Damien Huglo

Damien Huglo
Centre Hospitalier Régional Universitaire de Lille · Division of Nuclear Medicine and Functional Imaging

MD, PhD

About

171
Publications
5,301
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
4,350
Citations

Publications

Publications (171)
Article
Full-text available
As protein-losing enteropathy (PLE) can lead to hypogammaglobulinemia and lymphopenia, and since common variable immunodeficiency (CVID) is associated with digestive complications, we wondered if (1) PLE could occur during CVID and (2) specific features could help determine whether a patient with antibody deficiency has CVID, PLE, or both. Eligible...
Article
Introduction L’hyperfixation cardiaque en scintigraphie osseuse au 99Tc-DPD/HMDP est quasi-pathognomonique de l’amylose cardiaque à transthyrétine, qui est une cause non rare et sous-diagnostiquée d’insuffisance cardiaque. Les quelques faux positifs correspondent le plus souvent à des amyloses cardiaques AL. La relecture systématique des dizaines d...
Article
Full-text available
Background: The aim of this study was to evaluate the role of dual isotope 123Iodine/99mTc-MIBI thyroid scintigraphy in discriminating malignant from benign nodules with indeterminate or non-diagnostic cytology using quantitative analysis methods. Methods: 35 patients with thyroid nodules of indeterminate or non-diagnostic cytology, and cold on 123...
Article
Full-text available
Background Interstitial lung disease is a common complication of systemic sclerosis (SSc-ILD), and it remains difficult to accurately predict its course. Progressing ILD could be more metabolically active, suggesting that the ¹⁸ F-FDG tracer could be a tool in the managing of SSc-ILD. Methods In our center, SSc patients and controls (non-Hodgkin l...
Article
Background: Chemotherapy is increasingly used before hepatic resection, with controversial impact regarding liver function. This study aimed to assess the capacity of 99mTc-labelled-mebrofenin SPECT-hepatobiliary scintigraphy (HBS) to predict liver dysfunction due to chemotherapy and/or chemotherapeutic-associated liver injuries (CALI), such as si...
Article
We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline ¹⁸FDG PET-CT. Semi-automatically segmented (41% SUVmax) total metabolic tumor volume (TMTV) and MBV underwent receiver operating cha...
Article
Introduction La multiplication des TEP-FDG au cours du suivi du mélanome confronte souvent le dermatologue à la découverte fortuite d’hypermétabolismes thyroïdiens (HMT), posant la question, peu étudiée dans la littérature, de leur nature et de la conduite à tenir. Matériel et méthodes Analyse rétrospective de 1762 TEP-FDG chez 744 patients suivis...
Article
Introduction On désigne par entéropathie exsudative (EE) toute pathologie conduisant à une perte anormale de sérum dans la lumière digestive, comme les maladies inflammatoires chroniques intestinales (MICI), la maladie caeliaque (MC), l’hypertension portale et la maladie de Waldmann. Ainsi, les EE sont responsables d’hypogammaglobulinémie et de lym...
Article
Introduction Dans le contexte actuel de médecine personnalisée, l’analyse texturale se révèle être prometteuse dans l’évaluation pronostique des néoplasies. Cependant, l’absence de standardisation et la multitude des paramètres de texture limitent la reproductibilité des études de radiomique et constituent un obstacle à l’introduction de l’analyse...
Article
Background: The kinetics of remnant liver (RL) function is unknown after major hepatectomy (MH), especially in case of post-hepatectomy liver failure (PHLF). This study investigated the change in RL function after MH using 99mTc-labelled-mebrofenin SPECT-scintigraphy and its correlation with RL volume and PHLF. Methods: From 2011 to 2015, 125 pa...
Article
Une patiente de 62 ans est présentée en RCP des tumeurs hépatiques pour un nodule hépatique de 2,5 cm considéré comme carcinome hépatocellulaire (CHC) sur cirrhose probablement en rapport avec une NASH. Du fait des conclusions de la RCP, un traitement par radiofréquence de ce CHC est programmé un mois plus tard. Mais son médecin traitant lui a fait...
Article
Full-text available
Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis deemed unresectable due to inadequate future remnant liver (FRL). Nevertheless, high morbidity and mortality rates have been reported. In this setting, including hepatobiliary scinti...
Article
Full-text available
Abstract Monoclonal antibodies (mAbs) are key components in several therapies for cancer and inflammatory diseases but current knowledge of their clinical pharmacokinetics and distribution in human tissues remains incomplete. Consequently, optimal dosing and scheduling in clinics are affected. With sequential radiolabeled mAb-based imaging, radiati...
