Daniel König

Daniel König
University Medical Center Freiburg · Medical Center (MVZ)

Prof. Dr.

About

237
Publications
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Publications

Publications (237)
Article
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People with multiple sclerosis (MS) suffer from sensorimotor deficits with the distal extremities being more severely affected than proximal ones. Whole-body vibration (WBV) training is known to enhance voluntary activation and coordination in healthy people. However, evidence about beneficial effects of WBV in MS patients is scarce. The current st...
Article
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The purpose of this study was to investigate the effect of specific collagen peptides (SCP) combined with resistance training (RT) on changes in tendinous and muscular properties. In a randomized, placebo‐controlled study, 40 healthy male volunteers (age: 26.3 ± 4.0 years) completed a 14‐week high‐load resistance training program. One group receive...
Article
The present study investigated the effect of a 4-week high fat low carbohydrate (HFLC-G) versus high carbohydrate low glycaemic (LGI-G) or high glycaemic (HGI-G) diet on power output at lactate thresholds, peak oxygen uptake and peak performance during an incremental cycle test in 28 male endurance athletes. All participants showed improved levels...
Article
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Introduction The widespread prevalence of type 2 diabetes (T2D) not only influences patients’ daily lives but also has an economic impact on society. Increasing physical activity and a healthy diet can delay the progression of T2D. Although there are evidence-based recommendations on diet and physical activity, patients with T2D have difficulties i...
Article
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The coronavirus disease 2019 (COVID-19) pandemic has induced unhealthy lifestyles, particularly an increase in overweight and obesity, which have been shown to be associated with an increased risk of unfavorable COVID-19 outcomes. Web-based health programs could be a helpful measure, especially in times of severe restrictions. Therefore, the presen...
Article
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Previous evidence suggests that resistance training in combination with specific collagen peptides (CP) improves adaptive responses of the muscular apparatus. Although beneficial effects have been repeatedly demonstrated, the underlying mechanisms are not well understood. Therefore, the primary objective of the present randomized trial was to eluci...
Article
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Consuming low glycemic carbohydrates leads to an increased muscle fat utilization and preservation of intramuscular glycogen, which is associated with improved flexibility to metabolize either carbohydrates or fats during endurance exercise. The purpose of this trial was to investigate the effect of a 4-week high fat low carbohydrate (HFLC-G: ≥65%...
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Web-based lifestyle interventions have attracted considerable research interest. Available evidence on such interventions suggests health-promoting effects, but further research is needed. Therefore, this study aims to investigate short-, medium-, and long-term health effects of a web-based health program (“TK-HealthCoach”, TK-HC) offered by a nati...
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Bioactive peptides are physiologically active peptides mostly derived from proteins following gastrointestinal digestion, fermentation or hydrolysis by proteolytic enzymes. It has been shown that bioactive peptides can be resorbed in their intact form and have repeatedly been shown to have a positive effect on health-related parameters such as hype...
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Introduction: Low-load resistance training with blood flow restriction (LL-BFR) has emerged as a viable alternative to conventional high-load (HL) resistance training regimens. Despite increasing evidence confirming comparable muscle adaptations between LL-BFR and HL resistance exercise, only very little is known about tendinous mechanical and mor...
Article
Numerous weight-loss interventions promoting healthy and weight-reducing eating behavior have been developed over the past years. To evaluate the effectiveness of such interventions for eating behavior change, short, validated and sensitive instruments are needed. In this study series, we developed and validated a new outcome measure to assess heal...
Article
Background: The effects of specific collagen peptides on bone mineral density (BMD) in subjects with osteoporosis or osteopenia have already been investigated in 131 postmenopausal women in a randomized controlled trial. The purpose of this follow-up observation was to determine the longer-term effects of the same specific bioactive collagen pepti...
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It has been shown that specific collagen peptides combined with resistance training (RT) improves body composition and muscle strength in elderly sarcopenic men. The main purpose of this RCT study was to investigate the efficacy of the identical specific collagen peptides combined with RT on body composition and muscle strength in middle-aged, untr...
