Daniel van Steenberghe

KU Leuven | ku leuven · Faculty of Medicine

Purpose: To prospectively assess marginal bone loss and implant survival with Astra Tech (Dentsply Sirona, Charlotte, NC, USA) (group A) and Brånemark (Nobel Biocare, Zurich, Switzerland) (group B) implants in a split-mouth study conducted over a 20-year follow-up period. Materials and methods: A total of 95 implants (n = 50, group A and n = 45,...

"If terms be incorrect, then statements do not accord with facts". (Confucius) "Words form the thread on which we string our experiences". (Aldous Huxley) Semantics is a term coined by Michel Bréal (1832 to 1915) a Jewish German-French linguist referring to the Greek semantikos (= meaning) in his 1897 book, "Essai de sémantique". He was a very gift...

Complete edentulism is a common problem in many countries and can be a serious disability. It concerns about one-fifth of the adult world population, in some countries reaching 50% at the age of 50. The decline in the prevalence of edentulism is offset by the increase of the elderly population. This leads to an increasing demand for implant-based t...

To describe the normal cortical projections of periodontal mechanoreceptors. A device using von Frey filaments delivered 1-Hz punctate tactile stimuli to the teeth during fMRI. In a block design paradigm, tooth (T) 11 and T13 were stimulated in ten volunteers and T21 and T23 in ten other subjects. Random-effect group analyses were performed for eac...

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Purpose: To reach through intense interactions among a group of renowned experts a better view of the treatment options available for marginal bone maintenance and eventual inflammation and/or loss around oral implants. The working group was intended to generate guidelines useful for th clinical community at large. FORMAT: Two days of interactive...

Our aim was to unveil the cortical neural correlates of osseoperception, i.e. the tactile sensation perceived when loading a bone-anchored implant, by taking oral implants as a model. This was performed in a cross-sectional observational study with 9 volunteering patients and 10 age-matched controls. For each patient, functional magnetic resonance...

Many studies have dealt with the clinical outcome of oral implants, yet none applied a randomized split-mouth design for a long-term follow-up of similar implant systems. To evaluate two oral implant systems with different surface characteristics in a randomized split-mouth design and to radiologically analyse peri-implant bone level and density ov...

Objectives: The aim of the present study was to evaluate two comparable titanium oral implant systems but with different surface characteristics in a randomised split-mouth design and to radiologically analyse peri-implant bone density and level, over an up to 15-years follow-up period. Methods: The study comprised clinical and radiographic records...

To assess the accuracy of implants placed flapless by a stereolithographic template in partially edentulous patients. Eight patients, requiring two to four implants (maxilla or mandible), were consecutively recruited. Radiographical data were obtained by means of a cone beam or a multi-slice CT scan and imported in a software program. Implants (n=2...

The innervation of skin and oral mucosa plays a major physiological role in exteroception. This innervation is also clinically relevant as sensory changes occur after neurosurgical procedures. The goal of this study was to compare the perception of mechanical stimuli applied to the buccal mucosa in the vicinity of osseointegrated oral implants with...

Strips of teflon and cellulose acetate were glued to the upper lateral incisors of human volunteers in a split mouth, double blind study on the influence of the substratum surface free energy (s.f.e.) on supragingival dental plaque accumulation during a three day period of no oral hygiene. Plaque accumulation, microbial composition of the plaque an...

Previous studies have demonstrated that hydrogen sulfide and methyl mercaptan play a major role in oral malodor. In the present study, we tested the hypothesis that other compounds found in mouth air can also contribute to halitosis. Mouth air of 40 healthy volunteers and 40 persons with halitosis was analyzed and compared by gas chromatography-mas...

The aim of the present study was to assess the somatosensory function in the peri-implant soft tissues in the anterior jaw bone by means of two psychophysical tests. Light-touch sensation (LTS) and two-point discrimination (2PD) were performed before, and at planned intervals until 18 months after the placement of one or two implants in the anterio...

