Daniel-Clement Osei-Bordom

Daniel-Clement Osei-Bordom
University College London | UCL · Institute for Liver and Digestive Health

Bachelor of Medicine

About

46
Publications
14,993
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766
Citations
Introduction
Daniel-Clement Osei-Bordom currently works at UCLH-Royal Free Hospital and University College London as a Hepatopancreatobiliary Clinical Research Fellow at the UCL Institute for Liver and Digestive Health. He previously worked at the Centre of Liver and Gastrointestinal Research, University of Birmingham as an NIHR Academic Clinical Fellow in General Surgery and also at the Division of Transplantation Immunology and Mucosal Biology, King's College London.
Additional affiliations
August 2018 - August 2021
University of Birmingham
Position
  • Fellow

Publications

Publications (46)
Article
Full-text available
Background The relation between operative time and postoperative complications in liver surgery is unclear. The aim of this study is to assess the impact of operative time on the development of postoperative complications in patients who underwent minimally invasive or open liver resections of various anatomical extent and technical difficulty leve...
Article
Background: Pancreatic ductal adenocarcinoma (PDAC) is known to have a heterogeneous desmoplastic tumour microenvironment (TME) with a large number of immunosuppressive cells. Recently, high B-cell infiltration in PDAC has received growing interest as a potential therapeutic target. Methods: Our literature review summarises the characteristics of...
Article
Objective The aim of this study was to compare the perioperative outcomes of robotic liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings. Summary Background Data Clear advantages of RLS over LLS have rarely been demonstrated, and the associated costs of robotic surgery are generally higher than those of laparoscopic surger...
Article
Full-text available
The presence of CD8⁺ T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we characterise the mechanism of CD8⁺ T cell invasion into BEC. CD8⁺ T cells observed within BEC were large, eccentric, and expressed E-cadherin, CD103 and CD69. They were a...
Article
Full-text available
Introduction: Poor pain control after surgery is associated with chronic pain and opioid dependence. This study aimed to determine the incidence of patient reported pain control failure following gastrointestinal surgery, and to evaluate the impact of common preventative surgical and anaesthetic strategies. Methods: Data were extracted from an elec...
Chapter
Pancreaticobiliary cancers (pancreatic ductal adenocarcinoma, cholangiocarcinoma and gallbladder) are relatively uncommon tumors with a rising incidence. The 5-year survival rates for patients with this group of tumors are poor as the majority are diagnosed at a locally advanced or metastatic disease stage, when potentially curative surgical resect...
Data
EAGLE is an international study bringing together surgeons, anaesthetists and theatre teams around the world to share best practice. The common goal is to reduce the global anastomotic leak rate after right colectomy and ileocaecal resection. Feel free to join ESCP Safe-anastomosis programme.
Article
Full-text available
Background: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods: The internationally intended protocol, iteratively co-devel...
Article
Background & Aims Guidelines for the management of primary biliary cholangitis (PBC) were published by the British Society of Gastroenterology in 2018. In this study, we assessed adherence to these guidelines in the UK National Health Service (NHS). Methods All NHS acute trusts were invited to contribute data between 1 January 2021 and 31 March 20...
Article
Full-text available
Introduction CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). Methods The treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compare...
Article
Introduction Patients with liver disease and portal hypertension frequently require surgery carrying high morbidity and mortality. Accurately estimating surgical risk remains challenging despite improved medical and surgical management. Areas covered This review aims to outline a comprehensive approach to preoperative assessment, appraise methods...
Article
Full-text available
Background It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected patients. However, what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus far. The aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery...
Article
Introduction Hepatocellular carcinoma (HCC) is a disease with a high burden mainly affecting elderly patients. Most patients have underlying liver cirrhosis1,2. Elderly patients are increasingly seeking treatment for HCC in parallel with rising incidence and general life expectancy2–4. Resection is considered the most suitable curative option in el...
Poster
Background Although laparoscopic hepatectomy (LH) is associated with improved short-term outcomes compared to open hepatectomy (OH), it is unknown whether frail patients also benefit from LH. The aim of this study was to evaluate the impact of frailty on postoperative outcomes after LH and OH. Methods Consecutive patients who underwent LH and OH b...
Poster
Background The SARS-CoV-2 pandemic has had an unprecedented impact on healthcare systems, and cancer patients were amongst the most vulnerable. CONTACT is a national multidisciplinary study assessing the impact of the SARS-CoV-2 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). Methods A n...
Article
Full-text available
Background: Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study was therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS an...
Conference Paper
Background Patients with cirrhosis increasingly require major surgery carrying high morbidity and mortality. In Europe, surgical risk prediction remains a challenge, despite the availability of multiple prognostic systems (mainly US origin) in clinical practise to predict post-operative risk. In addition, there is lack of surgical outcome data in l...
Article
The seventh leading cause of cancer-related death globally, pancreatic ductal adenocarcinoma (PDAC) involves the exocrine pancreas and constitutes greater than 90% of all pancreatic cancers. Surgical resection in combination with systemic chemotherapy with or without radiation remains the mainstay of treatment and the only potentially curative trea...
