Daniel Wiswede

University of Lübeck · Klinik für Neurologie

Introduction Multisensory integration (MSI) enhances perception by combining information from different sensory modalities. In schizophrenia, individuals often exhibit impaired audiovisual processing, resulting in broader temporal binding windows (TBWs) which appear to be associated with symptom severity. Since the underlying mechanisms of these ab...

Introduction Little is known about cognitive control in adults with high-functioning forms of autism spectrum disorder because previous research focused on children and adolescents. Cognitive control is crucial to monitor and readjust behavior after errors to select contextually appropriate reactions. The congruency effect and conflict adaptation a...

Citation: Ghaneirad, E.; Saenger, E.; Szycik, G.R.;Čuš, A.; Möde, L.; Sinke, C.; Wiswede, D.; Bleich, S.; Borgolte, A. Deficient Audiovisual Speech Perception in Schizophrenia: An ERP Study. Brain Sci. 2023, 13, 970. Abstract: In everyday verbal communication, auditory speech perception is often disturbed by background noise. Especially in disadvan...

Deficits in audiovisual speech perception have consistently been detected in patients with Autism Spectrum Disorder (ASD). Especially for patients with a highly functional subtype of ASD, it remains uncertain whether these deficits and underlying neural mechanisms persist into adulthood. Research indicates differences in audiovisual speech processi...

Introduction: The present study was conducted to verify a promising experimental setup which demonstrated an inversed Stroop-effect (much faster responses for incongruent relative to congruent Stroop trials) following a mismatching tone. In the matching condition, which was an almost exact replication of the original study, participants were requir...

Audiovisual (AV) integration deficits have been proposed to underlie difficulties in speech perception in Asperger’s syndrome (AS). It is not known, if the AV deficits are related to alterations in sensory processing at the level of unisensory processing or at levels of conjoint multisensory processing. Functional Magnetic-resonance images (MRI) wa...

A basic process in regulating behavior that helps us to disentangle meaningful from distracting information is the binding of stimulus and response features into stimulus-response episodes or “event files”. Recent studies have shown that even irrelevant information is bound into event files; distractor repetition on the next trial can trigger the r...

The present experiment was designed to enhance our understanding of how response effects with varying amounts of useful information influence implicit sequence learning. We recorded event-related brain potentials, while participants performed a modified version of the serial reaction time task (SRTT). In this task, participants have to press one of...

Introduction: In the present study we were interested in the processing of audio-visual integration in schizophrenia compared to healthy controls. The amount of sound-induced double-flash illusions served as an indicator of audio-visual integration. We expected an altered integration as well as a different window of temporal integration for patien...

The steepness of the delay discounting function shows considerable interindividual differences. Moreover, faster devaluation of future rewards has been consistently observed in pathological gamblers (PGs). Here, we asked whether variability in delay discounting is at least partially driven by differences in the anatomy of gray and white matter. For...

Das Aufklärungsgespräch bei einer schwerwiegenden Erkrankung stellt nicht nur für die betroffenen Patienten und deren Angehörige, sondern auch für den gesprächsführenden Arzt eine emotional belastende Situation dar. Während des Aufklärungsgespräches muss der Arzt gleichzeitig den Erfordernissen der Aufklärungspflicht und dem Informationsbedürfnis d...

Pathological gambling is thought to result from a shift of balance between two competing neurobiological mechanisms: on the one hand the reward system involved in the regulation of the urge to get rewards and on the other hand the top-down control system. Fifteen pathological gamblers (PG) and fifteen healthy controls (HC) were studied in an event-...

Aggressive Patienten und Angehörige sind ein ernst zu nehmendes Problem innerhalb der Krankenversorgung, der Umgang mit ihnen hat bislang im klinischen Alltag als auch in der Forschung zu wenig Beachtung gefunden. So sind Ärzte und Pflegepersonal in Deutschland verglichen mit Großbritannien relativ wenig auf den Umgang mit Aggressionen im Klinikall...

Objective Neurobiological models of depression posit limbic hyperactivity that should normalize after successful treatment. For psychotherapy, though, brain changes in patients with depression show substantial variability. Two critical issues in relevant studies concern the use of unspecific stimulation experiments and relatively short treatment pr...

Synesthesia entails a special kind of sensory perception, where stimulation in one sensory modality leads to an internally generated perceptual experience of another, not stimulated sensory modality. This phenomenon can be viewed as an abnormal multisensory integration process as here the synesthetic percept is aberrantly fused with the stimulated...

Angehörige sollten bei der Behandlung schwerwiegender Erkrankungen mit einbezogen werden. Sie sind nicht nur Betroffene, sondern auch Unterstützer des Patienten. Angehörige haben einen erheblichen Einfluss auf die Krankheitsverarbeitung, die Compliance und den Verlauf der Therapie und sollten daher im Behandlungskonzept Berücksichtigung finden. Die...

Objective: The heterogeneity between patients with depression cannot be captured adequately with existing descriptive systems of diagnosis and neurobiological models of depression. Furthermore, considering the highly individual nature of depression, the application of general stimuli in past research efforts may not capture the essence of the disor...

