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Cristina Sanchez Castañeda

Cristina Sanchez Castañeda
University of Barcelona and Bellvitge University Hospital

PhD

About

32
Publications
4,919
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Citations
Introduction
My research line has focuses on identifying MRI markers of cerebral dysfunction or damage related to cognitive and behavioral impairment in Movement Disorders: Huntington's and Parkinson's disease patients. A second research line focuses on the neural circuits underlying children obesity. Methods used: Neuropsychological assessment and multimodal MRI assessment.
Additional affiliations
October 2014 - September 2016
University of Barcelona
Position
  • PostDoc Position
January 2010 - September 2014
Foundation Santa Lucia
Position
  • PostDoc Position
January 2007 - July 2007
University College London
Position
  • visiting PhD researcher

Publications

Publications (32)
Article
Full-text available
Background: Individuals with obesity are known to present cognitive deficits, especially in executive functions. Executive functions play an important role in health and success throughout the whole life and have been related to food decision-making and to the ability to maintain energy balance. It is possible to improve executive functions through...
Article
Computerised cognitive training (CCT) has been applied to improve cognitive function in pathological conditions and in healthy populations. Studies suggest that CCT produces near-transfer effects to cognitive functions, with less evidence for far-transfer. Newer applications of CTT in adults seem to produce certain far-transfer effects by influenci...
Article
Full-text available
Human brain-aging is a complex, multidimensional phenomenon. Knowledge of the numerous aspects that revolve around it is therefore essential if not only the medical issues, but also the social, psychological, and legal issues related to this phenomenon are to be managed correctly. In the coming decades, it will be necessary to find solutions to the...
Article
Full-text available
La obesidad se ha relacionado con cambios estructurales en los ganglios basales y alteraciones en dominios transversales como la velocidad de procesamiento. El objetivo del presente estudio es investigar la relación entre velocidad de procesamiento y volumen de los ganglios basales en adolescentes con y sin obesidad. Treinta y tres participantes ob...
Article
Aims: To analyze brain functional connectivity in the somatomotor and default-mode networks (DMNs) of patients with Huntington disease (HD), its relationship with gray matter (GM) volume loss, and functional changes after pridopidine treatment. Methods: Ten patients and ten untreated controls underwent T1-weighted imaging and resting-state funct...
Article
Background The spatial pattern of atrophy of a disease is related to its functional connectivity structure, mapped by resting-state functional magnetic resonance imaging (fMRI). Increased somatomotor and default mode resting-state networks play key roles in Huntington’s disease pathophysiology. Objectives To analyse brain functional connectivity i...
Article
Full-text available
Background: The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative di...
Article
Full-text available
White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weight...
Article
Background There is neuropathological evidence of iron accumulation in basal ganglia associated with the striatal volume loss in Huntington disease (HD). T2*-weighted imaging is a useful measure to study iron distribution in the brain since magnetic susceptibility maps correlate with chemically-determined iron concentration. Increased iron levels i...
Article
Background The spatial pattern of atrophy of a disease is related to its functional connectivity structure, mapped by resting-state fMRI. In Huntington disease (HD), the striatum is the most vulnerable brain structure, linked to specific frontal areas and thalamus by five parallel frontal-subcortical circuits. Motor (MN) and Default Mode (DMN) rest...
Article
In Huntington's disease, iron accumulation in basal ganglia accompanies neuronal loss. However, if iron content changes with disease progression and how it relates to gray matter atrophy is not clear yet. We explored iron content in basal ganglia and cortex and its relationship with gray matter volume in 77 mutation carriers [19 presymptomatic, 8 w...
Article
Increased iron in subcortical gray matter (GM) structures of patients with Huntington's disease (HD) has been suggested as a causal factor in neuronal degeneration. But how iron content is related to white matter (WM) changes in HD is still unknown. For example, it is not clear whether WM changes share the same physiopathology (i.e. iron accumulati...
Article
Full-text available
Huntington's disease (HD) is characterized by progressive motor impairment. Therefore, the connectivity of the corticospinal tract (CST), which is the main white matter (WM) pathway that conducts motor impulses from the primary motor cortex to the spinal cord, merits particular attention. WM abnormalities have already been shown in presymptomatic (...
Article
Full-text available
