Cyril Adonu

• Lecturer at Enugu State University of Science and Technology

Authors' contributions This work was carried out in collaboration among all authors. Author CCA conceptualized and designed the work, wrote the introduction and the reference list and sourced the reagents and chemicals used for the study. Authors IJA and RCO carried out plant extractions and conducted the various anti-inflammatory test studies and...

Background: Hemorrhoids are a very common anorectal condition defined as the symptomatic enlargement and distal displacement of the normal anal cushions. Aim: The research is aimed at investigating the ameliorative potential of ethyl acetate fraction of Polyaltha logifolia leaves on croton oil induced hemorrhoids in albino Wistar rats. Methodology:...

Background: Due to high frequency of use, many kinds of microbes may contaminate the ATM device resulting in the emergence and spread of infectious agents especially multi-antibiotic resistant (MAR) bacteria. Aim: This study was conducted to isolate and phenotypically characterize bacteria isolates from ATM devices in Enugu State, Nigeria. Study De...

Background: Nigerian currency notes act as fomites and thus can transmit pathogenic microorganisms from one person to another. Aim: This study was conducted to evaluate the prevalence and antibiotic susceptibility pattern of bacteria isolated from Nigerian currency notes circulating in Enugu East local government area of Enugu State. Methods: Isola...

ABSTRACT Background: Nigerian currency notes acts as fomites and thus can transmit pathogenic microorganisms from one person to another Aim: This study was conducted to evaluate the prevalence and antibiotic susceptibility pattern of bacteria isolated from Nigerian currency note circulating in Enugu East local government area of Enugu. Methods: Is...

Background: Due to high frequency of use, many kinds of microbes may contaminate the ATM device resulting in the emergence and spread of infectious agents especially multi-antibiotic resistant (MAR) bacteria. Aim: This study was conducted to isolate and phenotypically characterize bacteria isolates from ATM devices in Enugu State, Nigeria. Study De...

Background: This research investigates the Effect of Ethyl Acetate Fraction of Terminalia ivorensis on Ethanol Induced Infertility in Male Rats. Infertility is the inability to conceive after one year of unprotected intercourse for couples under 35, or after six months for those over 35. It affects both men and women, with various factors contribut...

Medicinal herb-infused oil is utilized in folkloric medicine due to its efficacy in ameliorating various diseases of humans; even with this evidence, most herbs are still underutilized and poorly investigated. This prompted the investigation of ginger-infused virgin coconut oil's chemical composition and antimicrobial and antiulcer activities (GIVC...

Microorganisms in any ecological niche exhibit some characteristics that contribute to their survival in the ecosystem. A good example of such survival strategies is the production of antibiotic hydrolyzing enzymes such as ESBL and MBL enzymes in Gram negative bacteria. The study was conducted to isolate, and characterize by phenotypic methods, bac...

Sphenostylis stenocarpa seeds are used locally to lower blood sugar level among diabetic patient in Southeastern Nigeria. The present study aimed at evaluating the effect of extract and fractions of Sphenostylis stenocarpa seeds on alloxan-induced diabetes in rat. The pulverized seed was soaked in methanol for 72h, filtered and concentrated to obta...

Introduction: Hospitals are breeding grounds for multidrug-resistant (MDR) bacteria, posing treatment challenges and increasing the risk of spreading "superbugs." This study investigates the prevalence of colistinresistant bacteria, a last-resort antibiotic, in wastewater from tertiary hospitals in Enugu, Nigeria. Methods: Twenty wastewater samples...

ARTICLE INFO This research work is aimed at evaluating the phytochemicals, antibacterial potentials of the Chrysophyllum albidum stem bark extracts. The ethyl acetate and methanol extracts were obtained using soxhlet extraction method. The extracts obtained were screened for the presence of phytochemicals by standard methods. Agar diffusion and aga...

Infections due to antimicrobial-resistant microorganisms have become widespread in recent years. Thus, searching for novel antimicrobial agents to combat such pathogens has become crucial. The current study aimed to evaluate the antimicrobial, antiplasmodial, and immunomodulatory activities of the extracts of endophytic fungi isolated from Psidium...

Infections due to antimicrobial-resistant microorganisms have become widespread in recent years. Thus, searching for novel antimicrobial agents to combat such pathogens has become crucial. The current study aimed to evaluate the antimicrobial, antiplasmodial, and immunomodulatory activities of the extracts of endophytic fungi isolated from Psidium...

Chrysophyllum albidum is a tropical plant commonly found in different parts of Sub-Saharan Africa used in folklore for the treatment of yellow fever, toothache, malaria, diarrhea, vaginal and dermatological infections. This study investigated the phytochemical constituents and antibacterial and antipyretic activities of the methanol, ethyl acetate,...

Chrysophyllum albidum is a tropical plant commonly found in different parts of Sub-Saharan Africa used in folklore for the treatment of yellow fever, toothache, malaria, diarrhea, vaginal and dermatological infections. This study investigated the phytochemical constituents and antibacterial and antipyretic activities of the methanol, ethyl acetate,...

Concerted efforts are needed to mitigate the development and transmission of bacterial resistance in the general environment. Metallo-beta-lactamase (MBL) is a carbapenemase that allows bacteria to resist the antimicrobial onslaught of carbapenems (e.g., imipenem [IPM]). We investigated the prevalence of MBL-producing Pseudomonas aeruginosa in poul...

The synthetic process, type of precursor material, and the phytochemical materials involved in the biological synthesis of metal nanoparticles influence the properties of the resulting nanoparticles. The physicochemical attributes of synthesized nanoparticles, in turn, influence their applicability for various purposes, hence the need to standardiz...

