D. Y von Cramon

D. Y von Cramon
Max Planck Institute for Metabolism Research | NF · In-vivo-NMR Research Group

Prof. Dr. med. habil.

About

730
Publications
79,332
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45,652
Citations

Publications

Publications (730)
Article
Full-text available
Objects are reminiscent of actions often performed with them: knife and apple remind us on peeling the apple or cutting it. Mnemonic representations of object-related actions (action codes) evoked by the sight of an object may constrain and hence facilitate recognition of unrolling actions. The present fMRI study investigated if and how action cod...
Article
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A number of recent functional Magnetic Resonance Imaging (fMRI) studies on intertemporal choice behavior have demonstrated that so-called emotion- and reward-related brain areas are preferentially activated by decisions involving immediately available (but smaller) rewards as compared to (larger) delayed rewards. This pattern of activation was not...
Data
Includes the Instructions and Tables S1 to S5. (DOCX)
Article
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Neuroanatomical studies using transneuronal virus tracers in macaque monkeys recently demonstrated that substantial interactions exist between basal ganglia and the cerebellum. To what extent these interactions are present in the human brain remains unclear; however, these connections are thought to provide an important framework for understanding...
Article
Attempts to specify the anatomical configurations of the septal region and surrounding structures, the consequences of different forms of damage on frontal regions, and the variations in the cognitive pattern following septal damage. Patients with surgery after anterior communicating artery aneurysms surgery are used as the main model for delineati...
Article
To test for potential changes in higher-order cognitive processes related to the exposure to a high static magnetic field. Twenty-four healthy volunteers participated in two experimental sessions inside a 3 Tesla (T) magnetic resonance imaging (MRI) magnet. During one session the magnetic field was ramped down. The tasks consisted of six well-estab...
Article
The objective of the study was to investigate creativity in relation to brain function by assessing creative thinking in various neurological populations. Several measures were employed to assess different facets of creative thinking in clinical groups with frontal lobe, basal ganglia or parietal-temporal lesions relative to matched healthy control...
Article
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When we observe an action, we recognize meaningful action steps that help us to predict probable upcoming action steps. This segmentation of observed actions, or more generally events, has been proposed to rely in part on changes in motion features. However, segmentation of actions, in contrast to meaningless movements, may exploit additional infor...
Article
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To recognize an action, an observer exploits information about the applied manipulation, the involved objects, and the context where the action occurs. Context, object, and manipulation information are hence expected to be tightly coupled in a triadic relationship (the COM triad hereafter). The current fMRI study investigated the hemodynamic signat...
Article
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First impressions profoundly influence our attitudes and behavior toward others. However, little is known about whether and to what degree the cognitive processes that underlie impression formation depend on the domain of the available information about the target person. To investigate the neural bases of the influence of verbal as compared to non...
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Auditory extinction and spatio-temporal order judgment (STOJ) were assessed in patients with acquired brain damage by systematically manipulating onset times in bilateral stimulation under free-field conditions. We tested the hypothesis that extinction will be reduced by increasing stimulus onset asynchrony. Two groups of patients with right-hemisp...
Article
Action observation engages higher motor areas, possibly reflecting an internal simulation. However, actions considered odd or unusual were found to trigger additional activity in the so-called theory of mind (ToM) network, pointing to deliberations on the actor's mental states. In this functional magnetic resonance imaging study, the hypothesis was...
Article
Two eye fields have been described in the human lateral frontal cortex: the frontal eye field (FEF) and the inferior frontal eye field (iFEF). The FEF has been extensively studied and has been found to lie at the ventral part of the superior precentral sulcus. Much less research, however, has focused on the iFEF. Recently, it was suggested that the...
Article
All of us regularly face situations that require the integration of the available information at hand with the established rules that guide behavior in order to generate the most appropriate action. But where individuals differ from one another is most certainly in terms of the different strategies that are adopted during this process. A previous s...
Article
Many studies have shown the involvement of the premotor cortex in action observation, recognizing this region as the neural marker of action simulation (i.e., internal modeling on the basis of the observer's own motor repertoire). So far, however, we have remained unaware of how action simulation differs from more general action representation in t...
