Daniel Abler

Daniel Abler
HES-SO Valais-Wallis | HES-SO · Bereich eHealth

PhD

About

45
Publications
4,098
Reads
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422
Citations
Citations since 2016
28 Research Items
281 Citations
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2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080

Publications

Publications (45)
Article
Full-text available
Abstract The hemodynamic behavior following endovascular treatment of patients with peripheral arterial disease plays a significant role on the occurrence of restenosis in femoro-popliteal (FP) arteries. The atheroprone flow conditions that are generally accepted to promote restenosis can be calculated by computational fluid dynamics (CFD) analyses...
Article
Full-text available
Background: Glioblastoma (GBM) is the deadliest and most common brain tumor in adults, with poor survival and response to aggressive therapy. Limited access of drugs to tumor cells is one reason for such grim clinical outcomes. A driving force for therapeutic delivery is interstitial fluid flow (IFF), both within the tumor and in the surrounding b...
Preprint
Background: Glioblastoma is the deadliest, yet most common, brain tumor in adults, with poor survival and response to aggressive therapy. Therapeutic failure results from a number of causes inherent to these tumors. Imaging, computational, and drug delivery approaches can aid in the quest to access and kill each tumor cell in patients. One factor,...
Article
Full-text available
While targeted therapies exist for human epidermal growth factor receptor 2 positive (HER2 +) breast cancer, HER2 + patients do not always respond to therapy. We present the results of utilizing a biophysical mathematical model to predict tumor response for two HER2 + breast cancer patients treated with the same therapeutic regimen but who achieved...
Preprint
Full-text available
While targeted therapies exist for human epidermal growth factor receptor 2 positive (HER2+) breast cancer, HER2+ patients do not always respond to therapy. We present the results of utilizing a biophysical mathematical model to predict tumor response for two HER2+ breast cancer patients treated with the same therapeutic regimen but who achieved di...
Chapter
There were two pretty dragons Hydra and Medusa who were known in ancient times as the best friends around.Once they had a small tiff with each claiming to be more beautiful and colorful.
Article
Full-text available
Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours. There is a desperate need to quantitatively study the factors that contribute to the efficacy of CAR T-cell therapy in solid tumours. In this wo...
Chapter
Gliomas are the most common malignant brain tumors in adults, with Glioblastoma (GBM) being the most agressive subtype. GBM is clinically evaluated with magnetic resonance imaging (MRI) and presents with different growth phenotypes, involving varying degrees of healthy tissue invasion and tumor induced herniation, also known as mass effect. GBM gro...
Article
Chimeric antigen receptor (CAR) T-cell therapy is an emerging targeted immunotherapy which has shown success in liquid cancers such as leukemias. CAR T-cells are also being used for the treatment of solid tumors such as glioblastoma, which is a primary brain tumor. Ongoing phase I trials have been designed to evaluate CAR T-cell dosing, scheduling,...
Preprint
Full-text available
Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of hematological cancers and is currently being investigated for solid tumors including high-grade glioma brain tumors. There is a desperate need to quantitatively study the factors that contribute to the efficacy of CAR T-cell therapy in solid tumors. In this work we...
Article
Purpose: To determine surgical parameters for arcuate keratotomy by simulating the intervention with a patient-specific model. Setting: University Eye Clinic Salzburg, Paracelsus Medical University, Austria, and Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland. Design: Computational modeling study. Methods:...
Chapter
Full-text available
Glioblastoma (GBM) is the most frequent malignant brain tumor in adults and presents with different growth phenotypes. We use a mechanically coupled reaction–diffusion model to study the influence of structural brain tissue anisotropy on tumor growth. Tumors were seeded at multiple locations in a human MR-DTI brain atlas and their spatiotemporal ev...
Conference Paper
Biomechanical forces are known to affect tumor growth and evolution [1]. Likewise, tumor growth drives physical changes in the micro-environment that affect tissue solid and fluid mechanics. Tumor mass effect, resulting from rapid tumor cell proliferation, has been shown to be prognostic for poor outcome in glioblastoma (GBM) patients and to be ass...
Conference Paper
Full-text available
