Daniel Courteix

Université Clermont Auvergne (UCA) - Clermont-Ferrand

Citation: Zak, M.; Wasik, M.; Sikorski, T.; Aleksandrowicz, K.; Miszczuk, R.; Courteix, D.; Dutheil, F.; Januszko-Szakiel, A.; Brola, W. Abstract: Individual mobility deficit in older adults induces a variety of medical conditions, diminishing their functional capacity in pursuing activities of daily living. In immobility syndrome patients, such co...

The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic synd...

While few studies pointed out low bone mineral densities in constitutionally thin women, little is known about potential explanations. The objective was to further explore bone architecture in both women and men with constitutional thinness to investigate their mechanical muscle-bone coupling (or uncoupling). Thirty constitutionally thin people and...

Aim: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. Methods:...

Modern technologies are presently harnessed in response to a complex challenge of providing physiotherapeutic management in older adults. Fully immersive virtual reality (VR) solutions are acknowledged to viably enhance the overall effectiveness of traditional physiotherapeutic methods. A total of 60 community-dwelling older adults (over 75 years o...

Abstract Background Puberty is a period of intense changes in human body and, additionally, participation in sports is viewed as prominent form of physical activity among male adolescent athletes. The current study was aimed to examine the intra-individual changes in body composition and bone tissue during years of maximal growth and the effect of...

Frailty, a physiological syndrome (FS) affecting primarily the older adults, manifests itself through significantly depleted bodily reserves, and appreciably higher (up to over threefold) individual exposure to fall risk. Concomitant medical conditions such as balance impairment, reduced visual acuity, limited mobility, and significantly diminished...

Background: The aim of the present study was to evaluate i) the presence of liver steatosis using Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI) and Liver Fat Score (LFS) in patients suffering from MS and ii) the association of FLI, HSI and LFS with the cardiometabolic risks. Methods: A total of 91 patients with MS (MS; 39 men, 52 women)...

Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are associated with changes in body composition. Ectopic intramuscular fat (IMAT) may alter muscle function and contribute to cardiometabolic disorders. In a pilot study, we analyzed IMAT in the calf with peripheral quantitative computed tomography (pQCT) and examined correlations between IMAT q...

Introduction: Since adolescents with obesity are prone to bone fragility during weight loss, the aim was to compare the impact of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on bone density, geometry, and strength. Methods: Sixty-one adolescents were randomly assigned to 2 cycling trainings (HIIT and...

A growing interest in constitutional thinness has been observed in the last decades, but the publications however cover various fields of study and report equivocal results. The present work systematically reviewed any clinical trials enrolling participants with constitutional thinness and bibliographic researches were performed between December 20...

Background Mild cognitive impairment (MCI) affects 10–20% of the individuals over the age of 65; this proportion being higher in the institutional care facilities than within a general population. Aim To assess whether dual-task cost in the individuals affected by MCI depends exclusively on gait, or possibly some other functional capacity componen...

Older adults are considered a vulnerable category within the population, which is exposed to an accelerated risk of functional degeneration. The purpose of this study was to explore different facilitating factors and possible existing barriers to being physically active in older age in urban areas of Romania. A cross-sectional survey was conducted...

Background Relationships between the severity of obesity and bone health remain underexplored. Objectives To compare whole-body and localized bone mineral content (BMC) and density (BMD), trabecular bone score (TBS) and hip geometry and strength between adolescents with obesity versus extreme obesity. Methods This cross-sectional study included 1...

Constitutional thinness is defined as a state of severe underweight with a body mass index similar to anorectic patients (BMI < 17.5 kg/m²), in the absence of any eating disorders or other obvious disruptive factors impacting energy balance. The analysis of body composition is essential as a first approach to characterize constitutional thinness an...

