Daniel W. McNeil

Daniel W. McNeil
West Virginia University | WVU

PhD

About

238
Publications
31,979
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
6,123
Citations

Publications

Publications (238)
Article
Full-text available
The objective of this study was to evaluate whether dietary habits at age 2 associate with sleep duration trajectories through age 5 in children from north and central Appalachia. A total of 559 children from the Center for Oral Health Research in Appalachia (COHRA) cohort 2 were followed via caregiver phone interviews up to six times between ages...
Article
Full-text available
Dental care-related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contribute to DFA. Therefore, we performed a genome-wide association study to identify genetic variants contributing...
Article
Background Dental caries is the most common chronic childhood disease. Past studies reveal that grandparents provide their grandchildren with cariogenic foods and beverages (e.g., those with free sugars and/or modified starches). Qualitative research can help identify what drives this phenomenon. Objectives To examine mothers’ explanations for why...
Article
Objective: To explore the association of racism in oral healthcare settings and dental care-related fear/anxiety with dental utilization among Black/African American women in Appalachia. Methods: We analyzed self-report measures of racism in oral healthcare settings, dental care-related anxiety and fear, recency of a dental visit, and demographi...
Article
Enamel hypoplasia causes reduction in the thickness of affected enamel and is one of the most common dental anomalies. This defect is caused by environmental and/or genetic factors that interfere with tooth formation, emphasizing the importance of investigating enamel hypoplasia on an epidemiological and genetic level. A genome-wide association of...
Article
Full-text available
The behavioral and social sciences are central to understanding and addressing oral and craniofacial health, diseases, and conditions. With both basic and applied approaches, behavioral and social sciences are relevant to every discipline in dentistry and all dental, oral, and craniofacial sciences, as well as oral health promotion programs and hea...
Article
Objectives To examine whether information that mothers received from dentists in their social network was consistent with professional recommendations for the first dental visit at age 1 y. Methods We performed a cross-sectional qualitative study on mothers in Pennsylvania and West Virginia from 2018 to 2020 to explore how their social networks in...
Article
Dental caries (cavities), one of the most common infectious diseases, is caused by a number of factors. Oral microbes, dietary practices, sociodemographic factors, and dental hygiene all inform caries risk. Assessing the impact of diet is complicated as individuals eat foods in combinations, and the interactions among the foods may alter caries ris...
Preprint
Background Early childhood caries (ECC) – dental caries (cavities) occurring in primary teeth up to age 6-years - is a prevalent childhood oral disease that includes a microbial etiology. Streptococcus mutans was previously considered a primary cause, but recent research promotes the ecologic hypothesis, in which a dysbiosis in the oral microbial c...
Preprint
Background Early childhood caries (ECC) – dental caries (cavities) occurring in primary teeth up to age 6-years - is a prevalent childhood oral disease with a microbial etiology. Streptococcus mutans was previously considered a primary cause, but recent research promotes the ecologic hypothesis, in which a dysbiosis in the oral microbial community...
Article
Full-text available
Use of dental services in childhood, especially preventive care, is associated with many important oral health outcomes throughout life. The Andersen behavioral model of healthcare utilization posits that predisposing characteristics, enabling resources, and need factors predict utilization in oral and other healthcare domains. Inequities that prod...
Article
Background The bacteriome is associated with susceptibility to some eukaryotic viruses, but no study has examined associations between the salivary bacteriome and human herpesviruses (HHVs). We provide new prevalence and incidence estimates for salivary herpesviruses detection and estimate associations with bacteriome diversity in young children....
Article
Background: While self-report measures of periodontal disease exist, no prior work has utilized a latent variable approach based on psychometric theory to validate such a measure. This study aimed to develop a psychometrically valid self-report measure of periodontal disease using latent variable factor analysis and other evidence-based psychometr...
Article
Full-text available
Objectives Oral health values, the degree to which one places importance on or demonstrates investment in improving or maintaining one's dental status, are believed to vary across individuals. Research on this construct is in its infancy, so a new Oral Health Values Scale (OHVS) was developed and validated. The aim was to create a multidimensional...
Article
Full-text available
Background The experience of pain is a complex interaction of somatic, behavioral, affective, and cognitive components. Negative psychological states (e.g., anxiety, fear, and depression) are intertwined with pain and contribute to poorer outcomes for individuals suffering from chronic and acute pain by exacerbating the overall experience of pain a...
Article
Background Pain continues to be an important public health concern, especially given the opioid crisis in industrialized countries. It is important to understand the association between emotions such as fear and anxiety and the experience of pain as both a physiological and affective experience. Fear or anxiety about pain is in fact a well-known pr...
Article
Various formats to deliver exposure stimuli have been developed, including video-based stimuli. Virtual reality-based exposure often utilizes a first-person perspective, which is associated with greater presence (e.g., feeling integrated in a virtual world) than third-person perspective. Yet, few have compared exposure stimuli presented in first-pe...
Chapter
Delivery of mental health and psychological services to clientele in the diverse rural areas of the United States requires a unique knowledge base and skill set from clinicians. Depression, suicidality, trauma, and substance use disorders are particular concerns in rural areas. Generalist training and an awareness of special ethical issues is neede...
