D. Marcu

Chronic pelvic pain syndrome (CPPS) presents a diagnostic challenge due to its multifactorial nature, often involving urological, gynecological, and psychological components. This study focuses on the effectiveness of prophylactic phytotherapy in preventing CPPS recurrence, aiming to mitigate symptoms and psychosocial impact. The study includes 74...

Background: The highlighting of possible risk factors for urinary colonization in patients with obstructive urolithiasis that needed double J catheters implanted to preserve renal function. Methods: We performed a descriptive, retrospective study, carried

1) Background: Human papillomavirus (HPV) E6 and E7 oncoproteins are vital for developing HPV induced penile carcinoma. The viral oncoproteins play a central role in oncogenesis by interacting with several cellular regulatory proteins, such as p16 INK4a and p53. Many studies suggest that these proteins showed clinical utility in predicting nodal di...

One of the most common types of cancer worldwide (9th most commonly diagnosed) is renal cell carcinoma (RCC). It is more common in developed countries and it usually develops in individuals between 60 and 70 years of age. The earlier the disease is identified, the lower the morbidity. Therefore molecular markers that exist in blood and urine may be...

Human papillomavirus (HPV) is one of the most widespread human pathogens. For a long time, it was treated as an opportunistic infection, but it is in actuality one of the most dangerous carcinogens. It is responsible for numerous malignancies: Cervical, penile, oropharyngeal, vaginal, vulvar and some anal neoplasia. The need for a long-term solutio...

malignant diseases with an extremely high recurrence rate compared to other neoplastic tumors. Urothelial bladder carcinomas are mostly identified in their incipient form, as non‑muscle invasive, but despite that, a third of them develop into aggressive recurrent disease. The diagnosis of bladder carcinoma at this moment is established using cytolo...

Androgen insensitivity syndrome (AIS) is an X-linked recessive genetic syndrome that occurs as result of an androgen receptor mutation; it affects the normal masculinization process in chromosomal male patients. More than 900 androgen receptor mutations that can lead to AIS have been identified. The complete androgen insensitivity is characterized...

Malignancy as an etiological factor involved in priapism pathogenesis is rare. Malignant priapism (MP) can arise as a result of penile tumor invasion, either from primary penile tumors or from metastatic penile tumors, or due to hematological malignancies. Non-urological penile metastases are associated with significant worse prognosis compared to...

Pelvic organ prolapse is a frequent health problem in women, encountered worldwide, its physiopathology being still incompletely understood. The integrity of the pelvic-supportive structures is a key element that prevents the prolapse of the pelvic organs. Numerous researchers have underlined the role of connective tissue molecular changes in the p...

Radical prostatectomy is one of the most frequent therapeutic options used for the management of patients diagnosed with prostate cancer. Normal erectile function after radical prostatectomy is a great problem for numerous patients and a real challenge for urologists worldwide. The advancements that have been made over the years in terms of minimal...

Radical prostatectomy is one of the most frequent therapeutic options used for the management of patients diagnosed with prostate cancer. Normal erectile function after radical prostatectomy is a great problem for numerous patients and a real challenge for urologists worldwide. The advancements that have been made over the years in terms of minimal...

Introduction. The concept of underactive bladder is relatively new. Currently there is no generally accepted definition of this pathology. Diagnosis depends on urodynamic findings, and symptoms are usually rare and intricated with the symptoms of other urinary pathology. Matherials and methods. This review examines the current literature on underac...

THE PRESENT ARTICLE IS A REVIEW IN THE MODERN MANAGEMENT OF THE RENO-URETERAL CALCULI. SEPARATE REVIEWS OF THE LITERATURE AND GUIDELINES WERE PERFORMED FOR EACH SEGMENT OF THE RENAL SYSTEM, REGARDING ONE OF THE MOST COMMON PATHOLOGY OF THIS SYSTEM: STONES. MOST IMPORTANT, ALL OF THE RECOMMENDATIONS REGARDING THE TREATMENT OF THIS DISEASE WERE BASED...

THERE ARE A FEW STUDIES WHICH LOOKED INTO THE OVERALL BENEFIT AND LONG TERM OUTCOME OF RADICAL OPEN PROSTATECTOMY VERSUS LAPAROSCOPIC PROSTATECTOMY, THE SECOND PROCEDURE BEING MORE AND MORE POPULAR WITH THE PATIENT BUT ALSO WITH THE UROLOGIST. THE PURPOSE OF THIS ARTICLE IS TO COMPARE THE BENEFITS TO THE PATIENT, THE ADVANTAGES AND DISADVANTAGES BE...

