Daniel Graham Delafield

Daniel Graham Delafield
University of Wisconsin–Madison | UW · Department of Chemistry

Master of Science

About

14
Publications
1,595
Reads
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142
Citations
Citations since 2017
14 Research Items
142 Citations
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20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Additional affiliations
August 2018 - present
University of Wisconsin–Madison
Position
  • Research Assistant
May 2016 - May 2018
University of Oklahoma
Position
  • Research Assistant
Education
May 2016 - May 2018
University of Oklahoma
Field of study
  • Analytical Chemistry

Publications

Publications (14)
Article
Citrullination is a key post-translational modification (PTM) that affects protein structures and functions. Although it has been linked to various biological processes and disease pathogenesis, the underlying mechanism remains poorly understood due to a lack of effective tools to enrich, detect, and localize this PTM. Herein, we report the design...
Article
Mass spectrometry-based discovery glycoproteomics is highly dependent on the use of chromatography paradigms amenable to analyte retention and separation. When compared against established stationary phases such as reversed-phase and hydrophilic interaction liquid chromatography, reports utilizing porous graphitic carbon have detailed its numerous...
Article
Mass spectrometry-based biomolecular analyses have become permanent fixtures of academic, industrial, and clinical research settings. The rise in utilization of mass spectrometry has, in turn, spurred on a technological arms race, with every major vendor seeking to provide instrumentation that is more sensitive, higher in resolution, or may otherwi...
Article
Full-text available
Lactylation was initially discovered on human histones. Given its nascence, its occurrence on nonhistone proteins and downstream functional consequences remain elusive. Here we report a cyclic immonium ion of lactyllysine formed during tandem mass spectrometry that enables confident protein lactylation assignment. We validated the sensitivity and s...
Article
Full-text available
Continual developments in instrumental and analytical techniques have aided in establishing rigorous connections between protein glycosylation and human illness. These illnesses, such as various forms of cancer, are often associated with poor prognoses, prompting the need for more comprehensive characterization of the glycoproteome. While innovativ...
Preprint
Full-text available
Soy-based diets are associated with increased seizures and autism. Thus, there is an acute need for unbiased protein biomarker identification in Fragile X syndrome (FXS) in response to soy consumption. Herein, we present a spatial proteomics approach integrating mass spectrometry imaging (MSI) with label-free proteomics in a mouse model of FXS to m...
Article
Full-text available
Innovations in medical technology and dedicated focus from the scientific community have inspired numerous treatment strategies for benign and invasive cancers. While these improvements often lend themselves to more positive prognoses and greater patient longevity, means for early detection and severity stratification have failed to keep pace. Dete...
Article
Full-text available
The extracellular matrix (ECM) is unique to each tissue and capable of guiding cell differentiation, migration, morphology, and function. The ECM proteome of different developmental stages has not been systematically studied in the human pancreas. In this study, we apply mass spectrometry-based quantitative proteomics strategies using N,N-dimethyl...
Preprint
Full-text available
Citrullination and homocitrullination are key post-translational modifications (PTMs) that affect protein structures and functions. Although they have been linked to various biological processes and disease pathogenesis, the underlying mechanism remains poorly understood due to a lack of effective tools to enrich, detect, and localize these PTMs. H...
Preprint
Full-text available
Citrullination and homocitrullination are key post-translational modifications (PTMs) that affect protein structures and functions. Although they have been linked to various biological processes and disease pathogenesis, the underlying mechanism remains poorly understood due to a lack of effective tools to enrich, detect, and localize these PTMs. H...
Article
Full-text available
Growing implications of glycosylation in physiological occurrences and human disease have prompted intensive focus on revealing glycomic perturbations through absolute and relative quantification. Empowered by seminal methodologies and increasing capacity for detection, identification, and characterization, the past decade has provided a significan...
Article
A variety of peptidic and proteinaceous contaminants (e.g., proteins, toxins, pathogens) present in the environment may pose risk to human health and wildlife. Peroxymonosulfate is a strong oxidant (EH0 = 1.82 V for HSO5–, the predominant species at environmental pH values) that may hold promise for deactivation of proteinaceous contaminants. Relat...
Article
Ion mobility-mass spectrometry (IM-MS) has emerged as a highly important analytical technique for the structural elucidation of a wide range of biomolecules, including neuropeptides, proteins and protein complexes. However, though the inherent value presented by powerful ion mobility techniques has garnered significant interest and spurred on the d...
Article
The microbial secretome, known as a pool of biomass (i.e., plant-based materials) degrading enzymes, can be utilized to discover industrial enzyme candidates for biofuel production. Proteomics approaches have been applied to discover novel enzyme candidates through comparing protein expression profiles with enzyme activity of the whole secretome un...

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