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People have present-biased preferences: they choose more impatiently when choosing between an immediate reward and a delayed reward, than when choosing between a delayed reward and a more delayed reward. Following McClure et al. [McClure, S.M., Laibson, D.I., Loewenstein, G., Cohen, J.D. (2004). Separate neural systems value immediate and delayed m...
Article
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Stroke may trigger a number of cellular and molecular events in perilesional and remote brain regions enabling cortical reorganization and recovery of function. We here investigated the pattern and time course of acute stroke-induced changes in motor system activity during motor recovery using functional magnetic resonance imaging. Hand movement–re...
Article
The present study employed an inventory of acoustic parameters in the quantitative evaluation of the recovery of normal phonation in dysphonia after severe closed head trauma. The amount of spectral energy in the 1 to 5 KHz range and above 5 KHz was sufficient to differentiate two subgroups of patients and their main patterns of reorganization of p...
Article
A spatial mismatch of up to 14 mm between optimal transcranial magnetic stimulation (TMS) site and functional magnetic resonance imaging (fMRI) signal has consistently been reported for the primary motor cortex. The underlying cause might be the effect of magnetic susceptibility around large draining veins in Gradient-Echo blood oxygenation level-d...
Article
Identifying and evaluating events which are novel in a particular environment is crucially important for adaptive behavior. These events are often not just novel, as they typically violate expectations which may be formulated based on numerous features of our surroundings, one of which includes the ordinal structure (temporal order) of relevant sti...
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Performance monitoring is an essential prerequisite of successful goal-directed behavior. Research of the last two decades implicates the anterior midcingulate cortex (aMCC) in the human medial frontal cortex and frontostriatal basal ganglia circuits in this function. Here, we addressed the function of the thalamus in detecting errors and adjusting...
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Error monitoring by the posterior medial frontal cortex (pMFC) has been linked to post-error behavioral adaptation effects and cognitive control dynamics in lateral prefrontal cortex (LPFC). It remains unknown, however, whether control adjustments following errors produce post-error behavioral adjustments (PEBAs) by inhibiting inappropriate respons...
Article
Simple heuristics exploit basic human abilities, such as recognition memory, to make decisions based on sparse information. Based on the relative speed of recognizing two objects, the fluency heuristic infers that the one recognized more quickly has the higher value with respect to the criterion of interest. Behavioral data show that reliance on re...
Article
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Cooper, Sagar, Jordan, Harvey, and Sullivan (1991) proposed a Digit Ordering Test (DOT) for the assessment of verbal working memory: A series of seven digits has to be memorized and immediately recalled in ascending order. In several studies Cooper and co-workers showed selectively reduced DOT performance in patients with Parkinson's disease (PD)....
Article
In the present study, a working memory paradigm was used to assess coordinative abilities required for the flexible control of a sequence of actions. Subjects had to maintain and recall a list of digits that functioned as an ensemble of activity cues used for guiding a sequence of forced-choice responses. In three task conditions, the demand on the...
Article
Perception and execution of actions share a common representational and neural substrate and thereby facilitate unintentional motor mimicry. Controlling automatic imitation is therefore a crucial requirement of such a "shared representational" system. Based on previous findings from neuroimaging, we suggest that resisting motor mimicry recruits the...
Article
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The lateral premotor cortex (PM) of the macaque monkey is an anatomically multifaceted area, which serves multiple sensorimotor and cognitive functions. While evidence for the functional organization of human premotor cortex accumulates, much less is known about the underlying anatomical properties of this brain region. We used diffusion tractograp...
Article
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The term "predictive brain" depicts one of the most relevant concepts in cognitive neuroscience which emphasizes the importance of "looking into the future", namely prediction, preparation, anticipation, prospection or expectations in various cognitive domains. Analogously, it has been suggested that predictive processing represents one of the fund...
Article
Background: Functional neuroimaging studies frequently demonstrated that stroke patients show bilateral activity in motor and premotor areas during movements of the paretic hand rather than the contralateral pattern seen in healthy subjects (1). A recent study applying effective connectivity analyses by dynamic causal modelling (DCM) to fMRI data...