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Exhaustive exercise can induce excessive generation of reactive oxygen species (ROS), which may enhance oxidative stress levels. Although physiological levels are crucial for optimal cell signaling and exercise adaptations, higher concentrations have been demonstrated to damage macromolecules and thus facilitate detrimental effects. Besides single...
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During the past two decades, metabolic dysfunction and concomitant reduction-oxidation reaction (redox) imbalances (i.e., oxidative stress) have been suggested to be associated with numerous age-related chronic diseases. One profound result of metabolic imbalances is endothelial dysfunction, a pathophysiological condition that increases risk of dow...
Article
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Background Numerous studies have demonstrated that the addition of blood flow restriction (BFR) to low-load (LL) resistance exercise leads to elevated levels of muscle hypertrophy and strength gains. In terms of main underlying mechanisms, metabolic accumulation and increased neuromuscular adaptations seem to play a primary role. However, this evid...
Article
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First evidence indicates that the supplementation of specific collagen peptides is associated with a significant reduction in activity-related joint pain in young adults. The purpose of the current investigation was to confirm the efficacy of the same collagen peptides in a comparable study population. In total, 180 active men and women aged betwee...
Chapter
This chapter discusses the uses of biologically active peptides in sports nutrition and their potential mechanisms. In the beginning, it presents physiological parameters that determine athletic performance and how they may be positively influenced by nutrition and potentially the intake of bioactive peptides. It then discusses the potential effect...
Article
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High-intensity interval training (HIIT) has been demonstrated to increase the generation of reactive oxygen species (ROS). Therefore, strategies to mitigate excessive ROS productions could be useful to reduce the negative consequences of oxidative damage for health, as well as for physical, performances. The aim of this study was to investigate the...
Article
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The purpose was to examine the effects of concurrent training (CT) combined with specific collagen peptides (SCP) intake on cardiometabolic parameters and performance indices in women. In a double-blind, placebo-controlled, randomized trial recreationally active women (n = 59) completed a 12-week CT training (3 day/week) and ingested 15 g of SCP (t...
Article
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The present study investigated whether changes in diet associated with an increased intake of micronutrients with antioxidant potential could affect reactive oxygen species (ROS) generation determined by EPR-spectroscopy. Out of initial 16 participants, 6 participants (28.3 ± 6.8 years) demonstrated a nutritional behavior below current national rec...
Article
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Centner, C, Ritzmann, R, Gollhofer, A, and König, D. Effects of whole-body vibration training and blood flow restriction on muscle adaptations in women: a randomized controlled trial. J Strength Cond Res XX(X): 000-000, 2019-The purpose of the present randomized controlled trial was to investigate potential synergistic effects of whole-body vibrati...
Article
Low-load blood flow restriction (LL-BFR) training has gained increasing interest in the scientific community by demonstrating that increases in muscle mass and strength are comparable to conventional high-load (HL) resistance training. Although adaptations on the muscular level are well documented, there is little evidence on how LL-BFR training af...
Article
Full-text available
Blood flow restriction (BFR) training has been shown to induce favorable changes in muscle mass and strength with a considerably low training load (20 - 30% 1RM). However, it has never been evaluated if an additional post-exercise protein supplementation enhances the effects of this training regimen. Thirty healthy older men (60.1 ± 7.6 years) were...
Article
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Purpose Whole-body vibration (WBV) training is frequently applied in sports and rehabilitation with the aim of inducing beneficial functional and structural adaptations. In the past decades, blood flow restriction (BFR) training has received increasing attention by enhancing the effectiveness of several low-load exercise regimens. The objective of...
Article
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The aim was to investigate the effects of resistance exercise combined with supplementation of specific collagen peptides (SCP) on body composition and muscle strength in premenopausal women. In a double-blind, placebo-controlled, randomized trial 77 premenopausal women completed a 12-week resistance training (3 day/week) and ingested 15 g of SCP o...
Article
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PURPOSE: Setting the optimal cuff pressure is a crucial part when prescribing blood flow restriction (BFR) training. It is currently recommended to use percentages of each individual's arterial occlusion pressure (AOP), which is most accurately determined by the Doppler ultrasound (DU). However, the practicality of this gold standard method in dail...