Interstitial fluid flow around brain tumors is increased above normal levels. This force has been shown to drive tumor cell invasion in brain tumors and alter the extracellular matrix, vasculature, immune and cellular niches in non-nervous tissues in ways that promote tumor progression [1]. Here, by applying our dynamic contrast enhanced MRI method...
Article
Elevated tumor mass-effect is associated to poor prognosis in GBM [1,2]. However, tumor mass-effect is poorly quantified in clinical practice. Recently, Steed et al. [2] proposed ‘Lateral ventricle displacement’ (LVd), defined as the change in center-of-mass position of the lateral ventricles between an undeformed reference and the tumor-bearing an...
Article
Chimeric antigen receptor (CAR) T-cell therapy is a promising emerging area of immunotherapy for the treatment of recurrent glioblastoma. In this therapy, T-cells are genetically modified to target tumor-specific antigens. Efficacy of CAR T-cell therapy depends on several factors, including CAR T-cell proliferation, persistence, and tumor cell kill...
Article
Full-text available
Glioblastoma (GBM), a highly aggressive form of brain tumor, is a disease marked by extensive invasion into the surrounding brain. Interstitial fluid flow (IFF), or the movement of fluid within the spaces between cells, has been linked to increased invasion of GBM cells. Better characterization of IFF could elucidate underlying mechanisms driving t...
Article
Full-text available
Background: This study proposes a method for inferring the premorbid glenoid shape and orientation of scapulae affected by glenohumeral osteoarthritis (OA) to inform restorative surgery. Methods: A statistical shape model (SSM) built from 64 healthy scapulae was used to reconstruct the premorbid glenoid shape based on anatomic features that are...
Article
Full-text available
Here we present a theoretical and mathematical perspective on the process of aging. We extend the concepts of physical space and time to an abstract, mathematically-defined space, which we associate with a concept of “biological space-time” in which biological dynamics may be represented. We hypothesize that biological dynamics, represented as traj...
Preprint
Full-text available
Background: This study proposes a method for inferring the premorbid glenoid shape and orientation of scapulae affected by glenohumeral osteoarthritis (OA) to inform restorative surgery. Methods: A statistical shape model (SSM) built from 64 healthy scapulae was used to reconstruct the premorbid glenoid shape based on anatomic features that are con...
Chapter
Full-text available
The macroscopic growth of brain tumors has been studied by means of different computational modeling approaches. Glioblastoma multiforme (GBM) is the most common malignant type and is commonly modeled as a reaction–diffusion type system, accounting for its invasive growth pattern. Purely biomechanical models have been proposed to represent the mass...
Preprint
Here we present a theoretical and mathematical perspective on the process of aging. We extend the concepts of physical space and time to an abstract, mathematically-defined space, which we associate with a concept of “biological space-time” in which biological clocks operate. We hypothesize that biological dynamics, represented as trajectories in b...
Article
GBMs present with different growth phenotypes, ranging from invasive lesions without notable mass-effect to strongly displacing lesions that induce mechanical stresses and result in healthy-tissue deformation, midline shift or herniation. Biomechanical forces, such as those resulting from displacive tumor growth, are recognized to shape the tumor e...
Article
Introduction: Continence results from a complex interplay between anal canal (AC) muscles and sensory-motor feedback mechanisms. The AC's passive ability to withstand opening pressure - its compliance - has recently been shown to correlate with continence. Functional lumen imaging probe (FLIP) is used to assess AC compliance, although it provides...
Conference Paper
Full-text available
The large scale integrating Euro-American research project CHIC (“Computational Horizons in Cancer: Developing Meta- and Hyper-Multiscale Models and Respositories for In Silico Oncology”) [1] which is funded by the European Commission aims at developing an efficient and robust scientific and technological framework able to support the development o...
Article
The vacuum window and in-beam ion detection of a radiobiological endstation have been studied using the Monte Carlo particle transport code MCNPX 2.5.0, investigating the effects of different elements on an incident beam of 50 MeV protons. The scattering and energy spread as well as secondary particle generation are analysed. A 200 nm thick silicon...
Article
The Low Energy Ion Ring (LEIR) at CERN has been proposed to provide ion beams with magnetic rigidities up to 6.7 T.m for biomedical research, in parallel to its continued operation for LHC and SPS fixed target physics experiments. In the context of this project, two beamlines are proposed for transporting the extracted beam to future experimental e...