Article
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There are many unresolved issues in the diagnosis and treatment of persons with traumatic brain injury (TBI) in its post-acute and chronic phases. This article deals with two problems of clinical importance: (i) the interrelationships between structural brain damage, brain function, and clinical outcome, and (ii) post-traumatic epilepsy. Explorator...
Chapter
Die neuropsychologischen Therapiemethoden sind unterteilt in Funktionstherapie, Kompensationstherapie und integrative Behandlungsmethoden. Die Wirksamkeit der Funktionstherapie in der Behandlung von Gedächtnisstörungen ist umstritten. Allerdings steht ein reiches therapeutisches Inventar an Kompensationsstrategien zur Verfügung. Sie werden untergli...
Article
Processing perceptual sequences relies on the motor system, which is able to simulate the dynamics of the environment by developing internal representations of external events and using them to predict the incoming stimuli. Although it has previously been demonstrated that such models may incorporate predictions based on exact stimulus properties a...
Article
Listening to music can induce us to tune in to its beat. Previous neuroimaging studies have shown that the motor system becomes involved in perceptual rhythm and timing tasks in general, as well as during preference-related responses to music. However, the role of preferred rhythm and, in particular, of preferred beat frequency (tempo) in driving a...
Article
Action observation leads to the automatic activation of the corresponding motor representation in the observer through "mirror-matching." This constitutes a "shared representational system," which is thought to subserve social understanding by motor simulation. However, it is unclear how these shared representations can be controlled and distinguis...
Article
It has often been suggested that the role of Broca's region in sentence comprehension can be explained with reference to general cognitive mechanisms (e.g. working memory, cognitive control). However, the (language-related) basis for such proposals is often restricted to findings on English. Here, we argue that an extension of the database to other...
Article
Full-text available
With the aim of understanding how different mental or intentional states are processed in the brain, the present functional magnetic resonance imaging (fMRI) study examined the brain correlates during the ascription of belief intentional states relative to desire intentional states as well as the effect of incongruent relative to congruent intentio...
Article
Processing of relational information is a prerequisite underlying a number of higher cognitive faculties. Different brain regions within the frontal cortex have been implicated in supporting this function. The present study aimed at differentiating the roles of two frontal areas - anterior prefrontal cortex (aPFC) and premotor cortex (PMC) - in rel...
Article
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For social beings like humans, detecting one's own and others' errors is essential for efficient goal-directed behavior. Although one's own errors are always negative events, errors from other persons may be negative or positive depending on the social context. We used neuroimaging to disentangle brain activations related to error and reward proces...
Article
Our identity consists of knowledge about our individual attributes (personal identity) as well as knowledge about our shared attributes derived from our membership in certain social groups (social identity). As individuals seek to achieve a positive self-image, they aim at comparing favorably with other individuals or their in-group comparing favor...
Article
The implementation of higher-order conditional motor behavior was investigated in the present fMRI study with the objective of answering three questions: (a) what happens in situations where one stimulus dimension alone does not sufficiently determine the correct response?; (b) does the implementation of second-order stimulus-response (S-R) rules o...
Article
Full-text available
In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIa polymorphism is associated with reduced expression of dopamine (DA) D(2) receptors in the striatum. Recently, it was observed that carriers of the A1 allele (A1+ subjects) showed impaired learning from negative feedback in a reinforcement learning task. Here, using functional MRI (fMRI), w...
Data
Descriptive data (mean and standard deviation) of the behavioral measures (RT: Reaction Time, PCR: Percentage of correct responses, Perceived Difficulty) for all conditions: friend-imaginative, friend-interactive, famous-imaginative, famous-interactive, fiction-imaginative, fiction-interactive, and control (0.04 MB DOC)
Data
List of activations from the Famous>Fiction inclusive mask contrast (Mask: Famous>Control). Cluster-wise control of family-wise error (p<0.05) was carried out to correct for multiple comparisons. (0.04 MB DOC)
Data
List of activations from the Friend>Fiction inclusive mask contrast (Mask: Friend>Control). Cluster-wise control of family-wise error (p<0.05) was carried out to correct for multiple comparisons. (0.06 MB DOC)
Data
List of activations from the Friend>Famous inclusive mask contrast (Mask: Friend>Control). Cluster-wise control of family-wise error (p<0.05) was carried out to correct for multiple comparisons. (0.04 MB DOC)
Article
Full-text available
Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies on a range of taxa have employed an orien...
