Daniel M Gore

Daniel M Gore
Moorfields Eye Hospital NHS Foundation Trust

FRCOphth

About

58
Publications
12,586
Reads
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947
Citations
Additional affiliations
June 2015 - April 2016
King's College Hospital NHS Foundation Trust
Position
  • Consultant
August 2012 - July 2015
Moorfields Eye Hospital NHS Foundation Trust
Position
  • Researcher
August 2010 - July 2011

Publications

Publications (58)
Article
Purpose To generate a prognostic model to predict keratoconus progression to corneal cross-linking (CXL). Design Retrospective cohort study. Methods We recruited 5025 patients (9341 eyes) with early keratoconus between January 2011 and November 2020. Genetic data from 926 patients was available. We investigated both keratometry or CXL as end-poin...
Article
Background: Keratoconus is a disorder characterized by progressive thinning and distortion of the cornea. If detected at an early stage, corneal collagen cross-linking can prevent disease progression and further visual loss. Although advanced forms are easily detected, reliable identification of subclinical disease can be problematic. Several diffe...
Preprint
BACKGROUND Keratoconus is a disorder characterized by progressive thinning and distortion of the cornea. If detected at an early stage corneal collagen cross linking can prevent disease progression and further visual loss. Whilst advanced forms are easily detected, reliably identifying subclinical disease can be problematic. A number of different m...
Article
Background: Keratoconus is a disorder characterized by progressive thinning and distortion of the cornea. If detected at an early stage, corneal collagen cross-linking can prevent disease progression and further visual loss. Although advanced forms are easily detected, reliable identification of subclinical disease can be problematic. Several diff...
Article
Corneal transplantation is the most commonly performed human tissue transplantation procedure worldwide. Because of the large number of transplants, corneal graft failure has become one of the most common indications for corneal transplantation. The relatively recently developed lamellar transplant techniques have brought about specific potential c...
Article
Purpose To report on 2-year results of accelerated corneal collagen cross-linking (CXL) in progressive ectasia using the Avedro KXL® system. Design Prospective interventional case series Methods 870 patients (1,192 eyes) attending Moorfields Eye Hospital after CXL were included. All patients undergoing CXL had progressive keratoconus. Corneas wit...
Article
Purpose To compare the clinical outcomes in femtosecond laser assisted deep anterior lamellar keratoplasty (F-DALK) to manual non-laser deep anterior lamellar keratoplasty (M-DALK) for keratoconus in a multi-surgeon public healthcare setting. Design Single-centre, comparative, retrospective interventional case series. Methods . Population Consec...
Article
Corneal cross-linking (CXL) is typically performed under topical anesthesia, which may be unsuitable in children and individuals with severe anxiety, poor cooperation, or neurodevelopmental issues. We describe a technique of CXL under general anesthesia that uses sevoflurane and propofol with laryngeal airway or nasal oxygen cannulas, and forceps o...
Article
To assess a Royston−Parmar flexible parametric survival model to generate a personalised risk profile for keratoconus progression. We re-analysed a historic database of 2723 individuals with keratoconus. A Royston−Parmar survival model was fitted to predict the likelihood of the worse eye progressing to corneal transplantation. We used a backwards...
Article
Importance Keratoconus is an important cause of visual loss in young adults, but little is known about its genetic causes. Understanding the genetic determinants of corneal biomechanical factors may in turn teach us about keratoconus etiology. Objectives To identify genetic associations with corneal biomechanical properties and to examine whether...
Article
Purpose: To present a case series of patients with corneal and scleral changes associated with the use of skin-lightening creams. This is the first report of corneal changes with these widely available creams. Methods: Three patients of West African origin presented with strikingly similar skin, corneal, and scleral changes and were found to hav...
Article
Purpose: We set out to describe the natural history of keratoconus. We included untreated patients, and our key outcome measures were vision, refraction, and corneal curvature. Clinical relevance: Keratoconus affects 86 in 100 000 people, causing visual loss due to increasing irregular corneal astigmatism, and the quality of life declines in pat...
Article
Cytomegalovirus (CMV) endotheliitis is a significant cause for acute corneal allograft rejection in East Asian populations, where there is a high CMV seroprevalence. To determine how frequently CMV is associated with corneal graft failure in the UK, we looked for the presence of CMV DNA in grafts that had failed and had been removed at repeat kerat...
Article
Purpose: To present 24-month results from the transepithelial photorefractive keratectomy (PRK)-corneal crosslinking (CXL) trial using simultaneous accelerated CXL and a new tissue-saving ocular wavefront-guided transepithelial PRK algorithm aiming to reverse visual loss in early-stage keratoconus without compromise to stabilization of disease pro...
