Daniel Jay Felleman

Daniel Jay Felleman
University of Texas Medical School | UTMB

About

51
Publications
7,759
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
16,650
Citations
Introduction
Skills and Expertise

Publications

Publications (51)
Article
Full-text available
Previous studies in rabbits identified an array of extrastriate cortical areas anatomically connected with V1 but did not describe their internal topography. To address this issue, we injected multiple anatomical tracers into different regions in V1 of the same animal and analyzed the topography of resulting extrastriate labeled fields with referen...
Article
Full-text available
Studying the brain in large animal models in a restrained laboratory rig severely limits our capacity to examine brain circuits in experimental and clinical applications. To overcome these limitations, we developed a high-fidelity 96-channel wireless system to record extracellular spikes and local field potentials from the neocortex. A removable, e...
Article
Full-text available
Purpose Determining how information is represented by populations of neurons in different cortical areas is critical to our understanding of the brain mechanisms of visual perception. Recently, information-theoretical approaches have been applied to the analysis of spike trains of multiple neurons. However, other neurophysiological signals, such as...
Article
Full-text available
Area V2 of macaque monkeys is traditionally thought to consist of 3 distinct functional compartments with characteristic cortical connections and functional properties. Orientation selectivity is one property that has frequently been used to distinguish V2 stripes, however, this receptive field property has been found in a high percentage of neuron...
Article
Visual cortex of primates consists of a large number of discrete cortical areas and less well-defined cortical zones that are organized according to a number of principles including (1) topographic organization, (2) horizontal segregation of functionally distinct cortical connections, (3) horizontal segregation of functional properties, and (4) col...
Chapter
Visual cortex in macaque monkeys consists of a large number of subdivisions extending from occipital cortex into the temporal, parietal, and frontal lobes. These subdivisions vary in the amount and type of information used in their identification, and thus they vary in the certainty that they represent functionally distinct cortical areas. Traditio...
Article
Full-text available
V2 has long been recognized to contain functionally distinguishable compartments that are correlated with the stripelike pattern of cytochrome oxidase activity. Early electrophysiological studies suggested that color, direction/disparity, and orientation selectivity were largely segregated in the thin, thick, and interstripes, respectively. Subsequ...
Chapter
Full-text available
DefinitionIntegrins are a family of alpha-beta-heterodimers, comprising of different beta chains that associate with different alpha chains. Integrins primarily mediate cell adhesion and recognize a variety of ligands including extracellular matrix proteins, cell surface proteins and plasma proteins.
Article
Full-text available
The primate visual system has been shown to be organized into an anatomical hierarchy by the application of a few principled criteria. It has been widely assumed that cortical visual processing is also hierarchical, with the anatomical hierarchy providing a defined substrate for clear levels of hierarchical function. A large body of empirical evide...
Article
Full-text available
A considerable amount of research over the last decades has focused on the apparent specialization of V2 thin stripes for the processing of color in diurnal primates. However, because V2 thin stripes are functionally heterogeneous in that they consist of largely separate color- and luminance-preferring domains and because the color-preferring domai...
Article
Abstract The mechanisms of center-surround summation, the process by which visual cortical neurons integrate the inputs from the classical receptive field and the non-classical surround, are poorly understood. We constructed,a set of 32 representative center-surround stimuli using a repertoire of four bar types, and recorded the responses of 83 neu...
Article
Full-text available
It has been controversial whether the cytochrome oxidase (CO)-dense blobs in primate primary visual cortex (V1) and CO-dense thin stripes in visual area 2 (V2) are parts of a cortical color-processing stream that is segregated from other functional streams. One of the key pieces of evidence for the segregated color stream is the previous report of...
Article
Full-text available
Many neurons in visual area V1 respond better to a pop-out stimulus, such as a single vertical bar among many horizontal bars, than to a homogeneous stimulus, such as a stimulus with all vertical bars. Many studies have suggested such cells represent neural correlates of pop-out, or more generally figure-ground segregation. However, preference for...
Article