Article
A proposal is here presented for a new slow extraction scheme for the Low Energy Ion Ring (LEIR) in the context of the feasibility study for a future biomedical research facility at CERN. The new slow extraction system is based on the third-integer resonance. Two resonance driving mechanisms have been studied: the quadrupole-driven method and the R...
Article
Full-text available
In light of the recent European developments in ion beam therapy, there is a strong interest from the biomedical research community to have more access to clinically relevant beams. Beamtime for pre-clinical studies is currently very limited and a new dedicated facility would allow extensive research into the radiobiological mechanisms of ion beam...
Article
Full-text available
The European PARTNER project developed a prototypical system for sharing hadron therapy data. This system allows doctors and patients to record and report treatment-related events during and after hadron therapy. It presents doctors and statisticians with an integrated view of adverse events across institutions, using open-source components for dat...
Article
Full-text available
Decision-making processes in medicine rely increasingly on modelling and simulation techniques; they are especially useful when combining evidence from multiple sources. Markov models are frequently used to synthesize the available evidence for such simulation studies, by describing disease and treatment progress, as well as associated factors such...
Conference Paper
Full-text available
To make reliable, safe, and effective use of data outside the context of its collection, we require an adequate understanding of its meaning. In data-intensive science, as in many other applications of computing, this necessitates the association of each item of data with complex, detailed metadata. The most important, most useful piece of metadata...
Article
LuAG:Ce single crystals with various activator concentrations were grown by the vertical Bridgman technique. Characterization of crystals was done in terms of actual doping level, macroscopic defects and degree of non-equivalent substitutions by Lu for Al in octahedral lattice sites. Scintillation measurements were performed using 2×2×8 mm3 shaped...
Article
Full-text available
The main objective of this contribution is to point out the potentialities of cerium doped LuAG single crystal as pixels and fibers. We first show that after optimization of growth conditions using Bridgman technology, this composition exhibits very good performances for scintillating applications (up to 26 000 photons/MeV). When grown with the mic...
Article
One of the main challenges for detectors at future high-energy collider experiments is high-precision measurement of hadrons and jet energy and momentum. Such measurement can be provided by the particle flow approach (PFA) that requires a complex highly segmented calorimeter system to identify and to track all particles in a jet. An alternative so-...
Conference Paper
One of the main challenges for detectors at future high energy collider experiments is high precision measurement of hadrons and jet energy and momentum. One possibility to enable such measurement is the particle flow approach (PFA) that requires a complex highly segmented calorimeter system to identify and to track all particles in a jet. An alter...
Conference Paper
High precision measurement of hadrons and jet energy and momentum is one of the main challenges for detectors at future high energy collider experiments. Currently, two approaches are considered to achieve this goal. In the particle flow approach (PFA), a complex highly segmented calorimeter system is required to identify and to track all particles...
Article
Full-text available
A long x-ray pathway based on an x-ray back-diffraction cavity for coherent x-ray beam experiments is presented. In the present work, such a setup was tested and used for propagation-based x-ray phase contrast imaging (PBI). This setup showed to be useful for PBI purposes, with the advantage of being compact (3 m long) when compared with long x-ray...

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Projects

Projects (5)
Archived project
Development of a prototype information sharing platform between emerging EU Charged-Particle Therapy Centers. In context of 'Particle Training Network for European Hadron Therapy' (PARTNER) project. http://partner.web.cern.ch/
Archived project
Development of coupled tumor-growth / tumor-biomechanics simulation tool as part of CHIC Hypermodeling architecture: CHIC aspires to make a breakthrough in multiscale cancer modeling through greatly facilitating multi-modeller cancer hypermodelling and its clinical adaptation and validation. http://www.chic-vph.eu