Daniel S Seidman

• MD, MMSc
• Medical Doctor at Tel Aviv University

Background Artificial intelligence (AI) models analyzing embryo time-lapse images have been developed to predict the likelihood of pregnancy following in vitro fertilization (IVF). However, limited research exists on methods ensuring AI consistency and reliability in clinical settings during its development and validation process. We present a meth...

The success of deep learning in identifying complex patterns exceeding human intuition comes at the cost of interpretability. Non-linear entanglement of image features makes deep learning a “black box” lacking human meaningful explanations for the models’ decision. We present DISCOVER, a generative model designed to discover the underlying visual p...

Study question Can calibrated AI ploidy screening test results provide reliable, biologically-justified estimates of embryo euploidy? Summary answer The AI ploidy screening test, rooted in the embryo’s morphokinetic profile and clinical metadata, provides reliable probabilistic estimates of euploidy. What is known already Published ploidy algorit...

Study question What is the impact of AI-based embryo triage on the number of IVF cycles needed to reach fetal heartbeat (FH)? Summary answer Simulated cohort ranking via the AIVF Day-5 AI model demonstrates a 27.5% reduction in the number of IVF cycles needed to achieve FH. What is known already Published reports show FH rates per first-time IVF/...

Study question Can an AI-based embryo ploidy screening tool effectively provide a genetic risk assessment on Day 5 embryos? Summary answer AI screening results showed strong predictive value for early detection of at-risk embryos warranting confirmatory diagnostic testing, based only on time lapse video assessment. What is known already Euploid e...

Study question Can we decipher the underlying visual properties that drive image-based AI embryo classification models to assist clinical decisions and biological discovery? Summary answer Our framework interpreted which annotated and non-explicitly-annotated phenotypes impact model predictions and rank their importance. These discoveries were ali...

Purpose: Oral contraceptives (OCs) are commonly used by female athletes raising concerns regarding the possible adverse effects of OCs on physical performance, musculoskeletal injuries, and bone density. We aimed to review all current studies on the physiological effects of OCs in physically active women. Materials and methods: A review of liter...

The success of deep learning in identifying complex patterns exceeding human intuition comes at the cost of interpretability. Non-linear entanglement of image features makes deep learning a "black box" lacking human meaningful explanations for the models' decision. We present DISCOVER, a generative model designed to discover the underlying visual p...

Study question Can EMATM (AIVF, Israel) artificial intelligence (AI) platform provide personalized success estimates based on the patient’s metadata and embryonic development? Summary answer Individual patients can be given an accurate estimation of their chances for a clinical pregnancy using AI-based embryo evaluation and patient metadata. What...

PurposeStaff management is the most cited ART/IVF laboratory inspection deficiency. Small ART/IVF clinics may be challenged to perform these activities by low staff volume; similarly, large ART/IVF networks may be challenged by high staff volume and large datasets. Here, we sought to investigate the performance of an automated, digital platform sol...

High content time-lapse embryo imaging assessed by machine learning is revolutionizing the field of in vitro fertilization (IVF). However, the vast majority of IVF embryos are not transferred to the uterus, and these masses of embryos with unknown implantation outcomes are ignored in current efforts that aim to predict implantation. Here, we explor...

Study question How demanding in terms of time and resource allocation is the full integration of an AI platform to the routine operation of an IVF clinic? Summary answer The rapid and effective implementation, and continuous performance, of EMA was qualitatively and quantitatively demonstrated for the first time in a real-world clinical setting....

Study question Is there a selection bias against embryos placed in higher-numbered wells inside a multi-well IVF culture dish. Does this selection bias alone impact implantation outcomes? Summary answer Top-quality embryos present in higher-numbered wells are statistically less likely to be selected for transfer, independent of any differences in...

Study question Can an AI based triage system noninvasively detect aneuploidy in preimplantation embryos in a precise and valid manner? Summary answer Using a feature extraction approach to identify features in time-lapse images, an AI model was validated and found to noninvasively detect ploidy with unprecedented accuracy. What is known already I...

Study question Can an AI deselection model identify distinct morphokinetic patterns in top-quality blastocyst with unknown ploidy that fail to implant? Summary answer An AI based deselection model was able to predict implantation failure based on morphokinetic features previously found to associate with aneuploidy. What is known already Aneuploid...

Study question Can we distinguish between top-grade euploid and aneuploid embryos by AI measurement of cell edges in time-lapse videos? Summary answer Aneuploid embryos can be distinguished from euploid embryos by AI determination of a longer time to blastulation and higher cell activity. What is known already Continuous monitoring of the embryo...

