Dal Williams

• BS Chemistry, University of Tennessee, Knoxville
• Research Assistant at University of Mississippi

This study summarizes the synthesis, characterization, and evaluation of a library of biocompatible self-assembling Janus dendrimers (JDs) and their resulting nanostructures possessing either a cationic (NH3+), anionic (COO-), or neutral (OH) surface. Strategically designed for applications in therapeutic delivery, the dendrimers are comprised of a...

This study represents a successful approach towards employing polycaprolactone - polyamidoamine (PCL-PAMAM) LDBC nano-aggregates as small molecule carriers in NIR imaging and photothermal therapy. A feasible and robust synthetic strategy was used to synthesize a library of amphiphilic LDBCs with well-controlled hydrophobic to hydrophilic weight rat...

Over the last decade, there has been an exponential development of polymeric­based therapeutic systems for the treatment and diagnosis of cancer­related diseases. In contrast with traditional molecular­based therapeutic agents, these new polymers facilitate a higher level of versatility and functionality such as simultaneous delivery, targeting and...

Herein, we present a facile and comprehensive synthetic methodology for the preparation of polyester‐polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) and polyamidoamine, PAMAM [hydrophilic]) polymers. A library of PLA‐PAMAM linear dendritic block copolymers (LDBCs) in which both l and d, l polylactide were employed in mass r...

Presented are design strategies towards hierarchically assembling a C2-symmetric π-conjugated oligomer (DAD-XB-Boc) based on a donor-acceptor-donor motif through hydrogen bonding (HB), halogen bonding (XB), and π-stacking interactions. Upon co-crystallization with tetrafluoro-1,4-diiodobenzene (TFDIB), single crystal X-ray analysis reveals highly d...

Therapeutic approaches employing polymer-based designs have emerged as essential methodologies for drug and gene administration. Scaffolds and carriers compromised of biocompatible and biodegradable polymeric components such as linear block or graft copolymers have been described in previous literature as suitable candidates for biomedical applicat...

Dendrimers comprised of heterogeneous polymeric segments (e.g., hydrophobic and hydrophilic) afford multiple properties in a single molecule. Such dendrimers are described as “Janus type” and can be obtained by coupling two dendrons—possessing chemically different properties—to a single core. A unique property exhibited by these Janus dendrimers is...

Self-assembling linear-dendritic hybrids as next generation drug delivery systems Dendrimers comprised of heterogeneous polymeric segments (e.g., hydrophobic and hydrophilic) afford multiple properties in a single molecule. Such dendrimers are described as "Janus type" and can be obtained by coupling two dendrons-possessing chemically different pro...

Although recognized as a significant force in crystal engineering, halogen bonding (XB) has been scarcely investigated in "bottom-up" approaches towards organic electronics. We report, herein, the use of a thiophene-based building block, pyridyl-thiophene (Pyr-T), to achieve an assembly driven by XB and π-π stacking interactions with iodopentafluor...