Since intra-bony pathologies might jeopardize implant outcome, their preoperative detection is crucial. In sixteen human cadaver bloc sections from upper and lower jaws, artificial defects with progressively increasing size (n=7) have been created. From each respective defect, analogue and digital intra-oral radiographs were taken, the latter proce...

Ademgeur komt bij meer dan de helft van de bevolking voor en dan vooral ’s morgens (Courtois, 1986). Een slecht riekende adem komt op alle leeftijden voor en even vaak bij mannen als bij vrouwen. Velen die te kampen hebben met ademgeur zijn zich er niet van bewust. De klachten worden dikwijls schuchter aangebracht door de omgeving, zodat ze tevens...

Ademgeur kan worden veroorzaakt door meestal intra-, maar ook verschillende extraorale factoren. De frequentste hiervan zijn keel-neus-ooraandoeningen en systemische ziekten, zoals diabetes mellitus, uremie,leverinsufficiëntie, longcarcinoom of bronchiëctasieën(Preti e.a., 1995; van Steenberghe, 1997).

Al geruime tijd is bekend dat een aantal systeemziekten (diabetes, immunosuppressie, enz.) en/of sociale gewoontes (o.a. roken, stress en alcohol) de evolutie en behandeling van parodontitis kunnen beïnvloeden. Het laatste decennium toonden tal van onderzoeken echter met enige zekerheid aan dat ook parodontale infecties een negatieve invloed kunnen...

De succesvolle behandeling van furcatieletsels blijft een moeilijk probleem De introductie van de regeneratieve technieken deed hoopvolle verwachtingen ontstaan, die niet helemaal werden ingelost. Het gebrek aan reproduceerbaarheid van de gebruikte methoden blijft een obstakel dat een veralgemeende toepassing in de weg staat.

We onderscheiden de inflammatoire aandoeningen, de premaligne aandoeningen en de solitair voorkomende verkleuringen. Letsels verdacht op maligniteit moeten worden doorgestuurd naar de KNO-arts of de kaakchirurg. Verkleuringen van de orale slijmvliezen hebben een brede differentiële diagnose. Een goede diagnose, soms door middel van een biopsie, is...

Mondvloeistof is een complexe vloeistof, grotendeels samengesteld uit een groot aantal klierspeeksels, met een geringe bijdrage van de creviculaire vloeistof en serum. Bij ontstekingen in mondweefsels neemt het aandeel van de creviculaire vloeistof en dat van serum toe. De secretie van speeksel bij de volwassene bedraagt ongeveer 500 ml/24 uur maar...

Ontstekingen van het parodontium ten gevolge van de biofilmvorming langs het oppervlak van tanden of implantaten komen veruit het meeste voor. Hierdoor bestaat de neiging om parodontale aandoeningen als synoniem hiervoor te gebruiken. Dit is echter een pars pro toto want er zijn tal van andere aandoeningen van het parodontium die geen verband houde...

Veel voorkomende gebitsproblemen vinden hun oorsprong in ziekten van de tandomgevende weefsels, het kaakbot en de orale mucosa. In Parodontologie is de meest actuele wetenschappelijke informatie op dit gebied samengebracht, met focus op de etiologie, de pathogenese en de behandeling van parodontale ontstekingen en de betekenis van deze aandoeningen...

The aim of this study was to evaluate longitudinally the bone-healing process by measuring volumetric changes of the extraction sockets in head and neck cancer patients undergoing radiotherapy after tooth extraction. A total group of 15 patients (nine males, six females) undergoing tooth extraction at the Department of Periodontology (University Ho...

Background: Chlorhexidine (CHX) 0.2% solution, still the golden standard as mouthrinse for the prevention of plaque formation and development of gingivitis, has some limited side‐effects such as extrinsic tooth staining, poor taste, taste disturbance, sensitivity changes in tongue, pain, and the content of alcohol. These side effects led to the sea...

To evaluate image quality by examining segmentation accuracy and assess radiation dose for cone beam CT (CBCT) scanners. A skull phantom, scanned by a laser scanner, and a contrast phantom were used to evaluate segmentation accuracy. The contrast phantom consisted of a polymethyl methacrylate (PMMA) cylinder with cylindrical inserts of air, bone an...