Neurons responding selectively to different colours have been found in various cortical areas in macaque monkeys; however, little is known about whether and how the representation of colour is spatially organized in any cortical area. Cortical area V2 contains modules that respond preferentially to chromatic modulation, which are located in thin cy...
Article
The organization of projections from V2 thin stripes and interstripes to V4 was investigated using a combination of physiological and anatomical techniques. The compartments of V2 were first characterized, in vivo, using optical recording of intrinsic signals. Multiple anterograde tracers were then injected into different V2 compartments. The distr...
Article
The target in a visual search task usually pops out if it can be distinguished from its background on the basis of only one visual feature but not if the target represents a conjunction of two or more features. However, several recent reports suggest that in certain cases, search targets defined by a conjunction of two features also pop out. We hav...
Article
Full-text available
The modular organization of cortical pathways linking visual area 4 (V4) with occipital visual area 2 (V2) and inferotemporal posterior inferotemporal ventral area (PITv) was investigated through an analysis of the patterns of retrogradely labeled cell bodies after injections of tracers into V4 and PITv. Although cytochrome oxidase or other stains...
Article
The cortical connections of visual area 3 (V3) and the ventral posterior area (VP) in the macaque monkey were studied by using combinations of retrograde and anterograde tracers. Tracer injections were made into V3 or VP following electrophysiological recording in and near the target area. The pattern of ipsilateral cortical connections was analyze...
Article
Purpose. To determine whether the functionally defined chromatic and luminance submodules contained within V2 thin stripes make horizontal, intrinsic connections with the same subsets of stripe compartments or whether they target different functional compartments within V2. Methods. Optical recording of intrinsic cortical signals was used to map th...
Article
D. C. Van Essen and D. J. Felleman [comment][1] on the analysis of Hilgetag et al. In addition, Hilgetag et al. have a brief [rejoinder.][1] [Further commentary][1] by D. J. Felleman and D. C. Van Essen can be found in the [Enhanced Perspective.][1] [1]: /lookup/doi/10.1126/science.271.5250.776
Article
Purpose. A blue vertical bar pops out from among yellow vertical bars, but usually not from among yellow vertical bars and blue horizontal bars. Psychophysical studies suggest that pop-out is an early visual process; it is believed to be a result of analysis of local contrasts, such as those take place in the primary visual cortex (area V1). Method...
Article
Full-text available
The classic view of how the brain areas that control vision are connected is a complicated wiring diagram devised by manual sorting on the basis of existing anatomical data [D. J. Felleman and D. C. Van Essen, Cereb. Cortex 1, 1 (1991)]. Now, in this issue's Enhanced Perspective, Hilgetag and co-workers have used a computer algorithm to test whethe...
Article
Full-text available
The earliest stages of cortical visual processing in areas V1 and V2 of the macaque monkey contain internal subdivisions ('blobs' and 'interblobs' in layer 4B in V1; thin, thick and interstripes in V2) that are selectively interconnected and contain neurons with distinctive visual response properties. Here we use anatomical pathway tracing to demon...
Article
Full-text available
The effect of X rays on brain weight of guinea pig pups at birth was studied in 21-day-old embryos exposed in utero to doses of 75 and 100 mGy. When compared to controls and when corrected for body weight, gestation time, litter size, sex, and examiner differences, the brains of irradiated pups weighed approximately 46 mg less than those of control...
Article
Full-text available
The primate visual system contains dozens of distinct areas in the cerebral cortex and several major subcortical structures. These subdivisions are extensively interconnected in a distributed hierarchical network that contains several intertwined processing streams. A number of strategies are used for efficient information processing within this hi...
Chapter
Full-text available
We have used voltage-sensitive dyes to monitor in vivo responses to focal electrical stimulation of visual cortex. This technique allows the visualization of local cortical activity patterns as well as foci in distant cortical targets. A novel chamber, headholder, and optical system provided high intensity epifluorescent images of a large cortical...
Article
In recent years, many new cortical areas have been identified in the macaque monkey. The number of identified connections between areas has increased even more dramatically. We report here on (1) a summary of the layout of cortical areas associated with vision and with other modalities, (2) a computerized database for storing and representing large...
Article
Most primates are highly visual creatures, capable of a wide variety of difficult tasks that must be carried out in a complex visual environment. It is therefore hardly surprising that a very large expanse of cerebral cortex is devoted to analyzing and interpreting the relatively raw messages transmitted from the retina. Over the past three decades...