Management of recurrent UTI is a very topical subject due to the high prevalence of the disease, its influence on the quality of life and the resulting social burden, as well as the increasing ecological adverse effects of the prolonged and repetitive antimicrobial therapy prescribed over the time. Sustained efforts should be made for a better unde...

Tumeurs de cellules germinales extragonadiques-pathogenèse, résultats histopathologiques, diagnostic et traitement Les tumeurs germinales extragonadiques primaires (EGCT) constituent un groupe rare de néoplasmes pouvant exister n'importe où le long de la ligne mé-diane du corps, sans preuve d'une tumeur gonadique primaire. Leur morphologie varie co...

Radical prostatectomy is the most commonly performed treatment option for localised prostate cancer. In the last decades the surgical technique has been improved and modified in order to satisfy both oncological safety and postoperative functional results. Urinary incontinence and erectile dysfunction (ED) are the main postoperative functional impa...

Penile carcinoma is a relatively frequent health issue in the developing countries such as Africa, Asia and South America, usually affecting men aged between 50 and 70 years. It is a highly treatable disease in its early stages, but has serious physical and psychological consequences. Usually, penile carcinoma is located in the penile glans, in app...

The role of beta-adrenergic receptor antagonists in cardiovascular therapy has been the subject of various studies over time, these agents representing one of the oldest class of drugs used for the treatment of cardiovascular diseases. Although beta-blockers have been excluded from guidelines as the first-line therapy in essential hypertension, the...

Pheochromocytoma is a neuroendocrine tumor characterized by the excessive production of catecholamines (epinephrine, norepinephrine, and dopamine). The diagnosis is suspected due to hypertensive paroxysms, associated with vegetative phenomena, due to the catecholaminergic hypersecretion. Diagnosis involves biochemical tests that reveal elevated lev...

Pelvic organ prolapse (POP) is the aberrant herniation or descent of the pelvic units from their regular sites or their normal location in the pelvis. The pelvic organs that may be interested include the vaginal apex or uterus, anterior wall of vagina-cystocele, or posterior wall of vagina-rectocele. A thorough review of the literature using PUB me...

Patients with cancer-associated venous thromboembolism (VTE) represent a real challenge in clinical practice. Patients with cancer have a greater risk both of VTE and bleeding. There are only a few studies regarding the therapeutic approach of VTE in patients with cancer, especially after cancer surgery, and on thromboprophylaxis during chemotherap...

Minimally invasive biopsy procedures have proven over the years to be essential for obtaining a correct diagnosis of retroperitoneal tumors,

Prostate cancer is the second most common form of cancer in men in Europe. The primary treatment of this type of cancer is radical prostatectomy, which has shown good oncological results. Radical prostatectomy (open, lapa‐ roscopic or robotic) has high success and low morbidity rates in patients with localized prostate cancer. The life expectancy i...

Introduction: A great number of comorbidities is often registered in patients with type 2 diabetes mellitus (T2DM), increasing the costs associated with the management of this disease. Our objective is to describe the characteristics and comorbidities of a study group of 219 T2DM patients. Methods: 219 T2DM patients were selected to partake in this...

Patients with inflammatory bowel diseases (IBD) have an increased risk of cardio-vascular events (myocardial infarction, cerebrovascular events and death of cardiovascular causes), because of some common pathophysiological mechanisms. Patients with IBD have high levels of cytokines, C-reactive protein and homocysteine, leading to endothelial dysfun...

Cardiovascular disease (CVD) and erectile dysfunction (ED) are two conditions that often coexist. Both diseases are consequences of the systemic vascular disease, sharing common risk factors, like diabetes mellitus, arterial hypertension, smoking, obesity, dyslipidaemia. Furthermore, they share the same pathological basis, endothelial dysfunction....

According to literature the primary retroperitoneal malignant pathology is rare, representing less than 0.5% of all malignancies. In spite of its low incidence, this pathology often proves challenging in terms of diagnosis and treatment. The most com¬mon retroperitoneal malignancy is represented by lymphoma that accounts for approximately 33 % of t...

Retroperitoneal tumors grow quietly and are generally large in size, more than half of them being larger than 20 cm at the time of diagnosis. They usually present several therapeutic challenges because of their rarity, relative late presentation and anatomical location, often in close relationship with several important structures in the retroperit...

