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Csaba András Dézsi

Csaba András Dézsi
1.Petz A University Teaching Hospital 2.Széchenyi István University · 1./Department of Cardiology 2./ Faculty of Health and Sport Sciences

Professor

About

57
Publications
11,244
Reads
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879
Citations
Citations since 2016
38 Research Items
847 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Additional affiliations
January 2002 - present
Széchenyi István University, Győr, Hungary
Position
  • Professor (Full)
October 1987 - April 2016
Aladar Petz County Teaching Hospital
Position
  • Head of Department
Education
May 2003 - May 2009
Semmelweis University
Field of study
  • Cardiology. Pacemaker Therapy

Publications

Publications (57)
Article
Full-text available
Introduction: Our objective was to determine the effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in a broad range of patient profiles, including subgroups with varying hypertension severity, age and cardiovascular risk profiles. Methods: Patient data from four large prospective observational studies (FORTISSIMO,...
Article
Full-text available
Összefoglaló. Bevezetés: A szociális szférában dolgozók túlterheltsége jelentős, és munkakörülményeik többnyire kedvezőtlenek. Bizonyított, hogy az életcélok meghatározzák a karrier, az egészségtudatosság és az életminőség területeit, de ez utóbbi a szociális dolgozók mintáján még nem került bizonyításra. Célkitűzés: A kutatás célja, hogy bemutassa...
Article
Full-text available
IntroductionTo assess real-life effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in patients with hypertension (HT) and type 2 diabetes mellitus (T2DM), obesity and/or metabolic syndrome (MetS).Methods This post hoc analysis pooled raw data from four large observational studies (FORTISSIMO, FORSAGE, ACES, PICASSO)....
Article
Full-text available
Introduction Atrial fibrillation (AF) is associated with a higher risk of mortality; however, detailed analysis on the excess risk of death of patients diagnosed with AF compared to a non-AF population has not been carried out. Material and methods In our nationwide study, all AF patients were included if the I48 ICD-code was recorded twice in the...
Article
Full-text available
This paper ana­lyses the im­pacts of the glob­ally dis­rupt­ive COVID-19 pan­demic, and local re­sponses to the above chal­lenges, more spe­cific­ally, the op­er­a­tion of ser­vices under the state of emer­gency through the ex­ample of Győr. With the out­break of the pan­demic, state and mu­ni­cipal stake­hold­ers re­spons­ible for pub­lic ser­vice...
Article
Aims: The value of platelet function testing (PFT) in predicting clinical outcomes and guiding P2Y12-inhibitor treatment is uncertain. In a pre-specified sub-study of the TROPICAL-ACS trial, we assessed ischaemic and bleeding risks according to high platelet reactivity (HPR) and low platelet reactivity (LPR) to ADP in patients receiving uniform pr...
Article
Introduction Hypertension and hypercholesterolaemia are important contributors to the development and progression of atherosclerosis. The coexistence of these two conditions is rather common: hypercholesterolaemia is present in 40–60% of hypertensive patients. Remarkably, patient compliance with antihypertensive regimens is better than with statin...
Article
Full-text available
The European Union (EU) law harmonization expects from each EU country to apply the same principles and same standards of the medical evaluation of driving licenses. All EU member states have to apply common evaluations of the driving licenses – based on the EU Regulation 2016/1006 – at the latest from January of this year. Hungary launched this ne...
Article
Background: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). Materials and methods: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2...
Article
Full-text available
Background: Transradial primary PCI has been shown to cut mortality risk and is gaining popularity worldwide. To reflect this change in practice, a new risk model including access site has been developed for predicting 30-day mortality. Though the ALPHA (Age, Life support, Pressure, Heart rate, Access site; https://alphascore.org) model underwent i...
Article
Full-text available
The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development. Recent studies have indicated the role of these chemokines also in cardiovascular diseases. We aimed to present current knowledge regarding the role of CXCR3-binding chemokine...
Article
Introduction: In everyday medical practice, physicians often need to manage patients whose blood pressure is not well controlled. Those with a history of cerebrovascular disease are a high-risk group in need of rapid blood pressure control. Methods: The PICASSO study was a real-life, observational trial involving 9257 inadequately treated hypert...
Article
Full-text available
