Dania Cheaha

Prince of Songkla University · Department of Biology

A 1:1 ratio of cannabidiol to tetrahydrocannabinol (CT) was suggested to be safer for therapeutic purposes in many illnesses. However, CT effects on methamphetamine (METH) conditioned place preference (CPP) remained largely unexplored. This study aimed to examine the effects of CT on METH CPP mice evaluated by animal behaviors accompanied by local...

Background Kratom is a psychoactive plant used to enhance productivity among laborers in Southeast Asian countries. Previous findings from in vitro research of mitragynine, a major component of kratom, suggested a possible risk of heart function abnormality. However, the cardiac autonomic function in long-term kratom users with chewing forms has ne...

Previously, bupropion (BUP), a norepinephrine (NE)/dopamine (DA) transporter blocker and nicotinic acetylcholine receptors (nAChRs) antagonist, was found to intensify methamphetamine (METH) craving behaviours in mice. Intense craving causes relapse in drug dependence. This study characterized local field potential (LFP) patterns in the brain region...

Purpose Chronic psychological stress aggravates painful bladder syndrome symptoms. Previous studies suggest roles of 5-HT3 receptors in regulating micturition and bladder hypersensitivity. This study aimed to investigate the roles of 5-HT3 receptors in modulating voiding patterns and spontaneous bladder contractile properties in water avoidance str...

Kratom (KT) typically exerts antidepressant (AD) effects. However, evaluating which form of KT extracts possesses AD properties similar to the standard AD fluoxetine (flu) remained challenging. Here, we adopted an autoencoder (AE)-based anomaly detector called ANet to measure the similarity of mice's local field potential (LFP) features that respon...

Water avoidance stress is an established animal model used to mimic psychological stress inhumans. Our study aimed to investigate changes in anxiety-related behavior using an openfield test and hippocampal neuron density in mice with repeated water avoidance stress. Adultmale C57BL/6NJcl mice (6-8 weeks old) were divided into sham stress (SS) and w...

Kratom (Mitragyna speciosa) is a tropical tree native to Southeast Asia including Thailand and Malaysia. Its leaves have been used by laborers and farmers to increase endurance to hard work and relieve fatigue. This study aimed to investigate the effect of water extract from kratom leave containing 10 mg/kg mitragynine on locomotor activity using a...

An increasing problem in today’s society is the spiraling number of people suffering from various sleep disorders. The research results presented in this paper support the use of a novel method that employs techniques from the classification of sleep disorders for more accurate scoring. Applying this novel method will assist researchers with better...

The synthetic amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy, is extensively used as a recreational drug by adolescents due to its psychoactive effect. Chronic MDMA administration causes irreversible damage to serotonergic (5-HT) neurons, resulting in a long-term persistent depletion of 5-HT levels in the brain. Long-ter...

Neurophysiological characteristics of long-term Kratom users have been challenged for identification due to the lack of evidence. Long-term and high Kratom consumption caused concern, particularly in older adults. Thus, the study aims to explore EEG biomarkers in long-term Kratom users (LKU) based on consumer-grade EEG systems. The fifty-two partic...

Ethnopharmacological relevance: Mitragyna speciosa (Korth.) Havil., popularly known as Kratom (KT), is a medicinal plant used for pain suppression in Southeast Asia. It has been claimed to assist drug users withdraw from methamphetamine (METH) dependence. However, its use was controversial and not approved yet. Aim of the study: This study was co...

KEYWORDS: Conditioned place preference; Craving behaviors; Kratom; Local field potential; Medial prefrontal cortex; Mitragyna speciosa INTRODUCTION: Mitragyna speciosa (Korth.) Havil. (MS), also known as kratom plant, has been used to alleviate craving for methamphetamine (METH) in communities of southeastern Asian countries. However, it remained t...

INTRODUCTION: Nucleus accumbens (NAc), which is part of the ventral striatum, plays a major role in reward processing, reinforcement learning, and impulsivity. Reward-related stimuli including addictive substances activate dopamine release in the NAc and produce euphoria. This brain area has been used as a target site for the study of addictive dru...

Phase-amplitude coupling (PAC) of local field potential (LFP) has been recognized as higher-order representation of brain states. Neuronal loss in the striatum leads to Parkinson's disease (PD) symptoms and modifies LFP oscillation. However, PAC in the striatum of PD mouse model induced by 6-hydroxydopamne (6-OHDA) remained to be investigated. Male...

The basolateral amygdala (BLA) plays a crucial role in conditioned place preference (CPP) for addictive drugs. However, neural signaling associated with methamphetamine (METH) craving and seeking remained to be investigated. This study characterized local field potential (LFP) oscillatory patterns in the BLA and conditioned place preference induced...

Ethnopharmacological relevance Lavandula angustifolia Mill. essential oil (Lavender EO) has a long history of medicinal use and is particularly claimed to possess anxiolytic and sedative properties. Lavender EO aromatherapy has been used to reduce distress and improve insomnia naturally. Increasing evidence appeared to show similarities between the...

There is an on-going debate about medicinal use of kratom plant (Mitragyna speciosa (MS)) on whether it has beneficial or adverse effects. This study aimed to examine long-term weight-reducing effects, toxicity, and dopamine pathway activation of MS alkaloid extract on adult male Wistar rats. In anorexic study, the rats were divided into 3 groups (...