Article
Objectifs L’objectif était d’évaluer les capacités de la scintigraphie hépatique (HIDA) et de l’isolement d’hépatocytes à prédire : – les lésions hépatiques induites par la chimiothérapie ; – leur impact sur la fonction et la viabilité hépatocytaires du futur foie restant. Méthodes De 2011 à 2015, la mesure de la fonction hépatique intrinsèque éta...
Article
Full-text available
Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis deemed unresectable due to inadequate future remnant liver (FRL). Nevertheless, high morbidity and mortality rates have been reported. In this setting, including hepatobiliary scinti...
Article
Introduction Une étude ancillaire du LYSA de l’étude de phase Ib/II de l’obinutuzumab, anticorps monoclonal anti-CD20 humanisé de type II, combiné au lénalidomide pour le traitement des lymphomes réfractaires ou en rechute (GALEN) s’est intéressée à la biodistribution de l’anticorps par l’imagerie et la pharmacocinétique. Les 6 premiers patients ét...
Article
Résumé Objectif L’évaluation de la réponse thérapeutique des lymphomes en TEP utilise l’activité hépatique comme référence pour définir une réponse complète. Nous avons étudié les facteurs de variabilité des SUVs hépatiques entre les TEP initiale (TEP1), intermédiaire (TEP2) et de fin de traitement (TEP3). Matériels et méthodes Deux cent trente-h...
Article
Objective: (18)F-FDG PET/CT can detect large-vessel involvement in giant-cell arteritis (GCA) with a good sensitivity. In patients with clinically and biologically controlled disease, we aimed to assess how vascular uptakes evolve on repetitive FDG-PET/CT. Patients and methods: All included patients had to satisfy the 4 following criteria: 1) di...
Article
Objectifs Évaluer les faisabilité et suites de l’ALPPS partiel (« associating liver partition and portal vein ligation for staged hepatectomy » avec split de 50 %) avec temps 1 laparoscopique (Lap-pALPPS). Méthodes Cinq patients avec métastases colorectales résécables après chimiothérapie avaient un Lap-pALPPS laparoscopique, avec évaluation volum...
Article
Objectif Les tumeurs neuro-endocrines (TNE) thymiques sont une atteinte rare de la NEM1, de prévalence estimée entre 2–8 %. Elles en grèvent cependant le pronostic par leur caractère invasif, notamment depuis les améliorations thérapeutiques des autres atteintes. Il n’existe pas de consensus de prise en charge. Patients et méthodes Cinq cas de TNE...
Article
Full-text available
To reduce post-hepatectomy liver failure (PHLF), associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been recently developed for patients with a limited future remnant liver (FRL). Nevertheless, high morbi-mortality rates have been reported . The current study aimed to analyze the kinetics of FRL function in pati...
Article
Contexte Peu d’études ont évalué le rôle de la TEP/TDM au 18F-Fluorodeoxyglucose dans le diagnostic de tumeurs surrénaliennes chez les patients non oncologiques. Objectif Évaluer la contribution de la TEP/TDM au 18F-FDG dans cette indication dans le cadre d’une étude prospective. Matériel et méthodes La population d’étude a consisté en 87 masses...
Article
Context Few prospective studies have evaluated the role of ¹⁸F-Fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in the characterization of adrenal masses. Objective To assess the performance of ¹⁸F-FDG PET/CT in the malignancy diagnosis of adrenal masses in non-cancer patients. Design Prospective multicenter st...
Article
Introduction: Erdheim-Chester disease is a rare form of non-langerhans histiocytosis and its etiology is still not well established. The aims of the study were to assess the value of the bone scintigraphy and the (18)F-FDG PET/CT for the diagnostic and for the latter in the therapeutic evaluation. Methods: We retrospectively reviewed 49 patients...
Article
Introduction: Idiopathic cyclic edema (ICE) is a rare cause of edema. To date, there is no standard of care. The physiopathology of ICE could be explained by an impairment of capillary permeability. In 1995, a study demonstrated the efficacy of metformin on symptoms and capillary permeability. We evaluated ICE-patients who were treated with metfor...
Article
CYP24A1 gene mutations induce infantile hypercalcemia, with high 1,25(OH)2D contrasting with low PTH levels. The adult phenotype is not well known. Two unrelated adult patients were referred for nephrolithiasis, hypertension, hypercalcemia, hypercalciuria, normal 25-OHD levels, and inappropriate PTH levels (22 to 92 pg/mL; N: 15–68) suggesting prim...
