Dang Duc Anh

Dang Duc Anh
National Institute of Hygiene and Epidemiology | NIHE

PhD

About

334
Publications
38,942
Reads
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6,934
Citations
Additional affiliations
March 2015 - April 2016
National Institute of Hygiene and Epidemiology
Position
  • Research Director

Publications

Publications (334)
Article
Full-text available
“Rotavin-M1” is an oral live-attenuated vaccine that prevents diarrhea in children under five years old, produced from rotavirus strains G1P [1] on Vero cells. This vaccine has been studied for 16 years beginning with monitoring the local circulating strain and eventually establishing a seed lots system. The safety and immunogenicity of the vac...
Article
Rotavirus (RV), Norovirus (NV), Sapovirus (SaV) and Astrovirus (Ast) are the leading causes of gastroenteritis and mortality in children worldwide. RV vaccines help to reduce the burden of diarrhea while the importance of other viruses is increasing. Therefore, we conducted a cross-sectional descriptive study to determine prevalence of these viruse...
Article
Nghiên cứu cắt ngang được thực hiện nhằm mô tả kiến thức, thái độ và thực hành liên quan đến kháng sinh và kháng kháng sinh trong chăn nuôi ở người làm chăn nuôi và một số yếu tố liên quan tại xã Yên Nam, huyện Duy Tiên, tỉnh Hà Nam năm 2019. Nghiên cứu thực hiện trên 139 đối tượng, sử dụng bộ câu hỏi và thang điểm để đánh giá kiến thức, thái độ và...
Article
This was a cross-sectional community-based serological survey of polio antibodies assessing the immunogenicity of inactivated poliovirus vaccine (IPV) focusing on poliovirus serotype 2. IPV was administered to 5-month-old children. Type 2 antibody seroprevalence when measured 1 month after IPV administration was >95%. One IPV dose successfully clos...
Article
Nghiên cứu cắt ngang nhằm mô tả thực trạng nhiễm HBV ở phụ nữ trong độ tuổi sinh đẻ từ 18 - 49 tuổi tạikhu vực Tây Bắc năm 2018. Nghiên cứu được thực hiện trên 1.064 phụ nữ trong độ tuổi sinh đẻ từ 18 - 49 tuổi tại khu vực Tây Bắc bao gồm 4 tỉnh Hoà Bình, Sơn La, Điện Biên, Lai Châu từ tháng 9/2018 đến tháng 3/2019. Kết quả nghiên cứu cho thấy tỉ l...
Article
Plasmid-Mediated Colistin Resistance 1 ( mcr-1 ) was first reported in 2015 and is a great concern to human health. In this study, we investigated the prevalence of mcr-1 and mcr-1 -positive Escherichia coli (MCRPEC) and the association in infection status among various reservoirs connected to livestock. The study was conducted in 70 poultry and sw...
Article
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Background: Infants are at highest risk of pneumococcal disease. Their added protection through herd effects is a key part in the considerations on optimal pneumococcal vaccination strategies. Yet, little is currently known about the main transmission pathways to this vulnerable age group. Hence, this study investigates pneumococcal transmission r...
Preprint
Background Vietnam has high rates of antibiotic resistance, driven by overuse in agriculture, hospital, and community healthcare. Measures of resistance in commensal bacteria could provide a hard indicator for progress in evaluating the impact of interventions to reduce antibiotic use in the community. This study aimed to evaluate the feasibility,...
Preprint
Background Vietnam has high rates of antibiotic resistance, driven by overuse in agriculture, hospital, and community healthcare. Measures of resistance in commensal bacteria could provide a hard indicator for progress in evaluating the impact of interventions to reduce antibiotic use in the community. This study aimed to evaluate the feasibility,...
Article
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Background Characterising dengue virus (DENV) infection history at the point of care is challenging as it relies on intensive laboratory techniques. We investigated how combining different rapid diagnostic tests (RDTs) can be used to accurately determine the primary and post-primary DENV immune status of reporting patients during diagnosis. Method...
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Wolbachia is an endosymbiotic bacterium that can restrict the transmission of human pathogenic viruses by Aedes aegypti mosquitoes. Recent field trials have shown that dengue incidence is significantly reduced when Wolbachia is introgressed into the local Ae. aegypti population. Female Ae. aegypti are anautogenous and feed on human blood to produce...
