Daniel James Miller

Daniel James Miller
University of Illinois, Urbana-Champaign | UIUC · Evolution Ecology and Behavior

PHD

About

11
Publications
5,721
Reads
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823
Citations
Introduction
My passion is to understand the structure-function relationships of the brain which enable behavior. My goal is to translate insight from basic science into actionable guidelines for the identification and treatment of brain injury and disease. In particular, I am interested in the development of cortical circuits and their reorganization following insult.
Additional affiliations
August 2019 - present
The University of Western Ontario
Position
  • PostDoc Position
Description
  • Developing novel methods to discover structure-function relationships in the brain using ultra-high-field imaging and next generation molecular histology.
September 2017 - August 2019
Yale University
Position
  • PostDoc Position
Description
  • Analysis of genes involved in the evolution and development of the cerebral cortex.
August 2011 - August 2017
Vanderbilt University
Position
  • PhD Student
Education
September 2017 - August 2021
Yale University
Field of study
  • Neuroscience
August 2011 - August 2017
Vanderbilt University
Field of study
  • Neuroscience
August 2009 - May 2011
George Washington University
Field of study
  • Biological Anthropology

Publications

Publications (11)
Article
Full-text available
Change in the timeline of neurobiological growth is an important source of biological variation, and thus phenotypic evolution. However, no study has to-date investigated sensory system development in any of the prosimian primates that are thought to most closely resemble our earliest primate ancestors. Acetylcholine (ACh) is a neurotransmitter cri...
Article
Full-text available
Nerve myelination facilitates saltatory action potential conduction and exhibits spatiotemporal variation during development associated with the acquisition of behavioral and cognitive maturity. Although human cognitive development is unique, it is not known whether the ontogenetic progression of myelination in the human neocortex is evolutionarily...
Article
The cerebral cortex is the hallmark of the mammalian nervous system, and its large size and cellular diversity in humans support our most sophisticated cognitive abilities. Although the basic cellular organization of the cortex is conserved across mammals, cells have diversified during evolution. An increasingly integrated taxonomy of cell types, e...
Article
Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development. Integrative analysis with complementary human data revealed tha...
Article
Unlabelled: We examined the functional macrocircuitry of frontoparietal networks in the neocortex of prosimian primates (Otolemur garnettii) using a microfluidic thermal regulator to reversibly deactivate selected regions of motor cortex (M1). During deactivation of either forelimb or mouth/face movement domains within M1, we used long-train intra...
Article
Full-text available
The number of cells comprising biological structures represents fundamental information in basic anatomy, development, aging, drug tests, pathology and genetic manipulations. Obtaining unbiased estimates of cell numbers, however, was until recently possible only through stereological techniques, which require specific training, equipment, histologi...
Article
Full-text available
Limbs may fail to grow properly during fetal development, but the extent to which such growth alters the nervous system has not been extensively explored. Here we describe the organization of the somatosensory system in a 6-year-old monkey (Macaca radiata) born with a deformed left foot in comparison to the results from a normal monkey (Macaca fasc...
Article
Full-text available
Determining the cellular composition of specific brain regions is crucial to our understanding of the function of neurobiological systems. It is therefore useful to identify the extent to which different methods agree when estimating the same properties of brain circuitry. In this study, we estimated the number of neuronal and non-neuronal cells in...
Data
Full-text available
Determining the cellular composition of specific brain regions is crucial to our understanding of the function of neurobiological systems. It is therefore useful to identify the extent to which different methods agree when estimating the same properties of brain circuitry. In this study, we estimated the number of neuronal and non-neuronal cells in...
Chapter
One of the more important trends in the last decade of research into the evolution and development of language is the parcellation of language, or the linguistic phenotype, into tractable subdivisions. Association of a gene or genes with language through causative mutations should provide direct evidence for the role of specific signaling pathways...

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Projects

Projects (3)
Project
Innovate neuroanatomical methods.
Project
Elucidate the evolution and plasticity of sensorimotor networks in primates.