Dalibor Nikolic

Institute of Information Technologies, University of Kragujevac · Department of Technical-Technological Sciences

Cancer stem cells (CSCs) play a key role in tumor progression, as they are often responsible for drug resistance and metastasis. Environmental pollution with polystyrene has a negative impact on human health. We investigated the effect of polystyrene nanoparticles (PSNPs) on cancer cell stemness using flow cytometric analysis of CD24, CD44, ABCG2,...

(1) Background: Cancer stem cells (CSCs) are a subpopulation of cells in a tumor that can self-regenerate and produce different types of cells with the ability to initiate tumor growth and dissemination. Chemotherapy resistance, caused by numerous mechanisms by which tumor tissue manages to overcome the effects of drugs, remains the main problem in...

3D bioprinting is the hi-tech approach in tissue engineering science. Applying of modern 3D bioprinting systems allows production of tissue-like structures that could be used in regenerative medicine. Such tissues or primitive organ constructs could be used for substituting the parts of damaged organs, or for changing of organs in whole. Biomateria...

Objectives The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively col...

Background/Aim. The best treatment for the occlusion of the largest artery in the thigh is a femorodistal (FD) bypass. Ankle-brachial index (ABI) and multi-detector computed tomographic (MDCT) angiography are the gold standards for diagnosing peripheral arterial occlusive disease. The finite element method can help measure the quantity of blood flo...

Stents made by different manufacturers must meet the requirements of standard in vitro mechanical tests performed under different physiological conditions in order to be validated. In addition to in vitro research, there is a need for in silico numerical simulations that can help during the stent prototyping phase. In silico simulations have the ab...

Introduction: In the last couple of decades, we have been working on the development ofadvanced drug delivery systems, which include the use of carriers of medically active substances,which enable precise and efficient therapy followed by reduction of the occurrence of side effects. The aim of this paper was to demonstrate the possibility of contro...

Preclinical experiments require reliable, physiologically relevant systems that can reproduce complex human physiology. Further technological advances are urgently needed to gain a better understanding of the important biological processes, like circulation networks for the discovery and screening of new drugs. Traditional 2D and 3D in vitro approa...

Coronary artery disease (CAD), one of the leading causes of death globally, occurs due to the growth of atherosclerotic plaques in the coronary arteries, causing lesions that restrict the flow of blood to the myocardium. Percutaneous transluminal coronary angioplasty (PTCA), including balloon angioplasty and coronary stent deployment, is a standard...

The human body, as a complex biomechanical system, is daily exposed to oscillatory movements. Vibrations are observed as small displacements of points compared to the dimensions of the system. The body's sensitivity to vibration depends on many factors, such as body position, muscle tension, frequency, amplitude, and direction of vibration. Comfort...

Development of plaques compositions caused by atherosclerosis inside of coronary arteries is known as coronary artery disease. Its treatment includes the possibility of stent deployment through operation called percutaneous transluminal coronary angioplasty. In this procedure stent is delivered using a balloon catheter and then inserted across the...

This is a feasibility study for the application of a novel concept of single-needle device for localized chemotherapy. Systemic chemotherapy has numerous and severe side effects. To conduct localized (electro)chemotherapy, we designed a novel device that does not currently exist on the market. Electrochemotherapy is based on the cell membranes temp...

With the development of computer technologies and especially the great breakthrough of smartphone technology, augmented reality (AR) has become present in various fields and, therefore, the research and development of this technology has become very important. Due to its specific properties, engineers apply it in many areas, and special priority is...

Vibrations are oscillatory movements of the mechanical system, in which displaments of points are small compared to the dimensions of the system. Exposure to whole body vibrations reduces the comfort of passengers in the vehicles, causing stress, fatigue and discomfort. Vibrations can affect the lumbar spine, the gastrointestinal system, the periph...

Software analysis of player’s motion tracking data during a football match became very important analytically-diagnostic mean for tracking of player’s functionality and efficiency in modern football. The aim of this study was to determine the intensity and structure of players’ motion during the qualification rounds for UEFA Europa League. To recor...

