Daniel Mackin

Dartmouth–Hitchcock Medical Center | DHMC · Department of Psychiatry

Background: Major Depressive Disorder (MDD) is characterized by negative recall biases, which may impact how individuals with depressive symptoms report physical activity (PA), sedentary, and sleep behaviors. Additionally, there are discrepancies between subjective and objective behaviors in MDD. Thus, the current study investigated whether individ...

Large language models (LLMs) show promise for health applications when combined with behavioral sensing data. Traditional approaches convert sensor data into text prompts, but this process is prone to errors, computationally expensive, and requires domain expertise. These challenges are particularly acute when processing extended time series data....

Ecological momentary assessment (EMA) offers advantages over retrospective questionnaires by reducing recall bias and capturing rapid symptom dynamics, and it is increasingly used to measure depression symptoms. However, few depression symptom measures are validated for EMA use in the manner expected for traditional questionnaires. Therefore, the c...

Ecological momentary assessment (EMA) offers advantages over retrospective questionnaires by reducing recall bias and capturing rapid symptom dynamics, and it is increasingly used to measure depression symptoms. However, few depression symptom measures are validated for EMA use in the manner expected for traditional questionnaires. Therefore, the c...

Negative rumination and emotion regulation difficulties have been consistently linked with depression. Despite anhedonia—the lack of interest in pleasurable experiences—being a cardinal symptom of depression, emotion regulation of positive emotions, including dampening, are considered far less in the literature. Given that anhedonia may manifest th...

The presentation of major depressive disorder (MDD) can vary widely due to its heterogeneity, including inter- and intraindividual symptom variability, making MDD difficult to diagnose with standard measures in clinical settings. Prior work has demonstrated that passively collected actigraphy can be used to detect MDD at a disorder level; however,...

Background: Despite major strides in conceptualizing and modeling the multifaceted nature of suicidal thought and behavior (STB) over the past few decades, the overall predictability of STB has not improved. This may be partly due to the dynamic nature of suicidal ideation (SI), which often fluctuates over hours, yet is largely overlooked in studie...

Anhedonia and depressed mood are two cardinal symptoms of major depressive disorder (MDD). Prior work has demonstrated that cannabis consumers often endorse anhedonia and depressed mood, which may contribute to greater cannabis use (CU) over time. However, it is unclear (1) how the unique influence of anhedonia and depressed mood affect CU and (2)...

Background:Chatbots powered by generative AI (Gen-AI) hold promise for building highly personalized, effective mental health treatments at scale, while also addressing existing user engagement and retention issues common among digital therapeutics. We present the first RCT testing an expert-fine-tuned Gen-AI-powered chatbot, Therabot, for mental he...

Objectives To examine the reliability and validity of a semi‐structured interview assessing the features of the DSM‐5 mixed features specifier. Our goal was to develop an instrument that could be used for both diagnostic and severity measurement purposes. Methods Four hundred fifty‐nine psychiatric patients in a depressive episode were interviewed...

Background: A commonly used measure to assess mixed features in depressed patients is the Young Mania Rating Scale (YMRS), which only partially aligns with the DSM-5 criteria. Different algorithms on the YMRS have been used to approximate the DSM-5 mixed features criteria. In the present report from the Rhode Island Methods to Improve Diagnostic A...

It has recently been recommended that treatment resistant depression be reconceptualized and renamed as difficult to treat depression (DTD). A consensus statement by an expert panel identified multiple variables associated with DTD and emphasized the importance of conducting a comprehensive evaluation of patients to identify predictors of inadequat...

Objective: Lower neural response to reward predicts subsequent depression during adolescence. Pubertal development and biological sex each have important effects on reward system development and depression during this period. However, relationships among these variables across the transition from childhood to adolescence are not well characterized...

Recent scholarship has highlighted the importance of understanding relations between hormones, rather than studying hormones in isolation. Considering neuroendocrine coupling, or the coordination of hypothalamic–pituitary–adrenal axis and hypothalamic–pituitary–gonadal axis hormones over time, is one way to investigate how systems governing stress...

Determinations of the efficacy of treatments for depression most commonly are based on changes in scores on symptom severity scales. This narrow symptom-focused approach towards evaluating outcome is at variance with patients’ broader conceptualization of the factors deemed important in evaluating the outcome of depression treatment. In the present...

