Dalia Aly

National Research Center, Egypt | NRC · Department of Dermatology and Venereology

Acne vulgaris results from a complex interaction between environment and genetic factors. While colonization of the pilosebaceous unit with Propionibacterium was previously considered to be the main cause of acne, the contribution of host-related factors that allow the growth of the bacteria and its immune response against bacterial components are...

Background and Objectives To investigate the therapeutic efficacy and safety of growth factors combined with fractional carbon dioxide (CO2) laser in comparison with fractional CO2 alone in a sample of patients with facial mature burn scars. Study Design/Materials and Methods Fifteen Egyptian patients with bilateral facial burn scars were treated...

Background The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results. Objective The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Egypt...

Background/purpose: Genetic factors play an important role in the pathogenesis of vitiligo. Cyclooxygenase 2 (COX2) gene induced by ultraviolet radiation controls the synthesis of prostaglandins, which are are found to be beneficial in treating vitiligo. COX2 gene polymorphism has been previously evaluated in Chinese population. We aimed to study...

Background: High interleukin (IL)-17 contributes to vitiligo pathogenesis. Vitamin D has been assessed in vitiligo, with no reports targeting its relation to IL-17. Objective: To evaluate a possible regulatory effect of vitamin D on IL-17 and their relation to disease activity in vitiligo. Methods: This study included 30 vitiligo patients and...

Background: Chronic venous leg ulcers drastically reduce the quality of life of affected patients. There is heightened interest in autologous platelet-rich plasma (PRP) as one of the promising therapies for leg ulcers. Aim: Our aim was to compare the clinical efficacy of PRP in the management of chronic venous leg ulcers vs conventional treatmen...

Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H & E and HMB-45. Methods: Thirty subject...

Background: Striae distensae (SD), a type of dermal scarring, are psychologically disappointing. To date, information and scientific research behind the role of hormonal factors in the development of SD are still unclear. It is vital to understand striae to offer patients the best therapeutic options. Objectives: To investigate early alterations...

Background: Several studies have addressed the association of metabolic syndrome (MetS) with androgenetic alopecia (AGA) in men with few reports focusing on this association in females. The aim of this work was to investigate the association of MetS among Egyptian women with different stages of female pattern hair loss (FPHL) and to compare the re...

Introduction: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an essential factor in the growth and maturation of blood cells as well as modulation of the immune system. Few studies have investigated its involvement in the development of vitiligo, and no studies have been performed on Egyptian patients. Aim: To assess GM-CSF serum l...

Endothelin-1 is an autocrine growth factor for keratinocytes, an effect controlled by its A and B receptors, with no previous comparison of endothelin axis expression in inflammatory and neoplastic skin diseases showing keratinocyte proliferation. The aim of the study was to investigate endothelin-1 axis expression in skin lesions of psoriasis, bas...

Abstract Background: Oral acitretin, a synthetic compound of retinoids, seems to be a promising modality in treating warts. To the best of our knowledge, no studies regarding its use have been performed on Egyptian patients. Objectives: Evaluating the role of acitretin in the treatment of multiple recalcitrant common warts. Patients and Methods: Fo...

Abstract Throughout a females’ life, scalp hair growth is variable in its extent and time course. Age-related changes can occur to it including changes in the hair cycling, hair density, hair diameter and pigmentation, and possibly in structural qualities of the hair fiber. Evidence is starting to appear that environmental factors also contribute,...

Objectives: Human papilloma viruses have been identified in cutaneous and genital warts with minimal reports targeting, in particular, the association of high risk HPV-16 and 18 in Egyptian patients with genital warts, together with the absence of studies investigating these 2 viruses in plantar warts. Aim: To assess the impact of the virus type an...

Endothelin-1 (ET-1), expressed by keratinocytes, has paracrine effects on melanocytes. The endothelin 1-axis [ET-1, endothelin A receptor (ETAR) and endothelin B receptor (ETBR)] is thought to play a role in the depigmentation process occurring in vitiligo, with no studies on the cutaneous protein expression of this axis in the disease. The aim of...

Background: Leptin, an adipocyte-derived hormone, has been shown to have several immunological effects similar to those of proinflammatory cytokines. The relationship between serum leptin, psoriasis, and obesity is still conflicted, and very few studies have investigated its role in skin diseases other than psoriasis. Aim: To evaluate the possib...

Abstract Background. Endothelin-1 (ET-1), expressed by keratinocytes, has paracrine effects on melanocytes. The endothelin 1-axis [ET-1, endothelin A receptor (ETAR) and endothelin B receptor (ETBR)] is thought to play a role in the depigmentation process occurring in vitiligo, with no studies on the cutaneous protein expression of this axis in th...

Background. Two preparations of botulinum A toxin (BTX-A) are commercially available for the treatment of palmar hyperhidrosis (PPH): Botox (Allergan; 100 U/vial) and Dysport (Ipsen Limited; 500 U/vial), which are not bioequivalent. Results regarding an appropriate conversion factor between them are controversial. Objectives. This paper aims to com...

Background. There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. Methods. Thirty patients with severe plaque ps...

Angiogenesis and microvascular endothelial injury play a role in the pathogenesis of systemic lupus erythematosus (SLE). Vascular endothelial growth factor (VEGF), a key regulator of angiogenesis, and nail fold capillaroscopy (NFC) have been investigated in few studies in SLE with no reports targeting SLE with cutaneous manifestations. To evaluate...

Objective: Vitiligo is a specific type of leukoderma characterized by depigmentation of the epidermis. This study aimed to compare the effectiveness of methotrexate, narrow-band phototherapy, and corticosteroid as three different treatment modalities for vitiligo. Patients and methods: The study included 52 patients suffering from nonsegmental viti...

Neo-angiogenesis is reported to be essential in the pathogenesis of oral lichen planus (LP). We aimed to investigate angiogenesis through CD34 staining and vascular endothelial growth factor (VEGF) expression in cutaneous LP lesions and to evaluate the relation of these markers with the degree of inflammation. Thirty patients with cutaneous LP and...

Psoriatic plaques have been shown to contain increased levels of pro-inflammatory cytokines. Also, serum levels of several cytokines have been reported elevated in psoriatic patients. It is postulated that changes in cytokine production both locally and systemically could be useful in monitoring disease activity. The aim of this study was to evalua...

Systemic Sclerosis (SSc) is characterized by skin thickening, fibrosis and vascular obliteration. The onset and course are heterogeneous. Prominent features include autoimmunity, inflammation and vascular damage. To measure the level of serum Anti-Annexin V antibodies in SSc patients and to study its significance in relation to vascular damage in t...

Increased reactive oxygen species (ROS) and lipid peroxides have been implicated in the pathogenesis of atopic dermatitis, psoriasis, vitiligo, and lichen planus (LP). We therefore evaluated the status of oxidative stress and the antioxidant defense system in Egyptian patients with LP. This study included 45 Egyptian LP patients and 45 healthy volu...