Article
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BACKGROUND Non-alcoholic steatohepatitis (NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content. AIM To investigate the effects of a 24-wk guided lifestyle intervention pro...
Article
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Background The combination of low-load resistance training with blood flow restriction (BFR) has recently been shown to promote muscular adaptations in various populations. To date, however, evidence is sparse on how this training regimen influences muscle mass and strength in older adults. Purpose The purpose of this systematic review and meta-an...
Article
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Introduction/Background Blood-flow-restriction (BFR) training is recently progressively applied in functional training settings. The optimal cuff pressure during BFR exercise, current literature recommends using percentages of each individual's arterial occlusion pressure (AOP). Most frequently, blood flow is determined by Doppler ultrasound (DU) t...
Article
Full-text available
Following an initial ankle sprain it is not unlikely that chronic ankle instability (CAI) will develop. CAI is associated with impaired perceived functional and mechanical properties of the ligaments. Nutritional supplementation with collagen peptides has been shown to improve the functional and mechanical properties of the connective tissue. The p...
Article
It is generally believed that several nutrients such as β-carotene, vitamin C, E and Zinc exert a protective effect against oxidative damage. However, there is little evidence if a healthy mixed diet affects antioxidant defense mechanisms through an increased intake of micronutrients. In an open-label study, we investigated the reactive oxygen spec...
Article
The main purpose of this study was to investigate the acute local and systemic effects of low-load resistance exercise (30% 1RM) with partial vascular occlusion on exercise-induced free radical production and to compare these effects with other established training methods. Fifteen young and healthy males (25 ± 3 years) performed the following four...
Article
Effect of specific collagen peptides with various dosages on body composition in untrained men - Volume 76 Issue OCE4 - D. Zdzieblik, S. Oesser, P. Dressler, A. Gollhofer, D. König
Conference Paper
Preservation of skeletal muscle mass and strength is of vital importance in older age for maintaining musculoskeletal and functional capacity and thus independence. Recent research has indicated that high-intensity resistance training (RT) is an effective strategy to counteract the age-related decline of muscle mass and function. According to the A...
Article
Recent interest has focused on maintenance of healthy levels of redox signalling and the related oxidants; these parameters are crucial for providing us with concrete nutritional targets that may help us to better understand and maintain "optimal health". Following the above hypothesis, we performed a pilot double-blind, crossover, placebo-controll...
Article
Recent interest has focused on maintenance of healthy levels of redox signaling and the related oxidants; these parameters are crucial for providing us with concrete nutritional targets that may help us to better understand and maintain “optimal health”. Following the above hypothesis we performed a pilot double blind, crossover, placebo controlled...
Article
The aim of the study was to evaluate the use of specific collagen peptides in reducing pain in athletes with functional knee problems during sport. 139 athletic subjects with functional knee pain ingested 5 g of bioactive collagen peptides (BCP) or a placebo per day for 12 weeks. The primary outcome of the study was a change in pain intensity durin...
Article
Full-text available
(1) Objective: To compare the effects of isomaltulose (Palatinose™, PSE) vs. maltodextrin (MDX) ingestion on substrate utilization during endurance exercise and subsequent time trial performance; (2) Methods: 20 male athletes performed two experimental trials with ingestion of either 75 g PSE or MDX 45 min before the start of exercise. The exercise...
Article
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The aim of the present study was to investigate the effect of a meal-replacement regimen vs. comprehensive lifestyle changes in overweight or obese subjects on intra-abdominal fat stores (Magnetic Resonance Imaging (MRI) measurements) and cardiometabolic risk factors. Forty-two obese men (n = 18) and women (n = 24) (age 49 ± 8 years; weight 96.3 ±...
Article
Full-text available
Protein supplementation in combination with resistance training may increase muscle mass and muscle strength in elderly subjects. The objective of this study was to assess the influence of post-exercise protein supplementation with collagen peptides v. placebo on muscle mass and muscle function following resistance training in elderly subjects with...
Article
The number of adults with type 2 diabetes (T2D) continues to rise; obesity and low levels of physical activity are contributing factors. As 25 % of the US population over 65 has diabetes, it is important to identify and test interventions to improve health behaviors and disease outcomes in this age group. This PubMed review was conducted to identif...
