Daniel Buysse

Daniel Buysse
University of Pittsburgh | Pitt · Department of Psychiatry

MD

About

611
Publications
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Publications

Publications (611)
Article
Study Objectives Using a large, nationally representative database, we aimed to estimate prevalence and trends of insomnia among pregnant women over a 12-year period. Additionally, we aimed to examine the interplay among insomnia, maternal comorbidities, and severe maternal morbidity (SMM). Methods We conducted a serial cross-sectional analysis of...
Article
Study Objectives We examined whether homeostatic sleep drive and circadian rhythmicity differ in older adults with insomnia (OAI) compared to older good sleepers (GS) Methods OAI (n=37) and GS (n=30) participated in a 60-hour in-lab study with sleep deprivation and constant routine paradigms. Homeostatic sleep drive was assessed by examining the e...
Article
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Objective Excessive gestational weight gain (eGWG) is associated with adverse long-term maternal outcomes. Most lifestyle interventions that incorporate physical activity have been ineffective at reducing eGWG. The purpose of this study was to determine if sleep modified the relationships between physical activity change from the 2nd to 3rd trimest...
Article
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Restorative sleep is a commonly used term but a poorly defined construct. Few studies have assessed restorative sleep in nationally representative samples. We convened a panel of 7 expert physicians and researchers to evaluate and enhance available measures of restorative sleep. We then developed the revised Restorative Sleep Questionnaire (REST-Q)...
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Objective Evidence regarding which activity patterns relate to depression symptoms can guide the development of approaches to prevent major depression and related consequences. While prior studies have linked activity pattern disruption and depression symptoms, little is known regarding these relationships in people who were previously exposed to t...
Article
Objective: Behavioral risk factors for dementia tend to co-occur and inter-relate, especially poor diet, physical inactivity, sleep disturbances, and depression. Having multiple of these modifiable behavioral risk factors (MBRFs) may predict a particularly shortened cognitive healthspan, and therefore, may signal high-risk status/high intervention...
Article
Objectives: Insomnia is highly prevalent among persons with chronic pain. Although cognitive behavioral therapy for insomnia is recommended as first-line treatment for insomnia, it is underutilized. We tested the feasibility of a potentially scalable alternative - Brief Behavioral Therapy for Insomnia (BBTI) for former National Football League (NF...
Article
Introduction Sleep disturbance is a risk factor for the development of mood disorders and up to 90% of mood disorder patients report sleep problems. However, the neural mechanisms by which poor sleep contributes to mood disorders are not well understood. We investigated whether sleep disturbance was associated with dysregulation of positive and neg...
Article
Introduction Circadian rhythms and sleep regularity relate to a range of negative health outcomes, such as mental illness and substance abuse including binge drinking. According to the social zeitgeber hypothesis, the timing of key modifiable daily behaviors serves as time cues that entrain circadian rhythms, ostensibly stabilizing them and thereby...
Article
Objective: The aim of this review was to summarize literature examining the prevalence, impact, and trajectories of sleep disturbance in cardiac rehabilitation (CR) patients and discuss how CR programs may incorporate targeted evaluation and interventions to promote sleep health. Review methods: A narrative review of literature allowed for an ex...
Preprint
Objective : Excessive gestational weight gain (eGWG) is associated with adverse long-term maternal outcomes. Most lifestyle interventions that incorporate physical activity have been ineffective at reducing eGWG. The purpose of this study is to determine if sleep modified the relationships between physical activity change from the 2 nd to 3 rd trim...
Chapter
This chapter provides an overview of research on spouse/partner and family involvement in positive airway pressure (PAP) therapy for the treatment of obstructive sleep apnea (OSA). The chapter begins with a summary of the literature examining the impact of untreated OSA and PAP treatment on partners’ and family members’ sleep and daytime functionin...
Article
Objective: We developed a Japanese version of RU-SATED (RU-SATED-J), a simple self-rated scale for measurement of multidimensional sleep health, and examined its reliability and psychometric validity. Method: The RU-SATED-J was developed by a rigorous reverse translation process. It consists of six questions, each with three Likert-type response o...
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Study Objectives Polysomnography (PSG) is considered the “gold standard” for assessing sleep, but cost and burden limit its use. Although wrist actigraphy and self-report diaries are feasible alternatives to PSG, few studies have compared all three modalities concurrently across multiple nights in the home to assess their relative validity across m...