Electrospinning is highly used technique in the tissue engineering field, particularly in biomedical application [1]. The constricted concepts of this process are based on generate nonwoven nanofibers. The method involves high voltage electricity which is applied to the liquid solution and a collector, which lets the solution force out from a nozzl...

Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloy...

Electrospinning is a highly used technique in the tissue engineering field, particularly for the development of tissue supportive scaffolds. Use of electrospun derived nano and microfibers is of crucial importance for extracellular matrix mimicking and cell adhesion and proliferation. This paper is focused on the electrospinning process and its ide...

Lab-on-chip systems are microfluidic devices that can be used as powerful tools for research in fields of molecular biology and bioengineering. Novel chip systems such as miniaturized microfluidic human tissue and organ models are powerful platforms to ex vivo study functional units of any important biological and physiological parameters of their...

Background and Objective : Peripheral arterial disease of the lower limbs, which affects 12-14% of the population, is often treated by bypassing a blocked portion of the vessel. Due to the limited ability of clinicians to predict the outcome of a selected bypass strategy, the five-year graft occlusion ranges from 50% to 90%, with a 20% risk of ampu...

Objective. Femoropopliteal bypass is indicated in the advanced stage of peripheral arterial occlusive disease. The indications for surgical treatment are determined on the basis of a clinical exam, "ankle-brachial index" and angiographic findings. Using the finite element analysis method, three-dimensional models can be made based on angiography, a...

Coronary artery disease (CAD), one of the leading causes of death globally, occurs due to the growth of atherosclerotic plaques in the coronary arteries, causing lesions which restrict the flow of blood to the myocardium. Percutaneous transluminal coronary angioplasty (PTCA), including balloon angioplasty and coronary stent deployment is a standard...

Today, endovascular prosthesis—stents are used as a solution for treating many health disorders and diseases. Their major application is found in treating cardiovascular diseases. One of the problems in stent implantation is a process called in stent restenosis (ISR). In the pre-stent era, the occurrence of restenosis ranged between 32 and 55% of a...

Atherosclerosis is a disease of arterial blood vessels characterized by the accumulation of lipids in the arterial wall, starting with endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. In this study, using DICOM images, a numerical model of atherosclerosis progression was developed. Fluid domain (blood...

In this chapter we described predictive model for plaque formation and progression in the coronary and carotid artery. A full three-dimensional model for plaque formation and progression, coupled with blood flow and LDL concentration is analysed. The Navier-Stokes equations together with the Darcy law for model blood filtration and Kedem-Katchalsky...

Serbia U toku dosadašnje kliničke prakse u oblasti nuklearno medicinske dijagnostike susreli smo se sa dva problema. Prvi je dobra preoperativna vizualizacija i što preciznija topografska lokalizacija sentinelnih limfnih nodusa, što je preduslov za njihovu brzu intraoperativnu detekciju i ekstirpaciju. Drugi problem je precizna topografska lokaliza...

Blood vessels diseases such as cardiac infarction with coronary artery occlusion, peripheral arterial disorders, or stroke of carotid or cerebral arteries, are the leading causes of death in the world. One of medical procedures for clinical treatment of vascular diseases is the blood vessels grafting. As the autologous blood vessels, which are the...

In this study a patient-specific computer model of stent deployment into the human stenosed coronary arteries is developed. The model is also able to predict atherosclerosis growing in the artery after stent deployment. We analyse shape post-implantation, possible damages to the endothelium as well as the effects of the stenting on the vessel wall,...

Coronary artery disease or coronary atherosclerosis (CATS) is the most common type of cardiovascular disease and the number one cause of death worldwide. Early identification of patients who will develop progression of disease is beneficial for treatment planning and adopting the strategy for reduction of risk factors that could cause future cardia...

The inflammation and lipid accumulation in the arterial wall represents a progressive disease known as atherosclerosis. In this study, a numerical model of atherosclerosis progression was developed. The wall shear stress (WSS) and blood analysis data have a big influence on the development of this disease. The real geometry of patients, and the blo...

Atherosclerosis is a leading cause of mortality in the all developed countries. This disease begins with endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. Interaction between the blood and the plaque can lead to plaque rupture. An important hemodynamic parameter in interaction between fluid and vessel...