Article
To demonstrate the feasibility of an algorithm for MRI whole-body quantification of internal and subcutaneous fat and quantitative comparison of total adipose tissue to air displacement plethysmography (ADP). For comparison with ADP, whole-body MR data of 11 volunteers were obtained using a continuously moving table Dixon sequence. Resulting fat im...
Article
Objektive To investigate the effect of a 6 week intervention with either lifestyle intervention (increased physical activity/low calorie diet) or a meal-replacement regimen on glycemic control in prediabetic subjects with impaired fasting glucose. Research Methods and Procedures 42 overweight or obese men and women (age 54 ± 8 y; weight 95.1 ± 11....
Article
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In addition to an increased risk for chronic illnesses, obese individuals suffer from social stigmatization and discrimination, and severely obese people may experience greater risk of impaired psychosocial and physical functioning. Lower health-related quality of life (HRQOL) has been reported among obese persons seeking intensive treatment for th...
Article
Rationale Dietary strategies to sustain descriptions of cellular immunity are often inadequately evaluated. We have tested the influence of a yeast-cells-based supplement on the blood concentration of TNF-alpha and IL-6 measured after invivo stimulation by LPS. Methods 11 healthy subjects (5 males, 6 females, and 20 to 50 yrs) were examined before...
Article
To determine the changes in endurance capacity as well as in metabolic, hormonal and inflammatory markers induced by endurance training combined with a soy,protein based supplement. Randomized controlled study consisting of moderate endurance training without (GO) or with (G1) a soy protein based supplement. Two groups of 15 subjects (10 males and...
Article
Ernährungsfragen für Sporttreibende sollten auch von Hausärzten und Ernährungsfachkräften beantwortet werden können. Für den Großteil der Freizeitsportler ist von einer gesicherten Nährstoffzufuhr auszugehen, bei einer ausgeglichenen Energiebilanz ist die Qualität der zugeführten Makronährstoffe entscheidend. Lesen Sie, warum die Empfehlungen zu ei...
Article
The beneficial role of physical exercise on glycemic control in patients with type 2 diabetes mellitus has been confirmed by several controlled trials including both aerobic and resistance exercise protocols. Exercise has been shown to increase insulin sensitivity, lower blood sugar levels, reduce body fat and improve physical fitness. Grade A scie...
Article
Full-text available
Dietary interventions with a low glycemic index have shown to be successful for the prevention and therapy of the metabolic syndrome. In the present study, we investigated the postprandial metabolic response at rest and during physical activity the low glycemic carbohydrate isomaltulose (Palatinose™) intake compared with a conventional carbohydrate...
Article
Chronic endurance training increases an athlete's aerobic capacity and results in improved cardiocirculatory work economy, maximum performance, and enhanced oxygen uptake. The extent of the adaptation depends on individual factors such as frequency, intensity, and duration of training, muscle fibre type, and genetics. The functional range of heart...
Article
Körperliche Aktivität steigert die Bildung freier Radikale und erhöht damit potenziell den oxidativen Stress. Sportlern wird daher eine vermehrte Zufuhr von antioxidativen Vitaminen empfohlen. Ziel soll angeblich eine verbesserte körperliche und muskuläre Belastbarkeit sein, die über den Weg der beschleunigten Regeneration und erhöhten Trainierbark...
Article
Fragen zur Ernährung in Zusammenhang mit Sporttreiben sollten auch von Hausärzten und Ernährungsfachkräften beantwortet werden können. Wichtige Kenntnisse zu den Grundlagen der sog. Sporternährung werden in dieser Übersicht angesprochen. Für den Großteil der Sporttreibenden ist von einer gesicherten Zufuhr der Nährstoffe auszugehen. Bei ausgegliche...
Article
Full-text available
To determine changes in body composition, physical performance, metabolic and hormonal parameters induced by lifestyle counselling, resistance training and resistance training with soy protein based supplemention in middle aged males. Randomised controlled study consisting of resistance training without (RT-G) or with (RTS-G) a soy protein based su...