Two major trials, EMPA-REG OUTCOME trial (with Empagliflozin) and CANVAS trial (with Canagliflozin) have demonstrated the beneficial effects of SGLT2 inhibitors in patients with type 2 diabetes at risk for heart failure. SGLT2 inhibitors possess a unique pharmacological profile and have shown a significant reduction of hospitalization for heart fai...

The retroperitoneum can host a wide variety of pathologies, including benign and malignant tumors. Primary retroperitoneal tumors are rare, usually large in size, more than half of them being larger than 20 cm at the time of diagnosis, due to their silent growth. They often present several therapeutic challenges because of their rarity, relatively...

Reno-ureteral lithiasis is a common pathology especially in socio-economically developed countries and may pose serious problems with renal function impairment. Urology is currently one of the surgical branches that benefit from a wide range of therapeutic options in reno-ureteral lithiasis, that revolutionized the criteria and indications of the l...

Radiation cystitis is a complex pathology, with a significant negative impact on the patient's quality of life, often proving to be a real challenge for physicians due to its bothersome symptoms and severe complications such as recurrent haematuria. The mechanism involved in radiation induced cystitis pathogenesis is the injury of the bladder's uro...

Retroperitoneal tumors, once considered uncommon, have been reported in the last years in such numbers that they cannot be considered anymore a rare condition. Tumor recurrence following surgical excision is quite common and a tumor that was considered originally as benign in many cases can recur as a malignant tumor. The purpose of this paper is t...

Patients with inflammatory bowel diseases (IBD) have an increased risk of cardiovascular events (myocardial infarction, cerebrovascular events and death of cardiovascular causes), because of some common pathophysiological mechanisms. Patients with IBD have high levels of cytokines, C-reactive protein and homocysteine, leading to endothelial dysfunc...

Renal angiomyolipomas (AML) are the most common benign renal tumors. By containing an important amount of fat tissue they are easily identifiable on CT and MRI images, thus no biopsy should be needed for a diagnosis. However there is a small percentage of AMLs that have very little fat tissue and are very difficult to differentiate from renal cell...

Ureteral stenting has become one of the most common endoscopic procedure in endourology. Its main purpose is to preserve urinary drainage if this is compromised and maintain a good renal function. Even if there were made significant improvements in the last 50 years, ureteral stenting is not without morbidity. The common ureteral stents cannot have...

WE PRESENT A CASE OF A 62 YEARS OLD MAN, WHO WAS ADMITTED RECENTLY IN OUR SURGICAL CLINIC. HE WAS OPERATED LAPAROSCOPICALLY, APPROXIMATELY 7 MONTHS BEFORE, FOR AN ACUTE CALCULOUS CHOLECYSTITIS. HE PRESENTED AT EMERGENCY ROOM FOR PERSISTENT RIGHT FLANK ABDOMINAL PAIN AND A PALPABLE MASS AT THE SAME LEVEL. COLONOSCOPY CONFIRMED THE ABDOMINAL ULT...

KEY WORDS: ACUTE DIVERTICULITIS, DIVERTICULOSIS, UNCOMPLICATED SYMPTOMATIC DIVERTICULAR DISEASE, THERAPEUTIC MANAGEMENT, SURGERY INTRODUCTION The frecquency of the colonic diverticulosis in Western Europe is high, affecting about 50-66% of people ≥ 80 years of age. Thus, diverticulosis represents a common pathology, taking into consideration the in...

Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are two conditions with an increased incidence and prevalence. Numerous studies highlight the pathophysiological links between HFpEF and AF and the common risk factors. Patients with HFpEF have a high incidence of AF. It is difficult to determine which of the pathol...

Systemic lupus erythematosus (SLE) is a complex autoimmune condition, which often evolves with severe complications. In SLE, autoantibodies appear, with systemic inflammation and multiple tissue destructions. SLE is the most common form of lupus and is considered more severe than other forms. SLE can affect many parts of the body, including the kid...

Heart failure is the final stage of evolution of a large number of cardiovascular diseases and represents a health problem worldwide, due to increased prevalence of cardiovascular diseases. The patients with heart failure with preserved ejection fraction (HFpEF) represent about a half of the patients with heart failure and the prevalence of HFpEF i...

Objective: The goal of this paper is to present the management of cases of deep endometriosis that affects the bladder, the ureters and the kidney. Materials and method: In this review we analyzed the sensitivity and specificity of imaging techniques for diagnosing deep infiltrating endometriosis, the optimal surgical technique and the surgical app...

