Daniel Rotten

Daniel Rotten
Delafontaine Hospital · Obstetrics and gynecology

MD, PhD

About

57
Publications
4,099
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1,141
Citations

Publications

Publications (57)
Article
Full-text available
Objectives Craniofacial deformities have a high psychosocial impact. The aim of this paper is to improve obstetric ultrasonography and prenatal detection of facial anomalies by providing a new fetal dental panorama. Material and methods The present study describes a new modality to visualize the fetal tooth germs and an easy step-by-step diagnosti...
Article
“What does the sonologist need to tell the orofacial team ?” was the question discussed by Mulliken and Benacerraf in 2001 (Mulliken and Benacerraf, 2001). Since that date, the prenatal diagnosis of orofacial clefts has made dramatic advances. Usually, the presence of a cleft is suspected through a noose-mouth coronal view using 2D ultrasonography....
Article
Lip analysis necessitates visualization of the coronal planes, and, in the case of bilateral clefts, the midsagittal plane. The palate (alveolus, maxilla, secondary palate) is best analyzed using coronal and axial planes. We have developed a surface-rendered representation, corresponding to the submental intraoral photograph of the neonatal palate...
Article
Objective As part of teenage pregnancies, it is often found vulnerability and pregnancy follow-up of poorer quality. This investigation aims to establish profiles of young women and to assess what followed. Methods A retrospective study (2007–2011) of 220 births to women aged 12 to 17. Results The monitoring of these teenage pregnancies remains g...
Article
OBJECTIVE: As part of teenage pregnancies, it is often found vulnerability and pregnancy follow-up of poorer quality. This investigation aims to establish profiles of young women and to assess what followed. METHODS: A retrospective study (2007-2011) of 220 births to women aged 12 to 17. RESULTS: The monitoring of these teenage pregnancies remains...
Article
Before 2003, diagnostic amniocentesis and other invasive procedures were not performed in most eligible pregnant HIV-infected patients because of concern over the risk of mother-to-fetus transmission of the virus. With the introduction and widespread use of antiretroviral therapy (especially HAART), the resulting marked decline in the overall verti...
Article
To assess the risk of vertical transmission in HIV-infected pregnant women undergoing diagnostic amniocentesis, and to identify possible predictive factors. This was a single center retrospective study. The records of 330 HIV-infected pregnant women booked in our antenatal clinic from 31 January 2001 to 31 January 2006 were analyzed. Women who actu...
Article
Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. It generally involves the peritoneum, ovaries and rectovaginal septum. Its characteristic symptoms include dysmenorrhea, pelvic pain, deep dyspareunia and infertility. It may also involve the gastrointestinal tract, urinary tract or extra abdominal sites, giv...
Article
Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. It generally involves the peritoneum, ovaries and rectovaginal septum. Its characteristic symptoms include dysmenorrhea, pelvic pain, deep dyspareunia and infertility. It may also involve the gastrointestinal tract, urinary tract or extra abdominal sites, giv...
Article
To describe the sonographic appearance of cleft lip with or without cleft palate (CL +/- P) using two-dimensional and three-dimensional (3D) ultrasound imaging. Also, to evaluate the accuracy of ultrasound to delineate with precision the bony extent of facial clefts, i.e. to differentiate clefts limited to the lips, or extending to the alveolus/pre...
Article
To detail fetal facial examination in utero using ultrasound, to distinguish between requirements for routine screening and those for precise analysis of fetal facial features, and to assess the use of three-dimensional (3D) ultrasound imaging in fetal facial examination. This was a retrospective study, based on the examination of approximately 10,...
Article
To define parameters that enable the objective diagnosis of anomalies of the position and/or size of the fetal mandible in utero. Fetuses at 18-28 gestational weeks were examined by two- and three-dimensional ultrasound. The study included normal fetuses and fetuses with syndromes associated with known mandible pathology: Pierre Robin sequence or c...
Conference Paper
Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospectiv...
Article
To describe the appearance of normal breast tissue and breast masses with three-dimensional ultrasound mammography, and evaluate the contribution of this to the diagnosis of breast masses. A total of 186 solid hypoechoic breast masses were analyzed with two- and three-dimensional ultrasonography. Three-dimensional planar reformatted sections were r...
Conference Paper
Full-text available
Background To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. Methods North American and European studies of at least 100 mother-child pairs were included in the meta-an...
