannabinoids: cannabidiolic acid (CBDA) and delta-9-tetrahydrocannabinolic acid (THCA...
Preprint
Full-text available
The National Institute on Drug Abuse (NIDA) is the sole producer of Cannabis for research purposes in the United States, including medical investigation. Previous research established that cannabinoid profiles in the NIDA varieties lacked diversity and potency relative to the Cannabis produced commercially. Additionally, microsatellite marker analy...
Preprint
Full-text available
Cannabis is one example in angiosperms that appears to have a recent origin of dioecy and X/Y sex chromosomes. Several evolutionary explanations for this transition have been proposed, with the most parsimonious beginning with a mitochondrial mutation leading to cytoplasmic male sterility (CMS). Our study utilized 73 Cannabis sativa whole genome sh...
Article
Full-text available
The widespread legalization of Cannabis has opened the industry to using contemporary analytical techniques for chemotype analysis. Chemotypic data has been collected on a large variety of oil profiles inherent to the cultivars that are commercially available. The unknown gene regulation and pharmacokinetics of dozens of cannabinoids offer opportun...
Article
Full-text available
Cannabis sativa L. is an important yet controversial plant with a long history of recreational, medicinal, industrial, and agricultural use, and together with its sister genus Humulus, it represents a group of plants with a myriad of academic, agricultural, pharmaceutical, industrial, and social interests. We have performed a meta-analysis of poole...
Preprint
Full-text available
Cannabis sativa L. is an important yet controversial plant with a long history of recreational, medicinal, industrial, and agricultural use, and together with its sister genus Humulus, it represents a group of plants with a myr-iad of academic, agricultural, pharmaceutical, industrial, and social interests. We have performed a meta-analysis of pool...
Preprint
Full-text available
The accelerating legalization of Cannabis has opened the industry to using contemporary analytical techniques. The gene regulation and pharmacokinetics of dozens of cannabinoids remain poorly understood. Because retailers in many medical and recreational jurisdictions are required to report chemical concentrations of cannabinoids, commercial labora...
Article
Full-text available
Gene copy number (CN) variation is known to be important in nearly every species where it has been examined. Alterations in gene CN may provide a fast way of acquiring diversity, allowing rapid adaptation under strong selective pressures, and may also be a key component of standing genetic variation within species. Cannabis sativa plants produce a...
Preprint
Full-text available
Gene copy number variation is known to be important in nearly every species where it has been examined. Alterations in gene copy number may provide a fast way of acquiring diversity, allowing rapid adaptation under strong selective pressures, and may also be a key component of standing genetic variation within species. Cannabis sativa plants produc...
Poster
Full-text available
This poster describes our team's work into analyzing whole genome shotgun data towards various breeding applications.
Poster
Full-text available
Describes Steep Hill Genetics Team's work into cloning the cannabinoid synthase family and functionally identifying the product profiles of each variant we studied.
Article
Full-text available
Rapid progress in the field of population genetics, in particular advances in DNA sequencing technology, calls for an up‐to‐speed textbook that is appropriate for current researchers and students. Molecular Population Genetics, by Matthew Hahn (2018), is an informative and entertaining text that attempts to satisfy this demand. Although it has nota...
Article
Asexual lineages should rapidly replace sexual populations. Why sex then? The Red Queen hypothesis proposes that parasite-mediated selection against common host genotypes could counteract the per capita birth rate advantage of asexuals. Under the Red Queen hypothesis, fluctuations in parasite-mediated selection can drive fluctuations in the asexual...
Article
Full-text available
Seasonal epidemics erupt commonly in nature and are driven by numerous mechanisms. Here, we suggest a new mechanism that could determine the size and timing of seasonal epidemics: rearing environment changes the performance of parasites. This mechanism arises when the environmental conditions in which a parasite is produced impact its performance-i...
Article
Full-text available
Background The repetitive content of the genome, once considered to be “junk DNA”, is in fact an essential component of genomic architecture and evolution. In this study, we used the genomes of three varieties of Cannabis sativa, three varieties of Humulus lupulus and one genotype of Morus notabilis to explore their repetitive content using a graph...
Patent
Full-text available
Compositions and methods for providing desired cannabinoid content in Cannabis plants. More particularly, the invention relates to compositions and methods for using cannabinoid synthase paralogs as guidance for breeding Cannabis plants with a desired cannabinoid content, including but not limited to cultivars, varieties, lines, and methods of bree...
Article
Full-text available
As the most widely used illicit drug worldwide, and as a source of numerous under-studied pharmacologically-active compounds, a precise understanding of variability in psychological and physiological effects of Cannabis varieties is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for use i...
Article
Full-text available
Plants of the Cannabis genus are the only prolific producers of phytocannabinoids, compounds that strongly interact with the evolutionarily ancient endocannabinoid receptors shared by most bilaterian taxa. For millennia, the plant has been cultivated not only for these compounds, but also for food, rope, paper, and clothing. Today, specialized vari...
Article
Full-text available
With the resurgence of interest in cannabis, forfiber, oil,and drug uses, we now can realistically look forward toconsider future needs required to establish it as a moderncrop. With the anticipation of future funding opportuni-ties, it is likely that many avenues for its further domesti-cation will become available. Here, we have asked theexperts...