Atherosclerosis is a disease of arterial blood vessels characterized by the accumulation of lipids in the arterial wall. Mechanical forces such as low shear stress are implicated in plaque formation and development. Using DICOM images, 3D models of human right coronary artery (RCA) were developed. This paper studies influence of wall shear stress (...

In this study we analysed computational model for plaque development and validation with clinical study. Mass transfer within the blood lumen and through the arterial wall was coupled with the blood flow. Plaque progression was modeled using three additional reaction􀀗diffusion partial differential equations. The results for plaque concentration for...

Benign Paroxysmal Positional Vertigo (BPPV) is the most common vestibular disorder. In this paper we tried to investigate a model of the semi-circular canal (SCC) with parametrically defined dimension and full 3D three SCC from patient-specific 3D reconstruction. Full Navier-Stokes equations and continuity equations are used for fluid domain with A...

In this study stent deployment modeling with plaque formation and pro- gression for specific patient in the coronary arteries are described. State of the art method for the reported investigations of blood flow in the stented arteries is described. In the met- hod section, image segmentation method for arteries with stent is shortly described. Bloo...

In this chapter a complex problem of stent deployment with plaque formation and progression for specific patient in coronary arteries is described. Stent enables widening of the stenosed part of the blood vessel. We firstly describe state of the art for blood flow in the stented arteries. Blood flow simulation is described by Navier-Stokes and cont...

Benign Paroxysmal Positional Vertigo (BPPV) is most common vestibular disorder which becomes from the presence of basophilic particles in the semicircular canals (SCC). Three-dimensional biomechanical model of the SCC is described with full 3D fluid-structure interaction of particles, wall, cupula deformation and endolymph fluid flow. The model of...

Atherosclerosis is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall. Determination of plaque location and plaque volume for a specific patient is very important for prediction of atherosclerotic disease progression. In this study coupled computer modeling of at...

In this study computer model of atherosclerosis progression was developed. Additional to mechanics approach with wall shear stress a biomolecular parameters Cholesterol, LDL, HDL and Triglycerides are also included for patient specific analysis. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the inti...

Objective: To describe a new method of 3D interactive modeling which integrates images obtained by separate SPET and multi slice computed tomography (MSCT) modalities using an original software in order to better localize SNL in BC patients. Subjects and Method: We used technetium-99m-colloid rhenium sulphate for identifying SNL in seven patients w...

The principal aim of this study was to define and apply numerical procedures to assess the durability of coronary stents based on the estimation of safety from fatigue to fracture. This procedure is carried out within three phases: a) initial fatigue analysis based on S-N approach; b) fatigue lifetime assessment based on fatigue crack growth simula...

Determination of plaque location and plaque volume for a specific patient is very important for prediction of atherosclerotic disease progression. Atherosclerosis is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall.

In this study we compared computer simulation of plaque development and Fractional Flow Reserve (FFR) with real clinical data from a specific patient. The Navier-Stokes and continuity equations were used for blood flow and pressure distribution for FFR. The Darcy law was used for model blood filtration, Kedem-Katchalsky equations for the solute and...

Today, stents are used as a solution for treating a number of health disorders and diseases. Their major application is found in treating cardiovascular diseases. According to the reports of world health organizations, cardiovascular diseases represent the greatest health problem of people in developed countries. Currently, about 500.000 coronary s...

Introduction Both, open and endovascular, procedures are related to higher complication rate in abdominal aortic aneurysm (AAA) with shorter neck. Previous study showed that long neck AAA might have lower risk of rupture. Estimation of biomechanical forces in AAA improves rupture risk assessment. Aim of this study was to compare morphological featu...

Research presented at 44th European Calcified Tissue Society Congress in section Bone biomechanics and quality

Coronary artery stents are routinely used in the management of patients with angina or myocardial infarction where percutaneous coronary intervention is the clinically appropriate procedure. Stress inside the artery wall and stress and strain in the stent are very important biomechanical parameters. For better understanding of the mechanical proces...

Computational study for plaque formation and development for the patient specific coronary arteries was performed. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the intimal area was implemented. Mass transport of LDL through the wall and the simplified inflammatory process was firstly solved. The Na...

