Daniel Uti

KAMPALA INTERNATIONAL UNIVERSITY UGANDA/ FEDERAL UNIVERSITY OF HEALTH SCIENCES OTUKPO · RESEARCH AND PUBLICATIONS/BIOCHEMISTRY

Background Breast cancer is a significant global health challenge, contributing substantially to cancer- related deaths. Conventional treatment methods, including hormone therapy, chemotherapy, surgical interventions, and radiation, have long been utilized. However, these traditional treatments are often associated with serious side effects and dru...

Introduction Energy system simulation modeling plays an important role in understanding, analyzing, optimizing, and guiding the change to sustainable energy systems. Objectives This review aims to examine energy system simulation modeling, emphasizing its role in analyzing and optimizing energy systems for sustainable development. Methods The pap...

This study investigated the effects of ethanol and aqueous root extracts of Rauwolfia vomitoria Oliv. on tocopherol, adenine deaminase, and antioxidant parameters in albino rats with induced arthritis. A total of 135 albino rats were utilized, divided into nine groups of 15 rats each. Arthritis was induced by intradermal injection of 0.1 ml Chicken...

Antiretroviral therapy, also known as antiretroviral therapy (ART), has been at the forefront of the ongoing battle against human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDs). ART is effective, but it has drawbacks such as side effects, medication resistance, and difficulty getting access to treatment, which highlights the u...

Antiretroviral therapy, also known as antiretroviral therapy (ART), has been at the forefront of the ongoing battle against human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDs). ART is effective, but it has drawbacks such as side effects, medication resistance, and difficulty getting access to treatment, which highlights the u...

Diabetes and mental illness are highly relevant issues due to their intricate relationship with the treatment and management of both conditions. Diabetes is a medical condition characterized by high blood sugar levels, and there is evidence of reciprocal interactions between the disorder and mental health. Depression, anxiety, and diabetes distress...

Cancer is one of the leading causes of morbidity and mortality in the world and has a significant psychosocial impact on patients, caregivers, and communities. The purpose of this study is to discuss psychosocial aspects of cancer treatment, which include psychological, social, emotional, and spiritual factors. This study examines the current globa...

Mental health interventions are important for pregnant and postpartum women, as they are at high risk of developing perinatal mental health disorders, including depression and anxiety. This review assesses the effectiveness and availability of different mental health treatments, which include psychotherapy, pharmacotherapy, and other multifaceted i...

Climate change, an emerging issue, significantly impacts international health, particularly malaria, a critical issue that affects tropical and subtropical areas. Researchers have identified climate variability as a major determinant of malaria transmission and distribution. This review aims to disentangle the interplay between climate variability...

Access to clean and safe water is crucial for human health and well-being. This study aimed to assess the physicochemical characteristics, heavy metal concentration, and microbial contamination in key water sources within the Benue South Senatorial District, Nigeria. A total of nine water samples were collected from three river sources, including O...

Prostate cancer remains a significant global health concern, and understanding the molecular drivers of this disease is crucial for developing effective diagnostic and therapeutic strategies. Steroid receptor coactivator-3 (SRC-3), a member of the SRC family, has emerged as a key player in prostate cancer pathogenesis. Aims: To examine the role of...

Plant extracts can influence electrolytes concentration and potentially have implications for rheumatoid arthritis (RA) management. 48 female albino rats weighing between 100 and 200g were used in this study. RA was induced in the rats using 0.1ml of complete Freund’s adjuvant (CFA). Arthritis index was tracked following the Chondrex technique, whi...

Plant-based medicines contained bioactive molecules and functions, as reported in our previous study in Psychotria vogeliana leaf using HPLC. This study investigated the effects of Psychotria vogeliana leaf ethyl acetate fractions on liver, kidney, and cytokine levels in albino rats with rheumatoid arthritis. Six groups of eight female albino rats...

The pursuit of advanced multifunctional compounds has gained significant momentum in recent scientific endeavours. This study is dedicated to elucidating the synthesis, rigorous characterization, and multifaceted applications—encompassing anti-corrosion, antimicrobial, and antioxidant properties—of Diethyl 4-(5-bromo-1H-indol-3-yl)-2,6-dimethyl-1,4...

