Dai Thi Xuan Trang

Can Tho University · Department of Biology

Ehretia asperula Zoll. & Moritzi was a common medicinal herb found in several Asian nations. This herb was found in many provinces in northern Vietnam, especially Hoa Binh province. Leaves of E. asperula cultivated in Tay Ninh Province were used to isolate compounds and evaluate their potential as antioxidants by five methods, including TAC, RP, FR...

Nghiên cứu được thực hiện nhằm tuyển chọn các dòng vi khuẩn nội sinh trong cây bướm bạc có khả năng kháng oxy hoá và kháng viêm in vitro. Ba mươi mốt dòng vi khuẩn nội sinh đã được phân lập từ cây bướm bạc. Hoạt tính kháng oxy hóa của các dòng vi khuẩn nội sinh được xác định nhờ vào phương pháp kháng oxy hóa tổng số, năng lực khử và trung hòa gốc t...

Nghiên cứu được thực hiện để xác định hóa thực vật và hoạt tính sinh học của các cao chiết từ cây màn màn tím (thân, lá và thân lá). Hoạt tính kháng oxy hóa được xác định dựa vào hoạt động trung hòa hoặc ức chế các gốc tự do phi sinh học. Hoạt tính kháng viêm được xác định dựa trên khả năng bảo vệ màng tế bào hồng cầu và ức chế sự biến tính protein...

Nghiên cứu hiện tại đã so sánh hoạt tính kháng oxy hóa và kháng đái tháo đường in vitro của cây xạ đen trồng tại Hòa Bình và 2 địa điểm của Tây Ninh (Hòa Thành và Châu Thành). Ngoài ra, hàm lượng polyophenol, flavonoid đã lần lượt được kiểm tra bằng thuốc thử Folin-Ciocalteau và aluminum chloride. Lá xạ đen trồng ở 2 địa điểm của Tây Ninh đều có po...

Vibrio phage KIT04 was isolated from muscle tissue samples collected from a local market in Vietnam. KIT04 is a lytic phage that is specific to Vibrio parahaemolyticus. The one-step growth curve determined the burst size and latent period of 0.01 multiplicity of infection KIT04 in V. parahaemolyticus as approximately 156 plaque-forming units/bacter...

Mục tiêu của nghiên cứu này là xác định hoạt động của malondialdehyde, glutathione và glucose-6-phosphatase trong gan, thận và tuyến tụy của chuột mắc bệnh đái tháo đường được điều trị bằng cao chiết rễ cây gáo vàng. Ngoài ra, nghiên cứu cũng đánh giá hoạt tính kháng oxy hóa và ức chế enzyme (α-amylase, α-glucosidase) của cao rễ gáo vàng. Sự tăng g...

Trong những năm gần đây, nhiều nghiên cứu cho thấy vi khuẩn nội sinh trong thực vật có vai trò quan trọng trong nông nghiệp, dược liệu, và có tiềm năng ứng dụng rất lớn. Nghiên cứu này được thực hiện nhằm đánh giá khả năng mang các vi khuẩn nội sinh trong cây bọ mắm (Pouzolzia zeylanica L.). Các thí nghiệm đã được bố trí để phân lập, nuôi cấy in vi...

The flowers of M. velutina were extracted with ethanol to obtain a crude extract that was consecutively extracted using n-hexane, dichloromethane, ethyl acetate and water. The crude extract and fractions were studied for the chemical composition and antioxidant and antidiabetic activities. The extracts had various phytoconstituents, namely steroids...

Pomelo peel contains a lot of important bioactive compounds having benefits for human health. This pomelo peel (Citrus grandis L.) products have important health benefits, so pomelo peel tea has been produced in order to enhance this great value. In-vitro and in-vivo studies on Nam Roi pomelo peel tea extract combined with identified acute toxicity...

Anthracnose disease caused by Colletotrichum spp. makes heavy losses for post-harvest mangoes of Cat Hoa Loc variety during storage, packaging, and transportation. The synthetic fungicides are commonly used to control the disease, but they are not safe for consumers’ health and environment. This study was aimed to investigate the use of essential o...

