Csilla Ari

Csilla Ari
University of South Florida | USF

PhD

About

79
Publications
31,246
Reads
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1,169
Citations
Introduction
www.csillaari.com www.mantamissions.org Manta ray research: neuroscience, sensory and cognitive abilities, social behavior, coloration changes Neuroprotection, psychological and physiological changes in extreme environments, physical and cognitive performance enhancement in extreme environments Development of nutritional supplements
Additional affiliations
March 2017 - present
University of South Florida
Position
  • Professor (Assistant)
September 2013 - March 2017
University of South Florida
Position
  • Research Associate
June 2010 - September 2013
University of South Florida
Position
  • PostDoc Position
Education
September 2002 - July 2008
Semmelweis University
Field of study
September 2002 - July 2008
Semmelweis University
Field of study
  • comparative neuroanatomy
September 2002 - July 2008
Semmelweis University
Field of study
  • comparative neuroanatomy

Publications

Publications (79)
Article
Continuous glucose monitoring (CGM) is extensively used in diabetic populations but understudied in non-diabetic patients. Glycemic variability is a risk factor for cardiovascular disease, and emerging evidence suggests close monitoring of glycemic control may have a positive impact on chronic disease. CGM increases awareness of glycemic dysregulat...
Article
Although mobulids (Mobulidae) are threatened with extinction, basic information about their biology and ecology is still lacking. Therefore, we analyzed impacts of fishing, morphology, coloration, and stomach content of mobulid carcasses stranded on the coast of Ilha Comprida, southeastern Brazil, found in protected areas of sustainable use. The ca...
Chapter
Emerging evidence from numerous studies suggests that administration of exogenous ketone supplements, such as ketone salts and ketone esters, may have a therapeutic influence on several central nervous system disorders through neuroprotective and behavioral effects. Therefore, ketone supplementation is a potential therapeutic tool for epilepsy, neu...
Article
Full-text available
It has been previously demonstrated that KEKS food containing exogenous ketogenic supplement ketone salt (KS) and ketone ester (KE) decreased the lipopolysaccharide (LPS)-generated increase in SWD (spike-wave discharge) number in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats, likely through ketosis. KEKS-supplemented food-generated ketosis may increa...
Article
ABSTRACT: Improving our knowledge on the behavior of threatened species is essential for developing effective conservation actions. The Paranaguá Estuarine Complex (PEC), southern Brazil, is the only estuary in the world where manta rays have been observed performing breaches seasonally. The exact role of this breaching behavior and the environment...
Article
Full-text available
Life expectancy of humans has increased continuously up to the present days, but their health status (healthspan) was not enhanced by similar extent. To decrease enormous medical, economical and psychological burden that arise from this discrepancy, improvement of healthspan is needed that leads to delaying both aging processes and development of a...
Article
To evaluate the neuroprotection exerted by ketosis against acute damage of the mammalian central nervous system (CNS). Search engines were interrogated to identify experimental studies comparing the mitigating effect of ketosis (intervention) vs non‐ketosis (control) on acute CNS damage. Primary endpoint was a reduction in mortality. Secondary endp...
Article
Full-text available
Both uridine and exogenous ketone supplements decreased the number of spike-wave discharges (SWDs) in a rat model of human absence epilepsy Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. It has been suggested that alleviating influence of both uridine and ketone supplements on absence epileptic activity may be modulated by A1 type adenosine receptors...
Article
Full-text available
Human adaptation to extreme environments has been explored for over a century to understand human psychology, integrated physiology, comparative pathologies, and exploratory potential. It has been demonstrated that these environments can provide multiple external stimuli and stressors, which are sufficient to disrupt internal homeostasis and induce...
Article
Full-text available
In certain disease states, such as epilepsy, the elevation of blood ketone levels with ketogenic diets (KDs) has beneficial effects, while exogenous ketone supplements (EKSs) were shown to increase the level of blood ketone bodies (such as β-hydroxybutyrate, βHB) and decrease blood glucose levels without dietary restrictions. It has been suggested...
Article
Full-text available
Nutritional ketosis has been proven effective for neurometabolic conditions and disorders linked to metabolic dysregulation. While inducing nutritional ketosis, ketogenic diet (KD) can improve motor performance in the context of certain disease states, but it is unknown whether exogenous ketone supplements—alternatives to KDs—may have similar effec...
Article
The objective of this study was to measure potential changes in cognitive function in response to living in an extreme underwater habitat. Chronic high stress and intense workload can affect individual and team cognition. As such, associated variables were monitored during the NASA Extreme Environment Mission Operation (NEEMO) 23 mission at the Aqu...