The multifaceted association between substance abuse and human immunodeficiency virus (HIV)infection is examined in this article, with particular attention paid to prevalence, risk behaviours, biological vulnerability, care-seeking barriers, and preventive measures. HIV continues to be a major worldwide health concern despite treatment breakthrough...

WITHDRAWAL STATEMENT The authors have withdrawn their manuscript owing to [some fundamental errors discovered in the methods and result of this study which was discovered during the review process which can obviously change our major findings and conclusion]. Therefore, the authors do not wish this work to be cited as reference for the project. If...

Objectives Xylopia aethiopica (XAE), commonly known as African pepper or Ethiopian pepper, is a plant native to West Africa and known for its aromatic and medicinal properties. It was used to investigate the antioxidative, antihepatotoxic, and antinephrotoxic potentials of XAE in benign prostatic hyperplasia (BPH) in Wister albino rats. Methods The...

In the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated strategies that encompass both traditional cancer vaccines and emerging viral vaccines. This comprehensive Review offers an in-depth exploration of the methodologies, clinical applications, success stories, and future prospects of these approaches. Traditional c...

As we navigate the modern era, the intersection of time-honoured natural remedies and contemporary scientific approaches forms a burgeoning frontier in global healthcare. For generations, natural products have been foundational to health solutions, serving as the primary healthcare choice for 80% to 85% of the world's population. These herbal-based...

Diabetes and mental illness are highly relevant issues due to their intricate relationship with the treatment and management of both conditions. Diabetes is a medical condition characterized by high blood sugar levels, and there is evidence of reciprocal interactions between the disorder and mental health. Depression, anxiety, and diabetes distress...

Pregnancy demands unique nutritional necessities different from those of women who are not pregnant, involving vital roles of vitamins, minerals, and omega-3 fatty acids. These elements are pivotal for the progression of a healthy pregnancy, aiding mothers in coping with common discomforts and averting complications. Presently, supplementation reco...

OBJECTIVES This study looked at how CMSO affected male Wistar albino rats' liver damage caused by bisphenol A. METHODS The standard HPLC method was used to assess the CMSO's phenolic content. Then, six (n = 8) groups of forty-eight (48) male Wistar rats (150 20 g) each received either CMSO or olive oil before being exposed to BPA for 42 days. Grou...

The human immunodeficiency virus (HIV) infection is one of the health burdens ravaging the world with severe impact in developing regions. Women and young girls are more threatened by HIV infection than their male counterparts. Notably, in 2022, 63% of all new HIV infections were attributed to women in sub-Saharan Africa. The anatomical architectur...

Background: Prostate cancer remains a significant global health concern, and understanding the molecular drivers of this disease is crucial for developing effective diagnostic and therapeutic strategies. Steroid Receptor Coactivator-3 (SRC-3), a member of the SRC family, has emerged as a key player in prostate cancer pathogenesis. This review compr...

The study aimed to investigate how the solvent extract of Buchholzia coriacea (BCE), a widely known hypolipidemic agent, could contribute to hyperlipidemia treatment and identify the potential bioactive compounds. We studied Wistar albino rats, dividing them into seven groups: the normal control, normal rats treated with 400 mg/kg.b.wt of BCE (NRG...

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Although the exact etiology of PD remains elusive, growing evidence suggests a complex interplay of genetic, environmental, and lifestyle factors in its development. Despite adv...

Xylopia aethiopica (XAE) is a commonly used herbal medicine and contains rich active ingredients for a variety of biological activities. The study aimed to explore the role of XAE in the management of benign prostatic hyperplasia (BPH). In the study, testosterone propionate-induced BPH in albino rats was established and treated with different conce...

Oral antidiabetic agents including the peroxisome proliferator-activated receptor gamma (PPARγ) agonists are available for the clinical management of diabetes mellitus (DM) but most are characterized by many adverse effects. In this study, we explore the antidiabetic properties of phytoconstituents from Trigonellafeonumgraecum (Fabaceae) as potenti...