Anti-aging effect is a stimulating topic that attracting serious consideration from many researchers. Medicinal plants with anti-aging properties thereby have become common research subjects in various fields of science. This study aims to determine phytochemical constituents, specifically the total of phenolic and flavonoid contents and evaluate t...

Background and Objective: Lasia spinosa L. Thwaites is an herbaceous perennials plant that is well- known for its multiple functions in terms of pharmacological effects. This study aimed to identify the capability to against free radicals and enzymatic glycosylation in vitro to examine its oxidative stress inhibition, thereby discover an innovative...

Nghiên cứu được thực hiện để đánh giá thành phần hoá học và hoạt tính kháng khuẩn của các cao chiết Sổ Trai. Thành phần hóa học của các cao chiết cây Sổ Trai được tìm thấy có chứa alkaloid, flavonoid, steroid, glycoside, saponin, tannin và sesquiterpene lactones. Cao chiết ethyl acetate của lá Sổ Trai và ethyl acatete của gỗ Sổ Trai có hàm lượng fl...

Nghiên cứu được thực hiện để đánh giá tác động điều hòa hoạt tính enzyme glucose-6-phosphatase trong gan và thận của cao chiết thân mớp gai trên chuột bị bệnh đái tháo đường do alloxan monohydrate. Trong nghiên cứu này, bệnh đái tháo đường ở chuột đã được gây ra bằng cách tiêm alloxan monohydrate vào trong xoang bụng chuột. Khởi phát bệnh đái tháo...

Germinated brown rice (GBR) consists of bioactive compounds (BCs) that are very useful for diabetes treatment. Modified GBR‐based flour (MGBRF) was produced by modifying the starch in GBR with 0, 299.19, 598.38, and 897.57 U/ml of cyclodextrin glycosyltransferase (CGTase) for 1 hr and then spray‐dried to examine its antidiabetic and cytotoxic effec...

Miliusa velutina (MV) stem bark has various medicinal uses, but its hepatoprotective effect has not yet been studied. This study investigated the antioxidant and hepatoprotective activity of the ethanol extract of MV stem bark against carbon tetrachloride (CCl4)-induced liver injury. The ethanol extract of MV stem bark was evaluated for in vitro an...

Lasia spinosa (L.) Thwaites was used as a traditional medicine to treat many inflammatory diseases for centuries. However, its effects on the inflammatory response are not yet characterized. In this study, we investigated the anti-inflammatory activities of L. spinosa leaf extract in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. We found...

Trang To (Ixora duffii) belongs to the genus Ixora in the family Rubiaceae. The in vitro total antioxidant and anti-inflammatory capacity of the methanol extract of Trang To leaf was investigated using the phosphomolypdenum method and the bovine serum albumin denaturation test, respectively. The results showed that the methanol extract of Trang To...

Trang To (Ixora duffii) belongs to Ixora genus in the family Rubiaceae. The in vitro total antioxidant and anti-inflammatory capacity of Trang To methanol leaf extract was investigated by using phosphomolypdenum method and Bovine serum albumin denaturation test. The results have shown that Trang To methanol leaf extract possessed relatively high an...

Lipids play important roles for the cell in storing energy, structuring cell membrane and signaling pathway. In numerous distinctive studies, the analysis of lipids is to examine for distinct purposes. In the current research, a reliable, rapid, and economical assay has been developed to quantify the total of lipid in samples. The development of co...

The aim of this study was to investigate antihyperglycemic, antihyperlipidemic and antioxidant activities of the extract of Coccinia grandis leaves (CGL) by methanol in alloxan induced diabetic mice. Hyperglycemic was induced in mice by administration of alloxan monohydrate (135 mg/kg, ip.). CGL was orally given to the normal mice (100 and 1000 mg/...

In this study, the antihyperglycemic and antihyperlipidemic effects of Mangifera indica L. (MIL) young leaves extract were investigated using diabetic mice models. Male Mus musculus L. mice were intratoripeneally injected by Alloxan monohydrate (AM) to induce diabetes and were observed for 28 days. The blood glucose, total cholesterol (TC), triglyc...

Tau protein and Aβ-amyloid have been studied as pathological aggregations, which form neurofibrillary tangles and amyloid plaques in Alzheimer’s disease brain. Tau protein plays a critical role in neuron that binds to microtubules and assists with their formation and stabilization. However, unbinding of hyperphosphorylated tau and microtubules lead...