Liver diseases can cause a sweet, musty aroma of the breath, called fetor hepaticus. Even in a stage of cirrhosis, the disease can be asymptomatic for many years. Breath analysis might be helpful to detect occult liver pathology. This study examined whether specific breath odor compounds can be found in liver patients, suffering from cirrhosis, whi...

The aim of this study was to evaluate longitudinally the bone-healing process by measuring volumetric changes of the extraction sockets in head and neck cancer patients undergoing radiotherapy after tooth extraction. A total group of 15 patients (nine males, six females) undergoing tooth extraction at the Department of Periodontology (University Ho...

This retrospective study was set to assess the influence of systemic and local bone and intra-oral factors on the occurrence of implant loss from abutment connection up to 2 years. The files of 700 patients, have been collected randomly from the total patient group treated by means of endosseous Brånemark system implants (Nobel Biocare, Gothenburg,...

The image quality of four cone-beam computed tomography (CBCT) scanners dedicated for dentomaxillofacial imaging and one multi-slice computed tomgoraphy (MSCT) scanner was compared. For the MSCT scanner, a clinical and a low-dose protocol for oral indications were evaluated. The image quality was assessed by dedicated software that allows an automa...

Adequate bone volume is imperative for the osseointegration of endosseous implants, but postextraction resorption and remodeling may challenge implant placement. The use of bone biomaterials has been advocated to fill extraction sites and to enhance primary implant stability during osseointegration. The objective of the case series was to evaluate...

The purpose of the present paper is to review the literature on the use of CT scan based planning for oral rehabilitation and its transfer to the surgical field by means of a surgical guide. The first part will deal with surgical guides based on tomographies or CT scan data often using dedicated software, but manually fabricated. In the second part...

This study used a tissue-engineering approach, which combined autologous periosteal cells with a scaffold material, to promote bone augmentation under an occlusive titanium barrier that was placed on the skull of rabbits. Because the cell-matrix interaction is of key importance in tissue engineering, two different calcium phosphate-based scaffolds...

To compare the accuracy of cone-beam computerized tomography (CBCT) and multislice CT (MSCT) for linear jaw bone measurements. An ex vivo formalin-fixed human maxilla was imaged with both CBCT (Accuitomo 3D; Morita, Kyoto, Japan) and MSCT (4-slice Somatom VolumeZoom and 16-slice Somatom Sensation 16; Siemens, Erlangen, Germany). The MSCT images wer...

Augmentation material used in plastic surgery such as facelift procedures can be radiopaque and thus become visible on extra- and intraoral radiographs. These objects may obscure anatomical structures and mask critical findings, therefore leading to potential misinterpretation of otherwise successful images. The present report describes a case in w...

Breath malodor constitutes a serious social, but also medically relevant, issue which affects a large fraction of the population. Unhappily the science of breath odor remains limited. Teaching of breath odor, and its potential diagnostic role, is often neglected in medical curricula. Recently, however, both the medical profession and the pharmaceut...

This randomized clinical trial compares the usefulness of pre- and post-operative antibiotics while strict asepsis was followed during periodontal surgery. Two groups of 40 consecutive patients each with fully or partially edentulous jaws were enrolled. Antibiotics group (GrAB(+)): 23 men, mean age 60, 128 implants, received oral amoxicillin 1 g, 1...

The objective of the present study was to evaluate the influence of immediate loading of implants on speech adaptation. Ten patients (mean age 54, 6 females) were examined before surgery and 1, 3, 6 and 12 months afterwards. Articulation analysis was done using objective DAT-recoded data evaluated by two groups of speech and language therapists and...

Aim: This study aimed to assess the influence of systemic and local bone and intra-oral factors on the occurrence of early TiUnite implant failures. Material and methods: A total of 283 consecutive patients (187 females; mean age 56.2), who received a total of 720 TiUnite implants, at the Department of Periodontology of the University Hospital o...

