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Publications
Publications (91)
There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS] and quantitative ultrasound index [QUI]) is rarely investigated. We aimed to disentangle the role of genetic, shared and unique environmental factors on TBS and QUI among Hungarian twins. Our study inclu...
Background and Objectives: Osteoporosis is a major risk of fractures, harming patients’ quality of life. Dual-energy X-ray absorptiometry (DXA), which can detect osteoporosis early, is too expensive to be conducted on a regular basis. Therefore, we aimed to evaluate a screening method using chest radiographs developed in Japan applied to another po...
Összefoglaló. A gyermekek közel fele szenved el csonttörést. Ez lehet traumás esemény vagy a csontfejlődést megzavaró genetikus, hormonális vagy egyéb eltérés a csontváz bármely részén. A leggyakoribb azonban az enyhe trauma kapcsán jelentkező csuklótáji törés, amely többnyire a pubertas alatt fordul elő. A jelenség alapja, hogy a serdülés során át...
Background and Objectives: Previous studies have demonstrated that risk of hip fracture is at least partly heritable. The aim of this study was to determine the magnitude of the genetic component of bone mineral density (BMD), using both X-ray and ultrasound assessment at multiple sites. Materials and Methods: 216 adult, healthy Hungarian twins (12...
Osteomalacia is a metabolic bone disease characterized by ineffective mineralization of osteoid in the remodeling of adult bone. It is called rickets in growing children if this process is accompanied by the deficient mineralization of cartilage in growth plates. The disease derives from calcium deprivation due to low calcium intake by any reason,...
Osteoporosis is a metabolic bone disease characterized by progressive loss of bone mass and qualitative changes in microarchitecture, resulting in high prevalence of fragility fractures. The disease is most common in older ladies, but older men and younger people with some chronic diseases or medications are also involved. Osteoporosis yearly cause...
Purpose:
The main objectives were to explore associations between self-perceived 10-year fracture risks of women with osteoporosis (OP) and their risks calculated by the FRAX® algorithm and to identify determinants of the underestimation of risk.
Methods:
We carried out a cross-sectional study in 11 OP centers in Hungary and collected data on th...
Rationale, aims, and objectives:
To compare the effect of osteoporotic fractures and complications of diabetes mellitus on quality of life (QoL).
Method:
A cross-sectional study was performed in 840 patients with osteoporosis and in 943 patients with diabetes in Hungary to estimate the effect of osteoporotic fractures and microvascular and macro...
Introduction:
Identification of patients with high fracture risk is a key-point in osteoporosis care.
Aim:
To assess the fracture risk among osteoporotic women attending osteoporosis care in Hungary.
Method:
A cross-sectional survey was conducted in 2009 in 11 centres among women with osteoporosis aged ≥50 years. Main risk factors were recorde...
Introduction: Over the past few years the clinical relevance of serum uric acid level has changed. The elevated serum uric acid level not only impairs the joints and the kidney function but it is also linked with an increased risk of cardivascular diseases. The aim of our study was to examine how bones are affected (change of bone mineral density (...
The main consequence of osteoporosis is bone fracture. Bone fracture risk is determined by several risk factors beyond osteodensitometric results. Some of these factors could be estimated by simple clinical questionnaires.
The aim of the present study (Score-HU) was to investigate the risk factors of bone fracture among osteoporotic postmenopausal...
The study demonstrates that wintertime surgeries are associated with impaired fracture healing and increases the risk of conversion to hip arthroplasty after osteosynthesis of femoral neck fracture. Furthermore, the results raise the possibility of association between seasonal changes in vitamin D levels and impaired fracture healing of femoral nec...
Information regarding bone mineral density and fracture characteristics of the equine metacarpus are lacking. The aim of this study was to characterize the relationship between mechanical properties of the equine metacarpal bone and its biomechanical and morphometric properties. Third metacarpal bones were extracted from horses euthanized unrelated...
CÉL - Keresztmetszeti vizsgálatunk célja az életminőség csontritkulásos törések miatti romlásának becslése volt.
MÓDSZEREK - A vizsgálatot csontritkulásos betegek gondozására és csonttörések akut ellátására szakosodott 21 centrumban végeztük, 840 beteg bevonásával. A betegeket véletlenszerűen választottuk, és a törés lokalizációja, illetve a törés...
Despite the fact that bone mineral density (BMD) is an important fracture risk predictor in human medicine, studies in equine orthopedic research are still lacking. We hypothesized that BMD correlates with bone failure and fatigue fractures of this bone. Thus, the objectives of this study were to measure the structural and mechanical properties of...
Purpose:
Static magnetic field (SMF) could improve pain sensation and bone turnover. In a single-center randomized double-blind placebo-controlled study we investigated the effects of SMF exposure on subjective pain and bone turnover.