Blood vessels diseases such as cardiac infarction with coronary artery occlusion, peripheral arterial disorders, or stroke of carotid or cerebral arteries, are the leading causes of death in the world. One of medical procedures for clinical treatment of vascular diseases is the blood vessels grafting. As the autologous blood vessels, which are the...

In this review we presented scientific results from three EC FP7 projects: ARTREAT, SIFEM and EMBALANCE. The title of FP7 ARTREAT project was: Multi-level patient-specific artery and atherogenesis model for outcome prediction, decision support treatment, and virtual hand-on training. Researchers from University of Kragujevac and BioIRC participated...

In this study, experimental and numerical stent modelling with plaque formation and progression for specific patient in the coronary arteries is described. In the method, section experimental stent testing is firstly described. Then numerical methods with finite element methods are given. Blood flow simulation is described with Navier-Stokes and co...

Benign paroxysmal positional vertigo (BPPV) is the most common type of vertigo. The symptoms of BPPV typically appear after angular movements of the head. BPPV leads to dizziness, nausea and imbalance. In this study, we examined a model of the semi-circular canal (SCC) with fully 3D three dimensional anatomical data from specific patient. A full Na...

There are a lot of studies regarding modeling of the middle and inner ear. The models of middle ear are simple mechanical models, because three ossicles and supported ligaments which are placed in the middle ear have only role to transmit mechanical vibrations of tympanic membrane. These mechanical vibrations are caused by acoustical excitations fr...

Human hearing system is very interesting for investigation. There are several parts in hearing system, but the most important parts in sense of conversion of audio signal in electrical impulse are cochlea and organ of Corti. The reason why scientists investigate mechanical behavior of human hearing system is hearing loss – a health problem that aff...

The semicircular canals (SCC) are fluid-filled inner ear structures designed to detect circular or angular motion. In this study we modeled three-dimensional biomechanical model of SCC and compared results with real patient case for the Benign Paroxysmal Positional Vertigo (BPPV) disease. Model consists of full 3D fluid-structure interaction incorp...

Vibration of the skull causes a hearing sensation. We call it Bone Conduction (BC) sound. There are several investigations about transmission properties of bone conducted sound. The aim of this study was to develop a software tool for easy generation of the finite element (FE) model of the human head with different materials based on human head ana...

Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vertigo syndrome that affects 15% of older persons. BPPV is characterized by sudden attacks of dizziness and nausea triggered by changes in head orientation, and primarily afflicts the posterior canal. We are modeling human semicircular canals (SSC) which considers the morph...

Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for hu...

Human hearing system in general, and particularly the cochlea, is very interesting for investigation. The most important reason for it is hearing loss - a health problem that affects a large part of the world's human population. The highest percentage of people with hearing problems are older people, but the problem also occurs in newborns. Experim...

Hybrid imaging combining CT and SPECT is becoming a state of the art nuclear medicine technique. Advantages of hybrid imaging are improved quality of the images using CT data for attenuation correction based on true transmission density data in an individual patient, and CT and SPECT fusion images providing accurate localization of the tracer uptak...

This study describes computer simulation of blood flow and plaque progression pattern in a patient who underwent surgical treatment for infected carotid prosthetic tube graft using carotid-carotid cross-over bypass. The 3D blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lu...

Cochlea is part of the inner ear. The role of the cochlea is to transform outer acoustic signal into electrical impulse which is further transmitted to the brain. Two important phenomena taking place inside the cochlea: transformation of outer acoustic signal into mechanical vibration and transforming of mechanical vibration into electrical impulse...

The main goal of this paper is to describe two different systems that were developed for the purpose of abdominal aortic aneurysm mechanical properties investigation and to present the results of the measurements. The first system is based on the "Bubble Inflated" method and it increases the pressure of physiological saline which affects blood vess...

In this chapter we described predictive model for plaque formation and progression in the coronary and carotid artery. A full Three-Dimensional model for plaque formation and progression, coupled with blood flow and LDL concentration is analysed. The Navier-Stokes equations together with the Darcy law for model blood filtration and Kedem-Katchalsky...