Purpose: The aim of this study was to develop and validate a Romanian version of the Three-Factor Eating Questionnaire-R21 for children and adolescents CTFEQ-R21 and to assess its psychometrie properties and factor structure. Associations between the present version of the CTFEQ-R21 and anthropometric measures as well as body composition were also...

The aim of this study was to evaluate the effect of a multidisciplinary weight loss intervention on energy intake and appetite sensations in adolescents with obesity, depending on the initial diagnosis or persistence of the metabolic syndrome. Ninety-two adolescents with obesity (12-15 years) followed a 16-week multidisciplinary weight loss interve...

Objectives: This study was performed to evaluate the long-term maintenance of nutritional changes promoted during an intensive initial intervention to induce body weight loss. The ability of these changes to predict long-term health outcomes was also examined. Methods: Nutritional variables, body composition, and metabolic markers collected in t...

Objectives. The aim of this paper was to emphasize the importance of HRV measured at rest, as a valuable cue for objectifying the training status of a young gymnast. Thus the coach can further integrate the data into the individualized sports training strategy. Material and methods. The HRV research methodology was applied in this ascertaining stu...

Capillary network of skeletal muscle has a crucial role in oxygen supply and is strongly associated with the phenotype and metabolic profile of muscle fibers. Abundant literature has explored capillarization of skeletal muscle in different populations and in response to different interventions. Capillary and fiber type identification techniques hav...

Invited Letter to Editor in response to: Constitutional thinness: body fat metabolism and skeletal muscle are important factors - Mélina Bailly, Natacha Germain, Bogdan Galusca, Daniel Courteix, David Thivel, Julien Verney

Constitutional thinness (CT) is a nonpathological state of underweight. The current study aimed to explore skeletal muscle energy storage in individuals with CT and to further characterize muscle phenotype at baseline and in response to overfeeding. Thirty subjects with CT (15 females, 15 males) and 31 normal-weight control subjects (16 females, 15...

Aim To assess muscle function and functional abilities in children with juvenile idiopathic arthritis (JIA). Methods Fourteen children with JIA and 14 healthy controls matched for age and sex were included. Muscle characteristics, both structural (thickness, cross‐sectional area (CSA) and fascicle angle) and qualitative (intermuscular adipose tiss...

The existing literature about the definition and diagnostic criteria of constitutional thinness appears equivocal. The present work systematically reviewed the criteria used in the diagnosis of adult individuals with constitutional thinness (PROSPERO registration number: CRD42019138236). Five electronic bibliographic databases were searched between...

Purpose: This study determined the impact of menstrual status on bone tissue in elite post-pubertal female soccer players over an entire season. Methods: Fifty-one elite female soccer players participated. At baseline, forty-one were assigned to the low hormonal androgenic profile (low-HAPL) and 10 to the high hormonal androgenic profile (high-HAPL...

BACKGROUND: Heart rate variability may reveal sensitive information about the athletes’ physiological adaptation when exercising for sport performance. OBJECTIVE: The aim of this study was to demonstrate whether heart rate variability (HRV) measurements were able to predict sport results and determine which type of measurements, at rest or during r...

OBJECTIVE The current study aimed to examine the body composition of adult male ultra-trail runners (UTR) according to their level of participation (regional UTR-R, vs. national UTR-N). METHODS The sample was composed of 44 adult male UTR (aged 36.5±7.2 years; UTR-R: n=25; UTR-N: n=19). Body composition was assessed by air displacement plethysmogr...

Introduction Stress and obesity are two public health issues. The relationship between obesity and stress is biological through the actions of stress on the major hormones that regulate appetite (leptin and ghrelin). Many spa resorts in France specialise in the treatment of obesity, but no thermal spa currently proposes a specific programme to mana...

Objective Work-related stress is a public health issue. Stress has multiple physical and psychological consequences, the most serious of which are increased mortality and cardiovascular morbidity. The ThermStress protocol was designed to offer a short residential thermal spa program for work-related stress prevention that is compatible with a profe...

