Damian Odimegwu

Damian Odimegwu
University of Nigeria | UNN

PhD

About

60
Publications
22,486
Reads
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523
Citations
Additional affiliations
September 2010 - December 2014
Ruhr-Universität Bochum
Position
  • Doctoral research fellow

Publications

Publications (60)
Article
Full-text available
Although aluminum-containing adjuvants are widely used in human vaccination due to their excellent safety profile, they exhibit low effectiveness with many recombinant antigens. This study investigated the adjuvanticity of snail mucin with recombinant Hepatitis B Vaccine (rHBsAg). Twenty-five (25) female mice distributed unbiasedly into 5 groups we...
Article
Full-text available
Background Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and...
Preprint
Full-text available
Abated immune responses against recombinant hepatitis-b protein vaccine by chitin in mice Majority of recombinant protein vaccines employ alum-based adjuvants to boost their immunogenicity in subjects. However, the safe-profiled alum-based adjuvants demonstrate relative ineffectiveness with these recombinant vaccines. This work investigated the adj...
Preprint
BACKGROUND Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and...
Preprint
Full-text available
Background: Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, respiratory and cardiovascu...
Preprint
Full-text available
Although aluminum-containing adjuvants are widely used in human vaccination due to their excellent safety profile, they exhibit low effectiveness with many recombinant antigens. This study investigated the adjuvanticity of snail mucin with recombinant Hepatitis B Vaccine (rHBsAg). Twenty-five (25) female mice distributed unbiasedly into 5 groups we...
Article
Full-text available
Respiratory syncytial virus (RSV), to date, is still the most frequent cause of infantile and childhood cause of viral lower respiratory tract illness on a global scale, and at the same time, causing significant impact in the elderly. Presently, there is no licensed vaccine or safe and specific antiviral agent that could be used against the virus....
Article
Full-text available
The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system. Even at the face of potential vaccine...
Article
Full-text available
There is a need for robust adjuvant for typhoid fever vaccine, as available licensed vaccines are saddled with challenges which include the need for revaccination after few years, which a suitable adjuvant can overcome. Efficacious typhoid fever vaccines are of importance because typhoid fever is a communicable disease that is endemic in developing...
Article
Full-text available
Typhoid fever, a systemic infection caused by Salmonella typhi has maintained a high morbidity and mortality profile around the globe especially in developing countries. Though currently licensed vaccines are efficacious in prevention of the infection, their potency is ephemeral; hence, they require a boost by employing adjuvants that are safe and...
Chapter
The revised edition of this chapter has been carefully and entirely rewritten. As a general rule, all sections have been revised and updated with current knowledge, more recent references included, and some sections expanded. Of particular note is the incorporation of significant additional materials in both sections dealing with some biological ac...
Article
Full-text available
Salmonella enterica serovar Gallinarum causes a disease in chickens known as fowl typhoid. Interferon-gamma has been shown to be crucial in eliminating salmonellosis infection because of its strong association with T-cell response. This study was undertaken to compare the expression of interferon-gamma (IFN-γ) in chickens generated by different vac...
Article
Aim of the study: Adjuvants can increase the efficiency and reduce the number of required doses for hepatitis B vaccination. Thus the study was designed to investigate whether V. amygdalina leaf extract may be used as an adjuvant to the conventional hepatitis B surface antigen-based vaccine through humoral response analyses. Methodology: The toxici...
Article
Full-text available
Background The lack of a vaccine for Hepatitis C virus (HCV) places children at a high risk of contracting the infection. It becomes necessary to accurately diagnose this infection for proper treatment as well as identifying potential risk factors for effective management. Aim This study was conceived to assess the test performance of the commonly...
Article
Full-text available
Background Though measures are being put in place for the management of Hepatitis B virus (HBV) infection in Nigeria, children remain the most vulnerable to develop chronic hepatitis. Routine screening in children is therefore necessary for effective control. However, the performance of the commonly used immunochromatographic test (ICT) strips has...
Article
Full-text available
Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to...
Conference Paper
Full-text available
Respiratory syncytial virus (RSV) is a known cause of severe respiratory infections with attendant high morbidity and mortality rates in all populations especially in infants younger than 2 years of age [1,2].Currently, the viral infection has no approved vaccine and the only approved drug, ribavirin, is expensive and is not likely to improve out...
Article
Background: Respiratory syncytial virus (RSV) is known to cause severe respiratory infections particularly in infants younger than 2 years of age. The only approved drug, ribavirin, is expensive and is not likely to improve therapeutic outcome, thereby necessitating the search for safer and more potent alternatives from natural sources such as endo...
Article
Full-text available
Preliminary investigations of Ramalina farinaceae (RF) plant extract sourced from Southeast, Nigeria for later possible antiviral usage lead to the identification of anti-proliferative activities against some mammalian cell lines and mouse splenocytes. The extract/cell systems were incubated for 1-2 days followed by analysis of cell viability statu...
Article
Context Alchornea floribunda Müll. Arg. (Euphorbiaceae) leaves are widely used in ethnomedicine for the management of rheumatism, arthritis and toothache. Objective In this study, flavonoid glycosides isolated from Alchornea floribunda were screened for their effect on the intracellular expression of interferon-gamma (IFNγ) and interleukin-2 (IL-2)...
Article
Full-text available
Section 7.1 will begin with broad and specific definitions of lichens and antiviral agents. Here, we will focus briefly on viruses and antiviral agents: their nature, characteristics, source, and effects. We shall also attempt to classify antiviral agents based on their mode of action and targeted virus cluster. Lichen as a broad group of useful so...
Article
Full-text available
