Daniel Gallardo Gómez

• PhD
• Senior Consultant at ICON Plc

Background: Together with environmental factors, intrinsic capacity (the composite of all the physical and mental capacities of an individual) has been proposed as a marker of healthy ageing. However, whether intrinsic capacity predicts major clinical outcomes is unclear. We aimed to explore the association of intrinsic capacity with functional dec...

This tutorial focuses on standardised mean differences (SMD) as effect measures in meta-analyses. We will explain what they are, when they should be used, how to correctly compute and interpret them, and some of the most common error made within evidence synthesis

This tutorial focuses on standardized mean differences (SMD) as effect measures in meta‐analyses. We will explain what they are when they should be used, how to correctly compute and interpret them, and some of the most common errors made within evidence synthesis. Additionally, we have created a micro‐learning module to accompany this article whic...

Objective To identify the optimal dose and modality of exercise for treating major depressive disorder, compared with psychotherapy, antidepressants, and control conditions. Design Systematic review and network meta-analysis. Methods Screening, data extraction, coding, and risk of bias assessment were performed independently and in duplicate. Bay...

Background: Physical behaviours (ie, physical activity and sedentary behaviour) might have a role in the development of sarcopenia, although the evidence is unclear. We aimed to explore the association of total and intensity-specific levels of physical activity and sedentary behaviour with sarcopenia and its components (ie, muscle mass, muscle stre...

BACKGROUND The optimal dose or type of physical activity to control glycosylated hemoglobin (HbA1c) in people with diabetes remains unknown. Current guidelines do not include consideration of baseline HbA1c for activity prescription. PURPOSE To examine the dose-response relationship between physical activity and HbA1c (%) in individuals with type...

Objective To identify the optimal dose and type of physical activity to improve functional capacity and reduce adverse events in acutely hospitalised older adults. Design Systematic review and Bayesian model-based network meta-analysis. Data sources Four databases were searched from inception to 20 June 2022. Eligibility criteria for selecting s...

Background: Physical exercise is effective at attenuating ageing-related physical decline in general, but evidence of its benefits for older adults in residential care, who often have functional dependency, multimorbidity, and polypharmacy, is inconclusive. We aimed to establish the effects of exercise interventions on the physical function of thi...

Background Psychopathology and side effects of antipsychotic drugs contribute to worsening physical health and long-term disability, and increasing the risk of mortality in these patients. The efficacy of exercise on these factors is not fully understood, and this lack of knowledge may hamper the routine application of physical activity as part of...

Background. Engaging in physical activity (PA) has been associated with lower sarcopenia rates, whereas the role of sedentary behavior (SB) as a sarcopenia modulator has been scarcely investigated. The recent incorporation of objective physical behaviors monitoring allows a better characterization of the exposure and might contribute to a better un...

Revisión Summary Introduction: Nowadays, asthma is a disabling disease with no cure, and the development of effective non-pharmacological treatments which can alleviate side effects of drugs and pathological symptoms is urgent. Some studies have shown that physical exercise may have beneficial effects in patients with asthma, but results were contr...

Background The long-term impact of cancer treatment is associated with respiratory dysfunction and physical fitness impairment. Although inspiratory muscle training (IMT) has been shown as an effective exercise therapy in cancer survivors, there is no evidence on the optimal dose, application moment nor specific population effects of this intervent...

Background & Aims Handgrip strength is a strong predictor of the risk of mortality. The objective of this systematic review was to analyse handgrip strength measurement protocols used in all-cause and cause-specific mortality studies. Method A systematic search of PubMed/MEDLINE, Web of Science and Scopus was conducted from inception to February...

OBJECTIVE We aimed to examine the dose-response associations between the number of steps per day and all-cause mortality among adults with prediabetes and diabetes. RESEARCH DESIGN AND METHODS This prospective study used data from 1,194 U.S. adults with prediabetes and 493 with diabetes for whom accelerometer-derived steps per day could be retriev...

Objective To examine the dose-response relationship between overall and specific types of exercise with cognitive function in older adults. Design Systematic Review and Bayesian Model-Based Network Meta-Analysis. Data sources Systematic search of MEDLINE, Web of Science, Scopus, PsycINFO and SPORTDiscus. Eligibility criteria for selecting studie...

Severe mental disorders are generally characterized by a combination of abnormal thoughts, perceptions, emotions, behavior, and relationships with others, often leading to decreased quality of life and increased anxious and depressive symptoms. A tool that is beginning to be used with this group is exergaming, with the objective to improve their ge...

El objetivo de este estudio fue conocer qué investigaciones de carácter longitudinal se han llevado a cabo que hayan analizado variables relacionadas con el sobrepeso, la obesidad y el sedentarismo en edad escolar, y qué datos se pueden extraer de las mismas. Se revisaron las siguientes bases de datos: MEDLINE (PubMed), Scopus, SportDiscus y WOS (W...