Daniela Martins

Universidade Federal Fluminense | UFF · Departamento de Química Orgânica (GQO)

Boron organometallic compounds are mainly known for their great value in organic synthesis to construct biaryls in Suzuki couplings, for arylations of olefins, for C‐S, C‐O and C‐N couplings or as organometallic catalysts. Herein, using arylboronic acids (Ar‐B(OH)2) as a illustrative case, we review the applications of these highly versatile molecu...

Schistosomiasis is the second most prevalent parasitic infectious disease after malaria, which affects millions of people worldwide and causes health and socioeconomic problems. The snail Biomphalaria glabrata is an intermediate host for the helminth, which is the causative agent of schistosomiasis: Schistosoma mansoni. One crucial strategy for con...

Extracellular ATP activates purinergic receptors such as P2X7, cationic channels for Ca2+, K+, and Na+. There is robust evidence of the involvement of these receptors in the immune response, so P2X7 receptors (P2X7R) are considered a potential therapeutic target for the development of anti-inflammatory drugs. Although there are many studies of the...

The P2X7 receptor (P2X7R) is an ion channel which is activated by interactions with the extracellular ATP molecules. The molecular complex P2X7R/ATP induces conformational changes in the protein subunits, opening a pore in the ion channel macromolecular structure. Currently, the P2X7R has been studied as a potential therapeutic target of anti-infla...

Caffeine is widely present in food and drinks, such as teas and coffees, being also part of some currently commercialized medicines, but despite its enhancement on several functions of human body, its exceeding use can promote many health problems. In order to develop new fast approaches for the caffeine sensing, graphite-epoxy composite electrodes...

Suzuki cross-coupling reactions between arylboronic acids and aroyl chlorides with phosphine-free palladium catalysis under microwave irradiation were performed to obtainment of aromatic ketones in good yields within short times. Heterogeneous and homogeneous catalysts were studied as well as their influence in the reaction selectivity relative to...

Molecules containing the aryl‐cyanovinyl moiety are known as tyrphostins because of their action inhibiting proteins from the tyrosine kinase family, an interesting target for the development of anticancer and trypanocidal drugs. In the present work, E‐(cyanovinyl)benzeneboronic acids were synthesized by Knoevenagel condensations without catalysts,...

Given the possibility of exposure to various metals by inappropriate use of some commercially available hygiene products, it becomes necessary to develop simpler and more cost-affordable procedures to quantify those analytes in different matrices, allowing a local quality control even for smaller producers and industries. In this context, electroan...

Four cobalt(III)-tpa complexes with 2-hydroxy-3-X-1,4-naphthoquinones (HNQ-X), X = methyl (1), chlorine (2), bromine (3) and iodine (4), were designed and investigated as potential bioreductively activated carriers for naphthoquinone-based drugs. The substituents X were used in order to avoid dimerization of the naphthoquinone ligands and evaluate...

P2X7 receptor (P2X7R) is an ATP-gated ion-channel with potential therapeutic applications. In this study, we prepared and searched a series of 1,4-naphthoquinones derivatives to evaluate their antagonistic effect on both human and murine P2X7 receptors. We explored the structure-activity relationship and binding mode of the most active compounds us...

Quinones are important scaffolds that are present in a variety of natural products or synthetic bioactive molecules. Arylation is an important strategy for accomplishing structural modifications, leading to new potential candidates for use as drugs. In the present work, palladium-catalysed, ligandless and phosphine-free Suzuki coupling reactions be...

Eumelanin is a heterogeneous polymer composed of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI). Studies have shown that DHICA promotes single strand breaks in plasmid DNA exposed to ultraviolet B radiation (UVB, 313 nm) and in DNA from human keratinocytes exposed to ultraviolet A radiation (UVA, 340-400 nm). Singlet mo...

Melanins have been associated with the development of melanoma and its resistance to photodynamic therapy (PDT). Singlet molecular oxygen ((1)O(2)), which is produced by ultraviolet A solar radiation and the PDT system, is also involved. Here, we investigated the effects that these factors have on DNA damage and repair. Our results show that both t...

Pd(0) nanoparticles stabilized by polyvinylpyrrolidone (Pd-PVP) with a diameter of 3–6nm in ethanol catalyzed Heck coupling of iodobenzene with different alkenes under microwave heating. Products were obtained in good yields (62–99%) and good selectivity to the E-isomers. Microwave heating proved to be superior to conventional heating, providing pr...

Suzuki cross-coupling reaction was successfully carried out in ethanol utilizing a palladium colloidal solution stabilized by polyvinylpyrrolidone (PVP). High isolated yields (75–97%) to biaryls were obtained using different bases, aryl halides, and aryl boronic acids with a small loading of the palladium catalyst. Pd(0)–PVP nanoparticles with 3–6...

Suzuki cross-coupling reaction was successfully carried out in ethanol utilizing a palladium colloidal solution stabilized by polyvinylpyrrolidone (PVP). High isolated yields (75–97%) to biaryls were obtained using different bases, aryl halides, and aryl boronic acids with a small loading of the palladium catalyst. Pd(0)–PVP nanoparticles with 3–6n...

Heck reaction is a powerful tool in organic synthesis to perform C-C couplings by which functionalized alkenes can be obtained under mild conditions and great selectivity. Developing alternative methodologies where arylating agents different from the conventional aryl halides or triflates can be introduced with success is one of the areas of res...

Cross-coupling reactions catalyzed by transition metal complexes are important tools in the synthesis of biaryls, building blocks in a variety of compounds with interesting applications. The contributions of the palladium-catalyzed cross-coupling reactions to organic synthesis were recognized in 2010 when R. F. Heck, E. Negishi and A. Suzuki were a...

Heck reaction is a powerful tool in organic synthesis to perform CC couplings by which functionalized alkenes can be obtained under mild conditions and great selectivity. Developing alternative methodologies where arylating agents different from the conventional aryl halides or triflates can be introduced with success is one of the areas of researc...

Cross-coupling reactions catalyzed by transition metal complexes are important tools in the synthesis of biaryls, building blocks in a variety of compounds with interesting applications. The contributions of the palladium-catalyzed cross-coupling reactions to organic synthesis were recognized in 2010 when R. F. Heck, E. Negishi and A. Suzuki were a...

The aldol reaction is one of the most powerful tools for C-C bond formation in organic synthesis. The C-C bond is formed by a reaction between an enolizable carbonyl compound and a carbonyl compound acting as an electrophile to produce a ?-hydroxycarbonyl compound named aldol. One or two stereocenters can be formed with stereochemical control. Sinc...

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A decarbonylative MH-type procedure is described using polar solvents under microwave irradiation in the presence of different palladium catalysts. Moderate to good yields were achieved employing 1,4-diazabicycle[2.2.2]octane as base in 10 min of reaction.

The first palladium-catalyzed cross-coupling reaction between arenediazonium tetrafluoroborate salts and chloroformates to afford the corresponding substituted aryl carboxylic esters, in the presence of catalytic amounts of Pd(OAc)2 is described.