Article
In recent years, many new cortical areas have been identified in the macaque monkey. The number of identified connections between areas has increased even more dramatically. We report here on (1) a summary of the layout of cortical areas associated with vision and with other modalities, (2) a computerized database for storing and representing large...
Article
Full-text available
Excerpt In the 1970s, a quiet revolution began in our understanding of how information processing occurs in regions beyond the primary visual cortex. Work from several laboratories indicated that there were more visual areas than just the three proposed by classic neuroanatomists. The number of extrastriate areas identified around that time was abo...
Article
Multiunit microelectrode recordings and injections of horseradish peroxidase (HRP) were used to reveal neuron response properties, somatotopic organization, and interconnections of somatosensory cortex in the lateral sulcus (sylvian fissure) of New World owl monkeys. There were a number of main findings. 1) Representations of the face and head in a...
Article
Receptive field properties of 147 neurons histologically verified to be located in area V3 were investigated during semichronic recording from paralyzed anesthetized macaque monkeys. Quantitative analyses were made of neuron selectivities for direction, orientation, speed, binocular disparity, and color. The majority of neurons in V3 (76%) were str...
Article
Full-text available
Previous studies have shown that the primary somatosensory cortex of adult mammals undergoes somatotopic reorganization in response to peripheral nerve transection. The present study assesses how cortical organization is affected when a transected nerve subsequently regenerates. The median nerve to one hand of adult owl monkeys was transected and r...
Article
This report provides an overview of the functional organization of cortex immediately anterior to area V2 in extrastriate visual cortex of the macaque monkey. Contrary to previous suggestions that a single area, V3, lies anterior to V2, we have obtained evidence that this strip of cortex includes two separate areas, V3 and the ventral posterior are...
Article
Response properties of single neurons in the middle temporal visual area (MT) of anesthetized owl monkeys were determined and quantified for flashed and moving bars of light under computer control for position, orientation, direction of movement, and speed. Receptive-field sizes, ranging from 4 to 25 degrees in width, were considerably larger than...
Article
The visual pathways of an albino green monkey have been studied electrophysiologically and by autoradiographic methods. The monkey had a white coat and pink eyes; it had a strabismus and a nystagmus. When comparisons were made with normal macaque and green monkeys, several abnormalities could be defined. In the retina there was no foveal pit. A who...
Article
In an earlier study (Neuroscience8, 33–55, 1983), we found that the cortex representing the skin of the median nerve within parietal somatosensory fields 3b and 1 was completely occupied by ‘new’ inputs from the ulnar and radial nerves, 2–9 months after the median nerve was cut and tied in adult squirrel and owl monkeys. In this report, we describe...
Article
Full-text available
After median nerve fibers to glabrous skin on the hands of monkeys were crushed and allowed to regenerate, normal topographical organization was recovered in the representation of the hand in primary somatosensory cortex. Similar recovery of normal cortical organization may underlie the sensory restoration that usually follows nerve crush injury in...
Article
Full-text available
In both cats and monkeys, the traditional region of the first somatosensory area of cortex, S-I, has been described as containing four strip-like architectonic fields, areas 3a, 3b, 1, and 2. In monkeys, a number of recent studies have provided evidence that each of these architectonic fields constitutes a separate representation of the body. Becau...
Article
The somatotopic organization of postcentral parietal cortex was determined with microelectrode mapping methods in a New World monkey, Cebus albifrons. As in previous studies in macaque, squirrel and owl monkeys, two separate representations of the body surface were found in regions corresponding to the architectonic fields 3b and 1. The two represe...
Article
Two to nine months after the median nerve was transected and ligated in adult owl and squirrel monkeys, the cortical sectors representing it within skin surface representations in Areas 3b and 1 were completely occupied by 'new' and expanded representations of surrounding skin fields. Some occupying representations were 'new' in the sense that (1)...
Article
The somatotopic organization of the postcentral parietal cortex of the Old World monkey, Macaca fascicularis, was determined with multi-unit microelectrode recordings. The results lead to the following conclusions: 1) There are at least two complete and systematic representations of the contralateral body surface in the cortex of the postcentral gy...

Network

Cited By