Background In patients with stable coronary artery disease, aspirin, a statin, and an angiotensin-converting enzyme inhibitor are recommended as first-line agents for secondary prevention. Subgroup analyses of the previously published Hungarian Perindopril plus Amlodipine in PAtients with Coronary Artery Disease (PAPA-CAD) non-interventional trial...
Article
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Aims: To develop a simplified model of FFR calculation (FFRsim) deriving from 3-dimensional (3D) coronary angiographic data and classic fluid dynamic equations without using finite element analysis. Methods and results: Intracoronary pressure measurements were performed by pressure wire sensors. Lumens of the interrogated vessel segments were re...
Article
Evidence is conflicting regarding the clinical benefits of selecting P2Y12-inhibitors based on platelet function testing (PFT). Between March 1, 2013 and March 1, 2014, we collected clinical characteristics and platelet function data in a nation-wide acute myocardial infarction (AMI) registry from 15 interventional cardiology centers in Hungary. Th...
Article
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The perioperative management of patients treated with antithrombotic medications who undergo surgical procedures represents a common clinical problem. Dental interventions are usually associated with a low risk of bleeding; however, the dental implications of new antithrombotic agents are not yet fully understood. The present review is based on the...
Article
Background Current guidelines recommend potent platelet inhibition with prasugrel or ticagrelor for 12 months after an acute coronary syndrome managed with percutaneous coronary intervention (PCI). However, the greatest anti-ischaemic benefit of potent antiplatelet drugs over the less potent clopidogrel occurs early, while most excess bleeding eve...
Article
Full-text available
Introduction: The etiology of essential hypertension is multifactorial. Therefore, treatment with combinations of antihypertensive agents acting on multiple targets is necessary for successful therapy in the majority of patients. According to the experience and clinical data accumulated so far, combination therapy with three agents from different...
Article
Full-text available
The role of beta-adrenoceptor antagonists (beta-blockers) in cardiovascular therapy has been subject to diverse trends and changes over the decades. With the advent of a wide variety of excellent drugs for the treatment of antihypertension, beta-blockers have been relegated from the first-line treatment of essential hypertension. However, they rema...
Article
Coronary artery disease coexists in a clinically relevant number of patients with atrial fibrillation and it often requires percutaneous coronary intervention. These patients represent a particular challenge for clinicians in terms of antithrombotic management. They require combined antiplatelet–anticoagulant therapy to reduce the risk of recurrent...
Article
Full-text available
Acute ischemic events occur most frequently at dawn and in the early hours of the morning. The development of these severe clinical events exhibits a temporal relationship with changes in various hemodynamic, prothrombotic, and hormonal processes. The authors highlight not only these relationships but also the potential protective effect of increas...
Article
Introduction: Long-term therapy with a combination of perindopril and amlodipine has shown a beneficial effect on the morbidity and mortality of patients with stable coronary artery disease (SCAD) and hypertension. On the basis of the antiproliferative, antithrombotic, and antiatherogenic effects of the active substances, we initiated data collect...
Article
Full-text available
The average wall shear stress (WSS) is in 1 Pa range in coronary arteries, while the stretching effect of an implanted coronary stent can generate up to 3 × 10⁵ times higher circumferential stress in the vessel wall. It is widely accepted that WSS plays a critical role in the development of restenosis after coronary stent implantation, but relevant...
Article
Background More than 50 % of hypertensive patients have lipid disorders, and one-third of hypertensive patients have impaired glucose metabolism. Owing to the high prevalence of metabolic risk factors and/or comorbidities, antihypertensives with favorable or neutral metabolic effects are preferred. Based on the available evidence, diuretics and β-b...
Article
Full-text available
The renin-angiotensin-aldosterone system plays an important role in the pathophysiology of hypertension and is closely related with cardio- and cerebrovascular events and chronic kidney diseases. Each angiotensin receptor blocker (ARB) is important in the treatment of hypertension, according to the results of recent years. This is a practical revie...
Article
Full-text available
Outcomes of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y12 receptor inhibitors like prasugrel. While most of the ischaemic risk reduction for prasugrel versus clopidogrel was demonstrated in the early treatment period, the risk of bleeding beca...