Study question Is there any visible variation in the development of aneuploid embryos depending on the type of chromosome abnormality? Summary answer There were significant visible differences in the development of euploid, monosomic, trisomic and, especially, chaotic embryos. What is known already Aneuploidy rates are remarkably high in in vitro...

We compared the prevalence of ultrasound signs of adenomyosis in women with endometriosis who underwent surgery to those who were managed conservatively. This was a retrospective study of women evaluated at a tertiary endometriosis referral center who underwent 2D/3D transvaginal ultrasound. Adenomyosis diagnosis was based on the presence of at lea...

The superiority of day 5 blastocysts compared to day 6 blastocysts in fresh cycle transfers was previously demonstrated and attributed mainly to endometrial asynchrony. Data from frozen blastocysts transfers showed conflicting results, possibly due to heterogeneous patient population and embryo quality. The aim of this study was to compare clinical...

“Add-on” procedures are actively promoted on some fertility clinic websites as proven means to improve IVF success rates, especially for couples with repeated implantation/IVF failures. However, the actual contribution of these interventions to live birth rates remains inconclusive. At present, little is known about the type and quality of the info...

objective: Oocyte pick-up (OPU) is a painful, but essential part of in-vitro fertilization (IVF) that is usually performed under sedation and analgesia (SaA). Our aim was to study why some women decide to undergo OPU without SaA? methods: This was a prospective study using patient questionnaires and the standardized 7-item Generalized Anxiety Disor...

Endometriosis may adversely affect ovarian reserve by direct and indirect mechanisms. Adolescents with severe endometriosis may therefore be at significant risk for ovarian tissue damage over many decades, which may lead to infertility and, occasionally, premature ovarian failure. The risk for a compromised ovarian reserve is especially high in ado...

How accurate is the information about Endometrial Scratching presented on fertility clinics websites, considering the conflicting evidence on its effectiveness?

Purpose How can elective egg freezing (EEF) be made patient centered? This study asked women to reflect on their experiences of EEF, which included their insights and recommendations on the optimal delivery of patient-centered care. Methods In this binational, qualitative study, 150 women (114 in the USA, 36 in Israel) who had completed at least o...

Research question: What pregnancy rates are achieved after transfer of cryopreserved double slow-frozen embryos in IVF cycles? Patients in whom surplus thawed cleaved embryos (day 2 or 3) were grown to the blastocyst stage, re-frozen and then re-thawed for transfer (double freezing) were included. Design: Data were collected on all patients who...

Purpose: What are the specific pathways that lead women to freeze their eggs? In this binational study, women were asked directly about the life circumstances that led them on the path to elective egg freezing (EEF). Methods: From June 2014 to August 2016, 150 women (114 in the USA, 36 in Israel) who had completed at least 1 cycle of EEF were in...

Objective To determine the association between early increase in the serum hCG levels (days 0–4) and treatment success rates following methotrexate therapy in ectopic pregnancy patients. Study design A level II-2 case-control study of involving 140 patients treated with methotrexate for ectopic pregnancy at the gynecology department in a tertiary...

Research question: What is the cumulative incidence of live birth (CILB) for high-order consecutive IVF cycles, and which factors are associated with live birth in women aged ≥41 years using autologous oocytes? Design: A retrospective cohort study including 146 patients aged 41 years to <44 years who started their first IVF cycle attempt using a...

Background: What are the underlying socio-demographic factors that lead healthy women to preserve their fertility through elective egg freezing (EEF)? Many recent reviews suggest that women are intentionally postponing fertility through EEF to pursue careers and achieve reproductive autonomy. However, emerging empirical evidence suggests that wome...

Endometriosis is a disease characterized by the development of endometrial tissue outside the uterus, but its cause remains largely unknown. Numerous genes have been studied and proposed to help explain its pathogenesis. However, the large number of these candidate genes has made functional validation through experimental methodologies nearly impos...

Objectives To determine the prevalence of ultrasound features suggestive of adenomyosis in women undergoing surgery for endometriosis compared with a control group of healthy women without endometriosis. Methods Retrospective case-control study comparing women with intractable pain or infertility, who underwent transvaginal ultrasound and subseque...

Study objective: Bladder involvement is rare in endometriosis. The prevalence is estimated to be ∼1% in patients with endometriosis. However, this figure seems to be an underestimation. The diagnosis of bladder endometriosis might be missed during laparoscopy. The aim of this study was to determine an intraoperative visual score of pelvic lesions...

