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Daniel Routledge

Daniel Routledge
The Company of Biologists

PhD in Cellular and Molecular Biology

About

4
Publications
1,244
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102
Citations
Introduction
My main research interests are in cellular and molecular biology; particularly cancer cell biology. I recently completed my PhD at the University of Exeter, where I studied Wnt transport and signalling in gastric cancer cells. Prior to that, I graduated from the University of Southampton with a Master's in Biomedical Science (1:1). I am currently a Cross-title Reviews Editor at The Company of Biologists.

Publications

Publications (4)
Article
Full-text available
The Wnt/β-catenin signalling pathway regulates multiple cellular processes during development and many diseases, including cell proliferation, migration, and differentiation. Despite their hydrophobic nature, Wnt proteins exert their function over long distances to induce paracrine signalling. Recent studies have identified several factors involved...
Preprint
Full-text available
The Wnt/β-catenin signalling pathway regulates multiple cellular processes during development and many diseases, including cell proliferation, migration, and differentiation. Despite their hydrophobic nature, Wnt proteins exert their function over long distances to induce paracrine signalling. Recent studies have identified several factors involved...
Article
Full-text available
Multiple mitochondrial quality control pathways exist to maintain the health of mitochondria and ensure cell homeostasis. Here we investigated the role of the endosomal organiser Tollip during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson’s disease associated E3 ubiquitin ligase Parkin. The int...
Article
Full-text available
Wnt proteins are secreted glycoproteins that regulate multiple processes crucial to the development and tissue homeostasis of multicellular organisms, including tissue patterning, proliferation, cell fate specification, cell polarity and migration. To elicit these effects, Wnts act as autocrine as well as paracrine signalling molecules between Wnt-...

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Projects

Project (1)
Project
My PhD project is investigating the propagation of Wnt signals via specialised filopodia (cytonemes) in gastric cancer cells to clarify the role of direct cell-cell contact in paracrine Wnt signalling.