Article
We investigated the association between retrospectively reported sleep disturbances during childhood and adolescence and current symptoms of depression and anxiety in older adults. Participants included 116 older adults ( M age = 68 years [ SD = 6.4 years]) who completed a battery of sleep and psychological assessments. We tested two multivariate r...
Article
Objective: Sleep changes over the human lifespan, and it does so across multiple dimensions. We used individual-level cross-sectional data to characterize age trends and sex differences in actigraphy and self-report sleep dimensions across the healthy human lifespan. Methods: The Pittsburgh Lifespan Sleep Databank (PLSD) consists of harmonized p...
Article
Study Objectives To identify actigraphy sleep health profiles in older men (Osteoporotic Fractures in Men Study; N=2,640) and women (Study of Osteoporotic Fractures; N=2.430), and to determine whether profile predicts mortality. Methods We applied a novel and flexible clustering approach (Multiple Coalesced Generalized Hyperbolic mixture modeling)...
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Background: Growing evidence has documented the adverse impact of the global COVID-19 pandemic on sleep quality among older adults. Given the negative consequences of poor sleep, it is critical to identify factors that provide older adults with resilience against worsening sleep quality. Social integration may represent one such resilience factor....
Chapter
Sleep is multidimensional on several levels; there are multiple domains of sleep, multiple characteristics representing each domain, and multiple ways it can be captured (e.g., subjective sleep captured through retrospective self-report or daily sleep diary, behavioral sleep captured through actigraphy, or physiological sleep captured through polys...
Article
Stress in the context of the COVID-19 pandemic may have a significant impact on health, including sleep health. Older adults may be particularly vulnerable. This study examined associations between perceived stress and sleep health, mental health, physical health, and overall perceived health outcomes among older adults. We also examined whether sp...
Article
Circadian Rest-Activity Rhythm (or RAR) disturbances are prospectively associated with major health outcomes including depression [1], dementia [2], and mortality [3]. These findings are from observational studies that cannot determine causality, but nonetheless suggest that certain RAR characteristics may contribute to or signal poor health outcom...
Preprint
BACKGROUND Family caregivers are more likely to experience insomnia relative to non-caregivers, but have significant barriers to accessing gold-standard Cognitive Behavioral Therapy for Insomnia (CBT-I) treatment. Delivering interventions for caregivers by the Internet may help increase access to care, particularly among higher-intensity caregivers...
Article
Background: Family caregivers are more likely to experience insomnia relative to noncaregivers but have significant barriers to accessing gold standard cognitive behavioral therapy for insomnia treatment. Delivering interventions to caregivers through the internet may help increase access to care, particularly among higher-intensity caregivers who...
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Purpose This study aimed to investigate cross-sectional associations between physical activity, sleep health, and depression symptoms using mediation models. Methods Participants (N = 1576, MAge = 39.3 years, 40% female) were recruited online from Amazon’s Mechanical Turk crowd-sourcing service. Physical activity was measured using a single-item s...
Article
Introduction: Disturbed sleep is a common feature of psychotic disorders that is also present in the clinical high risk (CHR) state. Evidence suggests a potential role of sleep disturbance in symptom progression, yet the interrelationship between sleep and CHR symptoms remains to be determined. To address this knowledge gap, we examined the associ...
Article
Introduction Sleep health is “a multidimensional pattern of sleep-wakefulness, adapted to individual, social, and environmental demands, that promotes physical and mental well-being”. The RU-SATED is a short practical self-reported symptom scale that is a reliable valid tool for the rapid evaluation of sleep health. This study sought to examine the...
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To understand how a population natively conceptualizes insomnia along with related mental health and related disabilities, understanding how an insomnia severity spectrum operates in any given population will be a goal for sleep epidemiology. To facilitate this international goal, the comparatively theory-tolerant 65-item Pittsburgh Insomnia Rating...
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The coronavirus disease 2019 (COVID-19) outbreak emerged at the end of 2019 and quickly spread around the world. Measures to counter COVID-19, including social distancing and lockdowns, created an unusual situation that had the potential to impact a variety of behaviours, including sleep, which is crucial for health and well-being. Data were obtain...
