Daniel Ruiz-GabarreCentro De Biología Molecular Severo Ochoa · Department of Neurobiology
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Citations since 2017
6 Research Items
Welcome everyone to my ResearchGate page! I am a predoctoral researcher at CBMSO in Madrid, Spain; also undertaking my PhD in Neurosciences and a Degree in English Studies and Linguistics. My interests range widely from molecular biology and neurodegeneration to sociolinguistics and anything in between. I'm currently researching molecular mechanisms of Alzheimer's disease, with a focus on new splicing isoforms of Tau and their role in Tau pathology. Don't be shy, say hi!
Background: An increase in tau protein is believed to be necessary for tau aggregation. However, whether this is due to increased expression of the endogenous tau promoter or protein accumulation due to proteostasis failure remains uncertain. Objective: To analyze the expression of GFP protein under endogenous tau promoter across different ages...
W-Tau, a new tau human-specific splicing isoform generated by intron retention, has been recently described. This isoform contains an 18-residue unique sequence corresponding to the translation of the retained region of intron 12. In this work, we have described that such 18-amino-acid peptide from the retained intron 12 can inhibit tau and β amylo...
Introduction: Tauopathies, including Alzheimer's disease (AD), are a group of neurodegenerative disorders characterised by Tau hyperphosphorylation. Post-translational modifications of Tau such as phosphorylation and truncation have been demonstrated to be an essential step in the molecular pathogenesis of tauopathies. Alternative splicing is the p...
Tau protein is a microtubule-associated protein encoded by the MAPT gene that carries out a myriad of physiological functions and has been linked to certain pathologies collectively termed tauopathies, including Alzheimer’s disease, frontotemporal dementia, Huntington’s disease, progressive supranuclear palsy, etc. Alternative splicing is a physiol...
Tauopathies, including Alzheimer’s disease (AD) and frontotemporal lobar degeneration with Tau pathology (FTLD-tau), are a group of neurodegenerative disorders characterized by Tau hyperphosphorylation. Post-translational modifications of Tau such as phosphorylation and truncation have been demonstrated to be an essential step in the molecular path...
As life expectancy is growing, neurodegenerative disorders, such as Alzheimer’s disease, are increasing. This disease is characterised by the accumulation of intracellular neurofibrillary tangles formed by hyperphosphorylated tau protein, senile plaques composed of an extracellular deposit of β-amyloid peptide (Aβ), and neuronal loss. This is accom...