Conference Paper
Background: High platelet reactivity (HPR) is an acknowledged risk factor among patients with myocardial infarction (MI). However, due to the futility of multiple prior studies platelet function testing (PFT)-based treatment modification is not recommended. In Hungary, prasugrel is only reimbursed in patients with HPR, and therefore, the Multiplate...
Article
Full-text available
To study the effects of various parameters on local hemostasis after dental extraction in patients receiving different combinations of medications who had previously confirmed effective dual inhibition of platelet aggregation. A total of 129 patients were enrolled. They underwent acute or planned percutaneous coronary intervention and their stomato...
Article
Purpose We studied the effects of various parameters on local hemostasis following dental extraction in patients receiving different combinations of medications, in whom we had previously confirmed the effective dual inhibition of platelet aggregation. Methods A total of 129 patients were enrolled. They underwent acute or planned percutaneous coro...
Article
Full-text available
The choice of treatment of patients with hypertension should not be based solely on the blood pressure value, because the risk of cardiovascular diseases are influenced by the presence and magnitude of other risk factors, too. The presence of a metabolic disease (diabetes mellitus, metabolic syndrome) itself categorizes the patient as a high risk i...
Article
Full-text available
All of the following traditional agents for the management of stable angina pectoris include the symptomatic treatment with heart rate-lowering agents such as [beta]-blockers or non-dihydropyridine Ca-channel blockers, or ivabradine-the first selective sinus node If channel inhibitor-vasodilatators and preventive use of angiotensin-converting enzym...
Article
Full-text available
Angiotensin II receptor blockers (ARBs) are one of the most frequently used antihypertensive drugs with good tolerability and are indicated for treatment of many cardiovascular morbidity. Findings from clinical studies conducted in the past decade, suggest a possible relationship between some ARB-active substances, and certain malignancies cannot b...
Article
Full-text available
Diabetes mellitus as comorbidity is present in 20-25% of patients suffering from high blood pressure. Because simultaneous presence of these two diseases results in a significant increase of cardiovascular risk, various guidelines focus greatly on the anti-hyperintensive treatment of patients with diabetes. Combined drug therapy is usually required...
Article
Full-text available
Aims: Renal denervation using the point-by-point application of radiofrequency (RF) energy delivered by the firstgeneration Symplicity system is effective in lowering office blood pressure however it is time-consuming. The Vessix Renal Denervation System with eight balloon-mounted bipolar electrodes shortens and simplifies the procedure. This has b...
Article
Full-text available
In the past two decades the number of diabetic patients has increased dramatically. According to the data of the International Diabetes Federation published in 2012, more than 371 million people suffer from diabetes mellitus, which is responsible for the death of 4.8 million people yearly. Diabetic nephropathy is the most frequent cause of terminal...
Article
Full-text available
The renin-angiotensin-aldosterone system plays a major role in the pathophysiology of hypertension and closely related cardio- and cerebrovascular events. Although both angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagonists (angiotensin receptor blockers; ARBs) are equally important in the treatment of hypertension, acc...
Article
Full-text available
The authors present a case of a 29-year-old woman who was diagnosed with pneumonia in the left side complicated with pleural effusion and hemorrhagic pericarditis one month after she had undergone tonsillectomy. Eikenella corrodens was identified as pathogenic agent when the empyema was removed during thoracotomy. After the patient was given antibi...
Article
Full-text available
Radiofrequency catheter ablation or modification of the atrio-ventricular junction is an effective therapy of drug refractory supraventricular tachyarrhythmias (ST). Higher endothelin (ET) levels were observed during nonsustained STs. We aimed to examine the effect of sustained STs and the applied rate-control therapy on plasma ET levels. Twenty-tw...
Article
Endothelin-1 (ET-1) is a potent endogenous arrhythmogenic substance. The aim of our study was to investigate the changes of serum ET-1 and big-endothelin levels in patients suffering from spontaneous, incessant ventricular tachyarrhythmias. The 11 consecutive patients' (mean age, 59 +/- 11 years) underlying diseases were ischemic heart disease, val...

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