In dit laatste hoofdstuk zullen drie typische voorbeelden getoond worden van het toenemend aantal patiënten dat profiteert van een protocol met één chirurgische fase en immediate belasting.

Lange tijd is aangenomen dat tijdens de inheling van enossale implantaten geen krachten aanwezig mogen zijn die microbewegingen zouden kunnen veroorzaken. Dit zou absoluut noodzakelijk zijn om osseointegratie te garanderen en om fibreuze inkapseling te voorkomen. Dit concept is gebaseerd op de experimentele observaties van de groep van Brånemark (B...

Het is klassiek in handboeken over orale implantaten te refereren aan voorbeelden uit de verre geschiedenis, zelfs uit de prehistorie. Bij archeologische vondsten van skeletten vindt men inderdaad voorbeelden van een vervanging van een verloren gegaan gebitselement door een of ander alloplas-tisch materiaal. Telkens opnieuw blijkt uit de geschieden...

In de beginjaren waarin orale implantaten werden toegepast (1980-1990), vond in onderzoeken meestal een zodanige selectie van patiënten plaats dat zelden mislukkingen werden gerapporteerd die terug te voeren waren op algemene gezondheidsproblemen of op lokale (anatomische) factoren van de behandelde patiënten (Albrektsson et al., 1988). Hierin kwam...

Zoals uit de voorgaande hoofdstukken duidelijk is geworden, is immediate belasting een biologisch logische en klinisch aanvaardbare keuze. Soms is het zelfs een voordelige optie. Na enkele vruchtbare pogingen, die aantoonden dat immediate belasting van implantaten een relevante behandeloptie was, stelde professor Brånemark een protocol voor immedia...

In dit laatste hoofdstuk zullen drie typische voorbeelden getoond worden van het toenemend aantal patiënten dat profiteert van een protocol met één chirurgische fase en immediate belasting.

Orale implantaten zijn niet meer weg te denken uit de mondzorg. Toch heeft het lang geduurd voordat het implantaat zijn weg vond in de geneeskunde. De opmars begon in de orale geneeskunde. Implantaten werden daarna steeds vaker toegepast bij amputaties in andere plaatsen in het lichaam.In 1965 behandelde de Zweedse chirurg Per–Ingvar Brånemark voor...

Osseointegratie, een revolutionaire techniek in de mondzorg, maakt het mogelijk prothesen stabiel te verankeren. Zo kunnen uitneembare tandprothesen door vaste prothesen worden vervangen of in elk geval stevig op enossale implantaten worden verankerd. Dit verhoogt de kwaliteit van leven bij veel patiënten. Osseointegratie wordt echter door de betro...

The periodontal ligament was examined by light microscopy at 3 different levels (apical, intermediate, coronal) on the 4 root sides of 43 extracted teeth. Epithelial rests were localised and serial LM and EM sections showed a close apposition (up to 0.03 gm) between Ruffini-like and free nerve endings and the basal lamina of the epithelial cell res...

The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effectiveness in the treatment of per...

The aim of this study was to determine the accuracy of volumetric analysis of extraction sockets using cone beam computed tomography (CBCT). The volume of 40 dental alveoli in nine dry skull specimens (four mandibles and five maxillae) was determined by measuring the volume of the tooth socket impression using the water displacement technique. This...

This review searched for a relationship between susceptibility to periodontitis and peri-implantitis, with implant outcome as the primary outcome variable and supportive periodontal therapy (SPT) and implant surface roughness as confounding factors. It is based on a MEDLINE search up to June 2006. Only 16 fulfilled the selection criteria. The heter...

To evaluate the precision of transfer of a computer-based three-dimensional (3D) planning, using re-formatted cone-beam images, for oral implant placement in partially edentulous jaws. Four formalin-fixed cadaver jaws were imaged in a 3D Accuitomo FPD cone-beam computed tomography (CT). Data were used to produce an accurate implant planning with a...

Data available regarding the treatment outcome for completely edentulous jaws by means of a prefabricated fixed complete denture placed immediately after flapless implant insertion using a surgical guide are only short term. The purpose of this study was to follow the survival of implants inserted in completely edentulous jaws using a flapless proc...