Materials and methods:
Postmenopausal osteoporotic women (aged 50-70 years) with bone deformity and back pain we...
Introduction: Lactose intolerance itself is linked with lower peak bone mass (PBM) and with decreased bone mineral density (BMD) which may decrease further with lactose intolerance associated comorbidities. The aim of our study was to examine how bone metabolic parameters are affected (change of bone metabolism markers, BMD and frequency of fractur...
Introduction: Polycystic ovary syndrome (PCOS), lactase deficiency, nephrolithisasis and thyroid diseases are considered endemic. The aim of our study was to evaluate which of the above-mentioned diseases affect the most the bone metabolic parameters, bone mineral density (BMD) and the prevalence of bone fractures in fertile aged women.
Materials a...
Dual energy X-ray absorptiometry (DXA) is a widespread method to assess bone mineral density (BMD) and bone mineral content (BMC) in human practice, and adaptation of its use in veterinary medicine has also started. Bone densitometry is the current method for the diagnosis of human calcipenic osteopathy. The authors briefly summarize the evolution...
In the first part of this methodological study eleven metacarpi of 9 skeletally normal horses were examined from 4 directions by dual energy x-ray absorptiometry (DXA). The differences between the dorsopalmar-palmarodorsal and lateromedial-mediolateral (opposite sites) bone mineral density (BMD) values were found to be nonsignificant. In the second...
The Hungarian national health insurance database was screened for fractures of patients aged 50-100, 1999-2003. On average, there were 343 hip, 1,579 forearm, 342 proximal humerus, 48 inpatient vertebral and 2,459 other fractures/100,000 inhabitants/year.
The incidence of fractures differs among populations. Our aim was to study the incidence of fr...
The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. Previously, the CYP3A7*1C polymorphism has been shown to cause a persistent high CYP3A7 enzyme activity, resulting in lower levels of DHEAS in men. We hypothe...
The aim of this study was to identify the differences in ultrasound bone variables (QUS) and to test the ability to discriminate male patients with and without vertebral fractures.
We therefore measured broadband ultrasound attenuation (BUA) and speed of sound (SOS) matched for bone mineral density (BMD) and vertebral deformity in idiopathic male o...
Objectif
L'objectif de cette étude était d'identifier des différences de variables ultrasonographiques osseuses (USQ) et de tester la capacité de discrimination de la technique entre hommes avec ou sans fractures vertébrales.
Méthodes
Nous avons pour cela mesuré le spectre d'atténuation des ultrasons (SAU) et la vitesse des ultrasons (VUS) apparié...
Our study was initiated to evaluate whether there are differences between the two sides, depending on hand dominance, in densitometry values and quantitative ultrasound parameters (QUS) of the lower limb. One hundred and six women and 44 men were involved. The hand dominance was determined by interview. The bone mineral density (BMD) of the left an...
Reference databases play a key role in the management of osteoporosis. The aim of this preliminary study was to compare the diagnostic consequences of using either an international or a local reference database in peripheral densitometry. For this purpose, standard curves for bone mineral density (measured by dual-energy X-ray absorptiometry at the...
Smoking is a risk factor for osteoporosis. In a previous study, the authors showed lower bone density among smokers in a group of postmenopausal women.
After this finding, the primary goal of current research was to investigate how smoking could influence bone quality.
Forty-five (age range: 25-72 ys) smoker women were compared with 45 nonsmoker wo...
Our aim was to investigate whether pollen-allergy can affect bone mass and fractures in postmenopausal women.
A total of 125 postmenopausal pollen-allergic women (mean age: 61.26 yr) were split into four groups: (1) treated with neither H1 histamine receptor (H1R) antagonist nor inhaled corticosteroid (n=43); (2) treated only with H1R antagonist (n...
To investigate the change of bone parameters in a new model of experimentally induced liver cirrhosis and hepatocellular carcinoma (HCC) in growing rats.
Fischer-344 rats (n = 55) were used. Carbon tetrachloride (CCl(4)), phenobarbital (PB), and a single diethylnitrosamine (DEN) injection were used. Animals were killed at wk 8 and 16. Bone mineral...
An increasing amount of evidence suggests that 25-hydroxy vitamin D3 (25(OH)D3) may contribute to the bone health of patients with chronic kidney disease (CKD). The underlying vitamin D status of these patients, however, has often been neglected. In a cross-sectional study we assessed the association between vitamin D status and parathyroid functio...
The pathophysiology of osteoporosis in chronic liver diseases is unknown. Recent data suggest that serum leptin is associated with bone mineral density (BMD). In animal studies leptin was found to be a potent inhibitor of bone formation. We investigated the relationship between serum leptin levels, soluble leptin receptor (sOB-R), free leptin index...