Article
Objective: To determine if the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) improves functional impairment, psychiatric symptoms, and sleep and circadian functioning. Method: Adults diagnosed with serious mental illness (SMI) and sleep and circadian dysfunction (N = 121) were randomly allocated to TranS-C plus usual...
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Objective: To examine the association between multidimensional sleep health and objective measures of physical functioning in older adults. Method: We conducted a secondary analysis of 158 adults ≥65 years who participated in Midlife in the United States (MIDUS) 2 and MIDUS Refresher studies. Physical functioning was assessed using gait speed durin...
Article
Clarifying whether physiological sleep measures predict mortality could inform risk screening; however, such investigations should account for complex and potentially non‐linear relationships among health risk factors. We aimed to establish the predictive utility of polysomnography (PSG)‐assessed sleep measures for mortality using a novel permutati...
Article
Study objectives: Black individuals and individuals of low socioeconomic status are at increased risk for obstructive sleep apnea (OSA). The Berlin Questionnaire is one of the most widely used screening tools for OSA; however, there is limited research on its diagnostic accuracy in low-income, Black populations. Methods: This study analyzed data...
Article
Study Objectives Structural brain maturation and sleep are complex processes that exhibit significant changes over adolescence and are linked to many physical and mental health outcomes. We investigated whether sleep-gray matter relationships are developmentally-invariant (i.e., stable across age) or developmentally-specific (i.e., only present dur...
Article
We performed a systematic review of four databases to determine if the evidence supports a short or long duration nap during night shifts to mitigate fatigue, and/or improve health, safety, or performance for emergency services and public safety personnel (PROSPERO CRD42020156780). We focused on experimental research and evaluated the quality of ev...
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Introduction: Daytime sleepiness is a common problem. Although sleepiness is primarily assessed at the self-report unit of analysis, factors that contribute to an individual's experience and report of sleepiness remain poorly understood. While sleepiness is known to impact vigilance performance, the impact of vigilance performance on sleepiness re...
Article
Study objectives Sleep quantity and continuity vary across the lifespan. Actigraphy is a reliable and widely-used behavioral measure of sleep in research and personal health monitoring. This meta-analysis provides a novel examination of whether age (in years) is associated with actigraphy-assessed sleep across the lifespan. Methods A systematic se...
Article
Background Sleep and circadian timing shifts later during adolescence, conflicting with early school start times, and resulting in circadian misalignment. Although circadian misalignment has been linked to depression, substance use, and altered reward function, a paucity of experimental studies precludes the determination of causality. Here we test...
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Prior research on the relationship between sleep and attempted weight loss failed to recognize the multidimensional nature of sleep. We examined the relationship between a composite measure of sleep health and change in weight and body composition among adults in a weight loss intervention. Adults (N = 125) with overweight or obesity (50.3 ± 10.6 y...
Article
Study Objectives Neighborhood disadvantage is associated with poor sleep, which may contribute to and exacerbate racial and socioeconomic health disparities. Most prior work has been cross-sectional and thus it has not been possible to estimate causal effects. Methods We leveraged a natural experiment opportunity in two low-income, predominantly A...
Article
Background Depressive symptoms and sleep disturbances disproportionately affect midlife women. While there may be a bidirectional association, few studies have examined whether depressive symptoms are longitudinally associated with subsequent sleep. Sleep is typically considered unidimensional, despite emerging evidence that multidimensional sleep...
Preprint
Importance: Structural brain maturation and sleep are complex processes that exhibit significant changes over adolescence and are linked to healthy physical and mental development. The precise timing and magnitude of these changes influence function throughout the lifespan. However, the relationships between gray matter structure and sleep patterns...
Chapter
This article provides an overview of the use of rating scales in the assessment of sleep disorders, using the International Classification of Sleep Disorders – Third Edition (ICSD-3) as an organizing framework. Considerations for rating scale use and selection are described. An overview of rating scales most commonly used to assess sleep disorders...
Chapter
Insomnia is the most prevalent sleep disorder and contributes to considerable personal suffering and social cost. Recent advances in conceptual models of insomnia and the ability to investigate these models across units of analysis have contributed to a greater understanding of the etiology and pathogenesis of insomnia. In this article, we review t...
