Damien Bachasson

Damien Bachasson
Institute of Myology · Neuromuscular Physiology Laboratory

PhD PT HDR

About

56
Publications
9,190
Reads
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637
Citations
Additional affiliations
May 2015 - March 2020
Institute of Myology
Position
  • Researcher
January 2014 - May 2015
University of California, San Diego
Position
  • PostDoc Position
January 2013 - September 2013
French Institute of Health and Medical Research
Position
  • PhD Student
Education
January 2014 - May 2015
University of California, San Diego
Field of study
  • Muscle Physiology
September 2009 - December 2012
University Joseph Fourier - Grenoble 1
Field of study
  • Exercise Physiology
September 2008 - September 2009
University Joseph Fourier - Grenoble 1
Field of study
  • Exercise physiology

Publications

Publications (56)
Article
Objective : This study aimed to investigate the relationship between changes in clinical status on daily life physical activity (PA) in patients with idiopathic inflammatory myopathy (IIM). Methods : Patients with dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) or overlap myositis (OM) who presented either a new-onset or relapsin...
Article
Key points: Twitch transdiaphragmatic pressure elicited by cervical magnetic stimulation of the phrenic nerves is a fully non-volitional method for assessing diaphragm contractility in humans, yet it requires invasive procedures such as oesophageal and gastric catheter balloons. Ultrafast ultrasound enables a very high frame rate allowing the capt...
Article
Full-text available
Background Diaphragm dysfunction is highly prevalent in mechanically ventilated patients. Recent work showed that changes in diaphragm shear modulus (ΔSMdi) assessed using ultrasound shear wave elastography (SWE) are strongly related to changes in Pdi (ΔPdi) in healthy subjects. The aims of this study were to investigate the relationship between ΔS...
Article
Full-text available
Background: The availability of non-invasive, accessible, and reliable methods for estimating regional skeletal muscle volume is paramount in conditions involving primary and/or secondary muscle wasting. This work aimed at (i) optimizing serial bioelectrical impedance analysis (SBIA ) by computing a conductivity constant based on quantitative magn...
Article
Full-text available
Fibrosis is a key pathological feature in muscle disorders, but its quantification mainly relies on histological and biochemical assays. Muscle fibrosis most frequently is entangled with other pathological processes, as cell membrane lesions, inflammation, necrosis, regeneration, or fatty infiltration, making in vivo assessment difficult. Here, we...
Article
Background The relationship between the diaphragm thickening fraction and the transdiaphragmatic pressure, the reference method to evaluate the diaphragm function, has not been clearly established. This study investigated the global and intraindividual relationship between the thickening fraction of the diaphragm and the transdiaphragmatic pressure...
Article
Full-text available
Although idiopathic inflammatory myopathies (IIM) are a heterogeneous group of diseases nearly all patients display muscle inflammation. Originally, muscle biopsy was considered as the gold standard for IIM diagnosis. The development of muscle imaging led to revisiting not only the IIM diagnosis strategy but also the patients’ follow-up. Different...
Article
Background: Muscle weakness and fatigability, the prominent symptoms of autoimmune myasthenia gravis (MG), impact negatively on daily function and quality of life (QoL). It is currently unclear as to what extent symptoms limit activity and whether physical activity (PA) behaviours are associated with reduced QoL. Objectives: This study aimed to...
Article
Background Inclusion body myositis is the most frequent myositis in patients older than 50 years. Classical immunosuppressants are ineffective in treating inclusion body myositis, and to date there are no recommendations for pharmacological approaches to treatment. When used after organ transplantation, sirolimus can block the proliferation of effe...
Conference Paper
Availability of noninvasive, robust, and reliable methods for assessing segmental skeletal muscle volume is essential in general population and conditions involving muscle wasting. This work aimed at: i) optimizing serial bioelectrical impedance analysis (SBIA) by computing a conductivity constant experimentally, ii) investigating the potential of...