Background: Essential oil (EO) of Cymbopogon citratus has been demonstrated to have antibacterial activities against both Gram negative and Gram positive bacteria. The study was, therefore, conducted to evaluate the effects of combined use of C. citratus and ciprofloxacin against fluoroquinolone-resistant Staphylococcus aureus (FQRSA) and Escherich...

Bacterial resistance to antibiotics is a public health menace that needs urgent efforts to mitigate and forestall their transmission in the general environment. Plasmid-mediated metallo beta-lactamase (MBL) gives bacteria an exceptional ability to transmit resistance genes. This study investigated plasmid-mediated resistance in MBL P. aeruginosa is...

Background: Chrysophyllum albidum is widely used by African people for the treatment of various types of diseases such as ear infection, sore throat, typhoid, cellulites, septicaemia, bactericemia, abscesses and tooth infections. Aim: The study was conducted to investigate the chemical components and antibacterial activity of the extract and fracti...

Background: Different parts of Anacardium occidentale (Cashew) are used in folk medicine to treat dysentery, diarrhea piles, toothache and sore gums. Evaluation of phytoconstituents or novel compounds from the plant is highly needed to authenticate these claims. Aim: The aim of the research was to conduct phytochemical analysis and antibacterial ev...

The objective of the current work was to design and characterize aceclofenac-loaded breadfruit seed oil-based self-emulsifying drug delivery systems (SEDDS) with intent to improve the gastrointestinal fluid solubility of the drug. The breadfruit oil was extracted by the soxhlet solvent extraction technique. The oil was then characterized for acid,...

Percentage parasitaemia and haematological parameters of ethanol leaf extract of Moringa oleifera were evaluated in a twenty four mice consisting of six groups. Groups 1 (positive control) and 6 (negative control) were treated with 5mg/kg body weight of distilled water, group 5 (standard control) was treated with 5mg/kg body weight of artesunate wh...

Aim: The phytochemicals, antioxidant and antimicrobial investigations of Combretum bauchiense leaves used in folkloric medicine to treat majorly infectious diseases were explored in the present study. Methodology: The methanol extract (MECB), n-hexane fraction (HFCB), ethyl acetate fraction (EFCB) and n-butanol fraction of C. bauchiense (BFCB) were...

This study reported the antiplasmodial and immunomodulatory activities of extracts of endophytic fungi isolated from Azadirachta indica. The extracts were evaluated for potential in-vivo and in-vitro antiplasmodial activity using murine malaria models and microtechnique methods respectively. Immunomodulatory potentials of the extracts were assessed...

Spenostylis stenocarpa popularly known as African yam bean is a neglected legume despite its nutritional potentials. The seeds are consumed in the southeastern parts of Nigeria either cooked as porridge or roasted as snacks. In traditional medicine, the powdered seeds are reported to be used in the management of high blood pressure diabetes, high c...

Globally, hepatitis B infection is a serious health problem as its morbities are difficult to handle with the commonly used antivirals. This study therefore aims to evaluate the serological, biochemical and hematological markers of Hepatitis B virus infection in a discordant partner in an attempt to aid proper diagnosis, management and control of t...

The phytochemical screening and antimicrobial activities of the methanol extract of Garcinia kola fruit mesocarp were investigated against four bacteria and two fungi in the study. The extract was investigated for the presence of phytochemicals using standard phytochemical screening methods. The results revealed the presence of flavonoids, tannins,...

The anticandidal potentials of extracts from the aerial parts of Cassytha filiformis were evaluated against some strains of Candida albicans isolated from clinical specimens. The plant parts were collected fresh, shade-dried, pulverized and extracted with hot water, methanol and n-hexane. Hot-water extraction was by 24 h maceration while extraction...

S The phytochemical analyses and the antifungal potentials of the methanol extract of leaves of Persea americana, Psidium guajava, Carica papaya and the fruits of Citrus lemoniumn, Citrus aurantifolia and Zingiber officinale Rosc were studied against some fungi isolates. The leaves of Persea americana, Psidium guajava and Carica papaya were collect...

The antimicrobial activities of leaf extracts of Cleistopholis patens and aerial parts of Cassytha filiformis against clinical pathogens were evaluated and compared by in vitro method. The plant parts were collected fresh, shade-dried, pulverized and extracted with hot-water, methanol and n-hexane. Hot-water extraction was by 24 h maceration while...

Currently, fluoroquinolone antibiotics are commonly used drugs for the treament of infections in Enugu State. Consequently, the rapid emergence and spread of antibiotic resistance especially of fluoroquinolones have caused serious public health problems. This study was conducted to determine the prevalence and plasmid profile of clinical and carrie...

Pathogenic strains of Staphylococcus including S. aureus could cause some community and hospital acquired infections in human population and many S. aureus strains are fast-becoming resistant to some available antibiotics because they possess multidrug resistance genes. This study was conducted to determine the prevalence and the plasmid profile of...

The antibacterial activity and the phytochemical analyses of both leaf extracts of Chromoleana odorata (Shear leaves) and Bulchholzia coriacea (Wonderful Kola) against some clinical isolates of Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Escherichia coli were evaluated and compared. The plants' leaves were collected fresh,...

Traditional medical practitioners often combine two or more different plants’ parts for the treatment of ailments. This study was conducted to evaluate the combined effects of extracts from aerial parts of Cassytha filiformis Linn and the root back of Cleistopholis patens (Benth) against some clinical isolates of Pseudomonas aeruginosa and Escheric...

Phytochemical studies of the aerial parts of Cassytha Filiformis Linn and leaves of Cleistopholis patens Benth were analysed. The phytochemical analyses of the methanol, hot water and n-hexane extracts of Cassytha Filiformis Linn and Cleistopholis patens showed the presence of glycosides, steroids, terpenoids, alkaloids, carbohydrates, acidic compo...