Article
In 2012, 19% of US adults reported regular insomnia or sleeping problems.¹ Medications most commonly used for insomnia are zolpidem (a benzodiazepine receptor agonist) and trazodone (a sedating antidepressant used in low doses for insomnia).² Prescriptions for these drugs increased during the 1990s and early 2000s,²,3 but recent trends have not bee...
Article
The multidimensional sleep health framework emphasizes that sleep can be characterized across several domains, with implications for developing novel sleep treatments and improved prediction and health screening. However, empirical evidence regarding the domains and representative measures that exist in actigraphy assessed sleep is lacking. We aime...
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Purpose: Physical activity has been associated with several individual dimensions of sleep. However, the association between physical activity and sleep health, a construct that emphasizes the multidimensional nature of sleep, has not been explored. This analysis examined the relationship between physical activity and a composite measure of sleep...
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Objective To examine violent crime in relation to sleep and explore pathways, including psychological distress, safety perceptions and perceived police presence, that may account for associations. Methods In 2018, 515 predominantly Black American (94%) adults (Pittsburgh, Pennsylvania, USA) provided survey data: actigraphy-assessed sleep duration...
Article
Objectives Higher 24-hour blood pressure (BP) and blunted BP dipping during sleep and night-time hours are associated with adverse health outcomes. Night shift work may affect 24-hour BP and dipping patterns, but empirical data in emergency medical services (EMS) clinician shift workers are sparse. We implemented ambulatory blood pressure monitorin...
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Background The aims of the study were to understand sleep problems and their effects in advanced cancer patients and spousal and intimate partner caregivers and to examine the directionality of the link between patients’ and caregivers’ sleep problems. Methods Fifty-four advanced cancer patients and their spousal and intimate partners were administ...
Article
Objectives The association between sleep and adiposity (indexed by body mass index or waist-to-hip ratio) has typically been evaluated using a single dimension of self-reported sleep. However, other dimensions and behavioral measures of sleep may also be associated with adiposity. This study evaluated whether multidimensional sleep health calculate...
Article
Study objectives The current study examined the prevalence and correlates of obstructive sleep apnea in a sample of low-income, predominantly African-American women using two waves of data. Methods Participants were adults from two urban neighborhoods who enrolled in the PHRESH Zzz Study (N = 828; Pittsburgh Hill/Homewood Research on Neighborhoods...
Article
Introduction Cognitive behavioral therapy for insomnia (CBT-I) reduces insomnia severity among individuals with insomnia and major depressive disorder (MDD). Understanding the long-term trajectories of insomnia symptom severity has the potential to inform optimization of CBT-I in this population. The objectives of this study were to examine traject...
Article
Introduction Early termination (i.e., dropout) from cognitive-behavioral therapy for insomnia (CBT-I) likely attenuates benefits and may reduce motivation for future treatment. The aim of the current study was to identify characteristics of participants who dropped out of CBT-I in an RCT of combined treatment for depression and insomnia. Methods P...
Article
Introduction Sleep quantity and continuity vary across the lifespan. Actigraphy is reliable, ecologically valid, and is the most widely-used behavioral measure of sleep in research and personal health monitoring. The extent to which age is associated with actigraphy-assessed sleep has not been evaluated across the lifespan. The aim of this meta-ana...
Article
Introduction Individual sleep health characteristics (e.g. efficiency, timing, duration, architecture) and signs and symptoms of sleep disorders (e.g., difficulty falling and staying asleep, apnea hypopnea index, measures of oxygen desaturation) predict mortality in adults using traditional regression methods. However, it is important to examine an...
Article
Introduction Approximately 15% of full-time employees in the U.S. work outside the traditional daytime schedule. These individuals exhibit circadian rhythm abnormalities and increased rates of cardiovascular disease compared to day shift workers. Altered circadian patterns of cardiovascular function may persist into retirement even after returning...
Article
Introduction Insomnia is commonly comorbid with, and may contribute to, hypertension. Cognitive-behavioral treatments improve insomnia, but their effects on hypertension are uncertain, and they are often unavailable in primary care practices, where most INS-HTN patients are treated. We evaluated the efficacy of Brief Behavioral Treatment for Insomn...
Article
Study objectives: High frequency electroencephalographic (EEG) activity (>16 Hz activity) is often elevated during non-rapid eye movement (NREM) sleep among individuals with insomnia, in line with the hyperarousal theory of insomnia. Evidence regarding sleep depth marked by slow-wave activity (<4 Hz) is more mixed. Distinguishing subcomponents of...