Neural adaptation associated with formation of morphine conditioned place preference remained largely unexplored. This study monitored longitudinal changes in neural signaling during pre-conditioning, conditioning and post-conditioning periods of morphine conditioned place preference (CPP) paradigm for investigation of adaptive mechanisms of opiate...

Social behaviors can be defined as any modality of communication and/or interaction between two conspecifics of a given species. The social behaviors displayed in an inappropriate way can have detrimental effects. Impaired sociability had also associated with various kinds of neuropsychiatric disorders including depression, anxiety, or schizophreni...

Addictive-like eating behavior has been studied to understand the underlying mechanisms of food addiction-induced obesity disease. The highly palatable food including chocolate can trigger addiction processing by activating the same drug-generated reward system in the brain. However, the influences of chocolate consumption especially without fastin...

Background Citrus essential oil (EO) has been used for mood elevation and sedative hypnotic purposes. However, scientific proofs of its central nervous system (CNS) action remained largely unexplored. This study investigated chemotypes, electrical brain waves and sleep-wake effects of the essential oil from Citrus reticulata in rat model. Material...

The efficacy of pseudoephedrine (PSE) as a nasal decongestant has been well‑demonstrated; however, PSE is strictly prescribed as a control substance due to its controversial psychostimulant effects. Although standard stimulatory drugs increase exploratory behavior and stimulate the dopamine system, the exact effects of PSE on locomotion and electri...

The hippocampus is one of the stress-sensitive limbic structures implicated in the pathophysiology of mood-associated disorders, including depression. Convergent lines of research implicate the hippocampus in the pathogenesis of major depression disorders (MDD). Fluoxetine, a selective serotonin inhibitor (SSRI), has been effectively used in the cl...

Previously, satiated animals or human subjects can still be motivated to eat by palatable food-associated cues. However, neural circuitries of hedonic hunger have not been well investigated. This study identified neural network connectivities between major brain areas in response to chocolate-associated cues following repeated exposures to chocolat...

Food deprivation is known to trigger hunger sensation and motivation to eat for energy replenishing. However, brain mechanisms associated with hunger and neural circuitries that mediate hunger driven responses remained to be investigated. To understand neural signaling of hunger, local field potentials (LFPs) in the lateral hypothalamus (LHa), nucl...

Purpose: To investigate the relationship between BMI and selected ocular parameters. Subjects and methods: Fifty-three left eyes of normal weight subjects and 67 age-sex matched overweight subjects were studied. Inclusion criteria for the normal weight and overweight groups included BMI between 18.5–22.9 and 23.0–29.9 kg/m², respectively. Subjects...

Glucocorticoids arising from chronic stress and long-term inflammatory treatment with corticosteroids are both associated with neuropathology and cognitive impairments. Many previous studies have focused on changes in brain morphology and deficits in learning behavior. However, effects of long-term exposure to stress hormones on electrical brain si...

In the past decade, neural processing has been extensively studied in cognitive neuroscience. However, neural signaling in the nucleus accumbens (NAc) that might clarify reward process remained to be investigated. Male Swiss albino ICR mice implanted with intracranial electrodes into the NAc and the ventral tegmental area (VTA) were used for morphi...

Ethnopharmacological relevance: Mitragyna speciosa (Korth.) Havil. (M. speciosa) is among the most well-known plants used in ethnic practice of Southeast Asia. It has gained increasing attention as a plant with potential to substitute morphine in addiction treatment program. However, its action on the central nervous system is controversial. Aim...

Eating motivation is induced not only by negative energy balance but also food related cues. However, neural processing for acquisition of learned food preference remains to be established. This study aimed to identify hippocampal neural signaling in response to olfactory cue (chocolate scent) after completion of repetitive chocolate sessions. Male...

Background: Essential oils (EOs) have been claimed to modulate mental functions though the most of data were obtained from subjective methods of assessment. Direct effects of EO on brain function remained largely to be confirmed with scientific proof. This study aimed to demonstrate quantifiable and reproducible effects of commercial vetiver (Veti...

Background Many antidepressants are effective in alleviating ethanol withdrawal symptoms. However, most of them suppress rapid eye movement (REM) sleep. Thus, development of antidepressants without undesirable side effects would be preferable. Previously, crude alkaloid extract from Mitragyna speciosa (MS) Korth was found to produce antidepressant...

The lateral hypothalamus plays an important role in homeostasis. It is sensitive to negative energy balance and believed to interact with other brain regions to mediate food seeking behavior. However, no neural signaling of hunger in the lateral hypothalamus has been studied. Male Swiss albino mice implanted with intracranial electrodes into the la...

Valroic acid (VPA) mouse model of autism spectrum disorder (ASD) has been characterized mostly by impaired ultrasonic vocalization, poor sociability and increased repetitive self-grooming behavior. However, its neural signaling remained unknown. This study investigated the local field potentials (LFPs) in the dorsal hippocampal CA1 and the olfactor...

Previously, autism spectrum disorder (ASD) has been identified mainly by social communication deficits and behavioral symptoms. However, a link between behaviors and learning process in the brain of animal model of autism remained largely unexplored. Particularly, spontaneous neural signaling in learning-related brain areas has not been studied. Th...

Antidepressants have been used for treatment of ethanol withdrawal symptoms mainly in observational studies. However, cortical frequency oscillation of ethanol withdrawal treatment with antidepressants remained to be elucidated. This study aimed to identify surrogate biomarkers that represent intact biological or ethanol withdrawal processes and re...