Article
Full-text available
The Cannabis industry is currently one of the fastest growing industries in the United States. Given the changing legal status of the plant, and the rapidly advancing research, updated information on the advancement of Cannabis genomics is needed. This versatile plant is used as medicine and for food, fiber, and bioremediation. Insights from modern...
Article
Full-text available
The freshwater snail Potamopyrgus antipodarum has become a model system for studying invasion ecology, host–parasite coevolution, the maintenance of sexual reproduction and ecotoxicology. One understudied aspect of this snail is the variation in morphology within and among populations, which could provide insights into ecological differences across...
Article
Full-text available
The following report details the first annotated mitochondrial genome for the Carmagnola variety of Cannabis sativa, the first reference genome for the Cannabaceae family. The total length is 415,499 bp and contains 54 genes, which sub-divide into 38 protein-coding genes, 15 tRNA genes, and 3 rRNA genes.
Preprint
Full-text available
As the most widely used illicit drug, the basis of the fastest growing major industry in the US, and as a source of numerous under-studied psychoactive compounds, understanding the psychological and physiological effects of Cannabis is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for us...
Article
Full-text available
Cannabis and Humulus are sister genera comprising the entirety of the Cannabaceae sensu stricto, including C. sativa L. (marijuana, hemp), and H. lupulus L. (hops) as two economically important crops. These two plants have been used by humans for many purposes including as a fiber, food, medicine, or inebriant in the case of C. sativa, and as a fla...
Poster
Full-text available
An early exploration into the cannabinoid synthase paralogs, and targeting specific paralogs to correlate to cannabinoid content
Article
Full-text available
Abstract The persistence of sexual reproduction is a classic problem in evolutionary biology. The problem stems from the fact that, all else equal, asexual lineages should rapidly replace coexisting sexual individuals due to the cost of producing males in sexual populations. One possible countervailing advantage to sexual reproduction is that, on a...
Article
Full-text available
Under the Red Queen hypothesis, outcrossing can produce genetically variable progeny, which may be more resistant, on average, to locally adapted parasites. Mating with multiple partners may enhance this resistance by further increasing the genetic variation among offspring. We exposed Potamopyrgus antipodarum to the eggs of a sterilizing, trematod...
Article
Full-text available
Abstract Understanding how sexual and asexual forms of the same species coexist is a challenge for evolutionary biology. The Red Queen hypothesis predicts that sex is favored by parasite-mediated selection against common asexual genotypes, leading to the coexistence of sexual and asexual hosts. In a geographic mosaic, where the risk of infection va...
Article
Full-text available
Introducción. Diversos estudios a nivel taxonómico y molecular sugieren que Lutzomyia longipalpis, principal vector de la leishmaniasis visceral en Latinoamérica, es un complejo de especies con ampliadistribución a lo largo del continente y con adaptaciones a diferentes hábitats. Objetivo. Realizar vigilancia entomológica en el área de influencia...
Article
Full-text available
The larvae of two trematodes found in the freshwater mollusk Melanoides tuberculata (Gastropoda: Thiaridae) are described. 125 snails from the Medellin's Botanical Garden Joaquín Antonio Uribe were collected. In the laboratory, each individual was placed alone and stimulated with light in order to have cercaria emission. 9.6% of the snails released...
Article
Full-text available
Se describen e ilustran diversos casos de anomalías morfológicas de cinco diferentes especies de Lutzomyia França (Diptera Psychodidae). Estas teratologías se observan en varias estructuras importantes para la identificación taxonómica de dichas especies. Los diferentes individuos pertenecientes a las especies L. columbiana, L. hartmanni, L. reburr...
Article
Full-text available
Nine species of Lutzomyia were collected during the research of various cutaneous leishmaniasis foci in the department of Caldas, Colombia: Lutzomyia gomezi (Nitzulescu, 1931), Lu. ayrozai (Barretto & Coutinho 1940), Lu. panamensis (Shannon 1926), Lu. bifoliata Osorno, Morales, Osorno & Hoyos, 1970, Lu. trapidoi (Fairchild & Hertig 1952), Lu. yuill...
Article
Full-text available
Seven species of Lutzomyia and one of Brumptomyia were collected while surveying two cutaneous leishmaniosis foci in the department Antioquia, Colombia, these are: Lutzomyia gomezi, Lu. scorzai, Lu. trapidoi, Lu. triramula, Lu. panamensis, Lu. aragaoi, Lu. reburra and Brumptomyia galindoi. Lu. scorzai (subgenus Helcocyrtomyia) and Lu. reburra (subg...
Article
Full-text available
La presente publicación recopila la información de registros de triatominos y datos sobre infección natural con tripanosomátidos a nivel departamental y municipal, publicada hasta la fecha así como la reportada por los servicios departamentales de salud e institutos de investigación. Se presentan figuras elaboradas de acuerdo a la información sumin...
Article
Full-text available
Information concerning triatomine records from provinces and municipalities was accumulated-including data indicating natural infections with trypanosomatides-that has been previously published or reported by Colombian provincial health services and research institutes. Altitude appeared to be the main factor responsible for the distribution of the...
Article
Full-text available
Diverse morphological anomalies in fi ve different species of Lutzomyia França (Diptera: Pychodidae) are described and illustrated. These theratologies are observed in various structures important for the taxonomic identifi cation of the species. The different individuals that belong to the species L. columbiana, L. hartmanni, L. reburra, L. ayroza...

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