Daniel Olazabal

Universidad de la República de Uruguay | UdelaR · Departamento de Fisiología (Facultad de Medicina)

Oxytocin receptor (OXTR) distribution in the brain has been associated with different reproductive and social strategies of species. Rhabdomys pumilio (R. pumilio) and Rhabdomys dilectus (R. dilectus) are two sister rodent species that live in large/medium (but flexible) or small (mostly solitary) social groups respectively. In this study, we descr...

While most pup-naïve adult female mice can display, or be induced (by repeated exposure to pups) to display parental behavior rapidly, adult males are infanticidal or nonparental. The medial prefrontal cortex (mPFC) participates in attentional selection, decision-making, behavioral flexibility, and planning that may be critical in the rapid display...

There is significant variability in the immediate behavioral response displayed by inexperienced adult mice when exposed to pups for the first time. The aim of this study was to determine which brain regions were engaged (higher c-Fos-immunoreactivity, c-Fos-ir) when virgin females, that were exposed to pups for 15 or 60 min, displayed full parenta...

Most species have predominant forms of social and reproductive behavior driven by many years of selection pressures and evolution. For example, rodent species can live in small or large groups, behave more tolerant or aggressively toward conspecifics (including newborns), and form or not bonds with other members of the group (including sexual partn...

Copulation and/or cohabitation with a pregnant female facilitate paternal behavior in male mice. However, their contribution to the rearing of the offspring is still not well understood. Our aims were to investigate the behavior of sires toward own or alien pups; the immediate consequences of the presence of fathers on the offspring and the behavio...

Both animal and human studies have provided conclusive evidence that oxytocin (OXT) acts in the brain (e.g. medial preoptic area, ventral tegmental area, nucleus accumbens) to promote parental behaviour under different reproductive and physiological conditions. OXT seems to accelerate and strengthen the neural process that makes newborns attractive...

There is significant variability in the behavioral responses displayed by naïve young and adult mice when first exposed to pups. This variability has been associated with differences in the expression of oxytocin receptors (OXTR) in the brain in several species. Experiment I investigated the behavioral responses of juvenile, adolescent, and adult C...

Naïve female mice are usually described as spontaneously maternal. We investigated how many exposures to pups (15 min vs. 1 hr) were needed to induce full maternal behavior (FMB) in 20–22, 30–35, 60–65-days-old naïve female mice (C57BL/6), and how cohabitation with the parturient mother and newborn siblings facilitated juvenile maternal behavior (M...

Parental behavior is commonly displayed by progenitors. However, other individuals, genetically related (e.g. siblings, aunts, uncles) or not with the newborns, also display parental behavior (commonly called alloparental, or adoptive behavior). I hypothesize that species that live in family or social groups where other non-reproductive members (ma...

Maternal–infant interaction and behaviors are adapted to reduce the risk of predation and increase the probability of survival of the species. We determined how mother–young encounters and communication change by the development of the fawn (locomotion and feeding) throughout lactation in pampas deer (Ozotocerus bezoarticus). We registered the beha...

Maternal behavior is species-specific and expressed under different physiological conditions, and contexts. It is the result of neural processes that support different forms (e.g. postpartum, cycling sensitized and spontaneous maternal behavior) and modalities of mother-offspring interaction (e.g. maternal interaction with altricial/precocious youn...

Naïve female prairie voles show significant variability in their behavioral response to newborns. We investigated whether that behavioral response (a) was related to the quality of postpartum maternal behavior; (b) was affected by postpartum maternal experience; and (c) could be selectively bred. The behavior of females was recorded in three condit...

Social interactions among conspecifics are a fundamental and adaptively significant component of the biology of numerous species. Such interactions give rise to group living as well as many of the complex forms of cooperation and conflict that occur within animal groups. Although previous conceptual models have focused on the ecological causes and...

Prairie voles ( Microtus ochrogaster ) are socially monogamous rodents that display high levels of affiliative behavior and biparental care. Both males and females contribute to the rearing of their offspring with minimal or no difference in their response to pups. Sexually naive prairie voles of both sexes also display spontaneous parental respons...

The pampas deer (Ozotoceros bezoarticus) is a South American grazing deer which is in extreme danger of extinction. Very little is known about the biology of the pampas deer. Moreover, most information has not been published in peer-reviewed scientific journals, and is only available in local publications, theses, etc. Therefore, our aim was to upd...

Oxytocin and the nucleus accumbens have been extensively implicated in the regulation of maternal behavior, and the processing of pup-related stimuli relevant for this behavior. Oxytocin receptor density in the nucleus accumbens is highly variable in virgin female prairie voles, as is their behavioral response to pups, ranging from neglecting and i...

The neuropeptide oxytocin has been implicated in the regulation of affiliative behavior and maternal responsiveness in several mammalian species. Rodent species vary considerably in the expression of juvenile alloparental behavior. For example, alloparental behavior is spontaneous in juvenile female prairie voles (approximately 20 days of age), tak...

Juvenile rats (18-23 days old) interact avidly with pups as novel stimuli and show maternal behavior after only 1-3 days of pup exposure; adults initially avoid pups and require 3-9 days of pup exposure. Upon exposure to pups as novel stimuli, adults had more c-Fos-immunoreactive neurons in the hypothalamus and amygdala--regions associated with ave...

Juvenile female prairie voles (Microtus ochrogaster) are spontaneously maternal, while virgin adult females show significant variability in their response to first pup exposure, ranging from infanticidal to full maternal behavior. In the present study, we investigated whether differences in anxiety-like behavior and affiliation are associated with...

The molecular mechanisms underlying the evolution of complex behaviour are poorly understood. The mammalian genus Microtus provides an excellent model for investigating the evolution of social behaviour. Prairie voles (Microtus ochrogaster) exhibit a monogamous social structure in nature, whereas closely related meadow voles (Microtus pennsylvanicu...

Continuous exposure of non-parturient rats to pups can induce maternal behavior similar in most aspects to that found in the postpartum rat. Surprisingly, young juvenile rats (20-24 days of age) only require 1-3 days of exposure to pups, while adults require 4-8 days before maternal behavior emerges. Dopamine (DA) and possibly serotonin (5-HT) may...

Small neurotoxin lesions in the medial preoptic area (MPOA) block maternal behavior (MB) in adults but large lesions are required to produce the same effect in juvenile rats (23-27 days of age). To study the maturation of MPOA control of MB, in Experiment I, we compared the effects of small versus large neurotoxin MPOA lesions at midpuberty (38 day...

Jamming avoidance response (JAR) and aggressive behavior were evaluated in pairs of weakly electric fish Gymnotus carapo. JAR consists of brief frequency increases of the electric organ discharge (EOD) of the faster fish of the pair when a coincidence between the EODs is close to occur. Aggressive behavior is known to be very strong and robust in t...

OLAZÁBAL, D. E. AND A. FERREIRA. Maternal behavior in rats with kainic acid-induced lesions of the hypothalamic paraventricular nucleus. PHYSIOL BEHAV 61(5) 779–784, 1997.—The rat maternal behavior consists of different pup-caring activities, such as retrieving, licking, and crouching. Mothers also build a nest, consume more food, are more aggressi...