Objective Irritability is a common and clinically important problem in children and adolescents and a risk factor for later psychopathology and impairment. Irritability can manifest in both tonic (e.g., irritable, touchy mood) and phasic (e.g., temper outburst) forms, and recent studies of adolescents suggest that they predict different outcomes. H...

Youth personality is hypothesized to mediate the intergenerational transmission of internalizing disorders. However, this has rarely been examined. We tested whether the intergenerational transmission of depressive and anxiety disorders is mediated by youth neuroticism and extraversion, and how parent personality influenced these relationships. Par...

The current study examined changes in the agreement, stability, and concurrent and predictive validity of parent- and self-reports on a frequently used measure of youth anxiety symptoms, the Screen for Child Anxiety Related Emotional Disorders (SCARED), from age 9 to 15. A community sample of 531 families (youth, mothers, and fathers) completed the...

Few investigations have directly compared personality and internalizing symptoms stability within the same sample and have not included personality facets. This study examined rank-order stability and mean-level change of Big Five domains, facets of neuroticism and extraversion, and internalizing symptoms in a sample of 550 adolescent females. Pers...

The novel coronavirus COVID-19 pandemic is associated with elevated rates of anxiety and relatively lower compliance with public health guidelines in younger adults. To develop strategies for reducing anxiety and increasing adherence with health guidelines, it is important to understand the factors that contribute to anxiety and health compliance i...

Background Irritable mood is a transdiagnostic clinical feature that is present in multiple psychiatric disorders. Although irritability is frequently examined as a unitary construct, two dimensions of irritability, tonic (i.e., irritable mood) and phasic (i.e., temper outbursts), have been hypothesized. However, few studies have examined whether t...

Depressive disorders are common and impairing, and are currently the leading contributor to global disease burden. Over the past decade, dysfunction in neural processing of rewards has emerged as one of the most promising biological markers for the development of depressive disorders due to the role of reward processing in reward learning and in em...

Background: First onsets of depression are especially common in adolescent females and often develop into chronic/recurrent illness. Surprisingly few studies have comprehensively evaluated multiple domains of etiologically-informative risk factors for first onset in adolescents from the community. We investigated whether clinical, cognitive, person...

Objectives Disaster workers are at elevated risk for mental health problems as a result of trauma exposures during response efforts. One possible way to prevent mental health problems is to build-up coping resources that promote resilience to the effects of disaster work. The primary aim of this study was to evaluate the efficacy of a resilience bu...

Objective: Studies of the association between early childhood low temperamental fearfulness or behavioral inhibition (BI) and later externalizing symptoms are few and results are inconsistent, despite research from outside the temperament field that has linked fearlessness with externalizing problems. There is also a large literature showing that p...

Background: First onsets of depression are especially common in adolescent females and often develop into chronic/recurrent illness. Surprisingly few studies have comprehensively evaluated multiple domains of etiologically-informative risk factors for first onset in adolescents from the community. We investigated whether clinical, cognitive, person...

The Adult Separation Anxiety Symptom Questionnaire (ASA-27) is the most widely used self-report assessment of adult separation anxiety (ASA). Despite its widespread use, relatively little is known about its psychometric properties, specifically whether it is unidimensional, its degree of precision (or information) across latent levels of ASA, the f...

Blunted reward sensitivity and life stress are each depressogenic. Additionally, individuals with clinical and psychosocial vulnerabilities are prone to experience or evoke dependent life stressors (e.g., interpersonal conflict) that, in turn, increase depression risk. However, no previous study has investigated the role of neural vulnerability fac...

This article describes the development of a manualized, eight-session multiple health behavior change program which addresses sleep, exercise, nutrition, substance use, and working with one’s healthcare team. Our goal was to design a structured, evidence-based program that could be facilitated by a single health professional and could act as an act...

Background The effect of life stress on suicidal symptoms during adolescence is well documented. Stressful life events can trigger suicidality, but most adolescents are resilient and it is unclear which factors protect against the deleterious impact of stress. Social support is thought to be one such factor. Therefore, we investigated the buffering...