Cristina Sanchez de la Rosa

Cristina Sanchez de la Rosa
The University of Queensland | UQ · Institute for Molecular Bioscience

BSc Biotechnology

About

Additional affiliations
July 2017 - present
The University of Queensland
Position
  • PhD Student
Description
  • Oxytocin Receptor in Breast Cancer
October 2016 - May 2017
University of Birmingham
Position
  • Biomedical Intern
Description
  • Regulation of DNA replication and damage in X.laevis egg extract
July 2015 - July 2016
Universidad de Cádiz
Position
  • Collaborating Student
Description
  • Co-analysis of Δ6 FAD and Elovl 5 activities through heterologous expression in INVSc1 yeast

Projects

Project (1)
Project
Peptides are key mediators in many biological functions, interacting with target proteins in a potent and highly selective way. Nonapeptide oxytocin (OT) signals through its G protein-coupled membrane receptor OTR, which has multiple downstream signalling pathways. OTR has recently been identified to modulate breast cancer growth, although the exact mechanism that needs to be intercepted to block tumour growth has not been determined yet. This project focuses on the identification of this pathway through the chemical synthesis of the OT ligands, their pharmacological characterisation, analysis of the signalling pathways, and evaluation of leads in relevant breast cancer models.