Article
Full-text available
Background: Cataract is the leading cause of blindness in the world, and cataract surgery is one of the most commonly performed operations in the Western world. Preferred surgical techniques have changed dramatically over the past half century with associated improvements in outcomes and safety. Femtosecond laser platforms that can accurately and...
Article
Full-text available
Purpose: To measure corneal riboflavin penetration using different transepithelial iontophoresis protocols. Methods: Freshly enucleated rabbit eyes were divided into nine treatment groups of 4 eyes. One group, in which 0.1% wt/vol riboflavin was applied for 30 minutes without iontophoresis after corneal epithelial debridement, acted as a control...
Conference Paper
Keratoconus is a condition in which the corneal shape becomes steeper and more irregular between adolescence and the mid-thirties. It is a common cause of visual impairment with disease progression typically managed with rigid contact lens. Traditionally, no intervention has been available to arrest or slow disease progression. As a result, keratoc...
Article
Full-text available
To measure depth-specific riboflavin concentrations in corneal stroma using two-photon fluorescence microscopy and compare commercially available transepithelial corneal collagen cross-linking (CXL) protocols. Transepithelial CXL riboflavin preparations-MedioCross TE, Ribocross TE, Paracel plus VibeX Xtra, and iontophoresis with Ricrolin+-were appl...
Article
Purpose: To describe the epidemiology, clinical features, and treatment outcomes of Acanthamoeba sclerokeratitis (ASK). Design: Retrospective case series. Participants: All cases of both Acanthamoeba keratitis (AK) and ASK identified between January 1, 2000, and January 8, 2011, at Moorfields Eye Hospital. Methods: Acanthamoeba keratitis was...
Article
Full-text available
Purpose: To correct for attenuation in two-photon fluorescence (TPF) measurements of riboflavin absorption in porcine corneas. Methods: Two-photon fluorescence imaging of riboflavin was performed using excitation at a wavelength of 890 nm, with fluorescence signal detected between 525 and 650 nm. TPF signal attenuation was demonstrated by imagin...
Chapter
Full-text available
This is the protocol for a review and there is no abstract. The objectives are as follows: To compare the safety and effectiveness of femtosecond laser assisted lens surgery with conventional manual phacoemulsification lens surgery.
Article
Full-text available
To review the refractive outcome of cataract surgery in eyes with keratoconus. We retrospectively reviewed the medical records of 64 consecutive patients (92 eyes) who underwent cataract surgery with implantation of a spherical intraocular lens (IOL). We recorded the method of refractive correction and the effect of the keratometry (K) on the biome...
Article
Full-text available
The purpose of this study is to describe the functional and anatomical outcomes of cytomegaloviral retinitis (CMVR) patients undergoing vitrectomy for retinal detachment (RD) in South Africa. In this retrospective case series, CMVR diagnoses were based on clinical examination alone. All vitrectomies were performed by a single surgeon. Main outcome...
Article
Purpose: To describe the long-term outcomes of peripheral hypertrophic subepithelial corneal degeneration. Design: Retrospective case series. Participants: Twenty-two patients under the care of the External Disease Service, Moorfields Eye Hospital. Methods: All patients matching clinical diagnostic criteria were included. Symptomatic patient...
Conference Paper
Purpose To report single institution 6-month results of rapid corneal collagen cross-linking (CXL) in progressive ectasia using the Avedro KXL® system Methods Serial tomography (Pentacam, Oculus) and subjective refractions were used to confirm pre-operative ectasia progression, defined by: >1.5 dioptre (D) increase in Kmax and K2; 0.5D increase in...
Article
Full-text available
Pre-2000, the clinical management of keratoconus centred on rigid contact lens fitting when spectacle corrected acuity was no longer adequate, and transplantation where contact lens wear failed. Over the last decade, outcome data have accumulated for new interventions including corneal collagen crosslinking, intracorneal ring implantation, topograp...
Article
Full-text available
To describe the functional and anatomic outcomes of progressive outer retinal necrosis treated with intravitreal ganciclovir sodium injections. A retrospective, interventional case series of all patients fitting established clinical diagnostic criteria for progressive outer retinal necrosis was conducted at a single institution in South Africa. Eye...
Data
Full-text available
An interdisciplinary approach to children with peri-orbital cellu-litis is required for their effective management, yet in our hospital it was not always clear who should be doing what, and when. As several specialties are involved, there is the potential for confusion as to the most appropriate management [1]. An initial accurate examination, deli...
Article
Maria TsimpidaDepartment of OphthalmologyRoyal London HospitalLondon E1 1BBUKE-mail:maria.tsimpida@bartsandthelondon.nhs.ukMaterial from this article was presented as aposter at the 34th Annual Meeting of theAmerican Association for PediatricOphthalmology and Strabismus, Washington,USA.Present addresses: Daniel Gore: Queen’sHospital, Rom Valley Way...