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Background Trends in the public perception and awareness of COVID-19 over time are poorly understood. We conducted a longitudinal study to analyze characteristics and trends of online information during a major COVID-19 outbreak in Da Nang province, Vietnam in July-August 2020 to understand public awareness and perceptions during an epidemic. Meth...
Article
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The Infant Behavior Questionnaire-Revised (IBQ-R) assesses the temperament of infants in Western and non-Western countries. Although its factor analyses revealed three factors—surgency, negative affectivity, and effortful control—in the Western culture, the degree to which these are universal or culturally specific is unclear. This study developed...
Article
Background . To our knowledge, it is the first report on the seroprevalence of human leptospirosis and its epidemiological profile in three different geographical and climatic zones of Vietnam. Methodology . A hospital-based surveillance in eleven public hospitals in three provinces in Vietnam enrolled 3,815 suspected patients with leptospirosis....
Article
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Background/aim: Cervical cancer is the second most common malignancy among women in Vietnam, but the country is yet to introduce a national human papillomavirus (HPV) vaccine programme targeted at adolescents. We determined HPV prevalence and HPV vaccine knowledge among female university students in Vietnam. Patients and methods: We surveyed and...
Article
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Studies of successive vaccination suggest that immunological memory against past influenza viruses may limit responses to vaccines containing current strains. The impact of memory induced by prior infection is rarely considered and is difficult to ascertain, because infections are often subclinical. This study investigated influenza vaccination amo...
Article
Even one case of foodborne botulism constitutes a public health emergency. We report a series of cases with delayed treatment due to delayed diagnosis. Clostridium botulinum type A(B) was isolated from vegetarian home-canned pate, but not from stool samples. These are the first recorded cases of foodborne botulism in Hanoi.
Article
The objective of the study was to determine the prevalence of E. coli carrying the gene encoding ESBLs in patients with common diseases visiting primary health care centres in 8 provinces of the Northern region (Ha Noi, Ha Nam, Hai Duong, Bac Ninh), the Central region (Thua Thien - Hue, Khanh Hoa), and the Southern region (Can Tho, Ben Tre) of Viet...
Article
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Aim There are few reliable estimates of the half-lives of maternal antibodies to the antigens found in the primary series vaccines. We aimed to calculate the half-lives of passively acquired diphtheria, tetanus and pertussis (DTP) antibodies in infants. We aimed to determine whether decay rates varied according to country, maternal age, gestational...
Article
Nghiên cứu này nhằm mục tiêu đánh giá bộ sinh phẩm phát hiện kháng thể IgG/M kháng SARS-CoV-2 bằng ELISA do POLYVAC sản xuất (Polyvac SARS-CoV-2 IgG/M ELISA). Nghiên cứu được tiến hành trên 633 mẫu huyết thanh gồm 302 mẫu dương tính và 331 mẫu âm tính lấy từ bệnh nhân (2020) đã được khẳng định bằng RT-PCR. Có 200 mẫu dương tính và 200 mẫu âm tính đ...
Article
Tăng cường đảm bảo chất lượng xét nghiệm thông qua các bộ mẫu ngoại kiểm ngày càng phổ biến trong hệ thống xét nghiệm tại Việt Nam. Mục tiêu của nghiên cứu là xây dựng và đánh giá bộ mẫu ngoại kiểm máu toàn phần cho chương trình ngoại kiểm huyết thanh học HIV tại Việt Nam chocác phòng xét nghiệm (PXN) sử dụng mẫu máu đầu ngón tay. Bộ mẫu được sản x...
Article
Theo khuyến cáo của Tổ chức Y tế thế giới, từ năm 2013, Bộ Y tế giao nhiệm vụ cho Viện Vệ sinh dịch tễ Trung ương (VSDTTƯ) xây dựng và ban hành phương cách xét nghiệm HIV quốc gia để hạn chế các sai sót trong chẩn đoán. Mục tiêu của nghiên cứu là xây dựng ngân hàng mẫu chuẩn cho đánh giá phương cách xét nghiệm chẩn đoán HIV. Ngân hàng mẫu chuẩn đã...