Article
Background Women with prepregnancy overweight/obesity are at high risk for obstetric complications and cardiometabolic disease. Poorer sleep quality is associated with obesity in non-pregnant individuals and, during pregnancy, poor sleep predicts negative obstetric and health outcomes. This study examined sleep patterns among women with overweight/...
Article
Study Objectives To estimate the association of self-reported poor sleep in multiple dimensions with health care costs in older men. Methods Participants were 1413 men (mean [SD] age 76.5 [5.7] years) enrolled in both the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) study and Medicare Fee-for-Service. Poor sleep was characterized at the b...
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The concept of sleep health provides a positive holistic framing of multiple sleep characteristics, including sleep duration, continuity, timing, alertness, and satisfaction. Sleep health promotion is an underrecognized public health opportunity with implications for a wide range of critical health outcomes, including cardiovascular disease, obesit...
Article
Background: Compared to day workers, shift workers face an elevated risk of cardiovascular disease. We reviewed the evidence to address the research question: Does acute exposure to shift work impact (blunt) the natural drop (dip) in Blood Pressure (BP) occurring during sleep and/or nighttime hours? (PROSPERO CRD42018110847). Methods: We performed...
Article
Purpose: The aim of the study was to investigate associations between sleep disturbances and mental health in adolescents. Methods: Data are from a national sample of 11,670 U.S. participants (5,594 females, aged 9 -10 years, 63.5% white) in the Adolescent Brain Cognitive Development study. Initial longitudinal analyses were conducted for a subset...
Article
African Americans and socioeconomically disadvantaged individuals have higher rates of a variety of sleep disturbances, including short sleep duration, poor sleep quality, and fragmented sleep. Such sleep disturbances may contribute to pervasive and widening racial and socioeconomic (SES) disparities in health. A growing body of literature demonstr...
Article
Rationale: Sleep constitutes a fundamental pillar of health in individuals and is an indicator of the health of a population. Objectives: Aiming to develop an easy-to-use tool to measure sleep health, we translated into Spanish, adapted and validated the Satisfaction Alertness Timing Efficiency Duration (SATED) questionnaire. Methods: The reli...
Article
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Background: Individual dimensions of sleep health, including satisfaction, sleepiness/alertness, timing, efficiency, and duration, are associated with depression. We investigated whether a composite sleep health score is associated with symptoms of depression among Japanese female hospital nurses. Methods: Participants were nurses (n=2482, all wome...
Article
Study objectives: Determine the association of poor multidimensional sleep health with health-care costs and utilization. Methods: We linked 1,459 community-dwelling women (mean age 83.6 years) participating in the Study of Osteoporotic Fractures Year 16 visit (2002-2004) with their Medicare claims. Five dimensions of sleep health (satisfaction,...
Poster
Full-text available
Shiftwork status was negatively associated with sleep satisfaction (B=-7.11, SE=3.41, p=0.039) and optimal sleep timing in retirement (OR=0.392, SE=0.190, p=0.054) after adjusting for educational attainment. Mean sleep health composite scores differed significantly between DSW (M=4.31, SD=1.26) and NSW (M=3.61, SD=1.61); (t=2.52, p=0.013). * Impl...
Article
Introduction: The Patient Reported Outcomes Information System (PROMIS) includes two instruments to quantify sleep symptoms (sleep disturbance, SDA; sleep-related impairment, SRI) in diverse populations across a wide symptom spectrum. However, the responsiveness of PROMIS measures to treatment of sleep disorders is unknown. We examined the respons...
Article
Objectives Self-reported activity restriction is an established correlate of depression in dementia caregivers (dCGs). It is plausible that the daily distribution of objectively measured activity is also altered in dCGs with depression symptoms; if so, such activity characteristics could provide a passively measurable marker of depression or specif...
Article
Objectives: To reveal sleep health phenotypes in older adults and examine their associations with time to 5-year all-cause and cardiovascular mortality. Design: Prospective longitudinal cohorts. Setting: The Study of Osteoporotic Fractures and Outcomes of Sleep Disorders in Older Men Study. Participants: N = 1722 men and women aged ≥65 years...