Article
Full-text available
Objectives: This cross-sectional study assessed differences in oral health and related behaviours and risk indicators by rurality in a north-central Appalachian population using the Andersen behavioural model as a conceptual framework. Methods: Participants were residents aged 18-59 years (n = 1311) from the Center for Oral Health Research in Appal...
Article
Full-text available
Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We present a Fagerström Test for Nicotine Dependence (FTND)-based genome-wide association study in 58,000 European or African ancestry smokers. We observe five genome-wide s...
Article
Oral microbiomes vary in cariogenic potential; these differences may be established early in life. A major concern is whether mothers transmit cariogenic bacteria to their children. Here we characterize early salivary microbiome development and the potential associations of that development with route of delivery, breastfeeding, and mother’s oral h...
Article
Background The link between anxiety/fear and gut dysfunction has been robustly documented in both physical and mental health literatures. The current study explored distress tolerance as a potential mechanism in the relation between anxiety sensitivity and gut-specific anxiety. Method A cross-sectional sample of 828 adults completed measures of di...
Article
Full-text available
Objective: The interactions between yeast and streptococci species that lead to dental decay and gingivitis are poorly understood. Our study describes these associations among a cohort of 101 post-partum women enrolled in the Center for Oral Health Research in Appalachia, 2012–2013. Methods: All eligible women without dental caries were included (n...
Poster
Full-text available
Fear of Pain Questionnaire-9 measures a unique component of pain-related fear relative to other common assessment measures.
Preprint
Full-text available
Cigarette smoking is the leading cause of preventable morbidity and mortality. Knowledge is evolving on genetics underlying initiation, regular smoking, nicotine dependence (ND), and cessation. We performed a genome-wide association study using the Fagerström Test for ND (FTND) in 58,000 smokers of European or African ancestry. Five genome-wide sig...
Thesis
Full-text available
Fear of pain during pregnancy is an understudied phenomenon with important implications for prenatal and postpartum functioning. The aim of the current study was to understand the role of pregnancy and culture on pain-related fear in Appalachia. Archival datasets, and a new sample of women recruited via Amazon's Mechanical Turk, were sources of dat...
Article
Full-text available
Health psychology is multidisciplinary, with researchers, practitioners, and policy makers finding themselves needing at least some level of competency in a variety of areas from psychology to physiology, public health, and others. Given this multidisciplinary ontology, prior attempts have been made to establish a framework for understanding the ro...
Article
Objectives: High levels of dental care-related fear/anxiety, as well as phobia, result in delay or avoidance of dental care, which is associated with poorer oral and overall health. Both pharmacotherapeutic and psychosocial methods are available to treat those with high levels of dental fear/anxiety or phobia, but they are infrequently used and no...
Article
Full-text available
Background: Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African A...
Article
Background: Dental fear/anxiety are associated with numerous negative outcomes. State dental fear is known to be transmitted from parents to their children in the dental setting, but it is not known how trait fear/anxiety might be shared between parents and offspring long-term, and especially for adolescents. Aim: This study aimed to: (a) compar...
Poster
Full-text available
Using data from the Center for Oral Health in Appalachia (COHRA) cohorts and a national comparison sample, the aim of this study was to understand the effects of pregnancy and Appalachian culture on fear of pain.
Article
Objective: To determine the effectiveness of a single session of prenatal motivational interviewing (MI) to enhance breastfeeding outcomes. Design: A randomized controlled trial with two groups (MI and psychoeducation) with repeated measures: preintervention, postintervention, and at 1 month postpartum. Setting: The intervention was conducted...
Article
Background: Mothers play a primary role in the health of their children. This role may be of particular importance for children in Appalachia who have increased caries relative to children in other regions of the United States. The authors examined the degree to which a child's caries experience was in concordance with the mother's perception of t...
Article
Purpose: The purpose of this study was to examine whether perceived social support among mothers with high levels of dental caries was associated with their children experiencing high levels of dental caries. Methods: In West Virginia and Pennsylvania from 2002 to 2009, mothers were interviewed and clinical exams were conducted on their one- to six...
Article
Objectives Dental utilization is an important determinant of oral health and well‐being. The aim of this study was to evaluate potential associations between a variety of biopsychosocial factors and dental utilization in north‐central Appalachia, USA, a region where oral health disparities are profound. Methods This study used household‐based data...
Article
Hormonal changes have been implicated in the phenomenon of pain modulation during pregnancy. The role of psychosocial constructs such as fear and anxiety related to pain during pregnancy, however, has largely been overlooked. The current study investigated the cross-sectional associations between the report of pain-related fear among pregnant and n...
Article
Full-text available
Background: Heightened fear and anxiety related to pain may result in emotional and behavioral avoidance responses causing disability, distress, and depression. Fear and anxiety associated with pain can potentially change the course of the pain experience. It is plausible that fear and anxiety related to pain affect the duration and frequency of pa...
Article
Full-text available
Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide associa...