White matter abnormalities have been shown in presymptomatic and symptomatic Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) methods. The largest white matter tract, the corpus callosum (CC), has been shown to be particularly vulnerable; however, little work has been done to investigate t...
Article
Neurodegeneration of the striatum in Huntington disease (HD) is characterized by loss of medium-spiny neurons, huntingtin nuclear inclusions, reactive gliosis, and iron accumulation. Neuroimaging allows in vivo detection of the macro- and micro-structural changes that occur from presymptomatic stages of the disease (preHD). The aim of our study was...
Article
Visual agnosia is a deficit in shape perception, affecting figure, object, face and letter recognition. Agnosia is usually attributed to lesions to high-order modules of the visual system, which combine visual cues to represent the shape of objects. However, most of previously reported agnosia cases presented visual field defects and poor primary v...
Article
Full-text available
In Huntington's disease, iron accumulation in basal ganglia accompanies neuronal loss. However , if iron content changes with disease progression and how it relates to gray matter atrophy is not clear yet. We explored iron content in basal ganglia and cortex and its relationship with gray matter volume in 77 mutation carriers [19 presymptomatic, 8...
Conference Paper
Background In normal condition, the concentration of iron in various region of the brain varies greatly. There is a progressive iron accumulation during the brain development (Zecca et al, 2004), with iron concentration increases in the brain until age 40 (Thomas and Jankovic 2004). The iron brain delivery is critical for its effects on fibre myeli...
Article
Background Recent diffusion tensor imaging (DTI) studies suggest that abnormalities in Huntington's disease (HD) extend to white matter (WM) tracts in early HD and even in presymptomatic (PreHD) stages. However, DTI tractography, which allows precise localisation of WM abnormalities has not yet been used to investigate changes associated with HD. A...
Article
Background It has been hypothesised that changes in iron content in the brain may be involved in the pathogenesis of Huntington Disease (HD).1–5 T*2-weighted imaging may be a useful measure to study iron distribution in the brain since a strong linear correlation between chemically determined iron concentration and magnetic susceptibility has been...
Article
Full-text available
Recent magnetic resonance imaging (MRI) studies suggest that abnormalities in Huntington's disease (HD) extend to white matter (WM) tracts in early HD and even in presymptomatic stages. Thus, changes of the corpus callosum (CC) may reflect various aspects of HD pathogenesis. We recruited 17 HD patients, 17 pre-HD subjects, and 34 healthy age-matche...
Article
Background Neuroimaging studies showed impairment of the basal ganglia and thalamus in preclinical stages of Huntington's disease (HD) characterised by progressive volume loss, microstructural impairment and microglial activation. Therefore, biomarkers sensitive to all of these changes are needed. Aims We assessed the multimodal MRI as biomarker of...
Article
Full-text available
Visual Hallucinations (VH) are among the core features of Dementia with Lewy Bodies (DLB), but are also very frequent in demented patients with Parkinson's Disease (PDD). The purpose of this study was to investigate the pattern of gray matter and cognitive impairment underlying VH in DLB and PDD. We applied voxel-based morphometry and behavioral as...
Article
There is controversy regarding whether Dementia with Lewy Bodies (DLB) and Parkinson's disease with dementia (PDD) may or not be different manifestations of the same disorder. The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB a...
Article
Full-text available
Vanishing white matter disease (VWM, OMIM #306896) is an autosomal recessive leukoencephalopathy typically of childhood onset. Patients usually present with progressive cerebellar ataxia and spasticity. MRI shows a diffuse leukoencephalopathy. Part of the abnormal cerebral white matter has the signal intensity of CSF on all pulse sequences, reflect...
Article
Full-text available
The striatum is considered to mediate some forms of procedural learning. Complex dynamic control (CDC) tasks involve an individual having to make a series of sequential decisions to achieve a specific outcome (e.g. learning to operate and control a car), and they involve procedural learning. The aim of this study was to test the hypothesis that pat...
Article
Studies on dementia subtypes show a wide variation in the prevalence of Alzheimer's disease (AD) and vascular dementia (VD) worldwide. However, studies reporting on Lewy body dementia (LBD) and frontotemporal dementia (FTD) are sparse. To describe the prevalence of dementia and subtypes. A 34% sample of 5,150 subjects aged 70 years and over in El P...

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Projects

Projects (4)
Project
To evaluate how an intensive executive functions (EEFF) training program can modify eating habits in children with obesity, and how these changes are reflecting neural changes or plasticity by MRI connectivity.
Project
To identify MRI markers of cerebral dysfunction and/or damage related to cognitive and behavioral impairment in Huntington's disease patients