Article
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Influenza burden estimates are essential to informing prevention and control policies. To complement recent influenza vaccine production capacity in Vietnam, we used acute respiratory infection (ARI) hospitalization data, severe acute respiratory infection (SARI) surveillance data, and provincial population data from 4 provinces representing Vietna...
Article
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Objectives Carbapenem resistance among nosocomial Gram-negative bacteria in Vietnam is high and increasing, including among Enterobacterales. In this study, we assessed the presence of one of the main carbapenemase genes, blaKPC, among carbapenem-resistant Enterobacterales from four large hospitals in Hanoi, Vietnam, between 2010 and 2015, and desc...
Article
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Objectives Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. We determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population. Methods A cross-sectional study of 799 MSM aged 16 to 50 years old was conducted in Vietna...
Article
Objective: To investigate clinical characteristics and risk factors for atypical community-acquired pneumonia (CAP) in children. Methods: Multiplex polymerase chain reaction and specific IgM determination were used to detect atypical bacteria in 661 hospitalized children aged 1-15 years with CAP. Clinical and epidemiological patterns of were com...
Article
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Background MDR bacteria including carbapenem-resistant Pseudomonas aeruginosa are recognized as an important cause of hospital-acquired infections worldwide. This investigation seeks to determine the molecular characterization and antibiotic resistance genes associated with carbapenem-resistant P. aeruginosa. Methods We conducted WGS and phylogene...
Preprint
Background: Infants are at highest risk of pneumococcal disease. Their added protection through herd effects is a key part in the considerations on optimal pneumococcal vaccination strategies. Yet, little is currently known about the main transmission pathways to this vulnerable age group. Methods and findings: We conducted a nested cross-sectional...
Article
Một nghiên cứu mô tả cắt ngang đã được thực hiện năm 2018 để ước tính tỷ lệ nhiễm các chủng vi rút gây u nhú ở người (HPV) trong 700 phụ nữ bán dâm (PNBD) ở TP. Hà Nội và TP. Hồ Chí Minh. Kết quả cho thấy tỷ lệ nhiễm ít nhất một chủng HPV trong nhóm PNBD ở Việt Nam là 26,4%. Trong số người nhiễm HPV, nhiễm nhiều hơn một chủng chiếm 69,4% và chỉ nhi...
Article
Nghiên cứu mô tả cắt ngang được thực hiện nhằm mô tả tỷ lệ nhiễm HPV và kết quả xét nghiệm ThinPrep Pap ở 700 phụ nữ bán dâm ở Hà Nội và thành phố Hồ Chí Minh năm 2018. Kết quả cho thấy có 26,4% phụ nữ bán dâm nhiễm HPV và 13,6% có kết quả xét nghiệm ThinPrep Pap bất thường. Những phụ nữ bán dâm nhiễm bất kỳ týp HPV có kết quả xét nghiệm tế bào cổ...
Preprint
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a pandemic of acute respiratory disease in humans. This pandemic has now spread worldwide and caused more than 2,000,000 deaths by 15 January 2021. The complexity and the ongoing pandemic of coronavirus SARS-CoV-2 make it difficult to control the disease. Seq...
Article
Full-text available
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a pandemic of acute respiratory disease in humans. This pandemic has now spread worldwide and caused more than 2,000,000 deaths by 15 January 2021. The complexity and the ongoing pandemic of coronavirus SARS-CoV-2 make it difficult to control the disease. Seq...
Article
High-risk human papillomavirus (HPV) genotypes are the leading causes of anogenital cancer, including cervical cancer. Screening these genotypes will potentially alleviate the disease burden that HPV causes. Therefore, NIHERealtime PCR hrHPV was developed based on the principle of multiplex real-time PCR. The objective of this study is to establish...
Article
Background A nationwide measles outbreak occurred in Vietnam between 2013 and 2014. Objectives To provide an overview on the 2013–2014 measles outbreak in northern Vietnam using epidemiological and molecular analysis of the measles virus (MeV). Study design Epidemiological information was collected from all suspected cases of measles/rubella. Ser...