Article
Full-text available
Previous studies reported a 2- to 17-fold higher risk of aortic complications (dilation or dissection) in patients with giant-cell arteritis (GCA). We aimed to determine whether or not GCA patients with large-vessel involvement demonstrated by positron emission tomography with ¹⁸F-fluorodeoxyglucose combined with computed tomography (FDG-PET/CT) ha...
Article
Résumé Introduction L’objectif de notre étude était d’évaluer l’impact d’une acquisition TEP/TDM synchronisée à la respiration (méthode « multi-phases ») sur la détectabilité et la quantification de lésions hépatiques. Patients et méthodes Vingt-et-un patients adressés pour TEP au ¹⁸F- fluorodésoxyglucose (FDG) et ayant des lésions hépatiques sec...
Article
After detection of small cell lung cancer in a 67-year-old patient who had donated a kidney 7 months earlier, the graft recipient underwent FDG-PET/CT to determine the presence/absence of tumor cell transmission. It showed abnormal increased uptake of the renal graft, associated with hypermetabolic lymph nodes and hepatic, pulmonary and bone lesion...
Article
Introduction L’œdème cyclique idiopathique (OCI) est une cause rare d’œdème, pouvant être localisé aux membres ou s’étendre à la face ou au tronc, entraînant des variations de poids quotidiennes et survenant chez la femme jeune en l’absence de cause cardiaque, rénale ou hépatique [1]. Il a des conséquences importantes sur la qualité de vie en l’abs...
Article
Only 20% of patients with colorectal liver metastases are eligible for liver resection, which is the only potentially curative treatment. The main reason for non resectability is related to insufficient volume of the future remnant liver. Several strategies have been proposed to increase the resectability rate: portal vein embolization/ligation and...
Article
Objectifs Les inhibiteurs d’HDAC (HDACi), en agissant sur les phenomenes epigenetiques, constituent une voie de recherche dans le cadre des lymphomes refractaires. En l’absence de facteur predictif de reponse et de criteres d’evaluation valides en imagerie, nous avons evalue l’interet des parametres quantitatifs de la TEP au 18F-FDG. Patients et me...
Article
Objectifs Évaluer en scintigraphie hépatobiliaire à la 99mTc-mébrofénine (SHB) les modifications de la fonction hépatique et leur corrélation avec les modifications de volume chez des patients ayant bénéficié d’une hépatectomie majeure. Patients et méthodes Entre octobre 2011 et octobre 2013, 70 patients ont été inclus prospectivement dans une étu...
Article
Histoire clinique Six mois apres don d’un de ses reins a sa niece, un patient de 67 ans est adresse pour scintigraphie renale au citrate de gallium 67, du fait d’une discrete alteration de la fonction renale s’accompagnant d’une hematurie microscopique et d’une proteinurie. La scintigraphie est normale au niveau du rein restant (absence d’argument...
Article
CYP24A1 gene encodes 24-hydroxylase that inactivates 1-25-OHvitaminD. Mutations induce infantile hypercalcemia, with high 1-25-OHvitaminD, contrasting with low PTH levels. Adult phenotypes are not well known yet. We report two cases of post-surgical persistent hypercalcemia, related to CYP24A1 mutations. Two unrelated patients, a 40-year-old female...
Article
Full-text available
Background: Coexistence of thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) with Graves' disease has been rarely reported. We describe a female patient displaying TSHoma with Graves' disease and who presented initially with inappropriate TSH values. Case report: A 36-year-old woman presented with signs of thyrotoxicosis, sm...
Article
Full-text available
We report an international, multicenter phase II trial to evaluate the efficacy and toxicity of fractionated (90)Y-ibritumomab tiuxetan ((90)Y-IT) as initial therapy of follicular lymphoma (FL). A total of 74 patients, with a median age of 61 years (range, 28 to 80 years), were recruited requiring initial therapy by Groupe d'Etude des Lymphomes Fol...
Article
Aim The purpose of this study was to investigate some of the parameters likely to influence mebrofenin-99mTc hepatic clearance calculation and inter-and intra-observers reproducibility. Materials and methods Hepatic clearance (%/min m2) of 30 scintigraphies was calculated from the values of hepatic, cardiac, and total activities, according to the...