The binding of stimulus (S) and response (R) features into S-R episodes or 'event files' is a basic process for the regulation of behavior. Recent studies have shown that even irrelevant information is bound into event files. Associating distractors with responses leads to more efficient behavior if irrelevant and relevant stimuli are correlated, b...

We investigated processes of truth validation during reading. Participants responded to ‘true’ and ‘false’ probes after reading simple true or false sentences. Compatible sentence/probe combinations (true/‘true’, false/‘false’) facilitated responding compared with incompatible combinations (true/‘false’, false/‘true’), indicating truth validation....

Synesthesia is a condition in which stimulation in one processing stream (e.g., letters or music) leads to perception in an unstimulated processing stream (e.g., colors). Behavioral differences in mutisensory processing have been shown for multimodal illusions, but the differences in neural processing are still unclear. In the present study, we exa...

In synaesthesia certain external stimuli (e.g., music) trigger automatically internally generated sensations (e.g., colour). Results of behavioural investigations indicate that multisensory processing works differently in synaesthetes. However, the reasons for these differences and the underlying neural correlates remain unclear. The aim of the cur...

Although remarkable progress has been made in the search for the brain correlates of depression with neuroimaging methods, we still find a heterogeneity of results and lack of consensus. This short commentary proposes a theoretical reason for this situation linking it to the methods of conducting neuroimaging studies of depression and the ways to i...

In order to further understand the mechanisms involved in planning an aggressive act, we conducted an event-related potential (ERP) study of young men with and without a history of violence. Participants completed a competitive reaction time task (based on the Taylor aggression paradigm) against a virtual opponent. In "passive" blocks, participants...

Thema: Soziale Kognitionen werden als spezifisch menschlich betrachtet und bilden die Grundlage fur prosoziales Verhalten. Die Bindungsforschung hat die Entwicklung sozialer Kognitionen in den Kontext gelingender und sicherer fruher Bindung gestellt und fuhrt verzerrte soziale Kognitionen auf aversive und misslingende fruhe Bindungserfahrungen zuru...

In the search for neurobiological correlates of depression, a major finding is hyperactivity in limbic-paralimbic regions. However, results so far have been inconsistent, and the stimuli used are often unspecific to depression. This study explored hemodynamic responses of the brain in patients with depression while processing individualized and cli...

Social cognition creates the conditions for successful human interaction. Externalizing disorders are characterized by a failure of adequate social cooperation. Therefore, social cognition seems to be a key factor in understanding externalizing behavior, its etiology and treatment options. The present article combines the clinical theory of mentali...

Social cognition creates the conditions for successful human interaction. Externalizing disorders are characterized by a failure of adequate social cooperation. Therefore, social cognition seems to be a key factor in understanding externalizing behavior, its etiology and treatment options. The present article combines the clinical theory of mentali...

The present study examines the influence of induced affective state on performance monitoring. The electroencephalogram was recorded while human participants engaged in a speeded choice-reaction time task commonly used to examine performance monitoring processes. Prior to the experiment, participants were randomly allocated to receive either encour...

Recent research on the "embodiment of emotion" implies that experiencing an emotion may involve perceptual, somatovisceral, and motor feedback aspects. For example, manipulations of facial expression and posture appear to induce emotional states and influence how affective information is processed. The present study investigates whether performance...

The present study investigates whether performance monitoring and its electrophysiological indices in a choice reaction time task are modulated by affective information presented briefly prior to the critical stimuli. A flanker task known to elicit a sufficient number of performance errors was used and prior to each flanker stimulus a neutral, plea...

The neural effects of psychotherapeutic interventions are poorly investigated and understood compared to the neural effects of pharmacological treatments. However, there are 14 studies to date examining the functional neuroanatomy of psychotherapy. Most studies focused on cognitive-behavioral and interpersonal therapy and short-time-therapy setting...

Zusammenfassung Die funktionelle Neuroanatomie der Wirkung psychotherapeutischer Interventionen ist im Unterschied zu Effekten pharmakologischer Behandlungen wenig untersucht und kaum verstanden, obgleich derzeit bereits ca. 14 Studien vorliegen. Untersuchungen der neuronalen Korrelate von Therapieverfahren liegen bislang nur für kognitive-behavior...

Event-related brain potentials (ERPs) elicited by recalled and non-recalled words were recorded from 18 female subjects to investigate primacy and recency effects in free memory recall. The typical pattern of a serial position curve (SPC) was obtained with words presented at first and final positions in a list recalled better than words presented i...

Two cognitive processes, namely memory encoding and performance monitoring, are selected to examine how emotional processes interact with cognition. The main examination tool is event-related brain potentials (ERPs). The first section presents two experiments which require subjects to recall items from lists consisting of 12 words, which were prese...

Previous research has demonstrated a relationship between memory recall and P300 amplitude in list learning tasks, but the variables mediating this P300-recall relationship are not well understood. In the present study, subjects were required to recall items from lists consisting of 12 words, which were presented in front of pictures taken from the...