Article
Full-text available
Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for caries in participants aged 2.5-18.0 years from 9 contributing centres. Phenotype definitions were created for the presence or abse...
Article
Full-text available
Background: Dental caries is a common chronic disease among children and adults alike, posing a substantial health burden. Caries is affected by multiple genetic and environmental factors, and prior studies have found that a substantial proportion of caries susceptibility is genetically inherited. Methods: To identify such genetic factors, we co...
Conference Paper
Objectives: This study determined how rurality covaried with access to dental care, oral health behaviors, and oral health status among adults living in northern Appalachia. Methods: Participants were Appalachian resident adults aged 18-59 (n=1089) from the Center for Oral Health Research in Appalachia (COHRA). Rural-Urban Continuum codes correspo...
Data
Fig. S1. Results of the saliva sample collection process among the 346 preschool‐age children participating in the ZOE study. Fig. S2. Quantitation of DNA purified from saliva samples among the 213 preschool‐age children that donated a sample for the ZOE GWAS study. Fig. S3. Quantile‐Quantile (QQ) plot of GWAS results of ECC among the 212 prescho...
Article
Full-text available
Objective: Training programs exist that prepare college students, faculty, and staff to identify and support students potentially at risk for suicide. Kognito is an online program that trains users through simulated interactions with virtual humans. This study evaluated Kognito's effectiveness in preparing users to intervene with at-risk students....
Article
Background: The Fagerström Test for Nicotine Dependence (FTND), a derivation of the Fagerström Tolerance Questionnaire, was first published in 1991. The FTND remains one of the most widely used measures of nicotine dependence for studying genetic and epidemiological risk factors and the likelihood of smoking cessation. However, it is unclear wheth...
Article
Full-text available
Background: Fear and anxiety are important considerations in both acute and chronic pain. Effectively and efficiently measuring fear and anxiety associated with pain in healthcare settings is critical for identifying vulnerable patients. The length and administration time of current measures of pain-related fear and anxiety inhibit their routine u...
Preprint
Full-text available
Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for caries in participants aged 2.5-18.0 years from 9 contributing centers. Phenotype definitions were created for the presence or abse...
Poster
Emerging adulthood is an important point in the lifespan because it is associated with a transition from relying on parents and other care-givers to becoming more independent. The transition of independence is particularly important in regard to developing or maintaining health behaviors, and in particular dental care-related behaviors. During emer...
Poster
Exposure therapy, including its self-directed forms, effectively treats many anxiety disorders, including specific phobia. Various forms to deliver exposure stimuli are available (e.g., in-vivo, images, videos) when treating specific phobia. Despite the efficacy of exposure therapy to treat anxiety disorders, it is often underutilized and/or has lo...
Article
Full-text available
Objective: A genetic component in early childhood caries (ECC) is theorized, but no genome-wide investigations of ECC have been conducted. This pilot study is part of a long-term research program aimed to: (1) determine the proportion of ECC variance attributable to the human genome and (2) identify ECC-associated genetic loci. Methods: The stud...
Article
Full-text available
Background: Fear of pain and coping strategies are emotional-behavioral responses to pain and are known to play an important role in the development and maintenance of pain. It is highly likely that fear of pain and coping strategies influence each other, potentially affecting the course of chronic pain. To our knowledge, the relationship between...
Article
Full-text available
Background Orthodontics has inherent demands, requiring regular appointments and active patient engagement, but relatively little is established in regard to rates of completion of treatment and possible factors affecting successful completion. These factors may be particularly important for cultural minority groups, such as those in rural Appalach...
Article
Full-text available
Background Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contribu...
Data
Supplemental Figure 2: Box plots with scatter plot overlays showing the distribution of dental caries scores in each genotype group for the SNP rs17013735 in black adults. Each point represents the combination of DMFT and genotype of a participant. The box spans the first to third quartiles, and the horizontal line represents the median.
Data
Supplemental Figure 1: Association of chromosome 4q21 with dental caries observed in the previously-reported GWAS of white adults from the COHRA1 study8. In the present study we followed-up this results by testing an additional 49 variants in this region for evidence of association in 13 age- and race-stratified samples (one of which is the sample...
Article
We conducted a Bayesian analysis of the association between family-level socioeconomic status and smoking and the prevalence of dental caries among siblings (children from infant to 14 y) among children living in rural and urban Northern Appalachia using data from the Center for Oral Health Research in Appalachia (COHRA). The observed proportion of...
Article
Full-text available
Background . Oral health-related quality of life (OHRQoL) is impacted by periodontal disease and orofacial pain. There is a limited research examining the impact of avoidance of care or physiological arousal related to the fear of pain response on periodontal-related OHRQoL.Methods. Data are from the Center for Oral Health Research in Appalachia fa...
Article
Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 2...
Poster
Specific dental phobia is common and often un-treated. Self-directed exposure therapy, however, is available as an effective treatment for specific phobias. Various exposure stimuli are available (e.g., videos) to conduct self-directed exposure. The objectives of the study were to examine how smartphones may be harnessed to conduct self-directed ex...