Article
1598 Tumor bulk assessed by maximum tumor diameter was previously found to influence the outcome of young patients with low risk (aaIPI 0–1) DLBCL (Pfreundschuh et al Lancet Oncol, 2011; 12: 1013), but the prognostic impact of bulk and more generally tumor volume in high-risk DLBCL remains to be explored. Conversely, maximum SUV reduction calculate...
Article
Introduction After primary CRT, a non-invasive evaluation of the tumour response could help in the treatment decision to identify patients who may benefit from surgery. Whether FDG-PET provides clinically relevant information remains questionable. The objective of this prospective trial was to evaluate the role of 18F-Fluorodeoxyglucose-positron em...
Article
The prognosis value of interim positron emission tomography (PET) remains controversial in diffuse large B-cell lymphoma (DLBCL) patients because of the absence of consensus on criteria able to early identify good and bad responders to treatment. Visual interpretation using the International Harmonization Project (IHP) criteria, primarily establish...
Article
18F-fluorodeoxyglucose positron emission tomography (18FDG PET) is a nuclear medicine imaging technique of growing interest in oncology. In context of external radiotherapy, optimization of radiotherapy planning as well as objective patient monitoring require accurate tumor volume measurement. In this paper, a new, nearly automatic and operator-ind...
Article
Takayasu arteritis (TA) is a large-vessel vasculitis that can also involve pulmonary arteries. The aim of this study was to evaluate the frequency of pulmonary artery involvement in TA patients using pulmonary perfusion scintigraphy (PPS) and to determine the characteristics of patients with pulmonary artery involvement. Twenty-one patients classif...
Article
[¹⁸F]-Fluorodeoxyglucose PET has become an essential technique in oncology. Accurate segmentation is important for treatment planning. With the increasing number of available methods, it will be useful to establish a reliable evaluation tool. Five methods for [F]-fluorodeoxyglucose PET image segmentation (MIP-based, Fuzzy C-means, Daisne, Nestle an...
Article
Transurethral resection of the prostate (TURP) remains the gold standard in the operative management of symptomatic benign prostatic hyperplasia (BPH). The main morbidity of TURP is bleeding, which leads to clot retention and blood transfusion. Newer techniques have appeared, and photovaporization of the prostate (PVP) with the GreenLight™ laser ha...
Article
PurposeRadioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging. The goal of this work is to evaluate the value of 18F-fluorodeoxyglucose (FDG) positron emission tomograph...
Article
18F-fluorodeoxyglucose positron emission tomography (18FDG PET) has become an essential technique in oncology. Accurate segmentation and uptake quantification are crucial in order to enable objective follow-up, the optimization of radiotherapy planning, and therapeutic evaluation. We have designed and evaluated a new, nearly automatic and operator-...
Article
Full-text available
Fractionated radioimmunotherapy targeting CD22 may substantially improve responses and outcome in non-Hodgkin's lymphoma (NHL). A multicenter trial evaluated two or three weekly infusions of yttrium-90 ((90)Y) epratuzumab tetraxetan (humanized anti-CD22 antibody) in 64 patients with relapsed/refractory NHL, including 17 patients who underwent prior...
Article
AimTo assess the role of [18F]FDG-PET in solitary plasmacytoma with regards to staging, therapeutic follow-up and monitoring.
Article
This work deals with positron emission tomography segmentation methods for tumor volume determination. We propose a state of art techniques based on fixed or adaptive threshold. Methods found in literature are analysed with an objective point of view on their methodology, advantages and limitations. Finally, a comparative study is presented.
Article
Full-text available
The aim of this study is the 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) evaluation following radioimmunotherapy (RIT) with ibritumomab tiuxetan Y 90 in patients with non-Hodgkin's follicular lymphoma (FL). Materials and methods: We retrospectively analyzed data from 59 relapsed or refractory FL patients treated...
Article
Full-text available
Operative excision of abdominal extra-adrenal paragangliomas (EAPs) does not preclude the late development of local-regional recurrence. We describe the incidence, characteristics, and outcome of this rarely reported feature. Retrospective analysis of local-regional recurrence that occurred during follow-up of 51 consecutive patients operated for a...
Article
Radioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging. The goal of this work is to evaluate the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PE...
Article
From an experience of radio-immunotherapy of non Hodgkin lymphomas from March 2002 to December 2008 (near 7 years), corresponding to 160 treatments, an analysis of indications has been done: clinical research trials, authorized indications from AMM or medically justified. Some elements which could be problematic are pointed: coordination between th...