Article
The authors describe the interest and clinical application of 3 D ultrasound examination in obstetrics. The ultrasound equipment used is a Combison 530 (Kretz) with an abdominal and a vaginal 3 D transducer.
Article
To assess the reliability of growth hormone (GH) secretion tests using provocative agents in women of different ovarian status. Comparison of GH secretion in response to clonidine (Catapressan; Boehringer Ingelheim, Reims, France) and growth hormone-releasing factor (GH-RF). University Hospital, Hôpital Tenon, Paris, France. Women categorized as "n...
Article
The present study was designed to assess the performance of fine needle aspiration cytology (FNAC) and core-needle biopsy (CNB) of breast lesions when these procedures are performed under sonographic guidance. The results obtained in 1142 FNAC procedures and 180 CNB procedures were analysed. The study took place in a University Hospital and a priva...
Article
A series of 125 breast carcinomas studied by both radiological and ultrasound mammography, and which were observed in 102 patients, is presented. Of the lesions, 76.5% were less than 20 mm in diameter, and 16.8% had a diameter 10 mm or less. Sixteen lesions were in situ or microinvasive. Analysis of the results shows a 40.8% rate of false-negative...
Article
The aim of the study was to investigate the hypothesis that oral contraceptives (OC) lead to antiethinyl-estradiol antibody (AEEA) synthesis which might in turn be responsible for the thrombo-embolic complications observed in women users. The trial included 428 women divided into a) 204 healthy female volunteers as the control group (CONT), b) 139...
Article
Reconstructed three-dimensional sonographic images are presented from patients having different histological types of breast tumors. Scanning is manual and performed using two-dimensional annular array, sector transducers fitted on a mechanical arm, to provide spatial location. The three-dimensional data are displayed using two different modalities...
Article
Thirty-six women with immune thrombocytopenic purpura were studied during 37 pregnancies, and maternal characteristics with predictive value for the fetal platelet count were determined. Nine neonates were thrombocytopenic, with a platelet count of less than 50 x 10(9)/L in eight. Four of these nine neonates delivered to a subgroup of 31 mothers we...
Article
LHRH-like immunoreactive material was separated from human placental homogenates by chromatography and tested against two antibodies directed respectively against the C- or the N-terminus (N- and C-antibodies) of the synthetic peptide. Extraction yield was 94 per cent as assessed by the recovery of the radiolabelled LHRH added to the homogenates. P...
Article
The present data show that the contraceptive studied, a triphasic combination pill with gestodene, strongly depresses gonadotropin levels. Seric levels of both FSH and LH are below 1 mIU/ml as early as the third treatment cycle. Recovery of a normal pituitary function occurs rapidly after the administration is discontinued: both basal and stimulate...
Article
Full-text available
Mature erythrocytes contain a specific isozyme of pyruvate kinase (R-PK) while immature erythroblasts coexpress R-PK and another isozyme, M2-PK. To determine what roles degradation and decreasing of synthesis played in the disappearance of M2-PK during erythroid maturation, M2-PK and R-PK synthesis and degradation were studied in erythroblasts from...
Article
Full-text available
Mature erythrocytes contain a specific isozyme of pyruvate kinase (R- PK) while immature erythroblasts coexpress R-PK and another isozyme, M2- PK. To determine what roles degradation and decreasing of synthesis played in the disappearance of M2-PK during erythroid maturation, M2-PK and R-PK synthesis and degradation were studied in erythroblasts fr...
Article
Full-text available
A prospective study was performed to assess the reliability of sonographic mammography in mass screening for breast lesions and diagnosis of small, presumably early, breast cancers. 1350 women underwent a sonomammographic examination of the breasts. Sonomammographic images were described in terms of their elementary constituents. Final diagnosis wa...
Article
A prospective study was designed to assess the predictive value of gonadotropin measurements obtained during the early follicular phase upon the hormonal characteristics of the subsequent cycle. The data obtained in 12 normal cycles were used to compute the mean and confidence interval (mean +/- 2 SEM) of the FSH:LH ratio, FSH and LH plasma levels....
Article
To assess the evolution of the elastic fiber network of the human uterine cervix before, during and after pregnancy, biopsy samples were obtained from 49 women. The high affinity of the polyphenolic compound (+)-catechin for elastin was used to stain the elastic fibers selectively, and enabled automated image analysis. In the human uterine cervix,...
Article