A strong positive association between body mass index and bone mineral density is well defined in postmenopausal osteoporosis, but not in men.
The primary goal of the current research was to investigate this association in case of men.
According to WHO criteria (T-score below -1.0 at all measure site) seventy-two (mean age 55.7 +/- 0.99, range 38-7...
The majority of the patients with primary hyperparathyroidism (pHPT) recurrently produce kidney stones, while the rest have other clinical manifestations. The aim of this study was to examine the possibility of an association between the presence of kidney stones and the location of an underlying adenoma. This was a retrospective evaluation of the...
The aim of this study was to examine the effect of intranasal salmon calcitonin therapy on bone mineral density (BMD) in idiopathic male osteoporosis without vertebral fractures. We conducted a randomized, open label, controlled trial in 71 male patients (mean age 59 +/- 6 years) suffering from idiopathic osteoporosis (femoral neck T-score < -2.5)...
Targeted disruption of the histidine decarboxylase gene (HDC(-/-)), the only histamine-synthesizing enzyme, led to a histamine-deficient mice characterized by undetectable tissue histamine levels, impaired gastric acid secretion, impaired passive cutaneous anaphylaxis, and decreased mast cell degranulation. We used this model to study the role of h...
INTRODUCTION - The most frequent manifestations of primary hyperparathyroidism are renal stones or calcipenic osteopathy. The aim of authors was to examine how bones are affected (change of bone mineral density and frequency of fractures) in the renal form of primary hyperparathyroidism. METHODS - Mean age of the patients was 57 years (26-81 years)...
Patients with cow milk allergy (CMA) are potentially at risk for osteopenia because their milk-free diet usually contains a low calcium content. In our study, different parameters of bone mineralization in children with CMA were investigated.
Twenty-seven CMA patients (mean age, 4.3 years; range, 3-8 years) were enrolled in the study. During a mean...
Background
Patients with cow milk allergy (CMA) are potentially at risk for osteopenia because their milk‐free diet usually contains a low calcium content. In our study, different parameters of bone mineralization in children with CMA were investigated.
Patients and Methods
Twenty‐seven CMA patients (mean age, 4.3 years; range, 3–8 years) were enr...
Osteopathia has been reported in Wilson disease (WD), but bone density has not been measured; therefore, we performed bone mineral density (BMD), bone mineral content (BMC), and quantitative bone ultrasound (QUS) assessments, as well as measured the serum levels of osteocalcin (OCN), beta-cross-laps (beta-CTx's), and the recently discovered osteopr...
Calcium-sensing receptor (CaSR) is an attractive candidate gene for osteoporosis susceptibility. The CaSR "A986S" genotype has been shown to have an effect on serum calcium. Recently, an association has been reported between the CaSR gene A986S polymorphism and bone mineral density in healthy white girls. In this study, we examined whether CaSR gen...
A growing body of recently published results suggest the role of adrenal androgens in the onset and development of chronic inflammatory process due to autoantigens. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA)--the major androgen products of the adrenal gland--have immunosuppressive effect inhibiting interleukin-6 produc...
In thirty-seven patients undergoing parathyroidectomy from November 1999 to July 2000 with diagnosis of primary hyperparathyroidism the intraoperative intact parathyroid hormone level were studied. Preoperative samples of blood were taken from a peripheral vein before the beginning the operation. The second sample was taken 5 minutes after removal...
Osteopenia is a common complication in primary biliary cirrhosis (PBC). In this follow-up study the authors investigated the metabolic bone disease in postmenopausal PBC patients. 17 Ca and vitamin D supplemented, postmenopausal female patients with PBC (stage II-IV, age: 41-84, mean: 52, each AMA M2 positive, without ascites) were followed-up for...
The mechanism by which thyroid hormones promote bone growth has not yet been elucidated. In vitro, thyroid hormones stimulate insulin-like growth factor-I (IGF-I) production by osteoblasts, which is important for the anabolic effects of the hormone on bone. To determine whether the IGF-I/IGF binding protein (IGFBP) profile is affected when thyroid...
We studied the effect of alphacalcidol (1-alpha-hydroxycholecalciferol) on bone metabolism in patients who were placed on glucocorticoid therapy. We selected 41 women (age: 32-52 yrs) who were recently diagnosed with systemic lupus erythematodes, multiple sclerosis, rheumatoid arthritis or asthma bronchiale. Patients did not have other disease or t...
Erythrocyte sodium-potassium (Na+/K+) -ATPase and sodium-lithium (Na+/Li+) countertransport activities were measured in 18 children (aged 9.6 years, range 6–16 years) with idiopathic hypercalciuria
(IHU) to evaluate cellular Na handling. The effect of chronic thiazide administration on these parameters and on bone mineral
density was also evaluated...