Article
One fundamental property of voluntary action is the feeling of control and causation, also referred to as self agency. Recent research suggests that the sense of agency is based on low-level, sensory-motor control processes, which compare predicted and actual action-effects. Brain imaging research revealed that the temporo-parietal junction (TPJ) p...
Article
Background: The accuracy of stereotaxic frameless neuronavigation for transcranial magnetic stimulation (TMS) may dependent on the spatial validity of functional magnetic resonance imaging (fMRI) sequences. Nearly all fMRI studies use a gradient echo (GRE) sequence which, in contrast to spin echo (SE) and arterial spin labeling (ASL), provides a be...
Article
Full-text available
Although human beings regularly experience fictional worlds through activities such as reading novels and watching movies, little is known about what mechanisms underlie our implicit knowledge of the distinction between reality and fiction. The first neuroimaging study to address this issue revealed that the mere exposure to contexts involving real...
Article
In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review revealed different but related i...
Article
The sulcal morphology of the human frontal lobe is highly variable. Although the structural images usually acquired in functional magnetic resonance imaging studies provide information about this interindividual variability, this information is only rarely used to relate structure and function. Here, we investigated the spatial relationship between...
Article
Full-text available
Human decision-making almost always takes place under time pressure. When people are engaged in activities such as shopping, driving, or playing chess, they have to continually balance the demands for fast decisions against the demands for accurate decisions. In the cognitive sciences, this balance is thought to be modulated by a response threshold...
Article
With the aim of understanding how different mental or intentional states are processed in the brain, the present functional magnetic resonance imaging (fMRI) study examined the brain correlates during the ascription of belief intentional states relative to desire intentional states as well as the effect of incongruent relative to congruent intentio...
Article
Full-text available
According to the Oxford English Dictionary, intuition is "the ability to understand or know something immediately, without conscious reasoning." In other words, people continuously, without conscious attention, recognize patterns in the stream of sensations that impinge upon them. The result is a vague perception of coherence, which subsequently bi...
Article
Humans permanently monitor others' behaviour and reason about their goals and intentions. Recent studies provided evidence suggesting that a very simple mechanism might underlie these functions. When observing stereotypic actions of others, goal inference seems to work through internal simulation of these actions in the self. However, less is known...
Article
Previous research demonstrated that observing an action seems to automatically activate a corresponding motor representation in the observer. It has been argued that this direct matching of observed on executed actions is modulated by contextual factors. An open question is whether observing another person being physically restrained has an influen...
Article
The ability to ponder the future is a hallmark of human imagination. Neuroimaging research so far has focused on episodic prospection, or thinking about hypothetical future personal events. What has received no attention is semantic prospection or contemplating hypothetical future world events. Using functional magnetic resonance imaging (fMRI), we...
Article
Since the publication of our findings, further genetic and pharmacological studies have bolstered our conclusion that dopamine D2 receptors are essential for performance monitoring and learning. Although the functionally complex dopamine D2 receptor gene polymorphism DRD2-TAQ-IA may also affect cellular signaling components, the accumulated evidenc...
Article
Full-text available
When we observe an action, we know almost immediately what goal is pursued by the actor. Strikingly, this applies also to pretend action (pantomime), which provides relevant information about the manipulation itself but not about the manipulated objects. The present fMRI study addressed the issue of goal inference from pretend action as compared wi...
Article
Mental state reasoning or theory-of-mind has been the subject of a rich body of imaging research. Although such investigations routinely tap a common set of regions, the precise function of each area remains a contentious matter. With the help of functional magnetic resonance imaging (fMRI), we sought to determine which areas are involved when proc...