Objectives: The objective of this study was to evaluate muscular metabolic function in children with inactive juvenile idiopathic arthritis (JIA). Methods: Fifteen children with inactive JIA and fifteen healthy controls were matched by sex, biological age, and Tanner stage. Participants completed a submaximal incremental exercise test to determine...

Background: Although multidisciplinary weight management interventions have been shown effective in improving body composition and cardio-respiratory fitness, their effects on HRQOL and perceived health status remain uncertain in adolescents with obesity. Objective: To assess the impact of a 10-month multidisciplinary weight management intervent...

The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance-low-aerobic exercise (Re), low-resistance-high-aerobic ex...

Discipline Expérimental/mécanismes cellulaires et moléculaires. Introduction et but de l’étude Les mécanismes expliquant le gain de poids ont été très étudiés ces dernières années. Les stéroïdes et notamment les œstrogènes ont été montrés comme jouant un rôle important dans les processus de régulation du stockage et déstockage lipidique. Différent...

Objective: Purpose: The aim of this study was to develop and validate a Romanian version of the Three-Factor Eating Questionnaire-R21 for children and adolescents CTFEQ-R21, and to assess its psychometric properties and factor structure. Associations between the present version of the CTFEQ-R21 and anthropometric measures as well as body compositi...

We identified the determinants of 12-month changes of areal bone mineral density (aBMD), hip geometry and trabecular bone score (TBS) in adolescent male athletes. Changes in region-specific lean mass and the type of sport are the most consistent determinants in this population. Purpose This study aims to identify the determinants of 12-month chang...

Aims: Multidisciplinary interventions have shown some merits as anti-obesity strategies in youth; however, their impact on daily energy intake remains largely unknown. The aim of the present study was to evaluate the nutritional responses to a 10-month multidisciplinary intervention among adolescents with obesity, considering their eating behavior...

To evaluate the potential bone defect in neuromuscular diseases, we conducted a longitudinal study including three groups of patients: 14 Duchenne muscular dystrophies (DMD) and 2 limb-girdle muscular dystrophies (LGMD); 3 Becker muscular dystrophies (BeMD) and 7 spinal muscular atrophies (SMA). Yearly osteodensitometries assessed body composition...

Background: Exploring the osteogenic effect of different bone-loading sports is particular relevant to understand the interaction between skeletal muscle and bone health during growth. This study aimed to compare total and regional bone and soft-tissue composition between female adolescent swimmers (n=20, 15.71±0.93 years) and volleyball players (...

The effectiveness of structured multidisciplinary weight loss (WL) programs combining nutrition and physical activity on bone geometry and strength remains uncertain in adolescents with obesity. The study investigated the impact of a structured WL intervention on bone geometry and strength in adolescents with obesity. Thirty-one adolescents with ob...

Objective: To determine which modality of exercise program (endurance and/or resistance dominance) is the most effective for improving vascular function in the micro- and macrocirculation in metabolic syndrome (MetS). Methods: Sixty-two MetS patients were enrolled in a 6-month lifestyle intervention program based on diet and exercise training. E...

The aim of the present study was to assess the sensitivity of bio-impedance (BIA) in tracking body composition changes in adolescents with various degrees of obesity. We hypothesized that while BIA provides a reliable measure of body composition, its accuracy decreases with increasing obesity and its ability to track changes might be reduced with h...

Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eight...

Over the last two decades, the understanding of adipose tissue has undergone radical change. The perception has evolved from an inert energy storage tissue to that of an active endocrine organ. Adipose tissue releases a cluster of active molecules named adipokines. The severity of obesity-related diseases does not necessarily correlate with the ext...

Given the rise in pediatric obesity, clarifications on the relationship between obesity and bone health and on the impact of structured intervention on this relationship are needed. This systematic review and meta-analysis investigated the effect of obesity on bone health and assessed the effect of structured intervention in children and adolescent...