Conference Paper
Muscle weakness and fatigability, the hallmark symptoms of auto-immune myasthenia gravis (MG), impact negatively on daily function and quality of life (QoL). To what extent MG symptoms limit activity is unclear and whether QoL is related to physical activity (PA) behavior is unknown. PA data from females with generalized MG were compared to control...
Article
Full-text available
Objective: Muscle strength is a critical clinical hallmark in both health and disease. The current study introduces a novel portable device prototype (MyoQuad) for assessing and monitoring maximal voluntary isometric knee extension torque (MVIT). Approach: Fifty-six patients with inclusion body myositis were studied. Knee extension weakness is a...
Article
Objectives: Fibromyalgia (FM) is a chronic painful condition partly due to alterations in pain modulation by the central nervous system. Multicomponent therapy (MT) and repetitive transcranial magnetic stimulation (rTMS) had both been reported as pain modulators in FM patients. The aim of this study was to compare the effects of rTMS on pain with...
Conference Paper
Full-text available
This study aimed to evaluate physical activity (PA) monitoring using wrist-worn accelerometers in the assessment of myositis patients. Included patients had a diagnosis of dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM) or overlap myositis (OM) and were evaluated at baseline (M0) and 6 months (M6). IMACS core-set measures, ACR/EUL...
Article
The reference method for the assessment of diaphragm function relies on the measurement of transdiaphragmatic pressure (Pdi). Local muscle stiffness measured using ultrafast shear wave elastography (SWE) provides reliable estimates of muscle force in locomotor muscles. This study aimed at investigating whether SWE could be used as a surrogate of Pd...
Article
Introduction Les accéléromètres de poignet permettent une mesure objective de l’activité physique dans la vie quotidienne. Récemment, l’ENMC (European Neuromuscular Center) a recommandé d’implanter dans l’évaluation clinique courante l’activité physique pour améliorer le suivi des patients atteints de myopathies auto-immunes L’objectif était donc d...
Article
Degenerative muscle changes may be associated with changes in muscle mechanical properties. Shear wave elastography (SWE) allows direct quantification of muscle shear modulus (MSM). The aim of this study was to evaluate the feasibility and reliability of SWE in the severely disordered muscle as observed in inclusion body myositis. To explore the cl...
Article
Full-text available
This study introduces local pattern texture anisotropy as a novel parameter to differentiate healthy and disordered muscle and to gauge the severity of muscle impairments based on B-mode ultrasound images. Preliminary human results are also presented. A local pattern texture anisotropy index (TAI) was computed in one region of interest in the short...
Article
Introduction Les choix thérapeutiques des cliniciens reposent sur l’évaluation de l’activité des pathologies. Concernant les myopathies auto-immunes, l’évaluation repose principalement sur le testing musculaire manuel et sur le taux de créatine kinase (CK), mais elle reste très imparfaite. Si le taux d’enzymes musculaires est une mesure biologique...
Article
Availability of reliable outcomes for idiopathic inflammatory myopathies (IIM) is critical to optimize treatment strategies.¹ The current consensus for the assessment of IIM severity and treatment efficacy relies on the evaluation of core set measures comprising manual muscle testing, muscle enzymes, extramuscular disease activity assessment, physi...
Article
Full-text available
Background: Previous randomized controlled trials investigating exercise training programs in facioscapulohumeral muscular dystrophy (FSHD) patients are scarce and of short duration only. This study assessed the safety and efficacy of a 6-month home-based exercise training program on fitness, muscle, and motor function in FSHD patients. Methods: S...
Article
This study aimed to compare quadriceps function (i.e. strength, endurance, central, and peripheral fatigue) of young (Young-UnTr) and middle-aged (MidAge-UnTr) untrained men and young endurance-trained men (Young-Tr). Twenty-four male subjects (eight Young-UnTr (26 ± 4 yr), eight Young-Tr (29 ± 3 yr), and eight MidAge-UnTr (56 ± 4 yr) performed a m...