The data presented here summarize two previously performed studies. In a first study, we analysed prospectively 1350 sonographic examinations of the breasts. Every focal image was analytically described, using the following parameters: shape, size, orientation of the major axis relative to the surface of the skin, aspect of the margins, of the inte...
Article
Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membranes. The high concentrations of B...
Article
Ovulation induction in the postpartum rhesus monkey was attempted with the use of purified human pituitary gonadotropins for assessment of (1) whether this procedure could be used to provide a source of luteal tissue; (2) the extent of ovarian responsiveness to gonadotropic stimulation; (3) factors that might facilitate ovulation induction during t...
Article
Short-term (9 days) hyperprolactinemia induced by pituitary grafts reduced basal plasma LH levels in ovariectomized rats whereas long-term (31 days) grafts increased basal LH levels. Although long-term grafts inhibited estradiol-induced prolactin surges, hyperprolactinemia had no effect on the LH surge. It is concluded that the estrogen-treated ova...
Article
The effects of oestradiol and prolactin (Prl) on progesterone production by dispersed monkey luteal cells were examined. Corpora lutea were recovered from monkeys 5-7 days following ovulation induction during the puerperium. The tissue was dispersed by collagenase and mechanical disruption. The resulting cells were incubated in Dulbecco's modified...
Article
Results extend previous studies which showed the lack of effect of dopamine on prolactin secretion by decidual explants in vitro, and no lowering effect of bromocriptine on amniotic fluid PRL level in vivo. Furthermore, they show that this phenomenon is related to a complete absence of DA-binding sites rather than a defect at a post receptor level.
Article
These studies were performed to assess the concentrations of dehydroepiandrosterone sulfate (DHAS) in the rhesus monkey fetal circulation from midgestation through the neonatal period, to determine the relation between changes in fetal adrenal size and DHAS levels both during gestation and after surgical stress, and to explore possible relations be...
Article
A radioimmunoassay for dehydroepiandrosterone sulfate (DHAS) was established and validated for use in the rhesus monkey. The validation demonstrated the co-migration of immunoreactive material with tritiated dehydroepiandrosterone after hydrolysis and indicated the absence of other interfering steroids in the measurement. The application of this as...
Chapter
Although Wentz noticed the higher frequency of articles on luteal defect (LD)1, the effects of this disorder, its influence on fecundity, its physiopathology, and its therapy are still uncertain and debated. Following Jones2–4, we have used endometrial biopsy (EB) as the reference criterion for investigation of LD. Two different patterns of the pro...
Article
To determine whether vasoactive intestinal peptide (VIP) can be regulated by modification of plasma estradiol and prolactin levels, VIP concentrations in various structures of the rat brain and in the pituitary were measured in hyperprolactinemic female rats by means of a specific radioimmunoassay for the peptide. In ovariectomized rats treated wit...
Article
Steroid-protein interactions were studied in the antral fluid of preovulatory follicles of the human ovary. Two high affinity binding systems are described. These steroid-binding proteins do not differ from those identified in the plasma of women (transcortin and sex binding protein), as indicated by similar specificity, binding affinity, and elect...
Article
Our experience is based on 139 attempts of tissular pH electrode applications in the fetal scalp during labor and includes 119 records comprising 86 tracings of good quality and 33 tracings of bad quality. Technical progress in the electrode and application material allowed an increase in the good quality tracings rate (from 54.5–66%) and a decreas...
Article
The subcutaneous pH values of 42 fetuses has been measured continuously during labor with the use of the electrode designed by Stamm and associates. We have obtained 60 per cent good tracings. The results have confirmed the reliability of the subcutaneous pH measurement, if the electrode is correctly inserted, when compared with both capillary and...
Article
The subcutaneous pH values of 42 fetuses has been measured continuously during labor with the use of the electrode designed by Stamm and associates.2 We have obtained 60 per cent good tracings. The results have confirmed the reliability of the subcutaneous pH measurement, if the electrode is correctly inserted, when compared with both capillary and...
Article
In 3 cases of funnel shaped thorax without any cardiac or respiratory failure, filling of the hollow area with a silastic prosthesis prepared extemporaneously was carried out. The interest of this method is its benign nature and ease of realization. It may be used, above all, in patients with psychological disorders. This is a purely esthetic type...

Projects

Projects (2)
Project
Use of innovation and new technologies supporting a multidisciplinary group to optimise diagnosis of fetal craniofacial abnormalities.