Table S1. Comparison between one year treatment completers and non‐completers among RA patients Table S2. Available‐case analysis of RA patients treated with tocilizumab during 1 year follow‐up with TCZ treatment. [mean ± SD or number (%)]

Objectives: To demonstrate that lifestyle modifications will reduce the cost of routine medications in individuals with type 2 diabetes (T2D), through a mechanism involving glycaemic control. Design: A within-trial cost-medication analysis with a 1-year time horizon. Setting: Controlled environment within the spa resort of Chatel-Guyon, France...

Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and coul...

Erratum Following the publication of this article [1] it was brought to our attention that the affiliation for author Susana C. Póvoas is incorrect and for author Daniel A. Marinho incomplete. Susana C. Póvoas is erroneously affiliated with the Research Centre in Sport and Physical Activity, Maia Institute of Higher Education, Maia, Portugal. The a...

Background A variety of performance outputs are strongly determined by lower limbs volume and composition in children and adolescents. The current study aimed to examine the validity of thigh volume (TV) estimated by anthropometry in late adolescent female volleyball players. Dual-energy X-ray absorptiometry (DXA) measures were used as the referenc...

Aims: To analyse the effects of different modalities of exercise training on heart rate variability (HRV) in individuals with metabolic syndrome (MetS). Methods and results: Eighty MetS participants (aged 50-70 years) were housed and managed in an inpatient medical centre for 21 days, including weekends. Physical activity and food intake/diet we...

Introduction A need exists for sustainable and clinically effective weight management interventions, suitable for preventing well-linked chronic disease such as diabetes and cardiovascular disease and some less investigated secondary conditions such as bone alteration. The ADIposity and BOne metabolism: effects of eXercise-induced weight loss in ob...

Aims: The purpose of our study was to determine the effect of lifestyle intervention on left ventricular (LV) regional myocardial function in patients with metabolic syndrome (MetS) and investigate the relationships of the changes in myocardial function to changes in epicardial adipose tissue (EAT), inflammatory profile and MetS components. Metho...

Energy-dense food consumption and lack of physical activity are implicated in the development of the current obesity epidemic. The role of estrogen in adiposity and fuel partitioning is mediated mainly though the estrogen receptor alpha (ERα) isoform. We hypothesized that nutritional adaptation and exercise training, either individually or combined...

Background: Weight loss is a public health concern in obesity-related diseases such as metabolic syndrome (MetS). However, restrictive diets might induce bone loss. The nature of exercise and whether exercise with weight loss programs can protect against potential bone mass deficits remains unclear. Moreover, compliance is essential in interventio...

Traditional approaches for treating or managing children and adolescents with overweight or obesity have limited effectiveness. Current advances in smartphone technology may improve the attractiveness and accessibility of weight management support for children and adolescents with overweight or obesity. This systematic review aimed to provide a com...

Metabolic and bone effects were investigated in growing (G, n = 45) and mature (M, n = 45) rats fed a high-fat-sucrose diet (HFS) isocaloric to the chow diet of controls (C, n = 30 per group). At week-19, a subset of 15 rats in each group (HFS or C, at both ages) was analyzed. Then half of the remaining 30 HFS rats in each groups continued HFS and...

1519 Volume: 47 Issue: 5 Supplement 1

The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex int...

Some studies suggest that the signaling pathway of neuregulin 1 (NRG1), a protein involved in the regulation of skeletal muscle metabolism, could be altered by nutritional and exercise interventions. We hypothesized that diet-induced obesity could lead to alterations of the NRG1 signaling pathway and that chronic exercise could improve NRG1 signali...

The first objective of this study was to demonstrate differences within endothelial-dependent and endothelial-independent vasoreactivity in macro- and microcirculation beds among patients with metabolic syndrome (MetS) with and without type 2 diabetes mellitus (T2D) compared with healthy counterparts. The second objective was to determine relations...

Context and objective: Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were...