Preprint
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Background The controversial hypothesis that recalled immunological memory limits responses to variant virus strains has been revived by recent reports linking poor vaccine effectiveness against A(H3N2) influenza viruses with prior vaccination. The impact of memory induced by prior infection is rarely considered, and is difficult to ascertain becau...
Article
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Background: Laboratory facilities for etiological diagnosis of central nervous system (CNS) infection are limited in developing countries; therefore, patients are treated empirically, and the epidemiology of the pathogens is not well-known. Tubercular meningitis is one of the common causes of meningitis, which has high morbidity and mortality, but...
Article
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Background The importation of SARS-CoV-2 through air travel poses substantial risks to generate new COVID-19 outbreaks. Timely contact tracing is particularly crucial to limit onwards transmission in settings without established community transmission. Methods We conducted an in-depth analysis of the response to a big flight-associated COVID-19 ou...
Article
Leptospirosis is a zoonosis that spreads worldwide and causes major problems for animal health, but also for human in contact, direct or indirect, with infected animals. The disease is more prevalent in tropical areas because the survival, and then the transmission of the bacteria is favored by the humidity and the animal management conditions such...
Article
Kháng thể mẹ truyền qua nhau thai hoặc qua sữa có thể làm giảm hiệu lực của vắc xin rota uống ở các nước đang phát triển. Nghiên cứu này nhằm mô tả ảnh hưởng của kháng thể trong sữa mẹ đối với đáp ứng miễn dịch với vắc xin phòng tiêu chảy do rotavirus ở Việt Nam, 2015 – 2017. Trong nghiên cứu này 189 trẻ khoẻ mạnh, chia thành 3 nhóm có bú hoàn toàn...
Article
Nhằm ước tính tỷ lệ nhiễm Human Papillomavirus (HPV) và mô tả hành vi nguy cơ lây nhiễm HPV của nhóm nam quan hệ tình dục đồng giới (MSM), 400 MSM ở Hà Nội đã được chọn tham gia nghiên cứu cắt ngang theo phương pháp chọn mẫu “dây chuyền có kiểm soát” (RDS). Đối tượng tham gia nghiên cứu được phỏng vấn trực tiếp và thu thập mẫu dịch hậu môn. Kỹ thuậ...
Article
Bệnh tiêu chảy có tỷ lệ nhiễm và tử vong cao trong nhóm trẻ dưới 5 tuổi, đặc biệt là ở những nước đang phát triển như Việt Nam. Vi rút rota là một tác nhân quan trọng gây tiêu chảy bên cạnh trên 20 tác nhân vi khuẩn, vi rút và ký sinh trùng khác đã được xác định. Tuy nhiên có tới 20% những ca bệnh không xác định được nguyên nhân. Nghiên cứu này nhằ...
Article
Purpose Otitis media with effusion (OME) commonly occurs and persists in young children. It can cause hearing impairment and damage to the tympanic membrane without treatment. We aimed to determine the prevalence and association of Streptococcus pneumoniae in the nasopharynx of healthy children before the introduction of a pneumococcal conjugate va...
Article
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It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 res...
Article
A cluster of severe acute respiratory syndrome coronavirus 2 infections in Danang, Vietnam, began July 25, 2020, and resulted in 551 confirmed cases and 35 deaths as of February 2021. We analyzed 26 sequences from this cluster and identified a novel shared mutation in nonstructural protein 9, suggesting a single introduction into Vietnam.
Article
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Objective This is the first study was conducted to identify the Leptospirosis seroprevalence and serovar distribution among healthy people in different regions in Vietnam. Methods This cross-sectional study was conducted with 600 asymptomatic people in three provinces, representing for the North, the northern Central, and the South of Vietnam from...
Preprint
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Background: Multidrug-resistant bacteria including carbapenem resistant Pseudomonas aeruginosa are recognised as an important cause of hospital-acquired infections worldwide. To determine the molecular characterisation and antibiotic resistant genes associated with carbapenem-resistant P. aeruginosa. Methods: we conducted whole-genome sequencing an...
Article
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We studied sandfly (Diptera: Psychodidae) populations in six provinces of Vietnam. This work explores the diversity of sandfly species according to the province, as well as environment, and updated information on public health since leishmaniasis cases were reported in two provinces. Sandflies were collected using 428 CDC light traps from May 30 to...
