Dalinda Sanchez

Dalinda Sanchez
The Hong Kong Polytechnic University | PolyU · Department of Rehabilitation Sciences

PhD

About

15
Publications
12,678
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234
Citations
Introduction
I am particularly interested in understanding the underlying molecular mechanisms of psychiatric and neurological disorders as well as the therapeutic effect of complementary and alternative medicine (CAM). My research focuses on neurogenesis, a plasticity mechanism associated with the pathophysiology of neurological and affective disorders, and the effect of CAM on neurogenesis using animal models.

Publications

Publications (15)
Article
Full-text available
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons. During embryonic development, neurogenesis is crucial to produce neurons to establish the nervous system, but the process persists in certain brain regions during adulthood. In adult...
Article
Full-text available
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons. During embryonic development, neurogenesis is crucial to produce neurons to establish the nervous system, but the process persists in certain brain regions during adulthood. In adult...
Article
Full-text available
Cigarette smoke (CS) is the major risk factor for chronic obstructive pulmonary disease (COPD) and can induce systemic manifestations, such as skeletal muscle derangement. However, inconsistent findings of muscle derangement were reported in previous studies. The aim of the present study was to consolidate the available evidence and assess the impa...
Article
Full-text available
The COVID-19 outbreak significantly impacted people’s lives. Within the education system, the teaching mode drastically changed to adapt to the social distancing restrictions due to the pandemic. Consequently, teachers have been facing challenges associated with remote learning in addition to those of the pandemic. The aim of the present study was...
Article
COVID-19 has spread throughout the world, resulting in significant morbidity, mortality, and negative psychological effects among general population. However, university students are particularly vulnerable in terms of mental health. The present study evaluated the association between mental health, quality of sleep, aggression, and physical activi...
Article
Full-text available
Background The psychological well-being of university students is an important factor in successfully coping with the demands of academic life. This study aimed to assess the impact of a peer-led intervention of mental health promotion combined with coping-strategy-based group workshops on mental health awareness and help-seeking behavior among uni...
Article
Full-text available
Cerebral ischemic injury is the main manifestation of stroke, and its incidence in stroke patients is 70–80%. Although ischemic stroke can be treated with tissue-type plasminogen activator, its time window of effectiveness is narrow. Therefore, the incidence of paralysis, hypoesthesia, aphasia, dysphagia, and cognitive impairment caused by cerebral...
Article
Full-text available
Background: The exact mechanisms involved in the pathogenesis of neurodegenerative conditions are not fully known. The design of drugs that act on multiple targets represents a promising approach that should be explored for more effective clinical options for neurodegenerative disorders. B7C is s synthetic drug that has been studied for over 20 yea...
Article
Full-text available
Depression is a major health issue that causes severe societal economic and health burden. Aromatherapy, a practice that uses essential oils for preventive and therapeutic purposes, represents a promising therapeutic alternative for the alleviation of depressive symptoms. Lavender essential oil (LEO) has been the focus of clinical studies due to it...
Article
Dextromethorphan (DXM) is one of the common drugs abused by adolescents. It is the active ingredient found in cough medicine which is used for suppressing cough. High dosage of DXM can induce euphoria, dissociative effects and even hallucinations. Chronic use of DXM may also lead to depressive-related symptoms. Lycium barbarum, commonly known as wo...
Article
Full-text available
Hypercortisolemia is one of the clinical features found in depressed patients. This clinical feature has been mimicked in animal studies via application of exogenous corticosterone (CORT). Previous studies suggested that CORT can induce behavioral disturbance in anxious-depressive like behavior, which is associated with suppressed neurogenesis. Hip...
Article
Full-text available
Natural products represent one of the most important reservoirs of structural and chemical diversity for the generation of leads in the drug development process. A growing number of researchers have shown interest in the development of drugs based on Chinese herbs. In this review, the use and potential of omic technologies as powerful tools in the...
Article
Full-text available
Background . Depression is one of the greatest health concerns affecting 350 million people globally. Aromatherapy is a popular CAM intervention chosen by people with depression. Due to the growing popularity of aromatherapy for alleviating depressive symptoms, in-depth evaluation of the evidence-based clinical efficacy of aromatherapy is urgently...
Article
Rewarding social behaviors including positive social interaction and sexual behaviors are shown to regulate adult neurogenesis, but the underlying biological mechanisms remain elusive. Oxytocin, a neurohypophysial hormone secreted after exposure to social interaction or sexual behaviors, has a profound role in the formation of social bonding and re...
Article
Tejocote is the most common name for specimens of the genus Crataegus in Mexico. Although several Crataegus species are found in our country, only C. mexicana is a recognized cultivated species. The cultural aspects and uses of this fruit tree come from the pre-Hispanic time; however, few studies on its potential uses have been conducted. Tejocote...

Questions

Question (1)
Question
I need to plot the phosphorylated protein/non phosphorylated protein ratio relative to the control. I measured phospho Mek, Mek and beta actin. In my experiment I include a negative control, treatment and positive control at time points 0, 5, 10 and 15min. I got the volume values of the western blot bands, but I do not know how to do the calculation. What I see is that the starting point in my treatments should be 1. Has anybody done such analysis? I appreciate any thought!

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