Introduction: Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of pain is often insufficient and is associated with high rate of recurrence. Better pain management is therefore of urgent need. Me...

Religion is embedded in the culture of all societies. It influences matters of morality, ideology and decision making, which concern every human being at some point in their life. Although the different religions often lack a united view on matters such contraception and abortion, there is sometimes some dogmatic overlap when general religious prin...

Objective: To evaluate fertility outcomes in infertile women with severe endometriosis (The revised American Fertility Society classification [AFS] 3-4) and repeated IVF failures, who underwent surgery due to exacerbation of endometriosis-related symptoms. Design: Retrospective cohort study. Setting: University hospital. Patient(s): All wome...

Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presen...

Study objective: To assess the reproductive outcome (spontaneous and assisted conception rates) in women who underwent laparoscopic resection of bladder endometriosis. Design: This was a retrospective, observational study analyzing prospectively recorded data. Design classification: Canadian Task Force classification II-2. Setting: Tertiary...

Abstract Worldwide, IVF is often discontinued before a live birth is achieved due to high costs. Even when partial financial coverage is provided, often medical providers advise treatment discontinuation. In Israel, unlimited IVF is offered free of charge for a couples' first two children. Our objective was to assess the reasons couples discontinue...

Background The multinational CHOICE (Contraceptive Health Research Of Informed Choice Experience) study evaluated the effects of structured counseling on women’s contraceptive decisions, their reasons for making those decisions, and their perceptions of combined hormonal contraceptive (CHC) methods in eleven countries. The aim of this paper to pres...

Preterm birth is a global concern resulting in prematurity which is the leading cause of newborn death and long-term squeal in the survivors. In this review, we will summarize the data available to this date in regard to the causes, available interventions, and contemporary research for future applications.

The two major consequences of endometriosis are pain and infertility. Despite numerous studies and proposed guidelines, some aspects of the treatment for these complications are still under debate or lack convincing evidence that favors one approach over the other. Future studies will hopefully present new evidence in regard to the optimal treatmen...

To determine the incidence and severity of acute pelvic inflammatory disease (PID) or tubo-ovarian abscess (TOA) in hospitalised women with and without a history of endometriosis. Retrospective analysis of hospital records retrieved for all women hospitalised with PID or TOA between January 2008 and December 2011 in a tertiary referral centre. Wome...

This, the second edition of The Subfertility handbook: A Clinician’s Guide has been published 14 years after the First Edition that had appeared in print in 1997. This new edition takes an international view, with contributions from experts from around the world. The fully revised and updated second edition of this practical handbook provides compr...

Endometriosis is associated with an increased risk of ovarian cancer. Few studies have also shown increased risk of breast cancer. BRCA1/2 mutations are linked to an increased risk of breast and ovarian cancers but their relation to endometriosis is unknown. The objective of this study was to examine the mutation rate of BRCA1/2 among women with su...

To evaluate the efficacy and safety of 3 months of vaginal mifepristone treatment on leiomyoma volume and related symptoms. Prospective, open-label, two tertiary centers, phase II clinical trial. Two tertiary medical centers in Israel. Thirty-three enrolled women, ages 30-53 years, diagnosed with symptomatic uterine fibroids. Patients received 10 m...

To evaluate adequacy and adherence to American Society for Reproductive Medicine (ASRM) guidelines of internet information provided by Society for Assisted Reproductive Technology (SART)-affiliated clinics regarding social oocyte cryopreservation (SOC). Systematic evaluation of websites of all SART member fertility clinics. The internet. None. All...

To investigate the intraoperative features and long-term postoperative results of patients with ureteral endometriosis who underwent ureteral reimplantation. In this retrospective study, we reviewed records of all patients with ureteral endometriosis treated by ureteral reimplantation. Pre-, intra- and post-operative information was collected. Of p...

OBJECTIVE: To assess the efficacy and safety of laparoscopic treatment of bladder endometriosis, especially in cases of full thickness endometriotic nodules. DESIGN: Retrospective review of medical records. SETTING: Tertiary medical center and a referral center for endometriosis. POPULATION: Sixty-nine patients with bladder endometriosis that under...

Objective: To describe the daily work practice under the threat of defensive medicine among obstetricians and gynecologists. Study Design: A prospective cross-sectional survey of obstetricians and gynecologists working at tertiary medical centers in Israel. Results: Among the 117 obstetricians and gynecologists who participated in the survey, repre...