Article
Rotator cuff (RC) tendon tears lead to negative structural and functional changes in the associated musculature. The structural features of muscle that predict function are termed "muscle architecture". Although the architectural features of "normal" rotator cuff muscles are known, they are poorly understood in the context of cuff pathology. The pu...
Article
Transcranial magnetic stimulation (TMS) of the motor cortex during voluntary contractions elicits electrophysiological and mechanical responses in the target muscle. The effect of different TMS intensities on exercise-induced changes in TMS-elicited variables is unknown, impairing data interpretation. This study aimed to investigate TMS intensity e...
Article
Rotator cuff (RC) disease is an extremely common condition associated with shoulder pain, reduced functional capacities, and impaired quality of life. It primarily involves alterations in tendon health and mechanical properties that can ultimately lead to tendon failure. RC tendon tears induce progressive muscle changes that have a negative impact...
Article
Full-text available
Introduction: Positive end-expiratory pressure (PEEP) is commonly used in critical care medicine to improve gas exchange. Altitude sickness is associated with exaggerated reduction in arterial oxygenation. We assessed the effect of PEEP and pursed lips breathing (PLB) on arterial and tissue oxygenation under normobaric and hypobaric hypoxic condit...
Article
Full-text available
Exercise intolerance in COPD seems to combine abnormal ventilatory mechanics, impaired O2 transport and skeletal muscle dysfunction. However their relative contribution and their influence on symptoms reported by patients remain to be clarified. In order to clarify the complex interaction between ventilatory and neuromuscular exercise limiting fact...
Article
Purpose: The potential ergogenic effects of therapeutic inhaled salbutamol doses in endurance athletes have been controversially discussed for decades. We hypothesized that salbutamol inhalation may increase peripheral muscle contractility, reduce fatigability, and improve force recovery after a localized exercise in endurance athletes. Methods:...
Article
Objective: To assess quadriceps strength and fatigability by using femoral nerve magnetic stimulation (FNMS) and their relationship to exercise capacity in patients with fibromyalgia syndrome (FMS) and healthy controls. Methods: Twenty-two women (11 with FMS, 11 controls) performed a maximal incremental cycling test and a quadriceps fatigue test...
Article
OBJECTIVES: To (i) evaluate the feasibility and the reliability of a test assessing quadriceps strength, endurance and fatigue in patients with fascioscapulohumeral dystrophy (FSHD) and Charcot-Marie-Tooth disease (CMT), (ii) compare quadriceps function between patients and healthy controls. METHODS: Controls performed the test once and patients tw...
Thesis
Full-text available
Strength loss and enhanced neuromuscular fatigability are major contributing factors of decreased functional capacities, reduction of exercise capacity and impaired prognosis in patients with chronic diseases. These alterations can rely upon primary impairments of neuromuscular function and/or secondary impairments partly caused for instance, by a...
Thesis
Strength loss and enhanced neuromuscular fatigue are major contributing factors of impaired functional capacities, exercise tolerance and prognosis in patients with various chronic diseases. These alterations can rely on primary deficiencies of neuromuscular function and/or secondary impairments caused by decreased spontaneous physical activity pro...
Article
Full-text available
Neuromuscular function can change under different conditions such as ageing, training/detraining, long-term spaceflight, environmental conditions (e.g. hypoxia, hyperthermia), disease, therapy/retraining programs and also with the appearance of fatigue. Neuromuscular fatigue can be defined as any decrease in maximal voluntary strength or power. The...
Article
Full-text available
Greater diaphragm fatigue has been reported after hypoxic versus normoxic exercise, but whether this is due to increased ventilation and therefore work of breathing or reduced blood oxygenation per se remains unclear. Hence, we assessed the effect of different blood oxygenation level on isolated hyperpnoea-induced inspiratory and expiratory muscle...

Projects