Objective: This is an observational study to record the effect of Hyaluronic Acid instillations on the pain felt by patients with Interstitial Cystitis/Radiation Cystitis, measured via Visual Analogue Scale and measuring urination frequency and urinary volumes to the end of treatment. Material and method: 10 weeks study, with 10 weeks of treatment...

Current guidelines for the treatment of erectile dysfunctions indicate the need to a complete evaluation of the patient, which includes a detailed history, clinical and paraclinical tests. The primary assessment of the patient with erectile dysfunction follows sexual, medical and psychosocial history, clinical examination and paraclinical tests. De...

Incidence in reflux acute pyelonephritis in patients with JJ stent AbstractThis study has been conducted on patients admitted at the Urology Clinic in Brasov and who have developed reflux acute pyelonephritis due to JJ stents indwelling. In order to better understand the disease, important characteristics such as age,gender , environmental backgrou...

Testicular cancer is considered a rare pathology, only 1-1.1% of men develop this type of neoplasm. The aim of this study was to evaluate the clinical characteristics, the histopathological and management of the rare testicular tumors. We performed a systematic review of 18 studies extracted from several data bases (Pubmed, Medline, Embase). The ra...

The use of mesh plugs is something usual in nowadays surgery. Even if it has been used mostly in general surgery for almost 20 years there is a new application of this material and that is uro-gynecology. As all new surgical techniques initially there was a great momentum followed by the occurrence of various post-operative complications. Intraoper...

Male infertility is of the most important pathologies nowadays due to the negative impact both on men's life and on couples life. To deal with this pathology, it is important to know the cause and the risk factors that can lead to this condition. Also, the knowledge of the factors involved in this disease is of major importance not only for his tre...

Introduction Malignant hypertension is one of the most severe forms of arterial hypertension. Clinically it is defined as a sudden and rapid blood pressure growth, with possible severe vascular changes and potential lethal complications. Objectives The goal of this paper is to review the possible causes of malignant renal hypertension or reno-vascu...

Pelvic organ prolapse (POP) is a common medical problem, usually encountered in older female patients, but also in younger patients. This pathology can negatively affect the patient’s normal sexual function, which is an important aspect of the quality of life. Nowdays numerous patients undergo surgery for POP, but evidence from studies regarding th...

Penile neoplasia is a relatively rare cancer. There were made huge steps in determining risk factors and finally HPV – human papilloma virus holds its place. What is the most wrong attitude is people tend to neglect and to hide what happens to their sexual organs. More than 65% of penile neoplasia is neglected in the first 6 months of the disease....

Erectile dysfunction is a common problem that occurs in men with chronic renal failure on hemodialysis, with prevalence rates that may reach 70-80%. The pathogenesis of erectile dysfunction in this group of patients is most probably multifactorial. A number of factors are to be considered, such as: hormonal disturbances, peripheral vascular disease...

Pelvic organ prolapse (POP), the herniation of the pelvic organs to or beyond the vaginal walls, is a common condition affecting a large number of women, incidence increasing after menopause. The most common risk factors found among patients with POP are age, parity and obesity and it causes a variety of pelvic, urinary, bowel, and sexual symptoms....

Introduction Pelvic organ prolapse recurrence after initial surgical treatment is an important medical problem, it's management often proving to be a real challenge. Less than 35% of the patients with prolapse recurrence after surgical management will seek medical advice for another surgery. Material and methods We have analyzed the current regardi...

Introduction Pelvic organ prolpase is a frequent pathology, encountered especially in elder female patients, often asymptomatic, being estimated that less than 50% of the symptomatic patients will seek medical help for its bothersome symptoms and complications such as: chronic incomplete urinary retention, ureterohydronephrosis, acute and/or chroni...

Introduction Uro-gynecological surgery has seen a huge leap in the last decades due to minimal invasive methods involving the use of alloplastic mesh. As any new surgical method initially saw a significant advance followed by the occurrence of various post-operative complications. Intraoperative various injuries of neighboring organs have occurred....

Xanthogranulomatous pyelonephritis (XP) is a rare form of pyelonephritis that can lead to the distruction of the kidney if left untreated. The first man who described this type of desease was Schlagenhauer in 1961, and as back then, nowadays its still a rare but serious condition. This type of pyelonephritis is characterised by the replacement of n...

Atrial fibrillation is a commonly encountered pathology in medical practice, and its prevalence has shown a continuous rise over the past years. Atrial fibrillation has a significant impact on patients' quality of life, not only due to the standard anticoagulant treatment with vitamin K antagonists that require close monitoring and dose adjustment,...