Article
Full-text available
Background Although laparoscopic hepatectomy (LH) is associated with improved short-term outcomes compared to open hepatectomy (OH), it is unknown whether frail patients also benefit from LH. The aim of this study was to evaluate the impact of frailty on post-operative outcomes after LH and OH. Patients and methods Consecutive patients who underwe...
Article
Full-text available
Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multi...
Article
Full-text available
Pancreatic ductal adenocarcinomas (PDAC) represent one of the deadliest cancers worldwide. Survival is still low due to diagnosis at an advanced stage and resistance to treatment. Herein, we review the main types of liquid biopsy able to help in both prognosis and adaptation of treatments.
Article
Full-text available
Aim It was recognized that surgical wards often have a large number of patients outlied to them. Unfortunately, it was also noted that they often were not regularly seen and so had no daily medical plan. Evidence shows outliers have: The aim was to develop a means of increasing outlier reviews, plans and awareness of outlier parent speciality. Met...
Article
Full-text available
The tight relationship between the gut and liver on embryological, anatomical and physiological levels inspired the concept of a gut-liver axis as a central element in the pathogenesis of gut-liver axis diseases. This axis refers to the reciprocal regulation between these two organs causing an integrated system of immune homeostasis or tolerance br...
Article
Full-text available
(1) Background: colorectal cancer (CRC) is one of the deadliest causes of death by cancer worldwide. Its first main metastatic diffusion spreads to the liver. Different mechanisms such as the epithelial–mesenchymal transition and angiogenesis are the characteristics of this invasion. At this stage, different options are possible and still in debate...
Article
Full-text available
Background: Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions. However, the wide variability in donor and graft characteristics between individual donor livers limits the comparability of results. We investigated the hypothesis tha...
Article
Full-text available
Liver transplantation is the only recognized effective treatment for end-stage liver disease. However, organ shortages have become the main challenge for patients and physicians within the transplant community. Waiting list mortality remains an issue with around 10% of patients dying whilst waiting for an available organ. The post-transplantation p...
Article
Full-text available
Background: Robot-assisted surgery (RAS) has potential panspecialty surgical benefits. High-quality evidence for widespread implementation is lacking. This systematic review aimed to assess the RAS evidence base for the quality of randomized evidence on safety and effectiveness, specialty 'clustering', and outcomes for RAS research. Methods: A s...
Article
The human liver is regarded as a lymphoid organ that contributes to both local and systemic immune response. Intrahepatic immune cells including regulatory T cells (Tregs) reside in the hepatic microenvironment which is enriched with proinflammatory cytokines, chemokines and metabolites. In addition, the hepatic microenvironment has the unique abil...
Article
Full-text available
Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition associated with significant morbidity. The aim of this study was to describe current management and outcomes of patients with obst...
Article
Full-text available
The liver is an important contributor to the human immune system and it plays a pivotal role in the creation of both immunoreactive and tolerogenic conditions. Liver transplantation provides the best chance of survival for both children and adults with liver failure or cancer. With current demand exceeding the number of transplantable livers from d...
Article
Background: This study aimed to determine the impact of preoperative exposure to intravenous contrast for CT and the risk of developing postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. Methods: This prospective, multicentre cohort study included adults undergoing gastrointestinal resection, stoma rev...
Article
Full-text available
Abstract Background Trainee research collaboratives (TRCs) have pioneered high quality, prospective ‘snap-shot’ surgical cohort studies in the UK. Outcomes After Kidney injury in Surgery (OAKS) was the first TRC cohort study to attempt to collect one-year follow-up data. The aims of this study were to evaluate one-year follow-up and data completion...
Article
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Introduction Patients with cancer who develop small bowel obstruction are at high risk of malnutrition and morbidity following compromise of gastrointestinal tract continuity. This study aimed to characterise current management and outcomes following malignant small bowel obstruction. Methods A prospective, multicentre cohort study of patients with...
Article
Blood group O or B recipients wait longer for a kidney transplant. We studied the distribution of anti‐ABO blood group antibody titres in patients awaiting a kidney transplant, and modelled the effect of altering the UK National Kidney Allocation Scheme to allow for patients with ‘LOW’ titres (≤1:8, ≤3 dilutions) to receive a deceased donor ABOi (d...
Article
Full-text available
Background Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed group. The aim of this study was to describe the burden of small bowel obstruction in the UK. Methods This prospective cohort stu...
Article
Background The incidence of inflammatory bowel disease (IBD) is increasing with 10- 25% were diagnosed in the paediatric and adolescent population. For the young people and adolescents with IBD, they are more susceptible to more severe and extensive forms of the disease and require consistent and clear progression through their treatment pathway, f...
Article
Full-text available
Purpose To determine the heritability of spine curve using plain radiographs and to identify risk factors for spine curvature including age, body mass index, smoking, bone mineral density (BMD), and lumbar disc degeneration (LDD). Methods A classical twin study of 110 MZ and 136 DZ adult female twins. Demographic and clinical information obtained f...

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