Acanthus ilicifolius is a common medicinal herb used in treatment for hepatic diseases in Vietnamese traditional medicine. This study investigated hepatoprotective effects of methanol extract of A.ilicifolius roots at various concentrations on mice having carbon tetrachloride (CCl4)-induced liver damages by measuring levels of two liver enzymes (al...

Antibacterial activity of the methanolic extracts of Eclipta alba were carried out by the disc diffusion method on 12 strains of bacteria isolated from 30 samples of tiger shrimp (intestines) collected from shrimp farms in Tan Thanh hamlet, An Loi commune, Tran Van Thoi district, Ca Mau province. All strains isolated were grown for 24h on TCBS agar...

Diabetes with many dangerous complications is a major threat to global health. In this study, we evaluated the anti-diabetic potential of ethanol extract from Pandanus amaryllifolius leaves by determining their antioxidant ability. In the first step, mice were induced to be diabetes by using alloxan monohydrate (AM) solution. In the end of experime...

Hyperuricemia is associated with gout, and also closely related to cardiovascular diseases, renal calculus, diabetes and metabolic syndrome. Xanthine oxidase which catalyses the oxidation of hypoxanthine to xanthine and then to uric acid, plays a crucial role in gout. In treatment of gout, allopurinol is clinically used as xanthine oxidase inhibito...

Hyperuricemia is associated with gout, and also closely related to cardiovascular diseases, renal calculus, diabetes and metabolic syndrome. Xanthine oxidase which catalyses the oxidation of hypoxanthine to xanthine and then to uric acid, plays a crucial role in gout. In treatment of gout, allopurinol is clinically used as xanthine oxidase inhibito...

The spread of drug resistance in malaria parasites and the limited number of effective drugs for treatment indicates the need for new anti-malarial compounds. Current assays evaluating drugs against Plasmodium falciparum require expensive materials and equipment, thus limiting the search for new drugs, particularly in developing countries. This stu...

To gain insight into the mechanism of malarial hemozoin formation and to explore various biological groups for screening novel antimalarial drugs, we examined the effects of amino acids on the formation of beta-hematin (BH), which is a synthetic heme crystal structurally identical to hemozoin, in vitro. Our results showed that BH formation was sign...

The formation of the malarial pigment, a unique hemozoin crystal with unit cells comprised of heme dimers, has been proposed as an ideal target for antimalarial screening. The mechanism of beta-hematin formation (a synthetic crystal structurally identical to hemozoin) has been suggested that a hydrophobic interaction is needed to solubilize heme, b...

Current assays for screening new antimalarials need initiators of β-hematin formation that require laborious preparation, special devices, and substrates. In this study, based on reduction of heme absorption in β-hematin formation, we developed a simple colorimetric assay using Tween 20 as an initiator and a microplate reader for high-throughput sc...

Malarial pigment, a unique hemozoin crystal composed of unit cells of heme dimers, is present in large amounts in circulating monocytes and neutrophils and can persist unchanged in macrophages for several months. In the present study, we investigated the effect of hemozoin not only on macrophages, but also on neutrophils. We used beta-hematin (BH),...

Measurement of heme crystallization provides a tool for screening new antimalarial drugs. Current assays for heme crystallization have employed initiators such as thermo, histidine-rich proteins, and lipids extracted from parasites and infected plasma. These initiators are unnatural or require laborious steps to prepare. In this study, we used a co...

Isolation of a concentrated, living preparation of malarial parasite-infected red blood cells (PRBCs) that have low contamination of white blood cells (WBCs) facilitates research on the molecular, biochemical and immunological aspects of malarial parasites. This is currently carried out by a two-step method, including the concentration of PRBCs usi...

Plasmodium falciparum histidine-rich protein 2 (PfHRP2) has been suggested to be an initiator of the polymerization of heme, which is produced as by-product on the digestion of hemoglobin, and a promoter of the H(2)O(2)-induced degradation of heme in food vacuoles of the malarial parasite. In this work, we have designed PfHRP2 model peptides, R18 a...