A new luteoyl derivative, 1-O-galloyl-6-O-luteoyl-β-D-glucopyranoside, together with five known compounds were isolated from the methanol leaf extract of Alchornea cordifolia. The chemical structures of these compounds were confirmed by 1D and 2D NMR and HRMS analyses. The compounds exhibited significant antioxidant activity with IC50 values in the...
Article
Full-text available
Introduction: Antibiotic options in the treatment of extended spectrum beta-lactamase (ESBL) producing bacteria are very limited. The purpose of this study was to analyze several commonly applied antibiotics in quite various novel combinations for use against ESBL-producing bacteria isolates.Methods: Total of 460 samples of urine, throat and anal s...
Article
The extract of the Nigerian lichen Ramalina farinacea showed inhibitory activity against the respiratory syncytial virus in a preliminary assay. A follow-up chemical investigation of this lichen led to the isolation of thirteen phenolic compounds (1-13), including one new hydroquinone depside, designated 5-hydroxysekikaic acid (1), and one new orse...
Poster
Introduction: The human respiratory syncytial virus (RSV) is the most common respiratory tract pathogen accounting for approximately 20% of hospitalizations due to lower respiratory tract infections in children. Till date, there remains no vaccine or effective therapeutics against RSV. Our earlier findings show that vaccination with genetic RSV vac...
Article
Full-text available
The antimicrobial activity of methanol extract of Triumfetta rhomboidea leaves was evaluated against Staphylococcus aureus, Salmonella typhi and Klebsiella pneumoniae. Agar diffusion and agar dilution techniques were employed for the antimicrobial sensitivity and interaction studies. Phytochemical analysis of the crude extract was also carried out...
Article
Full-text available
Owing to the increasing epidemiological and therapeutic challenges associated with infections due to ESBL producers, ESBL prevalence rate among some bacteria isolates from healthy and non-healthy human population in a metropolitan Nigerian setting was evaluated. A total of one hundred and forty-five (145) bacteria strains were isolated from a total...
Article
Full-text available
Summary: Owing to the present upsurge in the utilization of medicinal herbal preparations, routine quality control assessment for their continued efficacy and safety is essential if the products are to continue to maintain their pharmacological usefulness under harsh use and storage temperature normally experienced, particularly in the tropics. As...
Chapter
Full-text available
The efficiency of antibiotics in combating microbial infections was very promising shortly after their introduction. It was even thought that the microbial war was as good as over as was declared by the Surgeon General of the United States. However, resistance to these agents developed rapidly afterward and the problem of antibiotic resistance has...
Article
Full-text available
This study was designed toevaluate the in vitro antimicrobial properties of the methanol extract of Garcinia kola seed and its syrup formulation and compare the latter with commercial antibiotic syrups against Escherichia coli and Staphylococcus aureus by the standard agar diffusion method. The physicochemical properties of the syrups were also ass...
Article
Full-text available
Owing to the increasing epidemiological and therapeutic challenges associated with infections due to ESBL producers, ESBL prevalence rate among some bacteria isolates from healthy and non-healthy human population in a metropolitan Nigerian setting was evaluated. A total of one hundred and forty-fi ve () bacteria strains were isolated from a tota...
Article
Full-text available
Purpose: The present work is an antimicrobial evaluation of lozenge dosage forms containing garlic and ginger extract. Methods: Lozenges containing pulverized garlic and ginger were produced by the moulding method and was evaluated against oropharyngeal microbial isolates after time-release in a normal saline-saliva sink solution. The solution was...
Article
Full-text available
Background. Antibiotic resistant bacteria have been a source of ever-increasing therapeutic problem with profound health and socioeconomic pressures. Hence, continued surveillance for bacteria susceptibility pattern is useful to determine the existing and future challenges of effective therapy. Aim. This study was carried out to evaluate the resist...
Article
Full-text available
The numbers of illegal and unauthorized outlets operated by charlatans, that market drugs in Nigeria, are too many compared to pharmacies and hospitals. The trend is that a great number of drug users depends on these drug sellers for the procurement of their drugs. We surveyed the pattern of drug storage practice in homes, patent medicine stores an...
Article
Full-text available
Beniseed (Sesame indicum) and its oil were evaluated for their physicochemical and nutritional profile,and also for possible pharmaceutical application as an adjunct in self- emulsifying oil formulations (SEOFS) forfuture use as drug delivery vehicle for poorly aqueous soluble drugs. Beniseed oil was extracted using standardprocedure. Both the seed...
Article
Purpose: To investigated the in vitro antimicrobial interaction between the crude water extract of Azadirachta indica and some standard antibiotics; doxycycline, gentamicin, streptomycin, erythromycin, ciprofloxacin, and norfloxacin. Methods: The in vitro interactions were evaluated using a combination of agar diffusion and Checkerboard techniques...
Article
Full-text available
In this study, we investigated a herbal ointment containing Dissotis theifolia extract for wound healing and antibacterial activities against clinical wound isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The ointment batches containing different concentrations of the D. theifolia extract was applied topically to both infected and uni...
Article
Full-text available
Garcinia kola seed is a commonly used social masticatory agent in Africa and is believed to possess many useful medicinal properties. The effect of the seed of G. kola Heckel on the salivary pharmacokinetics of ofloxacin was studied in healthy human volunteers. In a 2-way crossover design, ten healthy human volunteer received oral dose of 200 mg of...
Article
Full-text available
In this study, we screened Garcinia kola seed (GKS), Kola nitida seed (KNS) and Camellia sinensis Leaves (TEA) for adaptogenic potentials. The investigation was carried out in albino rats to determine the ability of these plant materials to increase non-specific resistance against physical, chemical and biological stressors. The results show that t...

Questions

Question (1)
Question
I am doing linear regression of a dose-response plot. I posted a negative value for the x-intercept (dose) instead of expected positive. What is wrong with my analysis? Or what is the implication of this outcome?