Article
Purpose: To provide data on the outcome of pseudophakic retinal detachment (PRD). Methods: In a retrospective case–control study, we identified a consecutive series of 63 298 cataract extractions (45 520 patients) performed in a single institution between 1994 and 2003. We included 249 cases with PRD and 845 controls that had cataract surgery on th...
Conference Paper
Purpose: To describe the functional and anatomical outcomes of cytomegaloviral retinitis (CMVR) patients undergoing vitrectomy for retinal detachment (RD) in South Africa. Methods: Retrospective case series. CMVR diagnoses were based on clinical examination alone. All vitrectomies were performed by a single surgeon. Main outcome measures were visua...
Article
The European Society of Cataract & Refractive Surgeons Endophthalmitis Study published preliminary results in 2006 showing a near 5-fold decrease in the rates of postoperative endophthalmitis with the use of intracameral cefuroxime. The study findings have generated considerable controversy, and 1 year later its recommendations had been heeded by o...
Article
Full-text available
Eye is the official journal of the Royal College of Ophthalmologists. It aims to provide the practising ophthalmologist with information on the latest clinical and laboratory-based research.
Article
Full-text available
Eye is the official journal of the Royal College of Ophthalmologists. It aims to provide the practising ophthalmologist with information on the latest clinical and laboratory-based research.
Article
Silicone Oil Maculopathy Figure. Fundus photograph with magnified insert showing numerous glistening subretinal silicone oil droplets of varying sizes at the macula. Six months previously, the patient had undergone surgery for diabetic tractional retinal detachment including vitrectomy and retinal tamponade with silicone oil.
Article
Purpose: To report a case of presumed infective meningoencephalitis complicated by bilateral optic neuritis. Methods: Interventional case report. Results: A 7-year-old Pakistani girl presented with fever and multiple right-sided focal seizures. Despite empirical treatment with antibiotic, anti-viral and anti-tuberculous therapy for presumed in...
Article
To report a case of presumed infective meningoencephalitis complicated by bilateral optic neuritis. Interventional case report. A 7-year-old Pakistani girl presented with fever and multiple right-sided focal seizures. Despite empirical treatment with antibiotic, anti-viral and anti-tuberculous therapy for presumed infective meningoencephalitis, she...
Article
Full-text available
This report describes the case of a mucinous cystadenocarcinoma of probable urachal origin that presented with mass effect, precipitating deep venous thrombosis and pulmonary embolism. The patient presented with acute symptoms of leg swelling, pain and dyspnoea, and a vague awareness of lower abdominal distension. Computer tomography showed a cysti...
Article
Full-text available
We identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the hereditary stomatocytosis and spherocytosis classes. Affected individuals in these families had an increase in membrane permeability to Na and K that is particularly marked at 0 degrees C. We found that disease in these pedigrees was associated with a series of...
Article
We report four pedigrees of the group of Na(+)-K(+)-leaky red cell disorders of the 'hereditary stomatocytosis' class. Each showed pseudohyperkalaemia because of temperature-dependent loss of K(+) from red cells on storage of whole blood at room temperature. All pedigrees showed an abnormality in the temperature dependence of the 'passive leak' of...
Article
'Cryohydrocytosis' is an unusual human haemolytic anaemia of the 'hereditary stomatocytosis' group, in which the red cell membrane is abnormally permeable to Na and K+ at both body and (even more prominently) refrigerator temperatures. If whole cryohydrocytosis blood is anticoagulated in heparin or EDTA and stored on ice overnight, about 50% of the...
Article
The tendency for thrombosis to occur if haemolysis persists after splenectomy is especially marked in "hereditary stomatocytosis", in which the red cell membrane "leaks" Na and K. A 21-year-old woman, who was splenectomized in childhood for a congenital haemolytic state, presented with major pulmonary embolism that recurred despite anticoagulation....
Article
We have investigated a Welsh pedigree showing the 'familial pseudohyperkalaemia' phenotype of dominantly inherited, red-cell-based, temperature-dependent pseudohyperkalaemia associated with normal haematology. The 'passive leak' to K across the membrane of these abnormal red cells showed a 'U-shaped' temperature dependence, with a minimum at about...

Questions

Question (1)
Question
Can anyone suggest a way to rapidly fixate ex vivo corneas soaked in a water soluble dye (riboflavin), such that the dye can not continue to migrate within the tissue? A cryostat would be quick enough, but once sections are cut and the tissue thaws the dye would presumably be able to move again? Thawing tissue to chemically fixate would carry the same problem. Any suggestions gratefully received.

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