Objectives: The incidence of erectile dysfunction in diabetic patients is much higher compared to the non-diabetic patients, resulting in important alterations of the patient's quality of life and self-esteem, creating a vicious circle that amplifies even more this sensible problem. The aim of this study is to review the available therapeutical opt...

Introduction: Pelvic organ prolapse (POP) is an important health problem due to its debilitating effects, with a lifelong risk for surgery estimated at 7-19 %. Over the years transvaginal mesh surgery for anterior vaginal wall prolapse has become the first line treatment due to its numerous advantages and good results when compared with classic pro...

Introduction: Stress urinary incontinence is a frequent and often underreported pathology, with important negative consequences on the patient's lives. The midurethral sling approach has proven over the years to provide good results, becoming the first line treatment in management of SUI. Material and methods: The aim of this study is to evaluate t...

Objectives: It is well known that diabetic patients associate a higher risk of urinary infections, over 80% affecting the upper urinary tract. The purpose of this paper is to underline the importance of prompt diagnosis and proper treatment of urinary infections in diabetic patients, infections that often evolve to severe and potential lethal compl...

One of the most frequent kidney pathologies encoun‑ tered in daily practice is represented by the presence of renal cysts. Most of them are asymptomatic and are found accidentally during periodical check‑ups be‑ cause they don’t have clinical signs until they grow and compress the surrounding organs. We have reviewed the current data regarding this...

The aim of this paper was to analyze the prognostic features, clinical presentation, diagnosis and treat‑ ment of primary renal sarcomas. A thorough review of the literature was made using the PubMed data‑ base. Sarcomas of the kidney are very rare malignant tumors, with a very poor prognosis compared with the other urogenital sarcomas. Several his...

Ureteral stents represent a minimally invasive alternative to preserve urinary drainage whenever the ureter is damaged or is under a significant risk to be occluded due to extrinsic or intrinsic etiology, even due to iatrogenic cause. Ureteral obstruction caused by extrinsic compression is often associated with intra-abdominal neoplasms. The first-...

Retroperitoneal space is called sometimes no man's land"and for a good reason: This is disputed anatomical territory for many surgical and medical specialties. Their wide histological diversity and unspecific clinical presentation make them a challenge for the surgeon. In order to improve their detection immunohistochemistry seems to show promising...

Alcoholism is a common condition and frequently clinicians are forced to confront its complications in general ho- spital settings. There are an estimated 3 million alcohol-dependent people in Romania alone, from which a signifi - cant number suffers episodes of withdrawal severe enough to require pharmacologic treatment. Alcohol withdrawal syndro...

Introduction. Iatrogenic injury of the urinary tract in women undergoing pelvic surgeries is one of the most feared complications and an important source of significant morbidity. Moreover, they cause a lot of anxiety to both patient and surgeon and they also create many legal concerns. The most commonly affected organs are the ureter, bladder and...

Potassium is a key electrolyte for the maintenance of cardiovascular system health, being involved in a broad array of vital physiological processes. Hyperkalemia is a common clinical problem and potentially life-threatening condition predominantly seen in patients with cardiac and kidney disease, especially if receiving treatment with inhibitors o...

Endometriosis is an important public health issues concerning women of reproductive age due to its debilitating painful symptoms. Deep infiltrating endometriosis is the severe form, involving uterosacral ligaments, rectum, bowel and bladder. There is no optimal treatment for this disease, but there are 3 main therapeutic options: medical, surgical...

Castleman's disease (CD) is a rare and benign lymphoproliferative pathology, characterized by lymphoid tissue hyperplasia, process that can occur at any site of the lymphoid chain. The purpose of this paper is to review the existing data regarding Castleman's disease etiopathogenesis and treatment. Considering the extent of the lymphoid tissue invo...

Objectives. Vulvar cancer is a rare gynecological malignancy, with an incidence of 1.5 per 100 000 women/year. The most common vulvar cancer is developed in squamous cells, the most encountered type of skin cells. Case report. We report a case of a 72-year-old female admitted in the Department of Plastic Surgery of Emergency Clinical Hospital “Prof...

Due to the high prevalence of cardiovascular diseases and better treatment strategies, with increased survival, heart failure is a condition with increasing prevalence, especially in developed countries. Heart failure patients often present electrolytic disorders, the most frequent one being hyponatremia. The objective of the study was to evaluate...