The study of natural products has given rise to the discovery of a variety of useful drugs for effective management of several diseases. Phytochemical constituents of plants are fingered to be biologically active compounds responsible for different activities such as analgesic, anti-inflammatory, antioxidant, antimicrobial, antifungal and anticance...

This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA-induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of (CMSO) on adipokine dysfunctions and dyslipidemia in Bisphenol-A (BPA)-induced male Wistar rats. Six-week-old 36 albino rats of 100 to 200 g w...

Introduction There are claims by traditional medicine practitioners in Nigeria and valuable scientific reports that the leaves of Tephrosia vogelii (TV) hook are used for the treatment of various diseases; however, there is paucity of information on it used in the management of cardiovascular complications despite the rich presence of phytochemical...

The study of natural products has given rise to the discovery of a variety of useful drugs for effective management of several diseases. Phytochemical constituents of plants are fingered to be biologically active compounds responsible for different activities such as analgesic, anti-inflammatory, antioxidant, antimicrobial, antifungal and anticance...

Physicochemical properties, selected metal contents, microbial load and antibiotic susceptibility pattern of three main drinking water sources in Amaozara Ozizza, Afikpo North L.G.A, Ebonyi State, Nigeria were investigated. Three drinking water samples were collected from three water sources: Ogo borehole, Ogbuku and Ugwuiyi. Physicochemical parame...

Introduction With the use of recent therapeutic data, several methods for finding medications from untapped natural materials continue to advance research and development. The antioxidant and antianemic effects of ethanol leaf extracts of Telfairia occidentalis and Mucuna poggei in phenylhydrazine-induced anemia in Wister albino rats were investiga...

The screening of plants as promising natural sources of medicinal agents against several diseases (both metabolic and infectious) is a well establish phenomenon in the scientific community of researchers. In this study,ethanolleaf extract of Datura stramonium (D. stramonium) was investigated for its anti-diabetic properties in diabetic rat model.A...

Bisphenol-A (BPA) and its analog are extensively utilized in the production of plastics which are rather ubiquitous in our environment. At high temperatures, BPA is leached into water and food packed in plastic containers. This research investigated the ameliorative effects of CMSO on adipokines dysfunction and dyslipidemia in male Wistar rats expo...

Aim:Saponinshave been reported to demonstrate glucose lowering potentials in diabetic conditions. This study was aimed at investigating the effect of Vernonioside E (VE), a steroidal saponin extract from Vernoniaamygdalina(VA) in diabetic rats. Main Methods: A total of 42 Wistarrats used in the study were distributed into seven (7) groups (n=6). Tr...

Background Obesity is characterized by increased body fat and involves an imbalance between synthesis and degradation of lipids. Objective To investigate the effect of African walnuts (Tetracarpidium conophorum) on storage lipids and the regulatory enzymes of hepatic lipid metabolism in obese rats. Methods The nuts were extracted in ethanol (WE)...

Aims: African walnuts were previously shown to modulate hepatic lipid bio-accumulation in obesity. Herein, we investigated the impact of the nuts on fat accumulation in adipose and ectopic regions, and associated oxidatiive stress status in obese rats. Materials and methods: Whole ethanol extract (WE) of the nuts, and its liquid-liquid fractions...

Abstract Background and Objective: Persistent hyperglycaemia in diabetes mellitus (DM) could result to compromised hepatic function. Telfairia occidentalis (TEL) and Gongronema latifolium (GON) have both demonstrated glucose lowering potentials in previous investigations due to a rich mix of bioactive compounds in the plants. This study investigate...

Effect of ethanolic leaf extract of Anacardium occidentale on histoarchitecture of brain and kidney. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013, May (Supplement 1); 30(30): S31-S35. The online version of this article, along with updated information and services, is located on the World Wide Web at: www.jpbms.info J...

This study was carried out to evaluate the anti-obesity effect of Vernonia amygdalina Del. (VA) supplemented diet. VA leaf powder was fed at 5% and 15% to diet-induced obese rats for 4 weeks and its effect compared with orlistat (5.14 mg/kg p.o.), an anti-obesity drug. Food intake, body and organ weights, total body fat, some lipid components and a...