The impact of recombinant human growth hormone (rhGH) treatment on growth, bone mineral metabolism, and bone mineral density (BMD) was evaluated in six children (3 girls, 3 boys) with familial hypophosphatemic rickets (XLH). Five were prepubertal (aged 6-8.8 years), one 15.3-year-old boy had combined XLH and GH deficiency, but had not been treated...
Metabolic bone disorders have attracted increasing attention in Hungary due to their significant impact on public health care. Measuring urinary calcium excretion is the first step in the biochemical assessment of bone metabolism. Fasting urinary calcium corrected by creatinine excretion is widely used all over the world. The aim of the present stu...
Postmenopausal women with endogenous subclinical hyperthyroidism seem to have reduced bone mass, which does not correlate with serum thyroid hormone levels. Relative insufficiencies of IGF-I and dehydroepiandrosterone sulphate (DHEAS) might be additional risk factors for low bone density in these patients. We measured IGF-I, IGF-binding protein-3 (...
To determine the possible involvement of interleukin-6 (IL-6) in the bone loss of hyperthyroidism, relationships between thyroid status, biochemical and densitometric parameters of bone metabolism, and IL-6 were studied in female subjects. Patients with hyperthyroidism caused by either toxic nodular goiter or Graves' disease had significantly highe...
INTRODUCTION - Effective therapy for glucocorticoid-induced osteoporosis has not been established yet, therefore new therapeutic modalities are still of major interest. PATIENTS AND METHODS - The effect of alphacalcidol (1-α- hydroxy-cholecalciferol) on bone metabolism was studied. 41 women were selected who had been recently given long-term glucoc...
Menopausal osteoporotic women (age: 49-69, mean: 59.5 years) with crush fractures of the spine were treated with low doses of calcitonin (Miacalcic, 350 U/month), or with calcitonin + anabolic steroid (Retabolil, 50 mg/month). Efficacy of the therapy was controlled by single foton absorptiometry of midshaft and distal radius, by X-ray morphometry a...
Patterns of bone loss in the axial and the appendicular skeleton were studied in 48 women with streak gonad syndrome (age: between 14-38 years, mean: 25.5 years). Bone mineral content was measured in vivo at the lumbar spine and right femoral neck by dual photon absorptiometry and at the midradius and distal radius by single photon absorptiometry....
Forty-five postmenopausal osteoporotic women with at least one osteoporotic vertebral crush fracture were randomized into three treatment groups. Each patient was on calcitonin, 50 U, on alternate days for 2 weeks monthly (350 U/month), and 500 mg/day oral calcium supplementation. In group II, this therapy was supplemented with phosphate (750 mg/da...
Bone mineral content and density of the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry in normal volunteers (89 women, 77 men) in different age groups. Peak values in both sexes occurred in the 3rd decade and are about 25% higher in men than those in women. In women the bone loss begins around 40 years at lumbar spin...
Osteoporosis is one of the most common complications of streak gonad syndrome (SGS), however its pathogenesis is still unclear. Bone Gla protein (BGP) has been found to be a serum marker of bone turnover in various metabolic disease states. In the present study serum BGP and alkaline phosphatase (AP) were measured in 13 osteoporotic patients with S...
The citrate concentration of the daily collected urine was measured by citrate lyase method in 25 untreated patients with recurrent calcium stone disease (10 hypercalciuric and 15 normocalciuric) and in 11 patients with stone disease treated with hydrochlorothiazide and in 16 healthy controls. We found a great variancy of the results what rather lo...
Osteoporosis in one of the most common complications of streak gonad syndrome (SGS), however, its pathogenesis is still unclear. To test whether SGS is associated with calcitonin (CT) deficiency, 11 affected individuals and 8 age-matched healthy women were studied. Calcium, 3.6 mg/kg b.w. as a 10% solution of calcium chloride, was given intravenous...
The mineral content of the radius was found to be lower in thyrotoxic than in euthyroid women, particularly in the case of elevated serum triiodothyronine levels. On examining the hormones influencing bone metabolism, the basal serum calcitonin level of thyrotoxic patients was identical with that of the controls. The Ca and calcitonin responses to...
The effects of sulpiride, a dopamine receptor blocking agent, and of thyrotrophin-releasing hormone (TRH) were studied on prolactin secretion in 17 patients with acromegaly and 25 control subjects. THe basal serum prolactin level was increased in 9 acromegalic patients. After sulpiride loading, maximum changes in prolactin level were significantly...
Kutatásaink azon a munkahipotézisen alapultak, hogy a csont törékenységét a mennyiségi megfogyás mellett a mikroszerkezetben és a csont rugalmasságában bekövetkező károsodások is jelentősen befolyásolják. Eredményeink szerint a perifériás osteoporosisos csonttörések előfordulásában az ultrahang sebesség (SOS) csökkenése a densitástól független tény...