Article
Full-text available
Background: It has been demonstrated that administration of exogenous ketone supplement ketone salt (KS) and ketone ester (KE) increased blood ketone level and delayed the onset of isoflurane-induced anesthesia in different rodent models, such as Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. The modulatory effect of adenosinergic system may have a...
Preprint
Full-text available
Background: It has been demonstrated that administration of exogenous ketone supplement ketone salt (KS) and ketone ester (KE) increased blood ketone level and delayed the onset of isoflurane-induced anesthesia in different rodent models, such as Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. The modulatory effect of adenosinergic system may have a r...
Preprint
Background It has been demonstrated that administration of exogenous ketone supplement ketone salt (KS) and ketone ester (KE) increased blood ketone level and delayed the onset of isoflurane-induced anesthesia (immobility) in different rodent models, such as Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. The modulatory effect of adenosinergic system...
Data
Video abstract for the paper: Ari, C.; Murdun, C.; Koutnik, A.P.; Goldhagen, C.R.; Rogers, C.; Park, C.; Bharwani, S.; Diamond, D.M.; Kindy, M.S.; D’Agostino, D.P.; Kovács, Z. Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models. Nutrients 2019, 11, 2330.
Article
Full-text available
Diseases involving inflammation and oxidative stress can be exacerbated by high blood glucose levels. Due to tight metabolic regulation, safely reducing blood glucose can prove difficult. The ketogenic diet (KD) reduces absolute glucose and insulin, while increasing fatty acid oxidation, ketogenesis, and circulating levels of β-hydroxybutyrate (βHB...
Article
Full-text available
Globally, psychiatric disorders, such as anxiety disorder, bipolar disorder, schizophrenia, depression, autism spectrum disorder, and attention-deficit/hyperactivity disorder (ADHD) are becoming more prevalent. Although the exact pathological alterations are not yet clear, recent studies have demonstrated that widespread changes of very complex met...
Article
Full-text available
It has been demonstrated previously that exogenous ketone supplements such as ketone ester (KE) decreased absence epileptic activity in a well-studied animal model of human absence epilepsy, Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. It is known that lipopolysaccharide (LPS)-generated changes in inflammatory processes increase absence epileptic a...
Article
The aim was to check the presence of cerebrovascular dystroglycan in vertebrates, since dystroglycan, which is localized in the vascular astroglial end‐feet has a pivotal function in glio‐vascular connections. In the mammalian brains the immunoreactivity of β‐dystroglycan subunit delineates the vessels. The present results demonstrate similar patte...
Article
Full-text available
The overall goal of this study is to describe the methodology of the elevated plus maze (EPM) test in combination with a video tracking software. The purpose of the method is to document the effect of various potential anxiolytic treatments on laboratory rodent models. The EPM test is based on the rodents' proclivity toward protected, enclosed dark...
Article
Full-text available
Central nervous system oxygen toxicity (CNS‐OT) manifests as tonic‐clonic seizures and is a limitation of hyperbaric oxygen therapy (HBOT), as well as of recreational and technical diving associated with elevated partial pressure of oxygen. A previous study showed that ketone ester (1,3‐butanediol acetoacetate diester, KE) administration delayed la...
Article
Full-text available
Background: Ketogenic diet (KD) and exogenous ketone supplements can evoke sustained ketosis, which may modulate sleep and sleep-like effects. However, no studies have been published examining the effect of ketosis on the onset of general isoflurane induced anesthesia. Therefore, we investigated the effect of the KD and different exogenous ketogen...
Article
Full-text available
Anxiety disorders are one of the most common mental health problems worldwide, but the exact pathophysiology remains largely unknown. It has been demonstrated previously that administration of exogenous ketone supplement KSMCT (ketone salt/KS + medium chain triglyceride/MCT oil) by intragastric gavage for 7 days decreased the anxiety level in genet...
Poster
Nutritional ketosis has beneficial therapeutic effect on epileptic seizures and on other neurological disorders, but many patients find the ketogenic diet (KD) unpalatable and difficult to sustain. In order to circumvent the need for strict dietary restrictions, exogenous ketone supplementation has been developed to increase blood ketone level to t...
Poster
The state of therapeutic/nutritional ketosis can be achieved by using exogenous ketone supplementation, which has been proven effective for seizure disorders and other neurological disorders, such as anxiety. Thus, we tested in the present study whether 2.5 g/kg/day exogenous ketone supplements (ketone ester: KE; ketone salt: KS; KS + medium chain...
Poster
Full-text available