The objective of this research was to determine if the essence of expert performance could be captured on a virtual reality simulation system. Six experts in operative dentistry, six experts in periodontology, and six novice dental students performed a Class II tooth preparation task on the lower left second premolar. All subjects performed a pre-t...

The aim of this retrospective study was to assess the influence of systemic and local bone and intra-oral factors on the occurrence of early implant failures, i.e. up to the abutment connection. The surgical records of 2004 consecutive patients from the total patient population who had been treated in the period 1982-2003 (with a total of 6946 Brån...

Halitosis can have an intra- or extra-oral origin. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. They can be specific for certain diseases or infections. This study explored the presence and concentration of these volatile compounds normally associated with halitosis...

Post-stimulus EMG complexes (PSECs) were elicited by means of electrical stimulation of the gingiva in six subjects during clenching in three biting positions, namely the maximal occlusion, the incisor edge-to-edge and the hyperpropulsive biting position. No interrelationship was found between the mechanically and electrically elicited PSECs. With...

Our breath contains an intraoral and an alveolar part, the latter being the last to be exhaled. As such, major differences in composition can be expected, with for alveolar air the inclusion of more metabolic compounds released during the blood-air exchange. This study explored the differences between breath air from the oropharynx and from the lun...

For proper preoperative planning of oral implants, the need has increased for tomographic imaging for precise determination of anatomic dimensions. However, concern for radiation exposure, which is substantial with computerized tomography (CT), has also grown. In the present study, the validity of jawbone width assessment and delineation by means o...

The study was set to evaluate the validity of subjective jaw bone quality assessment. A total of 298 patients (198 females, mean age 56.4) were treated with oral implants at the Periodontology Department at the University Hospital of KUL. A total of 761 TiUnite implants have been installed. Subjective bone quality assessment was performed on radiog...

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The aim of the study was to assess past and present neurosensory disturbances using a questionnaire and a psychophysical approach in patients treated with immediate loaded implants in the edentulous anterior mandible. A group of 65 patients (age range 30-84 years, mean 58 years, 30 women) was enrolled. All were treated by means of three immediately...

The replacement of teeth lost by children because of trauma can be an important indication for early implant therapy. Osseointegrated dental implants, like ankylosed teeth, alter position as growth-related changes occur within the jawbones (displacement, remodeling, mesial drift). Facial growth of the child and even of the adolescent, as well as th...

To cite this article:Hämmerle C. H. F., van Steenberghe D. The first EAO consensus conference 16.2.06–19.2.06, Pfäffikon, Schwyz, Switzerland.Clin. Oral Imp. Res., 17 (Suppl. 2), 2006; 1–1

Patients in need of bone augmentation procedures can be treated with a traditional hip graft or by neogenesis under a stiff occlusive titanium membrane, custom-fit on the basis of CT-scan data. Eighteen patients treated by means of a hip graft (H) were compared with 11 patients using a full titanium membrane (M) for the rehabilitation of upper jaws...

The study addressed the impact of the frequency of tutorial-enriched augmented visual feedback, provided by a virtual simulation system (DentSim), on the skill acquisition for a cavity preparation task in novice dental students. Thirty-six subjects were assigned to two training groups and a control group. The task consisted of a geometrical cross p...

The objective of this paper is to develop a novel digital subtraction technique for serial intra-oral radiography, which would allow the detection of subtle variations in grey values. Digital images of the maxilla of a dried human skull and of a fresh pig mandible were acquired using intra-oral photostimulable phosphor plates (Digora FMX, Soredex,...

The beneficial effects of the one-stage, full-mouth disinfection remain controversial in the scientific literature. This might be due to the fact that an entire mouth disinfection with the use of antiseptics has been confused with a full-mouth scaling and root planing. This parallel, single blind RCT study aimed to compare several full-mouth treatm...