To describe the daily work practice under the threat of defensive medicine among obstetricians and gynecologists. A prospective cross-sectional survey of obstetricians and gynecologists working at tertiary medical centers in Israel. Among the 117 obstetricians and gynecologists who participated in the survey, representing 10% of the obstetricians a...

Defensive medicine in daily practice (n = 117 physicians). (DOCX)

Physicians' Characteristics. (DOC)

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The insertion of a levonorgestrel-releasing intrauterine system (LNG-IUS) requires experience and is associated with a low failure rate. To assess the reasons given by gynecologists why they failed to insert a LNG-IUS. We obtained data from the sole distributor in Israel that prospectively recorded these cases when contacted by gynecologists follow...

Ibuprofen has an increasing role in the management of gynecologic pain, as well as other common benign gynecologic conditions. The use of ibuprofen in this context is mainly related to its inhibition of prostaglandins (PGs) production, mediators of pain sensation. Imbalance in various PGs levels is associated with dysmenorrhea and excessive menstru...

The aim of this study was to determine whether women with recurrent pregnancy loss (RPL) and concurrent premenstrual syndrome (PMS) who underwent desensitization with sex hormones had an improved obstetric outcome. This manuscript summarizes a 10 year open label prospective follow up study of 26 women with RPL, aged 25-42 with 3-8 previous miscarri...

To evaluate the clinical and surgical features of thoracic endometriosis syndrome (TES) represented by catamenial pneumothorax and pelvic endometriosis and to describe their association with infertility. Retrospective clinical study (Canadian Task Force classification: II-2). Academic tertiary referral endometriosis center. Seven patients who had u...

The modern era of infertility treatment was heralded over half a century ago with the introduction of new hormonal drugs that could effectively induce ovarian ovulation. However, it was quickly recognized that the birth of these new "miracle drugs" was associated with a remarkable increase in the incidence of high-order multiple births. Despite the...

The aim of this survey was to examine sexual behavior, use of contraception, and communication regarding these issues between mothers and their teenage daughters. This descriptive cohort study included 314 pairs of women aged 15-24 years and their mothers, from an urban area in Israel. The participants completed questionnaires about sexual history...

STUDY QUESTION What is the rate of spontaneous live births after successful IVF treatment in a cost-free environment, and were couples who achieved a spontaneous live birth referred prematurely? SUMMARY ANSWER Despite unlimited IVF treatments offered free of charge, the spontaneous live birth rate following successful IVF remained unchanged compar...

To determine the efficacy of pre-emptive administration of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen vs. a placebo on pain relief during medical abortion and to evaluate whether NSAIDs interfere with the action of misoprostol. Prospective, double-blind, randomized, controlled study. University-affiliated tertiary hospital. Sixty-one...

To determine the incidence of recurrent empty follicle syndrome (EFS) and to analyse the factors associated with this phenomenon. Retrospective analysis comparing all EFS cycles with cycles in which oocytes were retrieved in our in vitro fertilization (IVF) unit between 1998 and 2006. Of 8292 IVF cycles, 163 (2.0%) resulted in empty follicles. Risk...

The management of a malpositioned levonorgestrel (LNG)-releasing intrauterine system (IUS) can present a clinical challenge, complicated by the high cost of replacing it with a new device. We tried to challenge the guidelines and common practice that usually suggest prompt removal of any malpositioned IUS and replacement with a new one. We present...

To examine the efficiency of laparoscopic ureterolysis for ureteral endometriosis and to describe appropriate treatment. Prospective trial (Canadian Task Force classification II-2). University hospital. Forty-five patients who underwent surgery to treat ureteral endometriosis between 2005 and 2009. Laparoscopic ureteral ureterolysis. Long-term foll...

Hypersensitivity to estrogens and progestogens is often undiagnosed. The condition has many manifestations, including premenstrual syndrome, dysmenorrhea, and impaired fertility. Diagnosis is confirmed by skin testing for inflammatory responses to small doses of the hormone, and desensitization with small doses of the hormone is the most appropriat...

To assess the long-term success rate among couples with primary infertility offered unrestricted, free in vitro fertilization (IVF) treatments. Historical prospective cohort study. University-based tertiary medical center with unlimited coverage of IVF for couples' first two children. Women aged <35 years, with primary infertility, referred for the...

Aim: To explore the molecular basis of clinically observed volume reduction in uterine leomyoma, exposed to mifepristone. Background: Treatment of uterine leiomyomas with a selective progesterone receptor modulator (SPRM) as an alternative to surgery is of considerable clinical interest. Steroid homone receptors are overexpressed in leiomyoma tumo...