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Background Eosinophilic meningitis (EM) is a rare clinical syndrome caused by both infectious and noninfectious diseases. In tropical pacific countries, Angiostrongylus cantonensis is the most common cause. However, the EM definition varies in the literature, and its relation to parasitic meningitis (PM) remains unclear. Methodology/Principal find...
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Background: The cesarean section rate in Vietnam has been increasing especially in urban area. However, limited evidence identified regarding socio-demographic factors of the cesarean section birth. The objective of this study was to determine the current cesarean birth rate and the associated socio-demographic factors among mothers in Nha Trang c...
Article
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Background In dengue-endemic countries, targeting limited control interventions to populations at risk of severe disease could enable increased efficiency. Individuals who have had their first (primary) dengue infection are at risk of developing more severe secondary disease, thus could be targeted for disease prevention. Currently, there is no rel...
Article
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To assess the role of in-flight transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we investigated a cluster of cases among passengers on a 10-hour commercial flight. Affected persons were passengers, crew, and their close contacts. We traced 217 passengers and crew to their final destinations and interviewed, tested, and...
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To detect congenital ZIKV infection (CZI) in a birth cohort and among high-risk neonates in Vietnam, we collected umbilical cord blood plasma samples of newly delivered babies and peripheral plasma samples of high-risk neonates in Nha Trang, central Vietnam, between July 2017 and September 2018. Samples were subjected to serological and molecular t...
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Background: One hundred days after SARS-CoV-2 was first reported in Vietnam on January 23rd, 270 cases were confirmed, with no deaths. We describe the control measures used by the Government and their relationship with imported and domestically-acquired case numbers, with the aim of identifying the measures associated with successful SARS-CoV-2 co...
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Background: The extent to which influenza recurrence depends upon waning immunity from prior-infection is undefined. We used antibody titres of Ha-Nam cohort participants to estimate protection curves and decay trajectories. Methods: 270 households participated in influenza-like-illness surveillance and provided blood at intervals spanning RTPCR...
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We analyzed 2 clusters of 12 patients in Vietnam with severe acute respiratory syndrome coronavirus 2 infection during January-February 2020. Analysis indicated virus transmission from a traveler from China. One asymptomatic patient demonstrated virus shedding, indicating potential virus transmission in the absence of clinical signs and symptoms.
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The Caesarean section rate in urban Vietnam is 43% in 2014, which is more than twice the recommended rate (10%-15%) by the World Health Organization. This qualitative study aims to identify the perceptions of pregnant mothers and health care professionals on the medical and social factors related to the increased Caesarean section rate in Vietnam....
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To understand the epidemiological and genetic background of anthrax cases occurring in Vietnam from 2011 to 2015, we surveilled and genetically analyzed Bacillus anthracis isolated in the north of the country. Epidemiological surveillance showed that most human cutaneous anthrax cases occurred in association with animal dissection. Whole-genome seq...
Article
Influenza virus B belongs to the family Orthomyxoviridae with segmented negative-sense RNA genomes. Since 1970s, influenza B has diverged intoVictoria and Yamagata, which differs in antigenic and evolutionary characteristics. Yet, molecular-epidemiological information of influenza B from developing nations is limited. In central Vietnam, influenza...
Article
A rapid increase and dominance of G9P[8] Rotavirus A strains occurred in northern Vietnam between 2016 and 2018, during which period there appeared three G9P[8] strains possessing short RNA patterns. To understand how the first-ever G9P[8] strains possessing short RNA patterns were formed, next generation sequencing technology was used to examine t...
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Background: Methadone maintenance treatment (MMT) has been proven to be effective in treating opioid dependence. In Vietnam, MMT services are provided primarily by public clinics, with only one private MMT clinic established in recent years. Assessing the preferences of patients for different MMT models is important in evaluating the feasibility o...
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In recent years, serosurveillance has gained momentum as a way of determining disease transmission and immunity in populations, particularly with respect to vaccine-preventable diseases. At the end of 2017, the Oxford University Clinical Research Unit and the National Institute of Hygiene and Epidemiology held a meeting in Vietnam with national pol...