Integuments play a key role for the integrity of the bodily tissues. Both teeth and oral implants pierce the gingiva or alveolar mucosa with an interface acting as a relative seal. The epithelia adhering by means a basal membrane to either the implant or a tooth are not keratinized. They both contain laminin-5 with a similar structural relationship...

The impetus of the Bologna Process under the auspices of European Union governments has raised enormous expectations. It is the major educational change in Europe within the last 50 years and all the focus from university institutions, learned societies and thematic networks has shifted to this process, with the aim of developing consensus schemes...

Jaw motor inputs from endosseous oral implants have been investigated to a limited extent. Observations of jaw muscle reflexes in edentulous patients rehabilitated by means of implants do not prove that they originate from the implants unless the stimuli are properly defined. Few studies have isolated inputs, such as electrical of mechanical stimul...

Osseointegration of implants in the jaw bone has been studied thoroughly, dealing with various aspects such as bone apposition, bone quality, microbiology, biomechanics, aesthetics, etc. A key issue that has received much less attention is the physiologic integration of the implant(s) and the associated prosthesis in the body. The latter aspect is...

Amputation of a limb or a tooth leads to the loss of a large number of exteroceptors. These play an important role in sensory perception and feedback, which tune the motor control. Even after rehabilitation with a prosthetic device, tactile function remains impaired. This can present a subsequent risk of overloading the prosthesis. The peri-implant...

Orofacial diagnostic imaging has grown dramatically in recent years. As the use of endosseous implants has revolutionized oral rehabilitation, a specialized technique has become available for the preoperative planning of oral implant placement: cone beam computed tomography (CT). This imaging technology provides 3D and cross-sectional views of the...

The purpose of the study was to compare the failure rates of implants with either a machined surface or a TiUnite surface used to replace failing implants. The files of 578 patients, ie, of all patients who were treated at the Department of Periodontology of the University Hospital in Leuven by means of oral implants during 3 recent consecutive yea...

Periodontitis and peri-implantitis are linked to the presence of several key pathogens. The treatment of these infectious processes therefore involves the reduction/eradication of bacteria associated with periodontitis. This prospective, split-mouth, single-blind study followed the colonization of 'pristine' sulci created in 42 partially edentulous...

Virtual reality (VR) simulators can be used as tools in manual dexterity training. The visual feedback guides the subject towards proper performance but creates, at the same time, some dependency on this feedback. To overcome this drawback, the effect of adjunct tutorial input on motor learning behaviour was examined. Novice dental students were ra...

The aim of this report is to quantitatively and qualitatively describe the bone tissue response to Brånemark implants retrieved from grafted sites in patients. The material consists of consecutively received Brånemark implants retrieved from grafted sites. Thirty-five of these implants, retrieved from 16 patients, were suitable for the histologic e...

Quirynen M, Teughels W, van Steenberghe D. Impact of antiseptics on one-stage, full-mouth disinfection. J Clin Periodontol 2006; 33: 49–52. doi: 10.1111/j.1600-051X.2005.00868.x. © Blackwell Munksgaard, 2006.

We present a protocol for the evaluation of the geometric accuracy of bone segmentation algorithms in multi-slice and conebeam computed tomography (CT) Three important issues are resolved in this protocol: construction of a skull phantom with an accurate geometrical description serving as gold standard; registration between this geometric model and...

Bone augmentation underneath an occlusive titanium membrane is evaluated in most cases by means of serial histological sections and histomorphometry. Micro-computed tomography (micro-CT) is a less invasive and dynamic technique to measure bone volume in animals of a size that fits into the gantry. The aim of the present study was to evaluate whethe...

Recent case reports introduced the term retrograde peri-implantitis as a lesion (radiolucency) around the most apical part of an osseointegrated implant. It develops within the first months after insertion. This retrospective study aimed to find predisposing conditions for such peri-apical lesions and to evaluate treatment strategies. All single im...

Since smoking is an established risk factor for the development of periodontitis, the present study investigated whether nicotine and cotinine can make epithelial cells more prone to colonization by periodontopathogens. Primary epithelial cell mono-layers were inoculated with nicotine and cotinine prior to adhesion experiments with Actinobacillus a...