The state of therapeutic/nutritional ketosis can be achieved by using exogenous ketone supplementation, which has been proven effective for seizure disorders and other neurological disorders, such as anxiety. Thus, we tested in the present study whether 2.5 g/kg/day exogenous ketone supplements (ketone ester: KE; ketone salt: KS; KS + medium chain...
Poster
Full-text available
Nutritional ketosis has beneficial therapeutic effect on epileptic seizures and on other neurological disorders, but many patients find the ketogenic diet (KD) unpalatable and difficult to sustain. In order to circumvent the need for strict dietary restrictions, exogenous ketone supplementation has been developed to increase blood ketone level to t...
Article
Full-text available
The state of therapeutic ketosis can be achieved by using the ketogenic diet (KD) or exogenous ketone supplementation. It was suggested previously that the adenosinergic system may be involved in the mediating effect of KD on suppressing seizure activity in different types of epilepsies, likely by means of adenosine A1 receptors (A1Rs). Thus, we te...
Article
Full-text available
IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death from respiratory failure. There is currently no cure or effective treatment for ALS. The Deanna protocol (DP) is a comprehensive treatment approach that includes a metabolic therapy in t...
Article
Full-text available
Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronic...
Poster
Anxiety disorders are the most prevalent type of mental disorders, interfering with a person`s quality of life. Anxiety and depression are common problems affecting people with epilepsy, while the same brain regions involved in a significant proportion of patients with focal epilepsy, such as the amygdala and the hippocampus, also play a key role i...
Article
Full-text available
Elaborate cognitive skills arose independently in different taxonomic groups. Self-recognition is conventionally identified by the understanding that one’s own mirror reflection does not represent another individual but oneself, which has never been proven in any elasmobranch species to date. Manta rays have a high encephalization quotient, similar...
Article
Full-text available
Increased coexistence of Alzheimer's disease (AD) and type 2 diabetes (T2D) suggests that insulin resistance abets neurodegenerative processes, but linkage mechanisms are obscure. Here, we examined insulin signaling factors in brains of insulin-resistant high-fat-fed mice, ob/ob mice, mice with genetically-impaired muscle glucose transport, and mon...
Article
Full-text available
Nutritional ketosis induced by the ketogenic diet (KD) has therapeutic applications for many disease states. We hypothesized that oral administration of exogenous ketone supplements could produce sustained nutritional ketosis (>0.5 mM) without carbohydrate restriction. We tested the effects of 28-day administration of five ketone supplements on blo...
Chapter
Full-text available
Metabolic therapies that induce a state of mild ketosis from caloric restriction or the ketogenic diet offer neuroprotection against seizures and continue to emerge as a promising strategy for the metabolic management of Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Severe dietary restriction of calories or carbohydrates is typi...
Article
Full-text available
Manta rays (genus Manta) are listed as vulnerable on the IUCN Red List based partly on population studies that use body coloration and ventral spot patterns to identify and count individuals, as a result of such patterns being considered unique and permanent during their lifetime. The present study reports the first evidence of long-term coloration...
Article
Full-text available
Cancer cells express an abnormal metabolism characterized by increased glucose consumption due to genetic mutations and mitochondrial dysfunction. Previous studies indicate that unlike healthy tissues, cancer cells are unable to effectively utilize ketone bodies for energy. Furthermore, ketones inhibit the proliferation and viability of cultured tu...
Article
Full-text available
Changes of body coloration have not been described in manta rays (genus Manta) so far; therefore, their natural body coloration is used to distinguish species and their ventral spot markings are used to identify individuals worldwide to estimate their population size or seasonal migration. The present study describes the first evidence of rapid col...
Article
Full-text available
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death from respiratory failure. There is currently no cure or effective treatment for ALS. Besides motor neuron degeneration, ALS is associated with impaired energy me...
Article
Full-text available
The mechanism by which amyloid beta (Aβ) causes neuronal dysfunction and/or death in Alzheimer's disease (AD) is unclear. Previously, we showed that Aβ inhibits several microtubule-dependent kinesin motors essential for mitosis and also present in mature neurons. Here, we show that inhibition of kinesin 5 (Eg5) by Aβ blocks neuronal function by red...
Article
Full-text available
In the mature mammalian and avian central nervous systems, neuronal destructions are followed by reactive gliosis, but data on other vertebrates are rather controversial. Mammals and birds belong to different amniote groups (Synapsida and Diapsida, respectively), but exhibit common general features in their glial architecture, mainly the predominan...
Article
Full-text available
Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates...